Aliases for SPAAR Gene
External Ids for SPAAR Gene
Previous HGNC Symbols for SPAAR Gene
GeneCards Summary for SPAAR Gene
SPAAR (Small Regulatory Polypeptide Of Amino Acid Response) is a Protein Coding gene.
UniProtKB/Swiss-Prot for SPAAR Gene
Isoform 2: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).