SP7 Gene

Aliases
for SP7 gene

Previous GC identifers: GC12U990220 GC12P053775 GC12M053437 GC12M052006 GC12M050761

Summaries
for SP7 gene

Genomic Views
for SP7 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: SP7 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP7

SP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053721:  view genomic region     (about GC identifiers)

Proteins
for SP7 gene

Explore the universe of human proteins at neXtProt for SP7: NX_Q8TDD2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SP7 OriGene Custom Protein Services for SP7
	GenScript Custom Purified and Recombinant Proteins Services for SP7
	Novus Biologicals SP7 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SP7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SP7
	R&D Systems Antibodies for SP7 (Osterix/Sp7)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SP7
	GenScript Superior Antibodies for SP7
	Novus Biologicals SP7 Antibodies
	Search for Antibodies for SP7 at Abcam
	Uscn Antibodies for SP7
	ThermoFisher Antibodies for SP7

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SP7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SP7

Protein Domains /
Families
for SP7 gene

ProtoNet protein and cluster: Q8TDD2

Function
for SP7 gene

miRNA Products:		miRTarBase miRNAs that target SP7: hsa-mir-135b (MIRT004567)
		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP7
		8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate SP7 (see all 53):
		hsa-miR-100* hsa-miR-607 hsa-miR-642a hsa-miR-513a-5p hsa-miR-486-3p hsa-miR-346 hsa-miR-4267 hsa-miR-124
		SwitchGear 3'UTR luciferase reporter plasmid: SP7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP7 (see all 7) OriGene shRNA RFP: SP7 OriGene siRNA: SP7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SP7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP7 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP7 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SP7 (NM_033340)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SP7
		Search LifeMap BioReagents cell lines for SP7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP7

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Sp7)

Pathways & Interactions
for SP7 gene

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for SP7 gene

Transcripts
for SP7 gene

Expression
for SP7 gene

SP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTTGTGG

10/35 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 35)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneAutopod PeriosteumEndochondral Osteoblasts			Bone
	BoneAutopod PeriosteumEndochondral Osteocytes			Bone
	BoneAutopod PeriosteumImmature Endochondral Osteoblasts			Bone
	BoneCaudal Endochondral BonesEndochondral Osteoblasts			Bone
	BoneCaudal Endochondral BonesEndochondral Osteocytes			Bone
	BoneCaudal Endochondral BonesEndochondral Preosteoblasts			Bone
	BoneCervical VertebraeEndochondral Osteoblasts			Bone
	BoneCervical VertebraeImmature Endochondral Osteoblasts			Bone
	BoneEndochondral Facial BonesEndochondral Osteoblasts			Bone
	BoneEndochondral Facial BonesEndochondral Osteocytes			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	Osteoblast-like cells grown in monolayer (Osteogenic different...)
	Osteoblast-like cells grown in a 3D culture system (Osteogenic different...)
	HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage
	HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP7

Orthologs
for SP7 gene

Paralogs
for SP7 gene

Paralogs for SP7 gene

SP4²  SP3²  SP8²  SP5²  SP2²  KLF17²  SP1²  SP6²  

SP9²  

18/27 SIMAP similar genes for SP7 using alignment to 3 protein entries:     SP7_HUMAN (see all proteins) (see all similar genes):

SP3    ZFS-5    ZNF78L1    KLF9    kr-znf3    ZNF

DKFZp434J0650    ZFS-6    SP9    A-328A3.4    DKFZp686M04222    KLF16

SP8    SP4    ZNF72    SP1    Sp1    ZNF697

SP7 for paralogs           About GeneDecksing

Genomic Variants
for SP7 gene

10/199 NCBI SNPs in SP7 are shown (see all 199)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1127782091,2		--	50762982(+)	CAATAA/CATTAT	2	--	ut31		2		CSA WA	120
rs771215171,2		--	50763364(+)	GGATGG/ACATGC	2	--	ut31		1		WA	118
rs773089561,2	F,	--	50764863(+)	AGAGGG/CTGGAG	2	--	int1		1		WA	118
rs1127902901,2	C,	--	50765303(+)	CTCGGC/ACTCCC	2	--	int1		1		WA	2
rs1143782621,2	C,F,	--	50766279(+)	GTGAGC/AACCTC	2	--	int1		1		WA	118
rs1145082491,2	C,F,	--	50766292(+)	GCTTTG/ATGGTG	2	--	int1		1		WA	118
rs1129481841,2		--	50766376(+)	ACTAAG/AATACT	2	--	int1		2		CSA WA	120
rs772514851,2	F	--	50766806(+)	AAAAAG/AAAAGG	2	--	int1		2		NA CSA	4
rs740907501,2	C,	--	50766918(+)	CCTGGG/ATGAGG	2	--	int1		2		WA	120
rs1133184761,2	F,	--	50767197(+)	AATCCG/AAGAGG	2	--	int1		2		CSA	4

HapMap Linkage Disequilibrium report for SP7 (53720359 - 53739099 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SP7: --
Human Gene Mutation Database (HGMD): SP7

Locus Specific Mutation Databases (LSDB): SP7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP7

DNA2.0 Custom Variant and Variant Library Synthesis for SP7

Disorders / Diseases
for SP7 gene

17 diseases for SP7

4 Novoseek disease relationships for SP7 gene    About this table

Publications
for SP7 gene

PubMed articles for SP7 gene, integrated from 9 sources (see all 115): (articles sorted by number of sources associating them with SP7)

Utopia: connect your pdf to the dynamic world of online information

1. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. (PubMed id 11792318)^{1, 2, 3} Nakashima K....de Crombrugghe B. (2002)
2. Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. (PubMed id 15474293)^{1, 2, 9} Gao Y....Ganss B. (2004)
3. Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. (PubMed id 14604442)^{1, 2, 9} Milona M.-A.... Edgar A.J. (2003)
4. Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. (PubMed id 20579626)^{1, 2} Lapunzina P....Ruiz-Perez V.L. (2010)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Expression of Osterix in mechanical stress-induced osteogenic differentiation of periodontal ligament cells in vitro. (PubMed id 18471237)^{1, 9} Zhao Y....Chen J. (2008)
7. Gene expression in normotopic and heterotopic human bone: increased level of SP7 mRNA in pathological tissue. (PubMed id 18777089)^{1, 9} Chauveau C....Devedjian J.C. (2008)
8. Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells. (PubMed id 18829486)^{1, 9} Silvestris F....Dammacco F. (2008)
9. Osterix is a key target for mechanical signals in human thoracic ligament flavum cells. (PubMed id 17311298)^{1, 9} Fan D....Shang Y. (2007)
10. Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. (PubMed id 18482578)^{1, 9} Rich J.T....McAlinden A. (2008)

External Searches for SP7 gene

Genome Databases showing SP7 gene

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Specialized Databases showing SP7 gene

Products
for SP7 gene