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SPA17 Gene

protein-coding   GIFtS: 50
GCID: GC11P124545

Sperm Autoantigenic Protein 17

  See SPA17-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Autoantigenic Protein 171 2 3     SP172 3
Cancer/Testis Antigen 221 2 3     SP17-12
Sperm Protein 172 3     Sperm Surface Protein Sp172
CT222 3     Sp17-13

External Ids:    HGNC: 112101   Entrez Gene: 533402   Ensembl: ENSG000000641997   OMIM: 6086215   UniProtKB: Q155063   

Export aliases for SPA17 gene to outside databases

Previous GC identifers: GC11P126544 GC11P126057 GC11P124577 GC11P124081 GC11P124048 GC11P120486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPA17 Gene:
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human
cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ
calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions
in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the
zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion
functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome
10q22.(provided by RefSeq, Jan 2009)

GeneCards Summary for SPA17 Gene:
SPA17 (sperm autoantigenic protein 17) is a protein-coding gene. Diseases associated with SPA17 include myeloma, and ovarian cancer. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity.

UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high
affinity. Might function in binding zona pellucida and carbohydrates (By similarity)

Gene Wiki entry for SPA17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPA17 gene promoter:
         NF-1   GCNF   IRF-1   HNF-4alpha2   NF-AT   Egr-4   HNF-4alpha1   c-Ets-1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPA17 promoter sequence
   Search Chromatin IP Primers for SPA17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPA17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

SPA17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPA17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124545:  view genomic region     (about GC identifiers)

Start:
124,543,694 bp from pter      End:
124,567,414 bp from pter
Size:
23,721 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 (See protein sequence)
Recommended Name: Sperm surface protein Sp17  
Size: 151 amino acids; 17406 Da
Subunit: Homodimer (By similarity). May interact with ROPN1
Secondary accessions: B2R4F2 Q9BXF7

Explore the universe of human proteins at neXtProt for SPA17: NX_Q15506

Explore proteomics data for SPA17 at MOPED


See SPA17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_059121.1  
ENSEMBL proteins: 
 ENSP00000227135   ENSP00000432305  

SPA17 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR012105 Sp17
 IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
 IPR000048 IQ_motif_EF-hand-BS

Graphical View of Domain Structure for InterPro Entry Q15506

ProtoNet protein and cluster: Q15506

UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
Similarity: Contains 1 IQ domain


Find genes that share domains with SPA17           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SP17_HUMAN, Q15506
Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high
affinity. Might function in binding zona pellucida and carbohydrates (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with SPA17           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SPA17:
 Decreased telomerase activity 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPA17
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SwitchGear 3'UTR luciferase reporter plasmidSPA17 3' UTR sequence
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Predesigned siRNA for gene silencing in human, mouse, rat SPA17

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SP17_HUMAN, Q15506: Membrane; Peripheral membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
plasma membrane2
cytoskeleton1
golgi apparatus1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA18421703
GO:0016020membrane IEA--
GO:0031514motile cilium IDA18421703
GO:0072372primary cilium IDA18421703

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPA17
Interactions:

    GeneGlobe Interaction Network for SPA17

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPA17 (Q155063 ENSP000002271354) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
AKAP3O759693, ENSP000002288504I2D: score=3 STRING: ENSP00000228850
ROPN1Q9HAT03, ENSP000001841834I2D: score=2 STRING: ENSP00000184183
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001539cilium or flagellum-dependent cell motility IDA18421703
GO:0007283spermatogenesis TAS8688458
GO:0007338single fertilization TAS8688458
GO:0007339binding of sperm to zona pellucida IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPA17 (SP17)

1 Novoseek inferred chemical compound relationship for SPA17 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sp(1-7) 99.5 327 14712480 (13), 7578682 (11), 15257753 (10), 12015770 (9) (see all 42)



Find genes that share compounds with SPA17           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPA17 gene: 
NM_017425.3  

Unigene Cluster for SPA17:

Sperm autoantigenic protein 17
Hs.286233  [show with all ESTs]
Unigene Representative Sequence: AL527801
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000227135 ENST00000532692(uc001qap.3) ENST00000529498 ENST00000524614

miRNA
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6 qRT-PCR Assays for microRNAs that regulate SPA17:
hsa-miR-513b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3134 hsa-miR-664 hsa-miR-105
SwitchGear 3'UTR luciferase reporter plasmidSPA17 3' UTR sequence
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SPA17

Additional mRNA sequence: 

AF334735.1 AK307271.1 AK311806.1 BC019224.1 BC032457.2 

4 DOTS entries:

DT.95265897  DT.100881343  DT.75155024  DT.91918951 

Selected AceView cDNA sequences (see all 82):

BX097241 BC019224 CR625142 AA382958 AW439848 AL522317 BM704178 BM762370 
BC032457 AL522318 AA620983 BI825620 AA122324 AW139711 BE348235 AL527802 
AW204599 BU844909 CR602938 BU729714 CB157459 AI819318 CA314376 BP369357 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPA17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTTTGTTTA
SPA17 Expression
About this image


SPA17 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Gonad
         XY Germ Cells Testis Cord
 
 Neural Tube (Nervous System)
         Diencephalic Roof Plate
 
 Brain (Nervous System)
         Choroid Plexus
SPA17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPA17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.286233

UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506
Tissue specificity: Testis and sperm specific

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SPA17 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spa171 , 5 sperm autoantigenic protein 171, 5 81.92(n)1
74.65(a)1
  9 (20.78 cM)5
206861  NM_011449.21  NP_035579.11 
 376032955 
lizard
(Anolis carolinensis)
Reptilia SPA176
sperm autoantigenic protein 17
48(a)
1 ↔ 1
GL343322.1(151436-158084)
tropical clawed frog
(Xenopus tropicalis)
Amphibia spa171 sperm autoantigenic protein 17 57.04(n)
50.37(a)
  448437  NM_001006757.1  NP_001006758.1 
zebrafish
(Danio rerio)
Actinopterygii spa176
sperm autoantigenic protein 17
12(a)
1 ↔ 1
15(21229119-21249295) ENSDARG00000069361
worm
(Caenorhabditis elegans)
Secernentea F39H12.36
Protein F39H12.3 (F39H12.3) mRNA, complete cds
19(a)
1 ↔ 1
X(838302-841495) WBGene00018214


ENSEMBL Gene Tree for SPA17 (if available)
TreeFam Gene Tree for SPA17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPA17 gene

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1 Pseudogenes.org Pseudogene for SPA17
PGOHUM00000238544


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPA17 (see all 263)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1169934371,2
F--124548376(+) TATGCT/CATCAT 1 -- int11Minor allele frequency- C:0.02NA 120
rs723510811,2
C--124548413(+) TGTGT-/TG/TG 
TGTGTGTG
GTGTG
1 -- int10--------
rs1847978971,2
C--124548414(+) TAACTC/GTGTGT 1 -- int10--------
rs1388050161,2
--124548512(+) GTGTAA/CTCGTG 1 -- int10--------
rs1892131451,2
--124548591(+) GGCATA/GCACAA 1 -- int10--------
rs1117574851,2
F--124548653(+) GAGACG/AGGGTT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1458957681,2
--124548716(+) CCTCCA/GCCTCC 1 -- int10--------
rs800356721,2
C--124548760(+) GCCCAA/GCTTTG 1 -- int10--------
rs766267991,2
F--124549082(+) ACATAT/AGAGCC 1 -- int11Minor allele frequency- A:0.01NA 120
rs1815932791,2
--124549105(+) ACTGCA/GTGACA 1 -- int10--------

HapMap Linkage Disequilibrium report for SPA17 (124543694 - 124567414 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPA17: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SPA17
DNA2.0 Custom Variant and Variant Library Synthesis for SPA17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608621    OMIM disorders: --

2 diseases for SPA17:    
About MalaCards
myeloma    ovarian cancer

1 disease from the University of Copenhagen DISEASES database for SPA17:
Multiple myeloma

Find genes that share disorders with SPA17           About GenesLikeMe

9 Novoseek inferred disease relationships for SPA17 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
testicular cancer 58 4 18779750 (1), 20485677 (1), 17336323 (1), 12213290 (1)
ovarian cancer 53.3 13 19102497 (4), 14712480 (2), 19900363 (1), 18779750 (1) (see all 7)
ovarian carcinoma 48.1 4 12015770 (4)
myeloma 46.3 1 11222401 (1)
tumors 24.5 37 14712480 (9), 12015770 (3), 15148930 (2), 17336323 (2) (see all 15)
graft-versus-host disease 24 2 11477539 (1)
carcinoma squamous cell 8 4 19685492 (1), 17230514 (1)
cancer 1.09 5 12213290 (2), 16138340 (1), 16438728 (1)
metastasis 0 1 16311122 (1)

Genetic Association Database (GAD): SPA17
Human Genome Epidemiology (HuGE) Navigator: SPA17 (1 document)

Export disorders for SPA17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPA17 gene, integrated from 10 sources (see all 63):
(articles sorted by number of sources associating them with SPA17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PubMed id 8688458)1, 2, 3, 9 Lea I.A.... O'Rand M.G. (Biochim. Biophys. Acta 1996)
  2. Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PubMed id 12393185)1, 2, 9 Buchli R.... Robbins D.L. (Biochim. Biophys. Acta 2002)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Expression of sperm protein 17 (Sp17) in ovarian cancer. (PubMed id 14712480)1, 9 Straughn J.M....Strong T.V. (Int. J. Cancer 2004)
  5. Sequence and localization of the mouse sperm autoantigenic protein, Sp17. (PubMed id 7578682)1, 9 Kong M....O'Rand M.G. (Biol. Reprod. 1995)
  6. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PubMed id 15257753)1, 9 Lea I.A....O'Rand M.G. (amp 2004)
  7. Characterization of sperm protein 17 in human somatic and neoplastic tissue. (PubMed id 12213290)1, 9 De Jong A....Robbins D. (Cancer Lett. 2002)
  8. Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. (PubMed id 19685492)1, 9 Kausar T....Ralhan R. (Int. J. Cancer 2010)
  9. Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. (PubMed id 17230514)1, 9 Gupta G....Ralhan R. (Int. J. Cancer 2007)
  10. Sperm protein 17 is expressed in the sperm fibrous sheath. (PubMed id 19604394)1, 9 Chiriva-Internati M....Kast W.M. (J Transl Med 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 53340 HGNC: 11210 AceView: SPA17 Ensembl:ENSG00000064199 euGenes: HUgn53340
ECgene: SPA17 H-InvDB: SPA17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPA17 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPA17 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPA17 gene:
Search GeneIP for patents involving SPA17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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