SP9 Gene
protein-coding GIFtS: 36
GCID: GC02P175199
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Sp9 transcription factor(Previous name: Sp9 transcription factor homolog (mouse) )
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Aliases
for SP9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sp9 Transcription Factor1 2 | | Transcription Factor Sp92 | | ZNF9901 2 | | Zinc Finger Protein 9902 | | Sp9 Transcription Factor Homolog (Mouse)1 | | CRCRSP335 | | Sp9 Transcription Factor Homolog2 | | MED75 |
Export aliases for SP9 gene to outside databasesPrevious GC identifers: GC02P174908 GC02P167080 |
Summaries
for SP9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SP9_HUMAN, P0CG40Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in theapical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)
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Genomic Views
for SP9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SP9 gene promoter:
USF1 Pax-5 C/EBPalpha Egr-4 Arnt PPAR-alpha CHOP-10 POU2F1 Nkx6-1 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SP9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1SP9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P175199: view genomic region
(about GC identifiers)
Start:
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175,199,674 bp from pter |
End:
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175,203,220 bp from pter |
Size:
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3,547 bases |
Orientation:
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plus strand |
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Proteins
for SP9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: SP9_HUMAN, P0CG40 (See
protein sequence)Recommended Name: Transcription factor Sp9 Size: 484 amino acids; 48915 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for SP9: NX_P0CG40
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CG40
SP9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001138722.1
ENSEMBL proteins: ENSP00000378418
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
SP9 for ontologies About GeneDecksing
SP9 Antibody Products:
Assay Products for SP9: |
Protein
Domains /
Families
for SP9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SP9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CG40ProtoNet protein and cluster: P0CG40 UniProtKB/Swiss-Prot: SP9_HUMAN, P0CG40Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingers |
Function
for SP9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: SP9_HUMAN, P0CG40Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in theapical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SP9 (NM_001229) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SP9 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP9 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SP9 for ontologies About GeneDecksing
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Pathways & Interactions
for SP9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP9
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0030326 | embryonic limb morphogenesis |
IEA | -- |
SP9 for ontologies About GeneDecksing
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Drugs & Compounds
for SP9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for SP9
Search CenterWatch for drugs/clinical trials and news about SP9
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Transcripts
for SP9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SP9 gene: NM_001145250.1 Unigene Cluster for SP9: Sp9 transcription factor Hs.516603 [show with all ESTs]Unigene Representative Sequence: NM_0011452501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000394967(uc010zem.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SP9 (NM_001229) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SP9 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP9 |
1 DOTS entry: DT.101975340
GeneLoc Exon Structure
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Expression
for SP9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SP9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCCGGCGT
About this image
See SP9 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.516603
SABiosciences Custom PCR Arrays for SP9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP9
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SP9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP9 |
Orthologs
for SP9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for SP9 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SP86 |
Uncharacterized protein |
53(a) |
1 → many |
2(30187498-30190384) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
3(a) |
possible ortholog |
3(88021848-88042132) |
zebrafish
(Danio rerio) |
Actinopterygii |
sp91 |
sp9 transcription factor |
76.97(n)
85.02(a) |
|
405896 NM_212960.2 NP_998125.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sp16 |
Sp1 |
29(a) |
1 → many |
X(9623681-9650237) |
worm
(Caenorhabditis elegans) |
Secernentea |
sptf-16 |
Specificity Protein) Transcription Factor family m... |
13(a) |
possible ortholog |
I(10366612-10371685) |
ENSEMBL Gene Tree for SP9 (if available)
TreeFam Gene Tree for SP9 (if available) |
Paralogs
for SP9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SP9 gene
- SP42 SP32 SP82 SP52 SP22 KLF172 SP12 SP62
- SP72
18/34 SIMAP similar genes for SP9 using alignment to 1 protein entry: SP9_HUMAN(see all similar genes):DKFZp686O1631 SP8 SP3 A-328A3.4 DKFZp686N0199 ZFS-5
kr-znf3 ZNF78L1 DKFZp434J0650 ZNF SP4 KLF9
SP6 ZNF697 DKFZp686M04222 ZNF55 ZNF72 SP7
SP9 for paralogs About GeneDecksing
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Genomic Variants
for SP9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SP9 (175199674 - 175203220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SP9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP9 |
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Disorders
/ Diseases
for SP9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SP9 for disorders About GeneDecksing
OMIM gene information: 605045
OMIM disorders: --
2  diseases for SP9: About MalaCardsgout osteoarthritis
1 disease from the University of Copenhagen DISEASES database for SP9:Osteoarthritis Export disorders for SP9 gene to outside databases
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Publications
for SP9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for SP9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SP9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
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External Searches for SP9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SP9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing SP9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SP9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SP9 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SP9 gene:
Search GeneIP for patents involving SP9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SP9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SP9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP9 | | | OriGene Protein Over-expression Lysate for SP9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SP9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SP9 | | OriGene Custom Protein Services for SP9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP9 |
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 |  |  |  | |
| | | | Search Tocris compounds for SP9 |
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 | | | SP9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP9 |
|  |  |  | | | | Search ThermoFisher Antibodies for SP9 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP9 |
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