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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP6 Gene

protein-coding   GIFtS: 45
GCID: GC17M045922

Sp6 transcription factor
 Explore 3 diseases affiliated with
SP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SP6    

Aliases
for SP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sp6 Transcription Factor1 2     EPFN2
KLF141 2 3     EPIPROFIN2
Krueppel-Like Factor 142 3     Kruppel-Like Factor 142
Epfn1     Transcription Factor Sp62

External Ids:    HGNC: 145301   Entrez Gene: 803202   Ensembl: ENSG000001891207   OMIM: 6086135   UniProtKB: Q3SY563   

Export aliases for SP6 gene to outside databases

Previous GC identifers: GC17U990229 GC17M046396 GC17M043277 GC17M041291


Summaries
for SP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SP6:
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of
a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind
to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 (PubMed 11087666)).(supplied by OMIM, Mar
2008)

UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
Function: Promotes cell proliferation (By similarity)




Genomic Views
for SP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP6 gene promoter:
         Oct-B1   Bach1   oct-B3   POU2F1   oct-B2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

SP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M045922:  view genomic region     (about GC identifiers)

Start:
 45,922,279 bp from pter      End:
 45,933,240 bp from pter
Size:
 10,962 bases      Orientation:
 minus strand

Proteins
for SP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56 (See protein sequence)
Recommended Name: Transcription factor Sp6  
Size: 376 amino acids; 39840 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KXS4

Explore the universe of human proteins at neXtProt for SP6: NX_Q3SY56

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q3SY56

    • SP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245177.1  NP_954871.1  

    ENSEMBL proteins: 
     ENSP00000340799   ENSP00000438209  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SP6
    OriGene Protein Over-expression Lysate: SP6
    OriGene Custom Protein Services for SP6 
    GenScript Custom Purified and Recombinant Proteins Services for SP6
    Novus Biologicals SP6 Protein
    Novus Biologicals SP6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SP6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SP6 for ontologies           About GeneDecksing



    SP6 Antibody Products: 
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    Uscn Antibodies for SP6
    Search ThermoFisher Antibodies for SP6

    Assay Products for SP6: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SP6

    Protein Domains /
    Families
    for SP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SP6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q3SY56

    ProtoNet protein and cluster: Q3SY56

    UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for SP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
    Function: Promotes cell proliferation (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SP6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP6
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate SP6 (see all 34):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-3141 hsa-miR-765 hsa-miR-1260b hsa-miR-488 hsa-miR-29b-1* hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: SP6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP6 (see all 7)
    OriGene shRNA RFP: SP6
    OriGene siRNA: SP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SP6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SP6 (NM_032992)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SP6
    Search LifeMap BioReagents cell lines for SP6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    SP6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SP6:
     Cells with protrusions  Increased cell number in S and 

    Animal Models:
         Mouse knock-outs for SP6: Sp6tm1Yoya Sp6tm1.1Ibmm
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sp6):
     craniofacial  endocrine/exocrine gland  growth/size  integument  limbs/digits/tail 
     mortality/aging  normal  respiratory system 

    SP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP6

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0042481regulation of odontogenesis IEA--


    SP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP6
    Search CenterWatch for drugs/clinical trials and news about SP6 

    Transcripts
    for SP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SP6 gene (2 alternative transcripts): 
    NM_001258248.1  NM_199262.2  

    Unigene Cluster for SP6:

    Sp6 transcription factor
    Hs.253603  [show with all ESTs]
    Unigene Representative Sequence: AK127707
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342234(uc002imh.1) ENST00000536300(uc002img.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SP6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP6
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate SP6 (see all 34):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-3141 hsa-miR-765 hsa-miR-1260b hsa-miR-488 hsa-miR-29b-1* hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: SP6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP6 (see all 7)
    OriGene shRNA RFP: SP6
    OriGene siRNA: SP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SP6 (NM_032992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP6

    Additional cDNA sequence: 

    AK127707.1 AK127850.1 BC103951.1 BC103952.1 BC103953.1 BC103954.1 

    2 DOTS entries:

    DT.40292798  DT.97776385 

    24/46 AceView cDNA sequences (see all 46):

    BE047476 AI024904 BX397994 BQ899369 AI817264 AI273585 AW207058 BE300880 
    BF109399 AA443011 NM_199262 AK127850 AI123505 AW136253 BX366631 BX366632 
    AW672805 AA451898 AW137518 AA639559 BE264655 AK127707 AW731842 BX094659 

    GeneLoc Exon Structure


    Expression
    for SP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATGTGTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP6

    SOURCE GeneReport for Unigene cluster: Hs.253603

    UniProtKB/Swiss-Prot: SP6_HUMAN, Q3SY56
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for SP6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6

    Orthologs
    for SP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SP6 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SP66
    --
    		 --
    		 61(a)
    1(a)
    		 1 ↔ 1
    possible ortholog
    		 6(74601698-74602786)
    3(88021848-88042132)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:773581 zgc:77358 62.36(n)
    58.62(a)    		   402928  NM_205632.1  NP_991195.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG30656
    btd6
    		 buttonhead
    		 15(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 2R(19857830-19859756)
    X(9588221-9591606)
    worm
    (Caenorhabditis elegans)    		 Secernentea sptf-26
    sptf-36
    (see all 3)    		 Specificity Protein) Transcription Factor family m...
    Specificity Protein) Transcription Factor family m...
    (see all 3)    		 37(a)
    18(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 II(8625678-8627570)
    I(13360664-13366877)


    ENSEMBL Gene Tree for SP6 (if available)
    TreeFam Gene Tree for SP6 (if available) 

    Paralogs
    for SP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP6 gene
    SP42  SP32  SP82  SP52  SP22  KLF172  SP12  SP92  
    SP72  
    18/29 SIMAP similar genes for SP6 using alignment to 1 protein entry:     SP6_HUMAN(see all similar genes):
    DKFZp686O1631    SP3    KLF6    DKFZp686N0199    Sp1    ZNF697
    kr-znf3    DKFZp434J0650    ZFS-5    ZNF78L1    ZNF    SP8
    SP9    DKFZp313F0536    KLF7    PLZF    KLF9    A-328A3.4

    SP6 for paralogs           About GeneDecksing



    Genomic Variants
    for SP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 NCBI SNPs in SP6 are shown (see all 179)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1877028301,2
    		--45921782(+) AGGAGC/TCCATC 2 -- ds50010--------
    rs1923754731,2
    		--45921811(+) TCATCA/GCCTTG 2 -- ds50010--------
    rs1511175641,2
    		C,--45921846(+) GAAGT-/AATC  
                ACTGC     		2 -- ds50010--------
    rs23257521,2
    		C,F,A,H,--45921906(-) CCCATA/GGAGGG 2 -- ds500125Minor allele frequency- G:0.43NS EA NA WA CSA 2353
    rs43876321,2
    		C--45921976(+) GGAAAG/AAAGGG 2 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1170076641,2
    		F,--45921999(+) AAGAGG/AAAAGA 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1855673141,2
    		--45922016(+) TAGAAA/GCTTCT 2 -- ds50010--------
    rs1905063611,2
    		--45922067(+) ACCAAC/GCCAGA 2 -- ds50010--------
    rs1478048601,2
    		--45922096(+) CTGTAC/TCAGCC 2 -- ds50010--------
    rs1488189731,2
    		--45922190(+) GCATCC/TACCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SP6 (45922279 - 45933240 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SP6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP6
    DNA2.0 Custom Variant and Variant Library Synthesis for SP6

    Disorders / Diseases
    for SP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SP6 for disorders           About GeneDecksing

    OMIM gene information: 608613    OMIM disorders: --

    3 diseases for SP6:    About MalaCards
    facial paralysis    stomatitis    paralysis

    1 disease from the University of Copenhagen DISEASES database for SP6:
    Pain agnosia

    Export disorders for SP6 gene to outside databases

    Publications
    for SP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PubMed id 11087666)1, 3, 9 Scohy S.... Szpirer C. (2000)
    2. The Kruppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. (PubMed id 14551215)1, 3 Nakamura T....Yamada Y. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80320 HGNC: 14530 AceView: SP6 Ensembl:ENSG00000189120 euGenes: HUgn80320
    ECgene: SP6 H-InvDB: SP6

    Other Databases showing SP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SP6 gene:
    Search GeneIP for patents involving SP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SP6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
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     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SP6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP6  
     OriGene Protein Over-expression Lysate for SP6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SP6   OriGene 3'-UTR Clone for SP6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SP6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SP6   OriGene Custom Protein Services for SP6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP6
     GenScript Custom Purified and Recombinant Proteins Services for SP6 GenScript cDNA clones with any tag delivered in your preferred vector for SP6
     GenScript Custom Assay Services for SP6 GenScript Custom Superior Antibodies Services for SP6
     GenScript Custom overexpressing Cell Line Services for SP6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SP6 promoter
     Search Chromatin IP Primers for SP6
     RT2 qPCR Primer Assay in human, mouse, rat SP6
     Search GNC Networks for SP6
     SABiosciences Custom PCR Arrays for SP6
     Search Tocris compounds for SP6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SP6 antibodies
     SP6 proteins
     SP6 lysates
     Search for Antibodies for SP6 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SP6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP6
     SwitchGear 3'UTR luciferase reporter plasmids for SP6
     SwitchGear Promoter luciferase reporter plasmids for SP6
     Search ThermoFisher Antibodies for SP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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