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Aliases for SPACA3 Gene

Aliases for SPACA3 Gene

  • Sperm Acrosome Associated 3 2 3 5
  • Cancer/Testis Antigen 54 2 3 4
  • Lysozyme-Like Acrosomal Sperm-Specific Secretory Protein ALLP-17 3 4
  • Sperm Protein Reactive With Antisperm Antibodies 3 4
  • Sperm Lyzozyme-Like Acrosomal Protein 1 2 3
  • Sperm Protein Reactive With ASA 3 4
  • Sperm Lysozyme-Like Protein 1 3 4
  • Lysozyme-Like Protein 3 3 4
  • LYZL3 3 4
  • SLLP1 3 4
  • CT54 3 4
  • LYC3 3 4
  • Lysozyme-Like Sperm-Specific Secretory Protein ALLP17 3
  • Sperm Lysozyme Like Protein 1 3
  • Lysozyme C 3
  • ALLP17 3
  • SPRASA 4
  • LYZC 3

External Ids for SPACA3 Gene

Previous GeneCards Identifiers for SPACA3 Gene

  • GC00U991055
  • GC17P031167
  • GC17P031464
  • GC17P028342
  • GC17P031318
  • GC17P027504

Summaries for SPACA3 Gene

Entrez Gene Summary for SPACA3 Gene

  • The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for SPACA3 Gene

SPACA3 (Sperm Acrosome Associated 3) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

UniProtKB/Swiss-Prot for SPACA3 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

Gene Wiki entry for SPACA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA3 Gene

Genomics for SPACA3 Gene

Regulatory Elements for SPACA3 Gene

Enhancers for SPACA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPACA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPACA3 Gene

Chromosome:
17
Start:
32,970,376 bp from pter
End:
32,997,877 bp from pter
Size:
27,502 bases
Orientation:
Plus strand

Genomic View for SPACA3 Gene

Genes around SPACA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA3 Gene

Proteins for SPACA3 Gene

  • Protein details for SPACA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXA5-SACA3_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 3
    Protein Accession:
    Q8IXA5
    Secondary Accessions:
    • Q7Z4Y5

    Protein attributes for SPACA3 Gene

    Size:
    215 amino acids
    Molecular mass:
    23431 Da
    Quaternary structure:
    • Interacts with ASTL.

    Alternative splice isoforms for SPACA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA3 Gene

Proteomics data for SPACA3 Gene at MOPED

Post-translational modifications for SPACA3 Gene

  • The processed form derives from the membrane form by proteolytic processing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA3 Gene

No data available for DME Specific Peptides for SPACA3 Gene

Domains & Families for SPACA3 Gene

Gene Families for SPACA3 Gene

Protein Domains for SPACA3 Gene

Suggested Antigen Peptide Sequences for SPACA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXA5

UniProtKB/Swiss-Prot:

SACA3_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA3: view

Function for SPACA3 Gene

Molecular function for SPACA3 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
genes like me logo Genes that share phenotypes with SPACA3: view

Animal Model Products

miRNA for SPACA3 Gene

miRTarBase miRNAs that target SPACA3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPACA3 Gene

Localization for SPACA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA3 Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II membrane protein. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPACA3 Gene COMPARTMENTS Subcellular localization image for SPACA3 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SPACA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 5154881
genes like me logo Genes that share ontologies with SPACA3: view

Pathways & Interactions for SPACA3 Gene

SuperPathways for SPACA3 Gene

No Data Available

Interacting Proteins for SPACA3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269053%0d%0a9606.ENSP00000323929%0d%0a9606.ENSP00000378326%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000269053 Q8IXA5-SACA3_HUMAN for SPACA3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SPACA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009566 fertilization IEA --
GO:0009615 response to virus TAS 16150577
GO:0035036 sperm-egg recognition IEA --
GO:0042117 monocyte activation TAS 11591365
GO:0050830 defense response to Gram-positive bacterium TAS 16150577
genes like me logo Genes that share ontologies with SPACA3: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA3 Gene

Drugs & Compounds for SPACA3 Gene

No Compound Related Data Available

Transcripts for SPACA3 Gene

mRNA/cDNA for SPACA3 Gene

Unigene Clusters for SPACA3 Gene

Sperm acrosome associated 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - - - -
SP3:
SP4: - -

Relevant External Links for SPACA3 Gene

GeneLoc Exon Structure for
SPACA3
ECgene alternative splicing isoforms for
SPACA3

Expression for SPACA3 Gene

mRNA expression in normal human tissues for SPACA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPACA3 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for SPACA3 Gene

This gene is overexpressed in Ovary (32.9), Liver, secretome (17.7), Testis (10.1), and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPACA3 Gene



SOURCE GeneReport for Unigene cluster for SPACA3 Gene Hs.434112

mRNA Expression by UniProt/SwissProt for SPACA3 Gene

Q8IXA5-SACA3_HUMAN
Tissue specificity: The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.
genes like me logo Genes that share expression patterns with SPACA3: view

Protein tissue co-expression partners for SPACA3 Gene

- Elite partner

Primer Products

Orthologs for SPACA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPACA3 35
  • 81.6 (n)
  • 76.69 (a)
SPACA3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPACA3 35
  • 83.64 (n)
  • 77.3 (a)
SPACA3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spaca3 35
  • 81.8 (n)
  • 74.23 (a)
Spaca3 16
Spaca3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPACA3 35
  • 99.67 (n)
  • 99 (a)
rat
(Rattus norvegicus)
Mammalia Spaca3 35
  • 81.6 (n)
  • 73.62 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SPACA3 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPACA3 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
ManyToMany
CG16756 36
  • 31 (a)
ManyToMany
CG16799 36
  • 23 (a)
ManyToMany
CG30062 36
  • 29 (a)
ManyToMany
CG7798 36
  • 34 (a)
ManyToMany
CG8492 36
  • 4 (a)
ManyToMany
LysB 36
  • 31 (a)
ManyToMany
LysC 36
  • 31 (a)
ManyToMany
LysD 36
  • 31 (a)
ManyToMany
LysE 36
  • 31 (a)
ManyToMany
LysP 36
  • 31 (a)
ManyToMany
LysS 36
  • 31 (a)
ManyToMany
LysX 36
  • 32 (a)
ManyToMany
Species with no ortholog for SPACA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA3 Gene

ENSEMBL:
Gene Tree for SPACA3 (if available)
TreeFam:
Gene Tree for SPACA3 (if available)

Paralogs for SPACA3 Gene

Paralogs for SPACA3 Gene

(8) SIMAP similar genes for SPACA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPACA3: view

Variants for SPACA3 Gene

Sequence variations from dbSNP and Humsavar for SPACA3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16967845 - 32,995,613(+) CAGCT(A/G)CCTGC reference, missense
rs28963 - 32,995,673(-) AGTCA(C/T)GTAGC reference, missense
rs35420663 - 32,996,881(-) AGCAG(C/T)TGCGT reference, missense
rs28904 -- 32,997,059(-) GGAAT(G/T)GAACA intron-variant
rs28905 -- 32,994,846(-) CTGCC(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA3 Gene

Variant ID Type Subtype PubMed ID
nsv510705 CNV Loss 20534489
nsv833417 CNV Gain 17160897

Variation tolerance for SPACA3 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA3 Gene

Human Gene Mutation Database (HGMD)
SPACA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA3 Gene

Disorders for SPACA3 Gene

Relevant External Links for SPACA3

Genetic Association Database (GAD)
SPACA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA3

No disorders were found for SPACA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA3 Gene

Publications for SPACA3 Gene

  1. SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. (PMID: 12606493) Mandal A. … Herr J.C. (Biol. Reprod. 2003) 2 3 4 23 67
  2. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K. … Yu L. (Biol. Reprod. 2005) 3 23
  3. The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies. (PMID: 15475442) Wang Z. … Lim S.H. (Clin. Cancer Res. 2004) 3 23
  4. The role of SPRASA in female fertility. (PMID: 25038051) Wagner A. … Chamley L.W. (Reprod Sci 2015) 3
  5. Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. (PMID: 26088750) Yousef S. … Atanackovic D. (J Transl Med 2015) 3

Products for SPACA3 Gene

Sources for SPACA3 Gene

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