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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SP5 Gene

protein-coding GIFtS: 48
GCID: GC02P171571

Sp5 transcription factor

Explore 1 disease affiliated with
SP5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sp5 Transcription Factor¹ ²
Transcription Factor Sp5²

External Ids:	HGNC: 14529¹	Entrez Gene: 389058²	Ensembl: ENSG00000204335⁷	OMIM: 609391⁵	UniProtKB: Q6BEB4³

Export aliases for SP5 gene to outside databases

Previous GC identifers: GC02P171774 GC02P171398 GC02P171280 GC02P163460

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4

Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination

of changes in transcription required to generate pattern in the developing embryo (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SP5 gene promoter:
AML1a Pax-5 ATF-2 STAT1beta STAT1alpha GATA-1 Arnt MZF-1 CRE-BP1 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SP5 promoter sequence

Search SABiosciences Chromatin IP Primers for SP5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31

SP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP5 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P171571: view genomic region (about GC identifiers)

Start:	171,571,857 bp from pter	End:	171,574,588 bp from pter
Size:	2,732 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4 (See protein sequence)

Recommended Name: Transcription factor Sp5

Size: 398 amino acids; 41964 Da

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for SP5: NX_Q6BEB4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6BEB4

SP5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001003845.1

ENSEMBL proteins:

ENSP00000364430

Human Recombinant Protein Products for SP5:

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	Uscn Proteins for SP5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

SP5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SP5 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6BEB4

ProtoNet protein and cluster: Q6BEB4

UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4

Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SP5_HUMAN, Q6BEB4

Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination

of changes in transcription required to generate pattern in the developing embryo (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

SP5 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sp5):

limbs/digits/tail

normal

skeleton

SP5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SP5

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP5
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SP5 (see all 20):
		hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-374a hsa-miR-944 hsa-miR-486-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SP5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Regulation of Wnt-mediated beta catenin signaling and target gene transcription

1.00

1 BioSystems Pathway for SP5

Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SP5

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for SP5 (Q6BEB4³ ENSP00000364430⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKX3-1	Q99801³, ENSP00000370253⁴	I2D: score=1 STRING: ENSP00000370253
LEF1	ENSP00000265165⁴	STRING: ENSP00000265165
CTNNB1	ENSP00000344456⁴	STRING: ENSP00000344456

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0035121	tail morphogenesis	--	--
GO:0036342	post-anal tail morphogenesis	IEA	--
GO:0060349	bone morphogenesis	IEA	--

SP5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SP5
Search CenterWatch for drugs/clinical trials and news about SP5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SP5 gene:

NM_001003845.2

Unigene Cluster for SP5:

Sp5 transcription factor

Hs.368802 [show with all ESTs]

Unigene Representative Sequence: NM_001003845

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375281(uc002uge.3) ENST00000487037

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP5
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SP5 (see all 20):
		hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-374a hsa-miR-944 hsa-miR-486-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SP5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP5 (see all 7) OriGene shRNA RFP: SP5 OriGene siRNA: SP5
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SP5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SP5 (NM_004347)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP5

Additional cDNA sequence: AB096175.1

2 DOTS entries:

DT.204786 DT.99970248

24/27 AceView cDNA sequences (see all 27):

AI291584 CA866597 AI620770 BC069026 BQ064677 AA883311 AI161376 CA337181

BQ648306 AW450640 AI910361 BQ652868 AI278767 AB096175 AI553924 BQ643741

BV205926 AI393053 BV185594 AI275629 AI245906 CA866861 AI380207 NM_001003845

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATGTCTCT

About this image

SP5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Paraxial Mesoderm

Paraxial Mesoderm Cells

Mesoderm

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Primitive gut tube-like cells (A scalable, suspensi...)

Beating cell clusters (Spontaneous differen...)

See SP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SP5

SOURCE GeneReport for Unigene cluster: Hs.368802

SABiosciences Custom PCR Arrays for SP5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SP5 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SP5¹	Sp5 transcription factor	86.67(n) 90(a)		693261 NM_001044684.1 NP_001038149.1
lizard (Anolis carolinensis)	Reptilia	SP5⁶ --	--	73(a) 1(a)	1 ↔ 1 possible ortholog	GL343362.1(1042441-1047381) 3(88021848-88042132)
African clawed frog (Xenopus laevis)	Amphibia	spr1-A²	Sp1-like zinc-finger protein XSPR-1	69.94(n)		AY062264.1
zebrafish (Danio rerio)	Actinopterygii	sp5²	Sp5 transcription factor	76.37(n)		353154 AF388363.1
honey bee (Apis mellifera)	Insecta	--	--	5(a)	possible ortholog	GroupUn.224(42583-44730)
worm (Caenorhabditis elegans)	Secernentea	sptf-2¹	Protein SPTF-2	50(n) 57.89(a)		188733 NM_063432.1 NP_495833.1

ENSEMBL Gene Tree for SP5 (if available)
TreeFam Gene Tree for SP5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SP5 gene

SP1² SP4² SP3² SP8² SP6² SP2² KLF17² SP7²

SP9²

12 SIMAP similar genes for SP5 using alignment to 1 protein entry: SP5_HUMAN:

DKFZp686O1631 SP3 KLF9 KLF6 SP1 Sp1

KLF16 ZNF697 ZNF702P SP8 SP4 ZNF844

SP5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117354365^1,2	C,F	--	171569936(+)	`TGGGGG/AAGAAG`	2	--	us2k¹ nc-transcript-variant		1		EA	120
rs149152463^1,2		--	171569961(+)	`CAGGAC/TGTGCG`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs74686741^1,2	F	--	171570080(+)	`ATCCCC/GGACCC`	2	--	nc-transcript-variantus2k¹		1		WA	118
rs72885464^1,2	C,F	--	171570151(+)	`CTAACC/TTCTGA`	2	--	us2k¹ nc-transcript-variant		5		NA EA EU	785
rs143288706^1,2		--	171570393(+)	`GGTTCC/TGCACC`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs188874511^1,2		--	171570417(+)	`GGCGGC/TGAGCA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs7563812^1,2	C,A,H	--	171570488(+)	`CCCCGG/CGTCCG`	2	--	nc-transcript-variantus2k¹		8		NA CSA WA EA	367
rs191621728^1,2		--	171570656(+)	`CTTTTC/TCTTTC`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs183535293^1,2		--	171570691(+)	`ACTGAC/TTTTTC`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs201604239^1,2		--	171570744(+)	`GGACC-/ACAACAAC`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SP5 (171571857 - 171574588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SP5
1 CNV: 68199

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP5

DNA2.0 Custom Variant and Variant Library Synthesis for SP5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SP5 for disorders           About GeneDecksing

OMIM gene information: 609391    OMIM disorders: --

1 disease for SP5:    About MalaCards

prostatitis

Export disorders for SP5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SP5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SP5)

Utopia: connect your pdf to the dynamic
world of online information

Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (PubMed id 16380080)¹ Chen Y....Aburatani H. (2006)
Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. (PubMed id 16201967)¹ Simmons S.O. and Horowitz J.M. (2006)
Mammalian SP/KLF transcription factors: bring in the family. (PubMed id 15820306)¹ Suske G....Philipsen S. (2005)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389058	HGNC: 14529	AceView: SP5	Ensembl:ENSG00000204335	euGenes: HUgn389058
ECgene: SP5	H-InvDB: SP5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SP5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SP5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SP5 gene:
Search GeneIP for patents involving SP5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SP5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP5
	OriGene Protein Over-expression Lysate for SP5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SP5		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SP5		OriGene Custom Protein Services for SP5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP5
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP5

	GenScript Custom Purified and Recombinant Proteins Services for SP5		GenScript cDNA clones with any tag delivered in your preferred vector for SP5
	GenScript Custom Assay Services for SP5		GenScript Custom Superior Antibodies Services for SP5
	GenScript Custom overexpressing Cell Line Services for SP5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SP5 promoter
	Search Chromatin IP Primers for SP5
	RT² qPCR Primer Assay in human, mouse, rat SP5
	Search GNC Networks for SP5
	SABiosciences Custom PCR Arrays for SP5

Search Tocris compounds for SP5

	Browse Sino Biological Proteins and Antibodies
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	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for SP5
	See all of Abcam's Antibodies, Kits and Proteins for SP5
	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

SP5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SP5

	Gene Synthesis
	Protein Engineering
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	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP5

	SwitchGear 3'UTR luciferase reporter plasmids for SP5
	SwitchGear Promoter luciferase reporter plasmids for SP5

ThermoFisher Antibodies for SP5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SP5

Sirion Biotech Customized:

	stable knockdown cell line services for SP5
	inducible knockdown cell line services for SP5
	design and validation of potent shRNA sequences against SP5
	adenovirus for potent knockdown of SP5
	adenovirus for overexpression of SP5
	stable overexpressing cell line services for SP5
	inducible overexpressing cell line services for SP5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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SP5 Gene

Sp5 transcription factor

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SP5 Gene

Sp5 transcription factor

Aliasesfor SP5 gene

Summariesfor SP5 gene

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Functionfor SP5 gene

Pathways & Interactionsfor SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

Expression
for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene

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for SP5 gene