SPA17 Gene
protein-coding GIFtS : 48
GCID: GC11 P124577
sperm autoantigenic protein 17
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Aliasesfor SPA17 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sperm Autoantigenic Protein 17 1 2 3 Sperm Protein 172 3 CT221 2 3 SP17-12 SP171 2 3 Sperm Surface Protein Sp172 Cancer/Testis Antigen 222 3 Sp17-13
Export aliases for SPA17 gene to outside databases Previous GC identifers: GC11P126544 GC11P126057 GC11P124081 GC11P124048 GC11P120486
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Summariesfor SPA17 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SPA17 : This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.(provided by RefSeq, Jan 2009) UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 Function : Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with highaffinity. Might function in binding zona pellucida and carbohydrates (By similarity) Gene Wiki entry for SPA17
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Genomic Viewsfor SPA17 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SPA17 gene promoter: NF-1 GCNF IRF-1 HNF-4alpha2 NF-AT Egr-4 HNF-4alpha1 c-Ets-1 GCNF-1 GCNF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for SPA17 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SPA17
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.2 SPA17 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P124577: view genomic region
(about GC identifiers )
Start:
124,543,694 bp from pter
End:
124,567,414 bp from pter
Size:
23,721 bases
Orientation:
plus strand
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Proteinsfor SPA17 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 (See
protein sequence )Recommended Name: Sperm surface protein Sp17 Size : 151 amino acids; 17406 Da
Subunit : Homodimer (By similarity). May interact with ROPN1
Subcellular location : Membrane; Peripheral membrane protein (Potential)
Secondary accessions : B2R4F2 Q9BXF7Explore the universe of human proteins at neXtProt for SPA17: NX_Q15506 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q15506 SPA17 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_059121.1 ENSEMBL proteins: ENSP00000227135 ENSP00000432305 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
SPA17 for ontologies About GeneDecksing SPA17 Antibody Products: Assay Products for SPA17:
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Protein
Domains / Familiesfor SPA17 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SPA17 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q15506 ProtoNet protein and cluster: Q15506
UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 Similarity : Contains 1 IQ domain
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Functionfor SPA17 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 Function : Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with highaffinity. Might function in binding zona pellucida and carbohydrates (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SPA17 (NM_017425 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPA17 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPA17
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008603 cAMP-dependent protein kinase regulator activity
IEA --
SPA17 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SPA17 :
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Pathways & Interactionsfor SPA17 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPA17 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for SPA17 (Q15506 3 ENSP00000227135 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
SPA17 for ontologies About GeneDecksing
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Drugs & Compoundsfor SPA17 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
SPA17 for compounds About GeneDecksing Browse Tocris compounds for SPA17 1 Novoseek chemical compound relationship for SPA17 gene About this table
Search CenterWatch for drugs/clinical trials and news about SPA17 / SP17
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Transcriptsfor SPA17 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SPA17 gene: NM_017425.3 Unigene Cluster for SPA17:
Sperm autoantigenic protein 17 Hs.286233 [show with all ESTs ] Unigene Representative Sequence: AL527801 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000227135 ENST00000532692 (uc001qap.3 ) ENST00000529498 ENST00000524614 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SPA17 (NM_017425 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPA17 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPA17
Additional cDNA sequence: AF334735.1 AK307271.1 AK311806.1 BC019224.1 BC032457.2
4 DOTS entries : DT.95265897 DT.100881343
DT.75155024 DT.91918951 24/82 AceView cDNA sequences (see all 82 ):
BE348235 BM704178 AA122324 AL522317 BU844909 AL522318 AW139711 BM762370 AL527802 CR625142 CR602938 BX097241 BI825620 AA620983 AW204599 AW439848 AA382958 BC032457 BU729714 BC019224 CB851319 AA122286 BM760669 AA369666 GeneLoc Exon Structure
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Expression for SPA17 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SPA17 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGTTTGTTTA
About this image SPA17 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SPA17 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SPA17 SOURCE GeneReport for Unigene cluster: Hs.286233 UniProtKB/Swiss-Prot: SP17_HUMAN, Q15506 Tissue specificity : Testis and sperm specific SABiosciences Custom PCR Arrays for SPA17 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SPA17Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SPA17 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SPA17 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SPA17
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Orthologsfor SPA17 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SPA17 gene from 3/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for SPA17 (if available)TreeFam Gene Tree for SPA17 (if available)
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Paralogsfor SPA17 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SPA17 gene
SPA17 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SPA17 PGOHUM00000238544
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Genomic Variantsfor SPA17 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SPA17 (124543694 - 124567414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for SPA17 3 CNVs : 75835 75834 86063
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SPA17
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Disorders
/ Diseasesfor SPA17 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SPA17 for disorders About GeneDecksing
OMIM gene information: 608621
OMIM disorders : --20 diseases for SPA17 : About MalaCards graft versus host disease oral squamous cell carcinoma esthesioneuroblastoma clear cell adenocarcinoma squamous cell carcinoma testicular cancer epithelial ovarian cancer ovarian cancer multiple myeloma ovarian carcinoma rheumatoid arthritis myeloma esophageal cancer cervical cancer carcinoma esophagitis cervicitis arthritis infertility adenocarcinoma 9 Novoseek disease relationships for SPA17 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
testicular cancer
58
4
18779750 (1), 20485677 (1), 17336323 (1), 12213290 (1)
ovarian cancer
53.3
13
19102497 (4), 14712480 (2), 19900363 (1), 18779750 (1) (see all 7 )
ovarian carcinoma
48.1
4
12015770 (4)
myeloma
46.3
1
11222401 (1)
tumors
24.5
37
14712480 (9), 12015770 (3), 15148930 (2), 17336323 (2) (see all 15 )
graft-versus-host disease
24
2
11477539 (1)
carcinoma squamous cell
8
4
19685492 (1), 17230514 (1)
cancer
1.09
5
12213290 (2), 16138340 (1), 16438728 (1)
metastasis
0
1
16311122 (1)
Human Genome Epidemiology (HuGE) Navigator: SPA17 (1 document)Export disorders for SPA17 gene to outside databases
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Publicationsfor SPA17 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SPA17 gene, integrated from 9 sources (see all 61 ): (articles sorted by number of sources associating them with SPA17) Utopia : connect your pdf to the dynamic world of online information
Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PubMed id 8688458) 1 , 2 , 3, 9 Lea I.A.... O'Rand M.G. (1996) Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PubMed id 12393185) 1 , 2 , 9 Buchli R.... Robbins D.L. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Expression of sperm protein 17 (Sp17) in ovarian cancer. (PubMed id 14712480) 1 , 9 Straughn J.M....Strong T.V. (2004) Sequence and localization of the mouse sperm autoantigenic protein, Sp17. (PubMed id 7578682) 1 , 9 Kong M....O'Rand M.G. (1995) Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PubMed id 15257753) 1 , 9 Lea I.A....O'Rand M.G. (2004) Characterization of sperm protein 17 in human somatic and neoplastic tissue. (PubMed id 12213290) 1 , 9 De Jong A....Robbins D. (2002) Sperm protein 17 is a novel marker for predicting cis platin response in esophageal squamous cancer cell lines. (PubMed id 19685492) 1 , 9 Kausar T....Ralhan R. (2010) Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. (PubMed id 17230514) 1 , 9 Gupta G....Ralhan R. (2007) Sperm protein 17 is expressed in the sperm fibrous sh eath. (PubMed id 19604394) 1 , 9 Chiriva-Internati M....Kast W.M. (2009)
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External Searches for SPA17 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SPA17 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SPA17 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SPA17 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SPA17 gene: Search GeneIP for patents involving SPA17 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SPA17 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SPA17 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SPA17 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SPA17 OriGene Protein Over-expression Lysate for SPA17 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SPA17 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPA17 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SPA17 OriGene Custom Protein Services for SPA17 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPA17 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SPA17 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SPA17 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SPA17 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SPA17 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SPA17
Search Tocris compounds for SPA17
ThermoFisher Antibodies for SPA17
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPA17
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Aliases for SPA17
Databases for SPA17
Disorders / Diseases for SPA17
Domains / Families for SPA17
Drugs / Compounds for SPA17
Expression for SPA17
Function for SPA17
Genomic Views for SPA17
Intellectual Property for SPA17
Orthologs for SPA17
Paralogs for SPA17
Pathways / Interactions for SPA17
Products for SPA17
Proteins for SPA17
Publications for SPA17
Search Box for SPA17
Summaries for SPA17
Transcripts for SPA17
Variants for SPA17
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