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Aliases for SPAAR Gene

Aliases for SPAAR Gene

  • Small Regulatory Polypeptide Of Amino Acid Response 2 3 5
  • Small Regulatory Polypeptide Of Amino Acids Response 2 3
  • Long Intergenic Non-Protein Coding RNA 961 2 3
  • LINC00961 3 4
  • SPAR 3 4

External Ids for SPAAR Gene

Previous HGNC Symbols for SPAAR Gene

  • LINC00961

Summaries for SPAAR Gene

GeneCards Summary for SPAAR Gene

SPAAR (Small Regulatory Polypeptide Of Amino Acid Response) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPAAR Gene

  • Isoform 2: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).

Additional gene information for SPAAR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAAR Gene

Genomics for SPAAR Gene

GeneHancer (GH) Regulatory Elements for SPAAR Gene

Promoters and enhancers for SPAAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035904 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.8 -1.3 -1316 7.4 FOXA2 ZNF48 YY1 ZNF121 FOS DEK SP3 RXRA REST PPARG HRCT1 SPAAR TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09I035913 Enhancer 1.4 Ensembl ENCODE dbSUPER 16.1 +7.8 7759 7.7 HDGF ARNT ARID4B NEUROD1 YBX1 ZBTB7B YY1 ZNF766 ZNF207 MCM3 PIGO ARHGEF39 RGP1 TLN1 ENSG00000231393 GBA2 SPAAR CLTA RECK NDUFA5P4
GH09I035922 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +14.5 14491 3 HDGF FOXA2 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 FOS TMEM8B HINT2 SPAG8 GBA2 SPAAR GC09P035912 PGAM1P2
GH09I035948 Enhancer 0.6 Ensembl ENCODE 15.6 +39.7 39738 1.4 USF1 NR2F2 SPAAR OR2S1P OR2S2 PGAM1P2
GH09I035944 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.4 +36.0 35976 2.1 ARID4B YY1 E2F8 ARID2 ZNF143 RXRA REST MIER2 ZNF518A ZNF592 PGAM1P2 GBA2 OR2S1P SPAAR CCDC107 OR2S2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPAAR on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPAAR Gene

Genomic Locations for SPAAR Gene
chr9:35,909,483-35,937,153
(GRCh38/hg38)
Size:
27,671 bases
Orientation:
Plus strand
chr9:35,909,480-35,911,683
(GRCh37/hg19)

Genomic View for SPAAR Gene

Genes around SPAAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAAR Gene

Proteins for SPAAR Gene

  • Protein details for SPAAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A1B0GVQ0-SPAR_HUMAN
    Recommended name:
    Small regulatory polypeptide of amino acid response
    Protein Accession:
    A0A1B0GVQ0

    Protein attributes for SPAAR Gene

    Size:
    90 amino acids
    Molecular mass:
    9632 Da
    Quaternary structure:
    • Interacts with components of the lysosomal V-ATPase complex (PubMed:28024296). Interacts with ATP6V0A1 (PubMed:28024296). Interacts with ATP6V0A2 (PubMed:28024296).

    Alternative splice isoforms for SPAAR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPAAR Gene

Post-translational modifications for SPAAR Gene

No Post-translational modifications

Other Protein References for SPAAR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPAAR Gene

Domains & Families for SPAAR Gene

Gene Families for SPAAR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPAAR Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPAAR: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPAAR Gene

Function for SPAAR Gene

Molecular function for SPAAR Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).

Phenotypes From GWAS Catalog for SPAAR Gene

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPAAR Gene

Localization for SPAAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAAR Gene

Late endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPAAR gene
Compartment Confidence
lysosome 1

Gene Ontology (GO) - Cellular Components for SPAAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA,IDA 28024296
genes like me logo Genes that share ontologies with SPAAR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPAAR Gene

Pathways & Interactions for SPAAR Gene

SuperPathways for SPAAR Gene

No Data Available

Interacting Proteins for SPAAR Gene

Gene Ontology (GO) - Biological Process for SPAAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043416 regulation of skeletal muscle tissue regeneration ISS --
GO:0071230 cellular response to amino acid stimulus IMP 28024296
GO:1904262 negative regulation of TORC1 signaling IMP 28024296
genes like me logo Genes that share ontologies with SPAAR: view

No data available for Pathways by source and SIGNOR curated interactions for SPAAR Gene

Drugs & Compounds for SPAAR Gene

No Compound Related Data Available

Transcripts for SPAAR Gene

mRNA/cDNA for SPAAR Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPAAR Gene

No ASD Table

Relevant External Links for SPAAR Gene

GeneLoc Exon Structure for
SPAAR
ECgene alternative splicing isoforms for
SPAAR

Expression for SPAAR Gene

NURSA nuclear receptor signaling pathways regulating expression of SPAAR Gene:

SPAAR

mRNA Expression by UniProt/SwissProt for SPAAR Gene:

A0A1B0GVQ0-SPAR_HUMAN
Tissue specificity: Highly expressed in lung, heart and skeletal muscle.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPAAR Gene

Orthologs for SPAAR Gene

Evolution for SPAAR Gene

ENSEMBL:
Gene Tree for SPAAR (if available)
TreeFam:
Gene Tree for SPAAR (if available)

No data available for Orthologs for SPAAR Gene

Paralogs for SPAAR Gene

No data available for Paralogs for SPAAR Gene

Variants for SPAAR Gene

Sequence variations from dbSNP and Humsavar for SPAAR Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000979633 -- 35,909,999(+) C/A/T intron_variant
rs1001431638 -- 35,909,642(+) C/T intron_variant
rs1001578630 -- 35,908,641(+) T/C upstream_transcript_variant
rs1002525562 -- 35,907,585(+) G/A/C upstream_transcript_variant
rs1002631043 -- 35,909,424(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPAAR Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Additional Variant Information for SPAAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPAAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPAAR Gene

Disorders for SPAAR Gene

No disorders were found for SPAAR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPAAR Gene

Publications for SPAAR Gene

  1. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. (PMID: 28024296) Matsumoto A … Pandolfi PP (Nature 2017) 2 3 4 58
  2. LncRNA-encoded peptides: More than translational noise? (PMID: 28290465) Rion N … Rüegg MA (Cell research 2017) 3 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for SPAAR Gene

Sources for SPAAR Gene

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