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Aliases for SP5 Gene

Aliases for SP5 Gene

  • Sp5 Transcription Factor 2 3 5

External Ids for SP5 Gene

Previous GeneCards Identifiers for SP5 Gene

  • GC02P171774
  • GC02P171398
  • GC02P171280
  • GC02P171571
  • GC02P163460

Summaries for SP5 Gene

GeneCards Summary for SP5 Gene

SP5 (Sp5 Transcription Factor) is a Protein Coding gene. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP5 Gene

  • Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP5 Gene

Genomics for SP5 Gene

Regulatory Elements for SP5 Gene

Enhancers for SP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F170501 2.1 Ensembl ENCODE 5.2 -210.4 -210401 4.8 ZFP64 MAX ZNF140 ZNF266 ZNF384 ZNF101 ZNF664 NFE2 ZNF433 ZNF639 PHOSPHO2 GORASP2 DCAF17 DAP3P2 LOC101929753 SP5 MYO3B GC02P170510 GC02P170458
GH02F170737 0.9 Ensembl ENCODE 11.6 +24.2 24232 2.3 HLF BHLHE40 MNT TEAD3 FOSL1 JUND FOS MAFK NFE2L2 SPI1 LOC101926913 GAD1 SP5 LINC01124 EIF2S2P4
GH02F170713 2.1 ENCODE 0.8 +0.9 929 4.2 PKNOX1 CREB3L1 ARID4B DMAP1 CBX5 ZNF143 ZNF207 KLF13 PAF1 ZNF263 LOC101926913 DCAF17 GAD1 SP5 EIF2S2P4
GH02F170743 1.3 Ensembl ENCODE 0.3 +29.6 29552 1.9 MLX ARID4B DMAP1 ZNF48 YY1 GATA2 KLF13 SP5 ZHX2 MXD4 LOC101926913 GAD1 EIF2S2P4 SP5
GH02F170747 1 Ensembl ENCODE 0.3 +33.3 33314 1.3 ATF1 JUN BACH1 CHAMP1 ZNF316 POLR2A TRIM24 NFE2 CREM MAFK GAD1 LOC101926913 EIF2S2P4 SP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SP5 on UCSC Golden Path with GeneCards custom track

Promoters for SP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001829425 162 1401 PKNOX1 CREB3L1 MLX DMAP1 CBX5 KLF13 SP5 NFYC ZHX2 REST
ENSR00000602168 1362 201 SOX13 RNF2 SAP130 ARID4B RAD21 CHAMP1 POLR2A GABPB1 ZBTB33 EZH2

Genomic Location for SP5 Gene

Chromosome:
2
Start:
170,714,738 bp from pter
End:
170,718,078 bp from pter
Size:
3,341 bases
Orientation:
Plus strand

Genomic View for SP5 Gene

Genes around SP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP5 Gene

Proteins for SP5 Gene

  • Protein details for SP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6BEB4-SP5_HUMAN
    Recommended name:
    Transcription factor Sp5
    Protein Accession:
    Q6BEB4

    Protein attributes for SP5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP5 Gene

Post-translational modifications for SP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP5 Gene

Domains & Families for SP5 Gene

Protein Domains for SP5 Gene

Suggested Antigen Peptide Sequences for SP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6BEB4

UniProtKB/Swiss-Prot:

SP5_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP5: view

Function for SP5 Gene

Molecular function for SP5 Gene

UniProtKB/Swiss-Prot Function:
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

Gene Ontology (GO) - Molecular Function for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP5: view
genes like me logo Genes that share phenotypes with SP5: view

Animal Models for SP5 Gene

MGI Knock Outs for SP5:
  • Sp5 tm1b(KOMP)Wtsi

Animal Model Products

miRNA for SP5 Gene

miRTarBase miRNAs that target SP5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP5 Gene

Localization for SP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP5 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SP5: view

Pathways & Interactions for SP5 Gene

genes like me logo Genes that share pathways with SP5: view

Pathways by source for SP5 Gene

Gene Ontology (GO) - Biological Process for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0036342 post-anal tail morphogenesis IEA --
GO:0060349 bone morphogenesis IEA --
GO:0071407 cellular response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with SP5: view

No data available for SIGNOR curated interactions for SP5 Gene

Transcripts for SP5 Gene

mRNA/cDNA for SP5 Gene

Unigene Clusters for SP5 Gene

Sp5 transcription factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP5 Gene

No ASD Table

Relevant External Links for SP5 Gene

GeneLoc Exon Structure for
SP5
ECgene alternative splicing isoforms for
SP5

Expression for SP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP5 Gene

This gene is overexpressed in Cervix - Endocervix (x6.9) and Cervix - Ectocervix (x6.3).

Protein differential expression in normal tissues from HIPED for SP5 Gene

This gene is overexpressed in Retina (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SP5 Gene



Protein tissue co-expression partners for SP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SP5 Gene:

SP5

SOURCE GeneReport for Unigene cluster for SP5 Gene:

Hs.368802
genes like me logo Genes that share expression patterns with SP5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SP5 Gene

Orthologs for SP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP5 34 35
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia SP5 34 35
  • 92.7 (n)
mouse
(Mus musculus)
Mammalia Sp5 34 16 35
  • 91.12 (n)
oppossum
(Monodelphis domestica)
Mammalia SP5 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp5 34
  • 90.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SP5 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP5 34 35
  • 87.91 (n)
chicken
(Gallus gallus)
Aves SP5 34 35
  • 86.49 (n)
lizard
(Anolis carolinensis)
Reptilia SP5 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp5 34
  • 65.37 (n)
MGC76071 34
African clawed frog
(Xenopus laevis)
Amphibia spr1-A 34
zebrafish
(Danio rerio)
Actinopterygii sp5a 34 35
  • 66.76 (n)
SP5 (1 of 3) 35
  • 54 (a)
OneToMany
sp5l 35
  • 51 (a)
OneToMany
sp5 34
fruit fly
(Drosophila melanogaster)
Insecta Sp1 35
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRZ1 37
Species where no ortholog for SP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP5 Gene

ENSEMBL:
Gene Tree for SP5 (if available)
TreeFam:
Gene Tree for SP5 (if available)

Paralogs for SP5 Gene

Paralogs for SP5 Gene

(12) SIMAP similar genes for SP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SP5: view

Variants for SP5 Gene

Sequence variations from dbSNP and Humsavar for SP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1110002 -- 170,715,782(+) CTGGC(C/G)GAGAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112091854 -- 170,714,944(+) TGCAA(-/GTGTGT/GTGTGTGT/GTGTGTGTGT)GTGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112415907 -- 170,713,148(+) GCTTC(A/G)AGGGT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1134626 -- 170,716,675(+) CTGCC(G/T)CCAGG intron-variant, reference, synonymous-codon
rs115371253 -- 170,715,488(+) TCCGC(A/C)GCCAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SP5 Gene

Variant ID Type Subtype PubMed ID
nsv821786 CNV gain 20364138
esv26289 CNV loss 19812545
dgv7158n54 CNV loss 21841781

Variation tolerance for SP5 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.75; 94.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP5 Gene

Disorders for SP5 Gene

Relevant External Links for SP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP5

No disorders were found for SP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP5 Gene

Publications for SP5 Gene

  1. Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. (PMID: 16201967) Simmons S.O. … Horowitz J.M. (Biochem. J. 2006) 3 64
  2. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (PMID: 16380080) Chen Y. … Aburatani H. (Biochem. Biophys. Res. Commun. 2006) 3 64
  3. Mammalian SP/KLF transcription factors: bring in the family. (PMID: 15820306) Suske G. … Philipsen S. (Genomics 2005) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SP5 Gene

Sources for SP5 Gene

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