Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP8 Gene

protein-coding   GIFtS: 53
GCID: GC07M020788

Sp8 Transcription Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sp8 Transcription Factor1 2
Specificity Protein 82 3
BTD2 5
Transcription Factor Sp82

External Ids:    HGNC: 191961   Entrez Gene: 2218332   Ensembl: ENSG000001646517   OMIM: 6083065   UniProtKB: Q8IXZ33   

Export aliases for SP8 gene to outside databases

Previous GC identifers: GC07U990363 GC07M020532 GC07M020568 GC07M020566 GC07M020595


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SP8 Gene:
The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential
for proper limb development. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jun 2011)

GeneCards Summary for SP8 Gene: 
SP8 (Sp8 transcription factor) is a protein-coding gene. Diseases associated with SP8 include skin papilloma, and bipolar i disorder. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP8_HUMAN, Q8IXZ3
Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in
the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)

Gene Wiki entry for SP8 (Sp8 transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP8 gene promoter:
         AP-1   CUTL1   AREB6   S8   SRY   POU2F1   POU2F1a   Chx10   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.2   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.2

SP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M020788:  view genomic region     (about GC identifiers)

Start:
20,821,894 bp from pter      End:
20,826,508 bp from pter
Size:
4,615 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 20,873,227-20,877,855     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SP8_HUMAN, Q8IXZ3 (See protein sequence)
Recommended Name: Transcription factor Sp8  
Size: 490 amino acids; 48674 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB71297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q7Z615 Q7Z616 Q96MJ1
Alternative splicing: 4 isoforms:  Q8IXZ3-3   Q8IXZ3-1   Q8IXZ3-2   Q8IXZ3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SP8: NX_Q8IXZ3

Explore proteomics data for SP8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXZ3

  • SP8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SP8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_874359.2  NP_945194.1  

    ENSEMBL proteins: 
     ENSP00000408792   ENSP00000354482  

    Human Recombinant Protein Products for SP8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SP8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SP8
    GenScript Custom Purified and Recombinant Proteins Services for SP8
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SP8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SP8 for ontologies           About GeneDecksing



    SP8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SP8
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SP8
    GenScript Custom Superior Antibodies Services for SP8
    Abcam antibodies for SP8
    Cloud-Clone Corp. Antibodies for SP8 
    ThermoFisher Antibodies for SP8
    LSBio Antibodies in human, mouse, rat for SP8 

    Assay Products for SP8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SP8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SP8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SP8 
    Cloud-Clone Corp. CLIAs for SP8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IXZ3

    ProtoNet protein and cluster: Q8IXZ3

    UniProtKB/Swiss-Prot: SP8_HUMAN, Q8IXZ3
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    SP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP8_HUMAN, Q8IXZ3
    Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in
    the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    SP8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SP8:
     Increased HPV18 LCR reporter a 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sp8):
     cellular  craniofacial  digestive/alimentary  embryogenesis  limbs/digits/tail 
     mortality/aging  nervous system  respiratory system  skeleton 

    SP8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sp8tm1Smb for SP8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SP8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SP8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP8
    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SP8 (see all 99):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-607 hsa-miR-4254 hsa-miR-642a
    SwitchGear 3'UTR luciferase reporter plasmidSP8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SP8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SP8
    Sirion Biotech Customized adenovirus for overexpression of SP8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SP8 (see all 10)
    OriGene ORF clones in mouse, rat for SP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SP8 (NM_001228)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP8
    Sirion Biotech Customized lentivirus for stable overexpression of SP8 
                         Customized lentivirus expression plasmids for stable overexpression of SP8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SP8
    Search LifeMap BioReagents cell lines for SP8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for SP8 (Q8IXZ33 ENSP000004087924) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEYLQ9NQ873, ENSP000003619434I2D: score=1 STRING: ENSP00000361943
    ZNF273Q145933, ENSP000004187194I2D: score=1 STRING: ENSP00000418719
    ZNF519Q8TB693I2D: score=1 
    CELA3BENSP000003383694STRING: ENSP00000338369
    ENSG00000206457ENSP000003832634STRING: ENSP00000383263
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0009953dorsal/ventral pattern formation IEA--
    GO:0009954proximal/distal pattern formation IEA--
    GO:0030326embryonic limb morphogenesis IEA--

    SP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP8

    Search CenterWatch for drugs/clinical trials and news about SP8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SP8 gene (2 alternative transcripts): 
    NM_182700.4  NM_198956.2  

    Unigene Cluster for SP8:

    Sp8 transcription factor
    Hs.195922  [show with all ESTs]
    Unigene Representative Sequence: NM_198956
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418710(uc003suz.3) ENST00000361443(uc003suy.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP8
    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SP8 (see all 99):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-607 hsa-miR-4254 hsa-miR-642a
    SwitchGear 3'UTR luciferase reporter plasmidSP8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SP8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP8
    Clone
    Products:
         
    OriGene clones in human, mouse for SP8 (see all 10)
    OriGene ORF clones in mouse, rat for SP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SP8 (NM_001228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP8
    Sirion Biotech Customized lentivirus for stable overexpression of SP8 
                         Customized lentivirus expression plasmids for stable overexpression of SP8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SP8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP8

    Additional mRNA sequence: 

    AK056857.1 AK290465.1 AK299947.1 AK307969.1 AY167047.1 AY167048.1 BC038669.1 

    4 DOTS entries:

    DT.101981124  DT.40111629  DT.100738575  DT.101981123 

    24/29 AceView cDNA sequences (see all 29):

    AY167047 BF222742 AY167048 BX112237 AI095128 AW593821 AW297181 AI632278 
    BF447038 AI962477 NM_198956 AI675709 AW207154 BI522798 AI968383 NM_182700 
    AK056857 BC038669 BI547021 BI545569 AI341332 BI523417 AI652426 CA336853 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SP8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for SP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP8 expression in normal human tissues (normalized intensities)      SP8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SP8 Expression
    About this image


    SP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             N2/LSB induced-cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Fetal Neuronal Stem Cells (NSC)   
             Midbrain   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process

    See SP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP8

    SOURCE GeneReport for Unigene cluster: Hs.195922
        SABiosciences Custom PCR Arrays for SP8
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SP8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SP8 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp81 , 5 trans-acting transcription factor 81, 5 88.96(n)1
    98.15(a)1
      12 (63.48 cM)5
    3201451  NM_177082.41  NP_796056.21 
     1188463295 
    chicken
    (Gallus gallus)
    Aves SP81 Sp8 transcription factor 87.17(n)
    91.97(a)
      776034  NM_001198666.1  NP_001185595.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92842 Xenopus laevis transcribed sequence with moderate similarity more 80.38(n)    BJ031119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165882 Transcribed sequence with moderate similarity to protein more 82.06(n)    BI979366.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sp11 CG1343-PB 57.01(n)
    56.06(a)
      31913  NM_001103457.3  NP_001096927.2 


    ENSEMBL Gene Tree for SP8 (if available)
    TreeFam Gene Tree for SP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP8 gene
    KLF12  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    18/27 SIMAP similar genes for SP8 using alignment to 2 protein entries:     SP8_HUMAN (see all proteins) (see all similar genes):
    SP9    A-328A3.4    Sp1    ZFS-5    ZNF78L1    DKFZp434J0650
    smap-7    ZNF    SP6    KLF13    KLF9    ZNF72
    kr-znf3    DKFZp686M04222    KLF16    ZNF55    ZFS-2    ZNF697

    SP8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 SNPs in SP8 are shown (see all 156)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411682861,2
    --20795798(+) TTAGCA/TAAGAC 2 -- ds50010--------
    rs2012557221,2
    C--20795933(+) AAATAC/TTAATG 2 -- ds50010--------
    rs747106681,2
    C--20795938(+) ACTAAA/TGCAAT 2 -- ds50010--------
    rs779442201,2
    C--20795939(+) CTAATG/TCAATC 2 -- ds50010--------
    rs1884101941,2
    --20796079(+) AAATAA/GTCAAT 2 -- ds50010--------
    rs789367031,2
    C,F--20796146(+) CCAAAT/CAGATC 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1178353271,2
    C,F--20796203(+) CAAGGA/TTATAT 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1913659031,2
    --20796544(+) TTAGTC/TGAGTT 2 -- ut310--------
    rs1834625481,2
    --20796601(+) ATTATC/GAAATA 2 -- ut310--------
    rs2014549491,2
    C--20796701(+) ATCAAA/TATTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SP8 (20821894 - 20826508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SP8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv824024CNV Gain20364138


    Human Gene Mutation Database (HGMD): SP8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SP8
    DNA2.0 Custom Variant and Variant Library Synthesis for SP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608306    OMIM disorders: --

    4 diseases for SP8:    About MalaCards
    skin papilloma    bipolar i disorder    papilloma    brain injury

    1 disease from the University of Copenhagen DISEASES database for SP8:
    Skin papilloma

    SP8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SP8
    Human Genome Epidemiology (HuGE) Navigator: SP8 (2 documents)

    Export disorders for SP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP8 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of bipolar I disorder i n the Han Chinese population. (PubMed id 20386566)1, 4 Lee M.T....Cheng A.T. (2010)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic structure and cloning of two transcript isoforms of human Sp8. (PubMed id 15533246)1, 2 Milona M.A....Edgar A.J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    7. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. mBtd is required to maintain signaling during murine limb development. (PubMed id 14597661)1 Treichel D....Mansouri A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221833 HGNC: 19196 AceView: SP8 Ensembl:ENSG00000164651 euGenes: HUgn221833
    ECgene: SP8 H-InvDB: SP8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SP8 gene:
    Search GeneIP for patents involving SP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SP8
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SP8  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SP8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SP8  
     OriGene qSTAR qPCR primer pairs in human, mouse for SP8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SP8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SP8   OriGene Custom Protein Services for SP8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP8
     QIAGEN SeqTarget long-range PCR primers for resequencing SP8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP8
     GenScript Custom Purified and Recombinant Proteins Services for SP8 GenScript cDNA clones with any tag delivered in your preferred vector for SP8
     GenScript Custom Assay Services for SP8 GenScript Custom Superior Antibodies Services for SP8
     GenScript Custom overexpressing Cell Line Services for SP8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SP8 promoter
     Search Chromatin IP Primers for SP8
     RT2 qPCR Primer Assay in human, mouse, rat SP8
     Search GNC Networks for SP8
     SABiosciences Custom PCR Arrays for SP8
     Search Tocris compounds for SP8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for SP8
     See all of Abcam's Antibodies, Kits and Proteins for SP8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SP8
     Antibodies for SP8
     ELISAs for SP8
     CLIAs for SP8
     Search LifeMap BioReagents cell lines for SP8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP8
     SwitchGear 3'UTR luciferase reporter plasmids for SP8
     SwitchGear Promoter luciferase reporter plasmids for SP8
     ThermoFisher Antibodies for SP8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SP8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SP8
    Customized:
     lentivirus for stable overexpression of SP8
     lentivirus expression plasmids for stable overexpression of SP8
     adenovirus for overexpression of SP8
     LSBio Antibodies in human, mouse, rat for SP8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SP8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4