SPACA4 Gene
protein-coding GIFtS: 39
GCID: GC19P049110
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sperm acrosome associated 4
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Aliases
for SPACA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Acrosome Associated 41 2 | | SAMP141 2 3 5 | | Sperm Acrosomal Membrane-Associated Protein 142 3 | | Sperm Acrosomal Membrane Protein 142 | | Sperm Acrosome Membrane-Associated Protein 42 |
Export aliases for SPACA4 gene to outside databasesPrevious GC identifers: GC00U991082 GC19M049478 GC19P053786 GC19P053801 GC19P045489 |
Summaries
for SPACA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SACA4_HUMAN, Q8TDM5Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion duringfertilization
|
Genomic Views
for SPACA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPACA4 gene promoter:
AML1a p53 LUN-1 AP-4 Nkx5-1 RORalpha1 PPAR-alpha CP2 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPACA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q14SPACA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P049110: view genomic region
(about GC identifiers)
Start:
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49,110,000 bp from pter |
End:
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49,110,971 bp from pter |
Size:
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972 bases |
Orientation:
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plus strand |
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Proteins
for SPACA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SACA4_HUMAN, Q8TDM5 (See
protein sequence)Recommended Name: Sperm acrosome membrane-associated protein 4 precursor Size: 124 amino acids; 13004 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome.Note=Expressed in acrosomal matrix and outer and inner acrosomal membranesExplore the universe of human proteins at neXtProt for SPACA4: NX_Q8TDM5
SPACA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_598005.1
ENSEMBL proteins: ENSP00000312774
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SPACA4 for ontologies About GeneDecksing
SPACA4 Antibody Products:
Assay Products for SPACA4: |
Protein
Domains /
Families
for SPACA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPACA4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TDM5ProtoNet protein and cluster: Q8TDM5 1 Blocks protein family: IPB001526 CD59 antigen
UniProtKB/Swiss-Prot: SACA4_HUMAN, Q8TDM5Similarity: Contains 1 UPAR/Ly6 domain |
Function
for SPACA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SACA4_HUMAN, Q8TDM5Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion duringfertilization
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPACA4 (NM_133498) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPACA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA4 |
Animal Models:
Mouse knock-out Spaca4tm1Lex for SPACA4
1 MGI phenotypic allele  for Spaca4 (no phenotypes)
SPACA4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPACA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPACA4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
SPACA4 for ontologies About GeneDecksing
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Drugs & Compounds
for SPACA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPACA4
Search CenterWatch for drugs/clinical trials and news about SPACA4 / SACA4
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Transcripts
for SPACA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPACA4 gene: NM_133498.2 Unigene Cluster for SPACA4: Sperm acrosome associated 4 Hs.122599 [show with all ESTs]Unigene Representative Sequence: BC0473341 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000321762(uc002pjo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPACA4 (NM_133498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPACA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA4 |
Additional cDNA sequence: AF353721.2 AY358387.1 BC047334.1 2 DOTS entries: DT.409957 DT.75102004 2 AceView cDNA sequences: AF353721 AY358387
GeneLoc Exon Structure
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Expression
for SPACA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPACA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATATGGTA
About this image
See SPACA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPACA4
SOURCE GeneReport for Unigene cluster: Hs.122599
UniProtKB/Swiss-Prot: SACA4_HUMAN, Q8TDM5Tissue specificity: Testis specific. Expressed in spermatozoa
SABiosciences Custom PCR Arrays for SPACA4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPACA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA4 |
Orthologs
for SPACA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPACA4 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for SPACA4 (if available)
TreeFam Gene Tree for SPACA4 (if available) |
Paralogs
for SPACA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPACA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPACA4
1 CNV: 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA4 |
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Disorders
/ Diseases
for SPACA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SPACA4 for disorders About MalaCards
SPACA4 for disorders About GeneDecksing
OMIM gene information: 609932
OMIM disorders: --
Export disorders for SPACA4 gene to outside databases
|
Publications
for SPACA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPACA4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPACA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase- type plasminogen activator receptor superfamily with a role in sperm- egg interaction. (PubMed id 12788941)1, 2, 9 Shetty J.... Herr J.C. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPACA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPACA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPACA4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPACA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPACA4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPACA4 gene:
Search GeneIP for patents involving SPACA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPACA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPACA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPACA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA4 | | | OriGene Protein Over-expression Lysate for SPACA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPACA4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPACA4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPACA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPACA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA4 |
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| | | | Search Tocris compounds for SPACA4 |
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 | | | SPACA4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for SPACA4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA4 |
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