Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SP6 Gene

Aliases for SP6 Gene

  • Sp6 Transcription Factor 2 3 5
  • Krueppel-Like Factor 14 3 4
  • KLF14 3 4
  • Kruppel-Like Factor 14 3
  • Epiprofin 2
  • EPFN 3

External Ids for SP6 Gene

Previous GeneCards Identifiers for SP6 Gene

  • GC17U990229
  • GC17M046396
  • GC17M043277
  • GC17M045922
  • GC17M041291

Summaries for SP6 Gene

Entrez Gene Summary for SP6 Gene

  • SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SP6 Gene

SP6 (Sp6 Transcription Factor) is a Protein Coding gene. Diseases associated with SP6 include Premenstrual Tension and Bladder Neck Obstruction. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP6 Gene

  • Promotes cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP6 Gene

Genomics for SP6 Gene

Regulatory Elements for SP6 Gene

Enhancers for SP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SP6 Gene

47,844,908 bp from pter
47,876,190 bp from pter
31,283 bases
Minus strand

Genomic View for SP6 Gene

Genes around SP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP6 Gene

Proteins for SP6 Gene

  • Protein details for SP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor Sp6
    Protein Accession:
    Secondary Accessions:
    • B3KXS4

    Protein attributes for SP6 Gene

    376 amino acids
    Molecular mass:
    39840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP6 Gene

Proteomics data for SP6 Gene at MOPED

Post-translational modifications for SP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP6 Gene

Domains & Families for SP6 Gene

Protein Domains for SP6 Gene

Suggested Antigen Peptide Sequences for SP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP6: view

Function for SP6 Gene

Molecular function for SP6 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.
genes like me logo Genes that share phenotypes with SP6: view

Animal Models for SP6 Gene

MGI Knock Outs for SP6:

Animal Model Products

miRNA for SP6 Gene

miRTarBase miRNAs that target SP6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP6 Gene

Localization for SP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP6 Gene


Subcellular locations from

Jensen Localization Image for SP6 Gene COMPARTMENTS Subcellular localization image for SP6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SP6 Gene

Pathways & Interactions for SP6 Gene

SuperPathways for SP6 Gene

No Data Available

Interacting Proteins for SP6 Gene

Gene Ontology (GO) - Biological Process for SP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with SP6: view

No data available for Pathways by source and SIGNOR curated interactions for SP6 Gene

Drugs & Compounds for SP6 Gene

No Compound Related Data Available

Transcripts for SP6 Gene

Unigene Clusters for SP6 Gene

Sp6 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP6 Gene

No ASD Table

Relevant External Links for SP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP6 Gene

mRNA expression in normal human tissues for SP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.4) and Skin - Sun Exposed (Lower leg) (x10.0).

SOURCE GeneReport for Unigene cluster for SP6 Gene Hs.253603

mRNA Expression by UniProt/SwissProt for SP6 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SP6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SP6 Gene

Orthologs for SP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SP6 35
  • 90.76 (n)
  • 94.13 (a)
SP6 36
  • 96 (a)
(Canis familiaris)
Mammalia SP6 35
  • 93.71 (n)
  • 98.4 (a)
SP6 36
  • 98 (a)
(Mus musculus)
Mammalia Sp6 35
  • 90.78 (n)
  • 96.28 (a)
Sp6 16
Sp6 36
  • 96 (a)
(Pan troglodytes)
Mammalia SP6 35
  • 99.56 (n)
  • 99.47 (a)
SP6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sp6 35
  • 90.6 (n)
  • 96.01 (a)
(Monodelphis domestica)
Mammalia SP6 36
  • 90 (a)
(Anolis carolinensis)
Reptilia SP6 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sp6 35
  • 58.15 (n)
  • 57.54 (a)
(Danio rerio)
Actinopterygii zgc:77358 35
  • 62.4 (n)
  • 58.9 (a)
SP6 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sp1 36
  • 18 (a)
Species with no ortholog for SP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP6 Gene

Gene Tree for SP6 (if available)
Gene Tree for SP6 (if available)

Paralogs for SP6 Gene

Paralogs for SP6 Gene

genes like me logo Genes that share paralogs with SP6: view

Variants for SP6 Gene

Sequence variations from dbSNP and Humsavar for SP6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34309518 - 47,847,964(-) GCTAC(A/G)TCGGA reference, missense
rs729988 -- 47,849,091(-) GGGCC(C/G)GATGT intron-variant
rs757061 -- 47,849,482(-) GCACT(C/T)GCTTA intron-variant
rs2106800 -- 47,846,680(-) ATTAA(A/C)CCTTT utr-variant-3-prime
rs2001380 -- 47,862,944(-) GAAGC(C/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP6 Gene

Variant ID Type Subtype PubMed ID
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680

Variation tolerance for SP6 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SP6 Gene

Disorders for SP6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SP6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
premenstrual tension
  • premenstrual syndrome
bladder neck obstruction
  • obstruction of bladder neck or vesicourethral orifice
mononeuritis of lower limb
lesion of sciatic nerve
  • lesion of sciatic nerve, nos
- elite association - COSMIC cancer census association via MalaCards
Search SP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SP6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP6 Gene

Publications for SP6 Gene

  1. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PMID: 11087666) Scohy S. … Szpirer C. (Genomics 2000) 2 3 23 67
  2. The KrA1ppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. (PMID: 14551215) Nakamura T. … Yamada Y. (J. Biol. Chem. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  5. Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation. (PMID: 25344255) Nakamura T. … Yamada Y. (J. Cell. Sci. 2014) 3

Products for SP6 Gene

Sources for SP6 Gene