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Aliases for SPA17 Gene

Aliases for SPA17 Gene

  • Sperm Autoantigenic Protein 17 2 3 4
  • Cancer/Testis Antigen 22 2 3 4
  • Sperm Protein 17 3 4
  • SP17-1 3 4
  • SP17 3 4
  • CT22 3 4
  • Sperm Surface Protein Sp17 3

External Ids for SPA17 Gene

Previous GeneCards Identifiers for SPA17 Gene

  • GC11P126544
  • GC11P126057
  • GC11P124577
  • GC11P124081
  • GC11P124048
  • GC11P120486
  • GC11P124545

Summaries for SPA17 Gene

Entrez Gene Summary for SPA17 Gene

  • This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

GeneCards Summary for SPA17 Gene

SPA17 (Sperm Autoantigenic Protein 17) is a Protein Coding gene. Diseases associated with SPA17 include myeloma and esophageal cancer. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity.

UniProtKB/Swiss-Prot for SPA17 Gene

  • Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).

Gene Wiki entry for SPA17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPA17 Gene

Genomics for SPA17 Gene

Regulatory Elements for SPA17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPA17 Gene

Start:
124,673,798 bp from pter
End:
124,697,518 bp from pter
Size:
23,721 bases
Orientation:
Plus strand

Genomic View for SPA17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPA17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPA17 Gene

Proteins for SPA17 Gene

  • Protein details for SPA17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15506-SP17_HUMAN
    Recommended name:
    Sperm surface protein Sp17
    Protein Accession:
    Q15506
    Secondary Accessions:
    • B2R4F2
    • Q9BXF7

    Protein attributes for SPA17 Gene

    Size:
    151 amino acids
    Molecular mass:
    17406 Da
    Quaternary structure:
    • Homodimer (By similarity). May interact with ROPN1.

neXtProt entry for SPA17 Gene

Proteomics data for SPA17 Gene at MOPED

Post-translational modifications for SPA17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPA17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPA17 Gene

Domains for SPA17 Gene

Protein Domains for SPA17 Gene

Suggested Antigen Peptide Sequences for SPA17 Gene

Graphical View of Domain Structure for InterPro Entry

Q15506

UniProtKB/Swiss-Prot:

SP17_HUMAN :
  • Q15506
Domain:
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with SPA17: view

No data available for Gene Families for SPA17 Gene

Function for SPA17 Gene

Molecular function for SPA17 Gene

UniProtKB/Swiss-Prot Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).

Gene Ontology (GO) - Molecular Function for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15257753
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with SPA17: view

Phenotypes for SPA17 Gene

GenomeRNAi human phenotypes for SPA17:
genes like me logo Genes that share phenotypes with SPA17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPA17 Gene

Localization for SPA17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPA17 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPA17 Gene COMPARTMENTS Subcellular localization image for SPA17 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18421703
GO:0016020 membrane IEA --
GO:0031514 motile cilium IDA 18421703
GO:0035686 sperm fibrous sheath IDA 19604394
GO:0072372 primary cilium IDA 18421703
genes like me logo Genes that share ontologies with SPA17: view

Pathways for SPA17 Gene

SuperPathways for SPA17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement NAS 18421703
GO:0007283 spermatogenesis TAS 8688458
GO:0007338 single fertilization TAS 8688458
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with SPA17: view

No data available for Pathways by source for SPA17 Gene

Compounds for SPA17 Gene

(1) Novoseek inferred chemical compound relationships for SPA17 Gene

Compound -log(P) Hits PubMed IDs
sp(1-7) 99.5 196
genes like me logo Genes that share compounds with SPA17: view

Transcripts for SPA17 Gene

Unigene Clusters for SPA17 Gene

Sperm autoantigenic protein 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPA17

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPA17 Gene

No ASD Table

Relevant External Links for SPA17 Gene

GeneLoc Exon Structure for
SPA17
ECgene alternative splicing isoforms for
SPA17

Expression for SPA17 Gene

mRNA expression in normal human tissues for SPA17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPA17 Gene

This gene is overexpressed in Testis (22.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPA17 Gene

SOURCE GeneReport for Unigene cluster for SPA17 Gene Hs.286233

mRNA Expression by UniProt/SwissProt for SPA17 Gene

Q15506-SP17_HUMAN
Tissue specificity: Testis and sperm specific
genes like me logo Genes that share expressions with SPA17: view

In Situ Assay Products

Orthologs for SPA17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPA17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPA17 35
  • 100 (n)
  • 100 (a)
SPA17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPA17 35
  • 86.07 (n)
  • 78.77 (a)
SPA17 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPA17 35
  • 85.11 (n)
  • 75.33 (a)
SPA17 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spa17 35
  • 81.92 (n)
  • 74.65 (a)
Spa17 16
Spa17 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPA17 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPA17 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spa17 35
  • 82.31 (n)
  • 74.15 (a)
lizard
(Anolis carolinensis)
Reptilia SPA17 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spa17 35
  • 57.04 (n)
  • 50.37 (a)
zebrafish
(Danio rerio)
Actinopterygii spa17 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F39H12.3 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToOne
Species with no ortholog for SPA17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPA17 Gene

ENSEMBL:
Gene Tree for SPA17 (if available)
TreeFam:
Gene Tree for SPA17 (if available)

Paralogs for SPA17 Gene

Pseudogenes.org Pseudogenes for SPA17 Gene

genes like me logo Genes that share paralogs with SPA17: view

No data available for Paralogs for SPA17 Gene

Variants for SPA17 Gene

Sequence variations from dbSNP and Humsavar for SPA17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs483946 -- 124,688,113(-) tccct(C/T)gagca intron-variant
rs590577 -- 124,684,573(+) tactg(C/T)agaga intron-variant
rs681418 -- 124,682,641(-) TGTTC(C/T)ACTTA intron-variant
rs1940180 -- 124,686,112(+) caccc(A/C)aatct intron-variant
rs1954794 -- 124,688,577(+) ACCAA(C/T)TGAAG intron-variant

Relevant External Links for SPA17 Gene

HapMap Linkage Disequilibrium report
SPA17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPA17 Gene

Disorders for SPA17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SPA17 Gene including...

Search for SPA17 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SPA17 Gene

(9) Novoseek inferred disease relationships for SPA17 Gene

Disease -log(P) Hits PubMed IDs
testicular cancer 58 4
ovarian cancer 53.3 11
ovarian carcinoma 48.1 4
myeloma 46.3 1
tumors 24.5 29

Relevant External Links for SPA17

Genetic Association Database (GAD)
SPA17
Human Genome Epidemiology (HuGE) Navigator
SPA17
genes like me logo Genes that share disorders with SPA17: view

No data available for UniProtKB/Swiss-Prot for SPA17 Gene

Publications for SPA17 Gene

  1. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PMID: 8688458) Lea I.A. … O'Rand M.G. (Biochim. Biophys. Acta 1996) 2 3 4 23
  2. Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PMID: 12393185) Buchli R. … Robbins D.L. (Biochim. Biophys. Acta 2002) 3 4 23
  3. A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z. … Lim S.H. (Int. J. Cancer 2007) 3 4 23
  4. Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer. (PMID: 18779750) Chiriva-Internati M. … Kast W.M. (J. Immunother. 2008) 3 23
  5. Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. (PMID: 17230514) Gupta G. … Ralhan R. (Int. J. Cancer 2007) 3 23

Products for SPA17 Gene

Sources for SPA17 Gene

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