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Aliases for SPACA4 Gene

Aliases for SPACA4 Gene

  • Sperm Acrosome Associated 4 2 3 5
  • Sperm Acrosomal Membrane-Associated Protein 14 3 4
  • SAMP14 3 4
  • Sperm Acrosomal Membrane Protein 14 3
  • Testicular Tissue Protein Li 167 3

External Ids for SPACA4 Gene

Previous GeneCards Identifiers for SPACA4 Gene

  • GC00U991082
  • GC19M049478
  • GC19P053786
  • GC19P053801
  • GC19P049110
  • GC19P045489

Summaries for SPACA4 Gene

GeneCards Summary for SPACA4 Gene

SPACA4 (Sperm Acrosome Associated 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA4 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA4 Gene

Genomics for SPACA4 Gene

Regulatory Elements for SPACA4 Gene

Genomic Location for SPACA4 Gene

Chromosome:
19
Start:
48,606,743 bp from pter
End:
48,607,714 bp from pter
Size:
972 bases
Orientation:
Plus strand

Genomic View for SPACA4 Gene

Genes around SPACA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA4 Gene

Proteins for SPACA4 Gene

  • Protein details for SPACA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDM5-SACA4_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 4
    Protein Accession:
    Q8TDM5

    Protein attributes for SPACA4 Gene

    Size:
    124 amino acids
    Molecular mass:
    13004 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA4 Gene

Proteomics data for SPACA4 Gene at MOPED

Post-translational modifications for SPACA4 Gene

No Post-translational modifications

Other Protein References for SPACA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA4 Gene

Domains & Families for SPACA4 Gene

Gene Families for SPACA4 Gene

Protein Domains for SPACA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPACA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDM5

UniProtKB/Swiss-Prot:

SACA4_HUMAN :
  • Contains 1 UPAR/Ly6 domain.
Domain:
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with SPACA4: view

Function for SPACA4 Gene

Molecular function for SPACA4 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

Phenotypes for SPACA4 Gene

GenomeRNAi human phenotypes for SPACA4:
genes like me logo Genes that share phenotypes with SPACA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA4 Gene

Localization for SPACA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA4 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPACA4 Gene COMPARTMENTS Subcellular localization image for SPACA4 gene
Compartment Confidence
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SPACA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA4: view

Pathways & Interactions for SPACA4 Gene

SuperPathways for SPACA4 Gene

No Data Available

Interacting Proteins for SPACA4 Gene

Gene Ontology (GO) - Biological Process for SPACA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA4 Gene

Drugs & Compounds for SPACA4 Gene

No Compound Related Data Available

Transcripts for SPACA4 Gene

mRNA/cDNA for SPACA4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPACA4 Gene

Sperm acrosome associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA4 Gene

No ASD Table

Relevant External Links for SPACA4 Gene

GeneLoc Exon Structure for
SPACA4
ECgene alternative splicing isoforms for
SPACA4

Expression for SPACA4 Gene

mRNA expression in normal human tissues for SPACA4 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA4 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for SPACA4 Gene

This gene is overexpressed in Testis (58.9) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA4 Gene



SOURCE GeneReport for Unigene cluster for SPACA4 Gene Hs.122599

mRNA Expression by UniProt/SwissProt for SPACA4 Gene

Q8TDM5-SACA4_HUMAN
Tissue specificity: Testis specific. Expressed in spermatozoa.
genes like me logo Genes that share expression patterns with SPACA4: view

Protein tissue co-expression partners for SPACA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPACA4 Gene

Orthologs for SPACA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPACA4 35
  • 83.5 (n)
  • 80.2 (a)
SPACA4 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPACA4 35
  • 79.92 (n)
  • 80.68 (a)
SPACA4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spaca4 35
  • 74.86 (n)
  • 68.85 (a)
Spaca4 16
Spaca4 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPACA4 35
  • 98.66 (n)
  • 100 (a)
SPACA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spaca4 35
  • 74.14 (n)
  • 68.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SPACA4 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPACA4 36
  • 52 (a)
OneToOne
Species with no ortholog for SPACA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA4 Gene

ENSEMBL:
Gene Tree for SPACA4 (if available)
TreeFam:
Gene Tree for SPACA4 (if available)

Paralogs for SPACA4 Gene

No data available for Paralogs for SPACA4 Gene

Variants for SPACA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPACA4 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912228 CNV Loss 21882294

Variation tolerance for SPACA4 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA4 Gene

HapMap Linkage Disequilibrium report
SPACA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPACA4 Gene

Disorders for SPACA4 Gene

Relevant External Links for SPACA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA4

No disorders were found for SPACA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA4 Gene

Publications for SPACA4 Gene

  1. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase- type plasminogen activator receptor superfamily with a role in sperm- egg interaction. (PMID: 12788941) Shetty J. … Herr J.C. (J. Biol. Chem. 2003) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SPACA4 Gene

Sources for SPACA4 Gene

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