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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPACA3 Gene

protein-coding   GIFtS: 49
GCID: GC17P031318

sperm acrosome associated 3
 Explore 1 disease affiliated with
SPACA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPACA3    

Aliases
for SPACA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sperm Acrosome Associated 31 2     Sperm Lysozyme-Like Protein 12 3
LYC31 2 3 5     Sperm Protein Reactive With Antisperm Antibodies2 3
LYZL31 2 3 5     Sperm Protein Reactive With ASA2 3
SLLP11 2 3 5     1700025M08Rik2
CT541 2 3     Lysozyme-Like Sperm-Specific Secretory Protein ALLP172
ALLP171 2 5     Sperm Acrosome Membrane-Associated Protein 32
Cancer/Testis Antigen 542 3     Sperm Lysozyme Like Protein 12
Lysozyme-Like Acrosomal Sperm-Specific Secretory Protein ALLP-172 3     SPRASA3
Lysozyme-Like Protein 32 3     

External Ids:    HGNC: 162601   Entrez Gene: 1249122   Ensembl: ENSG000001413167   OMIM: 6127495   UniProtKB: Q8IXA53   

Export aliases for SPACA3 gene to outside databases

Previous GC identifers: GC00U991055 GC17P031167 GC17P031464 GC17P028342 GC17P027504


Summaries
for SPACA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SACA3_HUMAN, Q8IXA5
Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during
fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is
present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic
activity in vitro

Gene Wiki entry for SPACA3


Genomic Views
for SPACA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPACA3 gene promoter:
         ER-alpha   RFX1   p53   POU6F1 (c2)   AP-4   POU3F2   LCR-F1   HSF2   c-Myb   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPACA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPACA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q12

SPACA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPACA3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P031318:  view genomic region     (about GC identifiers)

Start:
 31,297,394 bp from pter      End:
 31,324,895 bp from pter
Size:
 27,502 bases      Orientation:
 plus strand

Proteins
for SPACA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SACA3_HUMAN, Q8IXA5 (See protein sequence)
Recommended Name: Sperm acrosome membrane-associated protein 3  
Size: 215 amino acids; 23431 Da
Subunit: Interacts with ASTL (By similarity)
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II
membrane protein (Probable). Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial
segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the
acrosome reaction (By similarity)
Subcellular location: Isoform 2: Secreted (Potential)
Caution: Although it belongs to the glycosyl hydrolase 22 family, Thr-122 and Asn-139 are present instead of the
conserved Glu and Asp which are active site residues. It is therefore expected that this protein lacks hydrolase
activity
Secondary accessions: Q7Z4Y5
Alternative splicing: 2 isoforms:  Q8IXA5-1   Q8IXA5-2   

Explore the universe of human proteins at neXtProt for SPACA3: NX_Q8IXA5

Post-translational modifications:

  • The processed form derives from the membrane form by proteolytic processing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IXA5

    • SPACA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_776246.1  
    ENSEMBL proteins: 
     ENSP00000463386   ENSP00000269053   ENSP00000378134  

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    Uscn Proteins for SPACA3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0002080acrosomal membrane IEA--
    GO:0005576extracellular region TAS16150577
    GO:0005764lysosome IDA5154881
    GO:0016021integral to membrane IEA--


    SPACA3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SPACA3

    Protein Domains /
    Families
    for SPACA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPACA3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000974 Glyco_hydro_22_lys
     IPR023346 Lysozyme-like_dom
     IPR001916 Glyco_hydro_22
     IPR019799 Glyco_hydro_22_CS

    Graphical View of Domain Structure for InterPro Entry Q8IXA5

    ProtoNet protein and cluster: Q8IXA5

    1 Blocks protein family: IPB000974 Lysozyme signature

    UniProtKB/Swiss-Prot: SACA3_HUMAN, Q8IXA5
    Similarity: Belongs to the glycosyl hydrolase 22 family


    Function
    for SPACA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SACA3_HUMAN, Q8IXA5
    Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during
    fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is
    present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic
    activity in vitro

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPACA3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SPACA3:
    hsa-miR-873
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SPACA3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003796lysozyme activity IDA5154881
    GO:0005515protein binding IPI19945174
    GO:0051635bacterial cell surface binding TAS16150577


    SPACA3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SPACA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPACA3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPACA3 (Q8IXA53 ENSP000002690534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
    ZP3ENSP000003783264STRING: ENSP00000378326
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009253peptidoglycan catabolic process TAS16150577
    GO:0009615response to virus TAS16150577
    GO:0016998cell wall macromolecule catabolic process TAS16150577
    GO:0035036sperm-egg recognition IEA--
    GO:0042117monocyte activation TAS11591365


    SPACA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPACA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPACA3
    Search CenterWatch for drugs/clinical trials and news about SPACA3 / SACA3 

    Transcripts
    for SPACA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPACA3 gene: 
    NM_173847.3  

    Unigene Cluster for SPACA3:

    Sperm acrosome associated 3
    Hs.434112  [show with all ESTs]
    Unigene Representative Sequence: AY358653
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580599 ENST00000269053(uc002hhs.1) ENST00000394638 ENST00000485015
    ENST00000394637

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: SPACA3
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF216311.1 AY358653.1 BC029867.1 BC100886.2 BC100887.1 

    4 DOTS entries:

    DT.447566  DT.101978614  DT.95151629  DT.100746851 

    16 AceView cDNA sequences:

    BC029867 BF511575 BF059484 BE502170 AI653691 NM_173847 AI190761 BX280724 
    AY358653 AF216311 BI827366 BQ438507 AA398583 AA393240 BI836120 AW002860 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPACA3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6
    SP1:                    -                       -                     
    SP2:                    -     -     -     -     -                     
    SP3:                                                                  
    SP4:                    -     -                                       


    ECgene alternative splicing isoforms for SPACA3

    Expression
    for SPACA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPACA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACAGCAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPACA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPACA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPACA3

    SOURCE GeneReport for Unigene cluster: Hs.434112

    UniProtKB/Swiss-Prot: SACA3_HUMAN, Q8IXA5
    Tissue specificity: The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and
    placenta

        SABiosciences Expression via Pathway-Focused PCR Array including SPACA3: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SPACA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPACA3 gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SPACA36
    		 --
    		 47(a)
    		 1 ↔ 1
    		 GL343252.1(99948-107776)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG84926
    CG111596
    (see all 13)    		 --
    		 4(a)
    33(a)
    (see all 13)    		 many ↔ many
    many ↔ many
    (see all 13)    		 3L(7720904-7725087)
    2R(16543261-16544114)


    ENSEMBL Gene Tree for SPACA3 (if available)
    TreeFam Gene Tree for SPACA3 (if available) 

    Paralogs
    for SPACA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPACA3 gene
    LYZL42  SPACA5B2  LALBA2  SPACA52  LYZL62  LYZ2  LYZL22  LYZL12  
    8 SIMAP similar genes for SPACA3 using alignment to 3 protein entries:     SACA3_HUMAN (see all proteins):
    SPACA5    SPACA5B    LYZ    LYZL2    LYZL1    LYZL4
    LALBA    LYZL6

    SPACA3 for paralogs           About GeneDecksing



    Genomic Variants
    for SPACA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/288 NCBI SNPs in SPACA3 are shown (see all 288)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1380819541,2
    		--31316909(+) TCATGA/CCACTT 1 -- us2k10--------
    rs560525191,2
    		C--31316972(+) AAAAAA/-GAAAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs2016584891,2
    		--31316977(+) AAAAA-/CAAAAA 1 -- us2k10--------
    rs1825373011,2
    		--31317032(+) TGAATA/GAGCTC 1 -- us2k10--------
    rs1131649701,2
    		--31317093(+) CATATC/TAAATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1436431591,2
    		--31317130(+) AAGTGC/TTCTTA 1 -- us2k10--------
    rs1879001821,2
    		--31317188(+) CATCCC/TTCAAT 1 -- us2k10--------
    rs1923551201,2
    		--31317247(+) GGTGCA/TACCAG 1 -- us2k10--------
    rs1481220331,2
    		--31317320(+) TACTAA/TGCACT 1 -- us2k10--------
    rs1834609761,2
    		--31317330(+) TTTGTC/TGCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPACA3 (31297394 - 31324895 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPACA3: --

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    Disorders / Diseases
    for SPACA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPACA3 for disorders           About GeneDecksing

    OMIM gene information: 612749    OMIM disorders: --

    1 disease for SPACA3:    About MalaCards
    infertility


    Export disorders for SPACA3 gene to outside databases

    Publications
    for SPACA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPACA3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SPACA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. (PubMed id 12606493)1, 2, 3, 9 Mandal A.... Herr J.C. (2003)
    2. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PubMed id 16014814)1, 2, 9 Zhang K.... Yu L. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies. (PubMed id 15475442)1, 9 Wang Z....Lim S.H. (2004)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. (PubMed id 19945174)1 Naz R.K. and Dhandapani L. (2010)
    8. Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. (PubMed id 16150577)1 Niyonsaba F. and Ogawa H. (2005)
    9. SPRASA, a novel sperm protein involved in immune-mediated infertility. (PubMed id 14747161)2 Chiu W.W.C.... Chamley L.W. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SPACA3 gene

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    Genome Databases showing SPACA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124912 HGNC: 16260 AceView: SPACA3 Ensembl:ENSG00000141316 euGenes: HUgn124912
    ECgene: SPACA3 H-InvDB: SPACA3

    Other Databases showing SPACA3 gene

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    Specialized Databases showing SPACA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for SPACA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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