Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPA17 Gene

protein-coding   GIFtS: 48
GCID: GC11P124577

sperm autoantigenic protein 17

 Explore 20 diseases affiliated with
SPA17 via our new
 Human Malady Compendium 
Biological research products
for SPA17
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sperm Autoantigenic Protein 171 2 3     Sperm Protein 172 3
CT221 2 3     SP17-12
SP171 2 3     Sperm Surface Protein Sp172
Cancer/Testis Antigen 222 3     Sp17-13

External Ids:    HGNC: 112101   Entrez Gene: 533402   Ensembl: ENSG000000641997   OMIM: 6086215   UniProtKB: Q155063   

Export aliases for SPA17 gene to outside databases

Previous GC identifers: GC11P126544 GC11P126057 GC11P124081 GC11P124048 GC11P120486


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPA17:
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent
protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding
motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion.
The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the
oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune
cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.(provided by RefSeq, Jan
2009)

UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high
affinity. Might function in binding zona pellucida and carbohydrates (By similarity)

Gene Wiki entry for SPA17


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPA17 gene promoter:
         NF-1   GCNF   IRF-1   HNF-4alpha2   NF-AT   Egr-4   HNF-4alpha1   c-Ets-1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPA17 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPA17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPA17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

SPA17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPA17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124577:  view genomic region     (about GC identifiers)

Start:
124,543,694 bp from pter      End:
124,567,414 bp from pter
Size:
23,721 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 (See protein sequence)
Recommended Name: Sperm surface protein Sp17  
Size: 151 amino acids; 17406 Da
Subunit: Homodimer (By similarity). May interact with ROPN1
Subcellular location: Membrane; Peripheral membrane protein (Potential)
Secondary accessions: B2R4F2 Q9BXF7

Explore the universe of human proteins at neXtProt for SPA17: NX_Q15506

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15506

  • SPA17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059121.1  
    ENSEMBL proteins: 
     ENSP00000227135   ENSP00000432305  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SPA17
    OriGene Custom Protein Services for SPA17 
    GenScript Custom Purified and Recombinant Proteins Services for SPA17
    Novus Biologicals SPA17 Proteins
    Novus Biologicals SPA17 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18421703
    GO:0016020membrane IEA--
    GO:0019861flagellum ----
    GO:0031514motile cilium IDA18421703
    GO:0072372primary cilium IDA18421703


    SPA17 for ontologies           About GeneDecksing



    SPA17 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPA17 
    GenScript Custom Superior Antibodies Services for SPA17
    Novus Biologicals SPA17 Antibodies
    Search for Antibodies for SPA17 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for SPA17

    Assay Products for SPA17: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPA17
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPA17 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012105 Sp17
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q15506

    ProtoNet protein and cluster: Q15506

    UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
    Similarity: Contains 1 IQ domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
    Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high
    affinity. Might function in binding zona pellucida and carbohydrates (By similarity)

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPA17
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SPA17:
    hsa-miR-513b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3134 hsa-miR-664 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidSPA17 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPA17 (see all 7)
    OriGene shRNA RFP: SPA17
    OriGene siRNA: SPA17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPA17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPA17

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPA17 (NM_017425)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPA17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPA17 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPA17
    Search LifeMap BioReagents cell lines for SPA17

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPA17

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008603cAMP-dependent protein kinase regulator activity IEA--


    SPA17 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SPA17:
     Decreased telomerase activity 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPA17

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPA17 (Q155063 ENSP000002271354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP3O759693, ENSP000002288504I2D: score=3 STRING: ENSP00000228850
    ROPN1Q9HAT03, ENSP000001841834I2D: score=2 STRING: ENSP00000184183
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539ciliary or flagellar motility IDA18421703
    GO:0007165signal transduction IEA--
    GO:0007283spermatogenesis TAS8688458
    GO:0007338single fertilization TAS8688458
    GO:0007339binding of sperm to zona pellucida IEA--


    SPA17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPA17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPA17
    1 Novoseek chemical compound relationship for SPA17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 99.5 327 14712480 (13), 7578682 (11), 15257753 (10), 12015770 (9) (see all 42)

    Search CenterWatch for drugs/clinical trials and news about SPA17 / SP17 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPA17 gene: 
    NM_017425.3  

    Unigene Cluster for SPA17:

    Sperm autoantigenic protein 17
    Hs.286233  [show with all ESTs]
    Unigene Representative Sequence: AL527801
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227135 ENST00000532692(uc001qap.3) ENST00000529498 ENST00000524614


    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPA17
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SPA17:
    hsa-miR-513b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3134 hsa-miR-664 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidSPA17 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPA17 (see all 7)
    OriGene shRNA RFP: SPA17
    OriGene siRNA: SPA17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPA17
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPA17 (NM_017425)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPA17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPA17 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPA17
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPA17
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPA17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPA17

    Additional cDNA sequence: 

    AF334735.1 AK307271.1 AK311806.1 BC019224.1 BC032457.2 

    4 DOTS entries:

    DT.95265897  DT.100881343  DT.75155024  DT.91918951 

    24/82 AceView cDNA sequences (see all 82):

    BE348235 BM704178 AA122324 AL522317 BU844909 AL522318 AW139711 BM762370 
    AL527802 CR625142 CR602938 BX097241 BI825620 AA620983 AW204599 AW439848 
    AA382958 BC032457 BU729714 BC019224 CB851319 AA122286 BM760669 AA369666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPA17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTTGTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SPA17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See SPA17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPA17

    SOURCE GeneReport for Unigene cluster: Hs.286233

    UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
    Tissue specificity: Testis and sperm specific

        SABiosciences Custom PCR Arrays for SPA17
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPA17
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPA17
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPA17
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPA17
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPA17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPA17 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spa171 , 5 sperm autoantigenic protein 171, 5 81.51(n)1
    73.29(a)1
      9 (20.78 cM)5
    206861  NM_011449.21  NP_035579.11 
     376032955 
    lizard
    (Anolis carolinensis)
    Reptilia SPA176
    --
    49(a)
    1 ↔ 1
    GL343322.1(151436-158084)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1537216
    zgc:153721
    11(a)
    1 ↔ 1
    15(21229119-21249295)


    ENSEMBL Gene Tree for SPA17 (if available)
    TreeFam Gene Tree for SPA17 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPA17 gene

    SPA17 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPA17
    PGOHUM00000238544


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/297 NCBI SNPs in SPA17 are shown (see all 297    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112197541,2
    C,F,H,--120484810(+) CAGGAT/CACGCA 2 -- int110Minor allele frequency- C:0.04NS EA NA WA 1094
    rs744257931,2
    --120484870(+) TGATGG/TAACAA 2 -- int10--------
    rs1129245311,2
    --120484881(+) TAAGAC/TCCAAA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs790693101,2
    C,--120485362(+) CCCTAT/CGCCAC 2 -- int14Minor allele frequency- C:0.19WA CSA 122
    rs118243161,2
    C,F,H,--120485729(+) TGCATG/ATCAGG 2 -- int116Minor allele frequency- A:0.09NS EA NA WA 1996
    rs28493321,2
    H--120485865(-) TCCGCG/TCCCCT 2 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1906489731,2
    C,--120486155(+) GTACTC/TGCCCC 2 -- ut51 int10--------
    rs127870791,2
    H--120486520(+) AATGGT/GTCGAT 2 -- us2k1 int14Minor allele frequency- G:0.00NS EA 420
    rs124170031,2
    C,H--120486736(+) TCCCAA/CCCTGG 2 -- int1 us2k10--------
    rs79441631,2
    C,F,H,--120486801(+) CAGGCC/TAGGTC 2 -- us2k1 int113Minor allele frequency- T:0.09NS EA NA WA CSA 1316

    HapMap Linkage Disequilibrium report for SPA17 (124543694 - 124567414 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SPA17
         3 CNVs: 75835 75834 86063

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPA17
    DNA2.0 Custom Variant and Variant Library Synthesis for SPA17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPA17 for disorders           About GeneDecksing

    OMIM gene information: 608621    OMIM disorders: --

    20 diseases for SPA17:    About MalaCards
    graft versus host disease    oral squamous cell carcinoma    esthesioneuroblastoma    clear cell adenocarcinoma
    squamous cell carcinoma    testicular cancer    epithelial ovarian cancer    ovarian cancer
    multiple myeloma    ovarian carcinoma    rheumatoid arthritis    myeloma
    esophageal cancer    cervical cancer    carcinoma    esophagitis
    cervicitis    arthritis    infertility    adenocarcinoma

    9 Novoseek disease relationships for SPA17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 58 4 18779750 (1), 20485677 (1), 17336323 (1), 12213290 (1)
    ovarian cancer 53.3 13 19102497 (4), 14712480 (2), 19900363 (1), 18779750 (1) (see all 7)
    ovarian carcinoma 48.1 4 12015770 (4)
    myeloma 46.3 1 11222401 (1)
    tumors 24.5 37 14712480 (9), 12015770 (3), 15148930 (2), 17336323 (2) (see all 15)
    graft-versus-host disease 24 2 11477539 (1)
    carcinoma squamous cell 8 4 19685492 (1), 17230514 (1)
    cancer 1.09 5 12213290 (2), 16138340 (1), 16438728 (1)
    metastasis 0 1 16311122 (1)

    Human Genome Epidemiology (HuGE) Navigator: SPA17 (1 document)

    Export disorders for SPA17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPA17 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with SPA17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PubMed id 8688458)1, 2, 3, 9 Lea I.A.... O'Rand M.G. (1996)
    2. Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PubMed id 12393185)1, 2, 9 Buchli R.... Robbins D.L. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Expression of sperm protein 17 (Sp17) in ovarian cancer. (PubMed id 14712480)1, 9 Straughn J.M....Strong T.V. (2004)
    5. Sequence and localization of the mouse sperm autoantigenic protein, Sp17. (PubMed id 7578682)1, 9 Kong M....O'Rand M.G. (1995)
    6. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PubMed id 15257753)1, 9 Lea I.A....O'Rand M.G. (2004)
    7. Characterization of sperm protein 17 in human somatic and neoplastic tissue. (PubMed id 12213290)1, 9 De Jong A....Robbins D. (2002)
    8. Sperm protein 17 is a novel marker for predicting cis platin response in esophageal squamous cancer cell lines. (PubMed id 19685492)1, 9 Kausar T....Ralhan R. (2010)
    9. Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. (PubMed id 17230514)1, 9 Gupta G....Ralhan R. (2007)
    10. Sperm protein 17 is expressed in the sperm fibrous sh eath. (PubMed id 19604394)1, 9 Chiriva-Internati M....Kast W.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53340 HGNC: 11210 AceView: SPA17 Ensembl:ENSG00000064199 euGenes: HUgn53340
    ECgene: SPA17 H-InvDB: SPA17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPA17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPA17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPA17 gene:
    Search GeneIP for patents involving SPA17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SPA17  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPA17   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPA17  
     OriGene Protein Over-expression Lysate for SPA17   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SPA17   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPA17  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPA17   OriGene Custom Protein Services for SPA17  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPA17
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPA17
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPA17
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPA17
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPA17
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPA17
     GenScript Custom Purified and Recombinant Proteins Services for SPA17 GenScript cDNA clones with any tag delivered in your preferred vector for SPA17
     GenScript Custom Assay Services for SPA17 GenScript Custom Superior Antibodies Services for SPA17
     GenScript Custom overexpressing Cell Line Services for SPA17 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPA17 promoter
     Search Chromatin IP Primers for SPA17
     RT2 qPCR Primer Assay in human, mouse, rat SPA17
     GNC Network for SPA17
     SABiosciences Custom PCR Arrays for SPA17
     Search Tocris compounds for SPA17
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPA17 antibodies
     SPA17 proteins
     SPA17 lysates
     Search for Antibodies for SPA17 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPA17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for SPA17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPA17
     SwitchGear 3'UTR luciferase reporter plasmids for SPA17
     SwitchGear Promoter luciferase reporter plasmids for SPA17
     ThermoFisher Antibodies for SPA17
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPA17
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPA17 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4