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Aliases for SP5 Gene

Aliases for SP5 Gene

  • Sp5 Transcription Factor 2 3

External Ids for SP5 Gene

Summaries for SP5 Gene

GeneCards Summary for SP5 Gene

SP5 (Sp5 Transcription Factor) is a Protein Coding gene. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP5 Gene

  • Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP5 Gene

Genomics for SP5 Gene

Genomic Location for SP5 Gene

Start:
170,715,347 bp from pter
End:
170,718,078 bp from pter
Size:
2,732 bases
Orientation:
Plus strand

Genomic View for SP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP5 Gene

Regulatory Elements for SP5 Gene

Proteins for SP5 Gene

  • Protein details for SP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6BEB4-SP5_HUMAN
    Recommended name:
    Transcription factor Sp5
    Protein Accession:
    Q6BEB4
    Secondary Accessions:

    Protein attributes for SP5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP5 Gene

Proteomics data for SP5 Gene at MOPED

Post-translational modifications for SP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP5 Gene

Domains for SP5 Gene

Gene Families for SP5 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • SP :Specificity protein transcription factors

Protein Domains for SP5 Gene

UniProtKB/Swiss-Prot:

SP5_HUMAN
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • Q6BEB4
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q6BEB4
genes like me logo Genes that share domains with SP5: view

Function for SP5 Gene

Molecular function for SP5 Gene

UniProtKB/Swiss-Prot Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

Gene Ontology (GO) - Molecular Function for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP5: view

Phenotypes for SP5 Gene

genes like me logo Genes that share phenotypes with SP5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SP5 Gene

Localization for SP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP5 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP5 Gene COMPARTMENTS Subcellular localization image for SP5 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SP5: view

Pathways for SP5 Gene

genes like me logo Genes that share pathways with SP5: view

Pathways by source for SP5 Gene

Gene Ontology (GO) - Biological Process for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0036342 post-anal tail morphogenesis IEA --
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with SP5: view

Transcripts for SP5 Gene

mRNA/cDNA for SP5 Gene

Unigene Clusters for SP5 Gene

Sp5 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP5 Gene

No ASD Table

Relevant External Links for SP5 Gene

GeneLoc Exon Structure for
SP5
ECgene alternative splicing isoforms for
SP5

Expression for SP5 Gene

mRNA expression in normal human tissues for SP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP5 Gene

This gene is overexpressed in Cervix - Endocervix (6.9) and Cervix - Ectocervix (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SP5 Gene

SOURCE GeneReport for Unigene cluster for SP5 Gene Hs.368802

genes like me logo Genes that share expressions with SP5: view

Orthologs for SP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP5 36
  • 99.16 (n)
  • 98.96 (a)
SP5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP5 36
  • 87.91 (n)
  • 90.93 (a)
SP5 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP5 36
  • 92.7 (n)
  • 98.24 (a)
SP5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp5 36
  • 91.12 (n)
  • 97.49 (a)
Sp5 16
Sp5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SP5 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SP5 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp5 36
  • 90.62 (n)
  • 97.49 (a)
chicken
(Gallus gallus)
Aves SP5 36
  • 86.49 (n)
  • 89.73 (a)
SP5 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP5 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia spr1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76071 36
sp5 36
  • 65.37 (n)
  • 76.32 (a)
zebrafish
(Danio rerio)
Actinopterygii sp5 36
SP5 (1 of 3) 37
  • 54 (a)
OneToMany
sp5a 36
  • 66.76 (n)
  • 70.17 (a)
sp5a 37
  • 70 (a)
OneToMany
sp5l 37
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sp1 37
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRZ1 39
Species with no ortholog for SP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP5 Gene

ENSEMBL:
Gene Tree for SP5 (if available)
TreeFam:
Gene Tree for SP5 (if available)

Paralogs for SP5 Gene

Selected SIMAP similar genes for SP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SP5: view

Variants for SP5 Gene

Sequence variations from dbSNP and Humsavar for SP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_052713 -

Structural Variations from Database of Genomic Variants (DGV) for SP5 Gene

Variant ID Type Subtype PubMed ID
nsv875409 CNV Loss 21882294
nsv821786 CNV Gain 20364138
esv26289 CNV Loss 19812545

Relevant External Links for SP5 Gene

HapMap Linkage Disequilibrium report
SP5

Disorders for SP5 Gene

No disorders were found for SP5 Gene.

No data available for UniProtKB/Swiss-Prot for SP5 Gene

Publications for SP5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. Mammalian SP/KLF transcription factors: bring in the family. (PMID: 15820306) Suske G. … Philipsen S. (Genomics 2005) 3
  4. Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. (PMID: 16201967) Simmons S.O. … Horowitz J.M. (Biochem. J. 2006) 3
  5. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (PMID: 16380080) Chen Y. … Aburatani H. (Biochem. Biophys. Res. Commun. 2006) 3

Products for SP5 Gene

Sources for SP5 Gene

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