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Aliases for SPACA1 Gene

Aliases for SPACA1 Gene

  • Sperm Acrosome Associated 1 2 3
  • SAMP32 3 4 6
  • Sperm Acrosomal Membrane-Associated Protein 32 3 4
  • Sperm Acrosome Membrane-Associated Protein 1 3

External Ids for SPACA1 Gene

Previous GeneCards Identifiers for SPACA1 Gene

  • GC06P088703
  • GC06P088753
  • GC06P088814
  • GC06P085972
  • GC06P088757

Summaries for SPACA1 Gene

Entrez Gene Summary for SPACA1 Gene

  • The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPACA1 Gene

SPACA1 (Sperm Acrosome Associated 1) is a Protein Coding gene. Diseases associated with SPACA1 include infertility.

UniProtKB/Swiss-Prot for SPACA1 Gene

  • May be involved in sperm-egg fusion

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA1 Gene

Genomics for SPACA1 Gene

Regulatory Elements for SPACA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPACA1 Gene

88,047,789 bp from pter
88,066,832 bp from pter
19,044 bases
Plus strand

Genomic View for SPACA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPACA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA1 Gene

Proteins for SPACA1 Gene

  • Protein details for SPACA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome membrane-associated protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SPACA1 Gene

    294 amino acids
    Molecular mass:
    32143 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA1 Gene

Proteomics data for SPACA1 Gene at MOPED

Post-translational modifications for SPACA1 Gene

  • Glycosylation at Asn31
  • Modification sites at PhosphoSitePlus

Other Protein References for SPACA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA1 Gene

Domains for SPACA1 Gene

Protein Domains for SPACA1 Gene


Suggested Antigen Peptide Sequences for SPACA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPACA1 Gene

Function for SPACA1 Gene

Molecular function for SPACA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sperm-egg fusion

Phenotypes for SPACA1 Gene

MGI mutant phenotypes for SPACA1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SPACA1: view

Animal Models for SPACA1 Gene

MGI Knock Outs for SPACA1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPACA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for SPACA1 Gene

Localization for SPACA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SPACA1 Gene COMPARTMENTS Subcellular localization image for SPACA1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPACA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA1: view

Pathways for SPACA1 Gene

SuperPathways for SPACA1 Gene

No Data Available

Interacting Proteins for SPACA1 Gene

Gene Ontology (GO) - Biological Process for SPACA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0007283 spermatogenesis --
genes like me logo Genes that share ontologies with SPACA1: view

No data available for Pathways by source for SPACA1 Gene

Transcripts for SPACA1 Gene

mRNA/cDNA for SPACA1 Gene

(12) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPACA1 Gene

Sperm acrosome associated 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPACA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -

Relevant External Links for SPACA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA1 Gene

mRNA expression in normal human tissues for SPACA1 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA1 Gene

This gene is overexpressed in Testis (52.2).

Protein differential expression in normal tissues for SPACA1 Gene

This gene is overexpressed in Testis (43.2) and Ovary (25.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPACA1 Gene

SOURCE GeneReport for Unigene cluster for SPACA1 Gene Hs.161241

mRNA Expression by UniProt/SwissProt for SPACA1 Gene

Tissue specificity: Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm.
genes like me logo Genes that share expressions with SPACA1: view

Expression partners for SPACA1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPACA1 Gene

Orthologs for SPACA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPACA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPACA1 35
  • 84.12 (n)
  • 76 (a)
  • 73 (a)
(Canis familiaris)
Mammalia SPACA1 35
  • 83.62 (n)
  • 76.45 (a)
  • 75 (a)
(Mus musculus)
Mammalia Spaca1 35
  • 76.56 (n)
  • 70.31 (a)
Spaca1 16
Spaca1 36
  • 68 (a)
(Pan troglodytes)
Mammalia SPACA1 35
  • 98.3 (n)
  • 97.28 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Spaca1 35
  • 78.61 (n)
  • 72.01 (a)
(Monodelphis domestica)
Mammalia SPACA1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia SPACA1 36
  • 54 (a)
(Gallus gallus)
Aves SPACA1 35
  • 63.73 (n)
  • 51.18 (a)
  • 39 (a)
(Anolis carolinensis)
Reptilia SPACA1 36
  • 43 (a)
Species with no ortholog for SPACA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA1 Gene

Gene Tree for SPACA1 (if available)
Gene Tree for SPACA1 (if available)

Paralogs for SPACA1 Gene

No data available for Paralogs for SPACA1 Gene

Variants for SPACA1 Gene

Sequence variations from dbSNP and Humsavar for SPACA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs806423 -- 88,046,038(+) GGATC(C/G)AGGGT upstream-variant-2KB
rs806424 -- 88,046,615(+) GATCA(A/T)ATCTA upstream-variant-2KB
rs806425 -- 88,047,182(+) ATCGA(A/G)TAAGT upstream-variant-2KB
rs806426 -- 88,048,576(+) ATGCC(A/G)ACAAA intron-variant
rs806427 -- 88,051,207(+) ACCAT(G/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA1 Gene

Variant ID Type Subtype PubMed ID
esv2732394 CNV Deletion 23290073

Relevant External Links for SPACA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA1 Gene

Disorders for SPACA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPACA1 Gene in MalaCards »

(1) Diseases for SPACA1 Gene including...

Relevant External Links for SPACA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPACA1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPACA1 Gene

Publications for SPACA1 Gene

  1. SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane- associated protein. (PMID: 11870081) Hao Z. … Herr J.C. (Biol. Reprod. 2002) 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 3 48
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 48

Products for SPACA1 Gene

Sources for SPACA1 Gene

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