Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SP6 Gene

protein-coding   GIFtS: 47
GCID: GC17M045922

Sp6 Transcription Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sp6 Transcription Factor1 2     EPFN2
Krueppel-Like Factor 142 3     EPIPROFIN2
KLF142 3     Kruppel-Like Factor 142
epiprofin1     Transcription Factor Sp62

External Ids:    HGNC: 145301   Entrez Gene: 803202   Ensembl: ENSG000001891207   OMIM: 6086135   UniProtKB: Q3SY563   

Export aliases for SP6 gene to outside databases

Previous GC identifers: GC17U990229 GC17M046396 GC17M043277 GC17M041291


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SP6 Gene:
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains
consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These
transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 (PubMed
11087666)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SP6 Gene:
SP6 (Sp6 transcription factor) is a protein-coding gene. Diseases associated with SP6 include facial paralysis, and agnosia. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
Function: Promotes cell proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SP6 gene promoter:
         Oct-B1   Bach1   oct-B3   POU2F1   oct-B2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP6 promoter sequence
   Search Chromatin IP Primers for SP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

SP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M045922:  view genomic region     (about GC identifiers)

Start:
45,922,279 bp from pter      End:
45,933,240 bp from pter
Size:
10,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56 (See protein sequence)
Recommended Name: Transcription factor Sp6  
Size: 376 amino acids; 39840 Da
Secondary accessions: B3KXS4

Explore the universe of human proteins at neXtProt for SP6: NX_Q3SY56

Explore proteomics data for SP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245177.1  NP_954871.1  

    ENSEMBL proteins: 
     ENSP00000340799   ENSP00000438209  

    SP6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SP6
    OriGene Protein Over-expression Lysate for SP6
    OriGene MassSpec for SP6
    OriGene Custom Protein Services for SP6
    GenScript Custom Purified and Recombinant Proteins Services for SP6
    Novus Biologicals SP6 Protein
    Novus Biologicals SP6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SP6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SP6
    Novus Biologicals SP6 Antibodies
    Abcam antibodies for SP6
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SP6
    LSBio Antibodies in human, mouse, rat for SP6

    SP6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SP6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SP6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q3SY56

    ProtoNet protein and cluster: Q3SY56

    UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    SP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP6_HUMAN, Q3SY56
    Function: Promotes cell proliferation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    SP6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SP6:
     Cells with protrusions  Increased cell number in S and 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sp6):
     craniofacial  endocrine/exocrine gland  growth/size/body  integument  limbs/digits/tail 
     mortality/aging  normal  respiratory system 

    SP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SP6: Sp6tm1Yoya Sp6tm1.1Ibmm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SP6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP6

    miRNA
    Products:
        
    miRTarBase miRNAs that target SP6:
    hsa-mir-16-5p (MIRT051059), hsa-mir-378a-3p (MIRT043907), hsa-mir-30d-5p (MIRT047783)

    Block miRNA regulation of human, mouse, rat SP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP6 (see all 34):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-3141 hsa-miR-765 hsa-miR-1260b hsa-miR-488 hsa-miR-29b-1* hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SP6
    Predesigned siRNA for gene silencing in human, mouse, rat SP6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SP6

    Clone
    Products:
         
    OriGene clones in human, mouse for SP6 (see all 7)
    OriGene ORF clones in mouse, rat for SP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SP6 (NM_032992)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SP6
    Browse ESI BIO Cell Lines and PureStem Progenitors for SP6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SP6_HUMAN, Q3SY56: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    chloroplast2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SP6
    Interactions:

        Search GeneGlobe Interaction Network for SP6

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0042481regulation of odontogenesis IEA--

    SP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SP6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SP6 gene (2 alternative transcripts): 
    NM_001258248.1  NM_199262.2  

    Unigene Cluster for SP6:

    Sp6 transcription factor
    Hs.253603  [show with all ESTs]
    Unigene Representative Sequence: AK127707
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342234(uc002imh.1) ENST00000536300(uc002img.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP6 (see all 34):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-3141 hsa-miR-765 hsa-miR-1260b hsa-miR-488 hsa-miR-29b-1* hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SP6
    Predesigned siRNA for gene silencing in human, mouse, rat SP6
    Clone
    Products:
         
    OriGene clones in human, mouse for SP6 (see all 7)
    OriGene ORF clones in mouse, rat for SP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SP6 (NM_032992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP6
      QuantiTect SYBR Green Assays in human, mouse, rat SP6
      QuantiFast Probe-based Assays in human, mouse, rat SP6

    Additional mRNA sequence: 

    AK127707.1 AK127850.1 BC103951.1 BC103952.1 BC103953.1 BC103954.1 

    2 DOTS entries:

    DT.40292798  DT.97776385 

    Selected AceView cDNA sequences (see all 46):

    AI123505 AW207058 BF109399 BX397994 AI024904 AA443011 AI273585 NM_199262 
    BE300880 AI817264 AW136253 BQ899369 AK127850 BE047476 BU528562 BX366631 
    BQ023576 AI352128 BX094659 AW672805 AI093637 AI367860 AW137518 AA639559 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SP6 expression in normal human tissues (normalized intensities)      SP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTGTGTT
    SP6 Expression
    About this image


    SP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Odontoblasts Dentin
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    SP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.253603

    UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for SP6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP6
    QuantiTect SYBR Green Assays in human, mouse, rat SP6
    QuantiFast Probe-based Assays in human, mouse, rat SP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SP6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp61 , 5 trans-acting transcription factor 61, 5 90.78(n)1
    96.28(a)1
      11 (60.51 cM)5
    833951  NM_031183.21  NP_112460.11 
     970133945 
    lizard
    (Anolis carolinensis)
    Reptilia SP66
    Sp6 transcription factor
    67(a)
    1 ↔ 1
    6(74601683-74602786)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sp61 Sp6 transcription factor 58.15(n)
    57.54(a)
      100494184  XM_002938022.2  XP_002938068.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:773581 zgc:77358 62.4(n)
    58.9(a)
      402928  NM_205632.1  NP_991195.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sp16
    Sp1
    18(a)
    1 → many
    X(9623681-9650237)


    ENSEMBL Gene Tree for SP6 (if available)
    TreeFam Gene Tree for SP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SP6 gene
    KLF12  SP82  KLF172  KLF52  KLF142  KLF152  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for SP6 using alignment to 1 protein entry:     SP6_HUMAN(see all similar genes):
    DKFZp686O1631    SP3    KLF6    DKFZp686N0199    Sp1    ZNF697
    kr-znf3    DKFZp434J0650    ZFS-5    ZNF78L1    ZNF    SP8
    SP9    KLF7    PLZF    KLF9    A-328A3.4    ZNF72

    SP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SP6 (see all 219)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877028301,2
    --45921782(+) AGGAGC/TCCATC 2 -- ds50010--------
    rs1923754731,2
    --45921811(+) TCATCA/GCCTTG 2 -- ds50010--------
    rs1511175641,2
    C--45921846(+) GAAGT-/AATC  
            
    ACTGC
    2 -- ds50010--------
    rs23257521,2
    C,F,A,H--45921906(-) CCCATA/GGAGGG 2 -- ds500125Minor allele frequency- G:0.43NS EA NA WA CSA 2353
    rs43876321,2
    C--45921976(+) GGAAAG/AAAGGG 2 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1170076641,2
    C,F--45921999(+) AAGAGG/AAAAGA 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1855673141,2
    --45922016(+) TAGAAA/GCTTCT 2 -- ds50010--------
    rs1905063611,2
    --45922067(+) ACCAAC/GCCAGA 2 -- ds50010--------
    rs1478048601,2
    --45922096(+) CTGTAC/TCAGCC 2 -- ds50010--------
    rs1488189731,2
    --45922190(+) GCATCC/TACCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SP6 (45922279 - 45933240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908574CNV Loss21882294
    nsv908573CNV Loss21882294
    nsv518892CNV Loss19592680
    nsv517880CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SP6
    DNA2.0 Custom Variant and Variant Library Synthesis for SP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608613    OMIM disorders: --

    4 diseases for SP6:    About MalaCards
    facial paralysis    agnosia    pain agnosia    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for SP6:
    Pain agnosia

    SP6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SP6

    Export disorders for SP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SP6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PubMed id 11087666)1, 3, 9 Scohy S.... Szpirer C. (Genomics 2000)
    2. The KrA1ppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. (PubMed id 14551215)1, 3 Nakamura T....Yamada Y. (J. Biol. Chem. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    5. Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. (PubMed id 18156176)4 Nakamura T....Yamada Y. (J. Biol. Chem. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80320 HGNC: 14530 AceView: SP6 Ensembl:ENSG00000189120 euGenes: HUgn80320
    ECgene: SP6 H-InvDB: SP6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SP6 gene:
    Search GeneIP for patents involving SP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SP6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SP6  
     OriGene MassSpec something-or-other for SP6   OriGene clones in human, mouse for SP6  
     OriGene qSTAR qPCR primer pairs in human, mouse for SP6   OriGene Purified Protein for SP6  
     OriGene ORF clones in mouse, rat for SP6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SP6   OriGene Custom Protein Services for SP6  

     
     
     Block miRNA regulation of human, mouse, rat SP6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SP6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP6 Predesigned siRNA for gene silencing in human, mouse, rat SP6
     QuantiFast Probe-based Assays in human, mouse, rat SP6 QuantiTect SYBR Green Assays in human, mouse, rat SP6
     Custom PCR Arrays for SP6 Search Chromatin IP Primers for SP6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP6  Search GeneGlobe Interaction Network for SP6
     Regulatory tfbs in SP6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SP6 GenScript cDNA clones with any tag delivered in your preferred vector for SP6
     GenScript Custom Assay Services for SP6 GenScript Custom overexpressing Cell Line Services for SP6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SP6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SP6 antibodies
     SP6 proteins
     SP6 lysates
     Antibodies for SP6
     See all of Abcam's Antibodies, Kits and Proteins for SP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6
     SwitchGear 3'UTR luciferase reporter plasmids for SP6
     SwitchGear Promoter luciferase reporter plasmids for SP6
     Search ThermoFisher Antibodies for SP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SP6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SP6
     LSBio Antibodies in human, mouse, rat for SP6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SP6 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4