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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP5 Gene

protein-coding   GIFtS: 47
GCID: GC02P171571

Sp5 Transcription Factor

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sp5 Transcription Factor1 2
Transcription Factor Sp52

External Ids:    HGNC: 145291   Entrez Gene: 3890582   Ensembl: ENSG000002043357   OMIM: 6093915   UniProtKB: Q6BEB43   

Export aliases for SP5 gene to outside databases

Previous GC identifers: GC02P171774 GC02P171398 GC02P171280 GC02P163460


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SP5 Gene: 
SP5 (Sp5 transcription factor) is a protein-coding gene. Diseases associated with SP5 include prostatitis. GO annotations related to this gene include sequence-specific DNA binding and zinc ion binding. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4
Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the
coordination of changes in transcription required to generate pattern in the developing embryo (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP5 gene promoter:
         AML1a   Pax-5   ATF-2   STAT1beta   STAT1alpha   GATA-1   Arnt   MZF-1   CRE-BP1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

SP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P171571:  view genomic region     (about GC identifiers)

Start:
171,571,857 bp from pter      End:
171,574,588 bp from pter
Size:
2,732 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4 (See protein sequence)
Recommended Name: Transcription factor Sp5  
Size: 398 amino acids; 41964 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for SP5: NX_Q6BEB4

Explore proteomics data for SP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6BEB4

  • SP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SP5 Protein Expression
    REFSEQ proteins: NP_001003845.1  
    ENSEMBL proteins: 
     ENSP00000364430  

    Human Recombinant Protein Products for SP5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SP5
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    GenScript Custom Purified and Recombinant Proteins Services for SP5
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SP5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SP5 for ontologies           About GeneDecksing



    SP5 Antibody Products: 
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    Abcam antibodies for SP5
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    LSBio Antibodies in human, mouse, rat for SP5 

    Assay Products for SP5: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SP5 
    Cloud-Clone Corp. CLIAs for SP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6BEB4

    ProtoNet protein and cluster: Q6BEB4

    UniProtKB/Swiss-Prot: SP5_HUMAN, Q6BEB4
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    SP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP5_HUMAN, Q6BEB4
    Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the
    coordination of changes in transcription required to generate pattern in the developing embryo (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    SP5 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sp5):
     limbs/digits/tail  normal  skeleton 

    SP5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SP5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SP5 (see all 20):
    hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-374a hsa-miR-944 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmidSP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SP5

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SP5 (see all 6)
    OriGene ORF clones in mouse, rat for SP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SP5 (NM_004347)
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                         Customized lentivirus expression plasmids for stable overexpression of SP5 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SP5
    Search LifeMap BioReagents cell lines for SP5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 BioSystems Pathway for SP5
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SP5 (Q6BEB43 ENSP000003644304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NKX3-1Q998013, ENSP000003702534I2D: score=1 STRING: ENSP00000370253
    LEF1ENSP000002651654STRING: ENSP00000265165
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0036342post-anal tail morphogenesis IEA--
    GO:0060349bone morphogenesis IEA--

    SP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP5

    Search CenterWatch for drugs/clinical trials and news about SP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SP5 gene: 
    NM_001003845.2  

    Unigene Cluster for SP5:

    Sp5 transcription factor
    Hs.368802  [show with all ESTs]
    Unigene Representative Sequence: NM_001003845
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375281(uc002uge.3) ENST00000487037
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SP5 (see all 20):
    hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-374a hsa-miR-944 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmidSP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP5
    Clone
    Products:
         
    OriGene clones in human, mouse for SP5 (see all 6)
    OriGene ORF clones in mouse, rat for SP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SP5 (NM_004347)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP5
    Sirion Biotech Customized lentivirus for stable overexpression of SP5 
                         Customized lentivirus expression plasmids for stable overexpression of SP5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SP5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP5

    Additional mRNA sequence: AB096175.1 

    2 DOTS entries:

    DT.204786  DT.99970248 

    24/27 AceView cDNA sequences (see all 27):

    BQ064677 AI291584 CA866597 AI620770 BC069026 BQ643741 BV205926 AI380207 
    AI910361 CA866861 CA337181 AI278767 AI161376 AI393053 AW450640 BQ652868 
    NM_001003845 BQ648306 AI553924 AI245906 AA883311 AI275629 AB096175 BV185594 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP5 expression in normal human tissues (normalized intensities)      SP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGTCTCT
    SP5 Expression
    About this image


    SP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalon
             future brain/future rhombencephalon/rhombomere 01   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS2
     
     Intestine (Gastrointestinal Tract)
             duodenum   
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm

    See SP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP5

    SOURCE GeneReport for Unigene cluster: Hs.368802
        SABiosciences Custom PCR Arrays for SP5
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SP5 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp51 , 5 trans-acting transcription factor 51, 5 91.12(n)1
    97.49(a)1
      2 (41.49 cM)5
    644061  NM_022435.21  NP_071880.11 
     704749235 
    chicken
    (Gallus gallus)
    Aves SP51 Sp5 transcription factor 86.67(n)
    90(a)
      693261  NM_001044684.1  NP_001038149.1 
    lizard
    (Anolis carolinensis)
    Reptilia SP56
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343362.1(1042441-1047381)
    African clawed frog
    (Xenopus laevis)
    Amphibia spr1-A2 Sp1-like zinc-finger protein XSPR-1 69.94(n)    AY062264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sp52 Sp5 transcription factor 76.37(n)   353154  AF388363.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sp16
    Sp1
    16(a)
    1 → many
    X(9623681-9650237)
    worm
    (Caenorhabditis elegans)
    Secernentea sptf-21 Protein SPTF-2 50(n)
    57.89(a)
      188733  NM_063432.1  NP_495833.1 


    ENSEMBL Gene Tree for SP5 (if available)
    TreeFam Gene Tree for SP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP5 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    12 SIMAP similar genes for SP5 using alignment to 1 protein entry:     SP5_HUMAN:
    DKFZp686O1631    SP3    KLF9    KLF6    SP1    Sp1
    KLF16    ZNF697    ZNF702P    SP8    SP4    ZNF844

    SP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/29 SNPs in SP5 are shown (see all 29)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0527134
    ----see VAR_0527132 A T mis40--------
    rs11346261,2
    C,F--171573185(+) CTGCCG/TCCAGG 2 P syn1 ese31Minor allele frequency- T:0.35NA 120
    rs2003059991,2
    C--171573597(+) AGAAGA/CAGCAG 2 K Q mis10--------
    rs1477800611,2
    F--171573716(+) TTCTGC/TGGGAA 2 C syn11Minor allele frequency- T:0.00NA 3700
    rs1381809261,2
    C--171573796(+) TCCCGA/TGTGCG 2 E V mis11Minor allele frequency- T:0.00NA 3856
    rs730153541,2
    C--171573861(+) ATAAGA/CAGCTC 2 K Q mis10--------
    rs2014658301,2
    --171573883(+) GGCCGA/GGGTTA 2 E G mis10--------
    rs758664121,2
    C,F--171573927(+) CGGAGG/ATGGAC 1 -- ut311Minor allele frequency- A:0.16EA 120
    rs1932972681,2
    C--171573959(+) AGAGAG/TCCGGG 1 -- ut310--------
    rs1855586751,2
    --171574029(+) TCCCAA/GAATGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SP5 (171571857 - 171574588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26289CNV Loss19812545
    nsv875409CNV Loss21882294
    nsv821786CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SP5
    DNA2.0 Custom Variant and Variant Library Synthesis for SP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609391    OMIM disorders: --

    2 diseases for SP5:    About MalaCards
    prostatitis    


    SP5 for disorders           About GeneDecksing


    Export disorders for SP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (PubMed id 16380080)1 Chen Y....Aburatani H. (2006)
    2. Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. (PubMed id 16201967)1 Simmons S.O. and Horowitz J.M. (2006)
    3. Mammalian SP/KLF transcription factors: bring in the family. (PubMed id 15820306)1 Suske G....Philipsen S. (2005)
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389058 HGNC: 14529 AceView: SP5 Ensembl:ENSG00000204335 euGenes: HUgn389058
    ECgene: SP5 H-InvDB: SP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SP5 gene:
    Search GeneIP for patents involving SP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Regulatory tfbs in SP5 promoter
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     Proteins for SP5
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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