SPACA1 Gene
protein-coding GIFtS: 43
GCID: GC06P088814
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sperm acrosome associated 1
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Aliases
for SPACA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Acrosome Associated 11 2 | | SAMP321 2 3 5 | | Sperm Acrosomal Membrane-Associated Protein 322 3 | | Sperm Acrosome Membrane-Associated Protein 12 |
Export aliases for SPACA1 gene to outside databasesPrevious GC identifers: GC06P088703 GC06P088753 GC06P085972 |
Summaries
for SPACA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPACA1:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodiesin blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification ofproteins for targeted contraception, are dependent on the identification and characterization of relevant spermantigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore,antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to theacrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesisand in sperm-egg binding and fusion, respectively. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SACA1_HUMAN, Q9HBV2Function: May be involved in sperm-egg fusion
|
Genomic Views
for SPACA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPACA1 gene promoter:
AML1a CUTL1 HNF-3beta POU3F2 C/EBPalpha GATA-1 POU2F1 HSF2 POU2F1a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPACA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15SPACA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P088814: view genomic region
(about GC identifiers)
Start:
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88,757,507 bp from pter |
End:
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88,776,550 bp from pter |
Size:
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19,044 bases |
Orientation:
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plus strand |
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Proteins
for SPACA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SACA1_HUMAN, Q9HBV2 (See
protein sequence)Recommended Name: Sperm acrosome membrane-associated protein 1 precursor Size: 294 amino acids; 32143 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)Explore the universe of human proteins at neXtProt for SPACA1: NX_Q9HBV2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HBV2
SPACA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112222.1
ENSEMBL proteins: ENSP00000237201
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SPACA1 for ontologies About GeneDecksing
SPACA1 Antibody Products:
Assay Products for SPACA1: |
Protein
Domains /
Families
for SPACA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HBV2 |
Function
for SPACA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SACA1_HUMAN, Q9HBV2Function: May be involved in sperm-egg fusion
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SPACA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA1 |
Animal Models:
Mouse knock-out Spaca1tm1.1Osb for SPACA1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Spaca1):
SPACA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPACA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPACA1
|
Drugs & Compounds
for SPACA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPACA1
Search CenterWatch for drugs/clinical trials and news about SPACA1 / SACA1
|
Transcripts
for SPACA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPACA1 gene: NM_030960.2 Unigene Cluster for SPACA1: Sperm acrosome associated 1 Hs.161241 [show with all ESTs]Unigene Representative Sequence: NM_0309603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000237201(uc003pmn.3) ENST00000462690 ENST00000462227
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPACA1 (NM_030960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPACA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA1 |
Additional cDNA sequence: AF203447.1 BC029488.1 2 DOTS entries: DT.40308979 DT.95367449 12 AceView cDNA sequences: BC029488 BX089091 BI463037 AI419884 BI825572 AF203447 BI830813 BI826637 NM_030960 BI829277 AA824354 AI809484
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SPACA1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
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| SP1: | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPACA1
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Expression
for SPACA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPACA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCACACA
About this image
See SPACA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPACA1
SOURCE GeneReport for Unigene cluster: Hs.161241
UniProtKB/Swiss-Prot: SACA1_HUMAN, Q9HBV2Tissue specificity: Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm
SABiosciences Custom PCR Arrays for SPACA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPACA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA1 |
Orthologs
for SPACA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPACA1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for SPACA1 (if available)
TreeFam Gene Tree for SPACA1 (if available) |
Paralogs
for SPACA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPACA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPACA1 (88757507 - 88776550 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPACA1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA1 |
|
Disorders
/ Diseases
for SPACA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPACA1 for disorders About GeneDecksing
OMIM gene information: 612739
OMIM disorders: --
1  disease for SPACA1: About MalaCardsinfertility
Human Genome Epidemiology (HuGE) Navigator: SPACA1 (1 document)
Export disorders for SPACA1 gene to outside databases
|
Publications
for SPACA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPACA1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPACA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane- associated protein. (PubMed id 11870081)1, 2, 9 Hao Z.... Herr J.C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1 Yokoyama K....Hosoya T. (2010)
- Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)1 Vasan R.S....Benjamin E.J. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. (PubMed id 10735589)1 Diekman A.B....Herr J.C. (2000)
- Mammalian sperm acrosome: formation, contents, and function. (PubMed id 10898932)1 Abou-Haila A. and Tulsiani D.R. (2000)
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External Searches for SPACA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPACA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPACA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPACA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPACA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPACA1 gene:
Search GeneIP for patents involving SPACA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPACA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPACA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPACA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA1 | | | OriGene Protein Over-expression Lysate for SPACA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPACA1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPACA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPACA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPACA1 |
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 | | | SPACA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA1 |
|  |  |  | | | | ThermoFisher Antibody for SPACA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA1 |
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