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Aliases for SP6 Gene

Aliases for SP6 Gene

  • Sp6 Transcription Factor 2 3
  • Krueppel-Like Factor 14 3 4
  • KLF14 3 4
  • Transcription Factor Sp6 3
  • Kruppel-Like Factor 14 3
  • Epiprofin 2
  • EPFN 3

External Ids for SP6 Gene

Previous GeneCards Identifiers for SP6 Gene

  • GC17U990229
  • GC17M046396
  • GC17M043277
  • GC17M045922
  • GC17M041291

Summaries for SP6 Gene

Entrez Gene Summary for SP6 Gene

  • SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SP6 Gene

SP6 (Sp6 Transcription Factor) is a Protein Coding gene. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP6 Gene

  • Promotes cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP6 Gene

Genomics for SP6 Gene

Regulatory Elements for SP6 Gene

Genomic Location for SP6 Gene

47,844,908 bp from pter
47,876,145 bp from pter
31,238 bases
Minus strand

Genomic View for SP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP6 Gene

Proteins for SP6 Gene

  • Protein details for SP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor Sp6
    Protein Accession:
    Secondary Accessions:
    • B3KXS4

    Protein attributes for SP6 Gene

    376 amino acids
    Molecular mass:
    39840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP6 Gene

Proteomics data for SP6 Gene at MOPED

Post-translational modifications for SP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP6 Gene

Domains for SP6 Gene

Gene Families for SP6 Gene

  • SP :Specificity protein transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SP6 Gene

Suggested Antigen Peptide Sequences for SP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q3SY56
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP6: view

Function for SP6 Gene

Molecular function for SP6 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for SP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP6: view
genes like me logo Genes that share phenotypes with SP6: view

Animal Models for SP6 Gene

MGI Knock Outs for SP6:

Animal Model Products

miRNA for SP6 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SP6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SP6 Gene

Localization for SP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP6 Gene


Subcellular locations from

Jensen Localization Image for SP6 Gene COMPARTMENTS Subcellular localization image for SP6 gene
Compartment Confidence
nucleus 3
chloroplast 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SP6: view

Pathways for SP6 Gene

SuperPathways for SP6 Gene

No Data Available

Interacting Proteins for SP6 Gene

Gene Ontology (GO) - Biological Process for SP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0042481 regulation of odontogenesis IEA --
genes like me logo Genes that share ontologies with SP6: view

No data available for Pathways by source for SP6 Gene

Transcripts for SP6 Gene

Unigene Clusters for SP6 Gene

Sp6 transcription factor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP6 Gene

No ASD Table

Relevant External Links for SP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP6 Gene

mRNA expression in normal human tissues for SP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.4) and Skin - Sun Exposed (Lower leg) (10.0).

SOURCE GeneReport for Unigene cluster for SP6 Gene Hs.253603

mRNA Expression by UniProt/SwissProt for SP6 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SP6: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for SP6 Gene

Orthologs for SP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SP6 35
  • 90.76 (n)
  • 94.13 (a)
SP6 36
  • 96 (a)
(Canis familiaris)
Mammalia SP6 35
  • 93.71 (n)
  • 98.4 (a)
SP6 36
  • 98 (a)
(Mus musculus)
Mammalia Sp6 35
  • 90.78 (n)
  • 96.28 (a)
Sp6 16
Sp6 36
  • 96 (a)
(Pan troglodytes)
Mammalia SP6 35
  • 99.56 (n)
  • 99.47 (a)
SP6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sp6 35
  • 90.6 (n)
  • 96.01 (a)
(Monodelphis domestica)
Mammalia SP6 36
  • 90 (a)
(Anolis carolinensis)
Reptilia SP6 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sp6 35
  • 58.15 (n)
  • 57.54 (a)
(Danio rerio)
Actinopterygii zgc:77358 35
  • 62.4 (n)
  • 58.9 (a)
SP6 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sp1 36
  • 18 (a)
Species with no ortholog for SP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP6 Gene

Gene Tree for SP6 (if available)
Gene Tree for SP6 (if available)

Paralogs for SP6 Gene

genes like me logo Genes that share paralogs with SP6: view

Variants for SP6 Gene

Sequence variations from dbSNP and Humsavar for SP6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs729988 -- 47,849,091(-) GGGCC(C/G)GATGT intron-variant
rs757061 -- 47,849,482(-) GCACT(C/T)GCTTA intron-variant
rs2074185 -- 47,853,218(-) AGTAA(C/T)AAGAA intron-variant
rs2074186 -- 47,853,174(-) CAATC(A/C)CCCGA intron-variant
rs2074187 -- 47,852,993(-) CACAG(G/T)TCTTT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP6 Gene

Variant ID Type Subtype PubMed ID
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680

Relevant External Links for SP6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP6 Gene

Disorders for SP6 Gene

(1) University of Copenhagen DISEASES for SP6 Gene

Relevant External Links for SP6

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SP6: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SP6 Gene

Publications for SP6 Gene

  1. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PMID: 11087666) Scohy S. … Szpirer C. (Genomics 2000) 2 3 23
  2. The KrA1ppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. (PMID: 14551215) Nakamura T. … Yamada Y. (J. Biol. Chem. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  5. Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. (PMID: 18156176) Nakamura T. … Yamada Y. (J. Biol. Chem. 2008) 48

Products for SP6 Gene

Sources for SP6 Gene

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