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Aliases for SP4 Gene

Aliases for SP4 Gene

  • Sp4 Transcription Factor 2 3 5
  • SPR-1 3 4
  • Transcription Factor Sp4 3
  • HF1B 3

External Ids for SP4 Gene

Previous GeneCards Identifiers for SP4 Gene

  • GC07P021112
  • GC07P021177
  • GC07P021212
  • GC07P021240

Summaries for SP4 Gene

Entrez Gene Summary for SP4 Gene

  • The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]

GeneCards Summary for SP4 Gene

SP4 (Sp4 Transcription Factor) is a Protein Coding gene. Diseases associated with SP4 include Bipolar Disorder and Schizophrenia. Among its related pathways are Mesodermal Commitment Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP1.

UniProtKB/Swiss-Prot for SP4 Gene

  • Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Gene Wiki entry for SP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP4 Gene

Genomics for SP4 Gene

Regulatory Elements for SP4 Gene

Enhancers for SP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G021352 1.5 FANTOM5 Ensembl ENCODE 17.5 -73.6 -73588 4.9 HDGF PKNOX1 WRNIP1 GATA2 CBX5 JUNB TBX21 SMARCB1 SMARCA4 NBN SP4 GC07M021324 RNU1-15P
GH07G021941 1.6 Ensembl ENCODE dbSUPER 12.6 +516.2 516185 5.9 SIN3A FEZF1 ZNF2 YY1 ZNF416 ZNF143 ZNF207 ZNF263 SP3 REST SP4 CDCA7L IL6 PIR47500
GH07G021616 1.2 Ensembl ENCODE 12.6 +189.8 189823 2.9 FOXA2 MLX ARID4B SIN3A YY1 GTF3C2 GATA2 ZNF143 FOS DEK DNAH11 SP4 GC07P021597 PIR48952
GH07G021365 0.9 ENCODE 12.4 -61.6 -61560 1.0 ELF3 FOXA2 INSM2 FEZF1 RAD21 RARA GATA4 GATA2 ZNF366 FOS SP4 RNU1-15P GC07M021324
GH07G021358 0.8 Ensembl ENCODE 12.4 -69.2 -69187 0.9 FOXA2 CEBPA BCL6B CEBPB SPI1 SP4 GC07M021324 RNU1-15P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SP4 on UCSC Golden Path with GeneCards custom track

Promoters for SP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209296 -34 2401 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SP4 Gene

Chromosome:
7
Start:
21,428,034 bp from pter
End:
21,514,822 bp from pter
Size:
86,789 bases
Orientation:
Plus strand

Genomic View for SP4 Gene

Genes around SP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP4 Gene

Proteins for SP4 Gene

  • Protein details for SP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02446-SP4_HUMAN
    Recommended name:
    Transcription factor Sp4
    Protein Accession:
    Q02446
    Secondary Accessions:
    • O60402
    • Q32M52

    Protein attributes for SP4 Gene

    Size:
    784 amino acids
    Molecular mass:
    81985 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP4 Gene

Post-translational modifications for SP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SP4 Gene

Domains & Families for SP4 Gene

Protein Domains for SP4 Gene

Suggested Antigen Peptide Sequences for SP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q02446

UniProtKB/Swiss-Prot:

SP4_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP4: view

Function for SP4 Gene

Molecular function for SP4 Gene

GENATLAS Biochemistry:
transcription factor SP4,GT box binding protein
UniProtKB/Swiss-Prot Function:
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Gene Ontology (GO) - Molecular Function for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with SP4: view
genes like me logo Genes that share phenotypes with SP4: view

Animal Models for SP4 Gene

MGI Knock Outs for SP4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP4 Gene

Localization for SP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SP4: view

Pathways & Interactions for SP4 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with SP4: view

Pathways by source for SP4 Gene

1 BioSystems pathway for SP4 Gene

Gene Ontology (GO) - Biological Process for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA,IEA 12560508
genes like me logo Genes that share ontologies with SP4: view

No data available for SIGNOR curated interactions for SP4 Gene

Drugs & Compounds for SP4 Gene

(1) Drugs for SP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SP4: view

Transcripts for SP4 Gene

Unigene Clusters for SP4 Gene

Sp4 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SP4

Alternative Splicing Database (ASD) splice patterns (SP) for SP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for SP4 Gene

GeneLoc Exon Structure for
SP4
ECgene alternative splicing isoforms for
SP4

Expression for SP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SP4 Gene

This gene is overexpressed in CD8 Tcells (26.7), CD4 Tcells (21.7), Spleen (7.9), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SP4 Gene



Protein tissue co-expression partners for SP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SP4 Gene:

SP4

SOURCE GeneReport for Unigene cluster for SP4 Gene:

Hs.88013

mRNA Expression by UniProt/SwissProt for SP4 Gene:

Q02446-SP4_HUMAN
Tissue specificity: Abundant in brain.

Evidence on tissue expression from TISSUES for SP4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SP4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP4 Gene

Orthologs for SP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP4 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia SP4 35 34
  • 96.51 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SP4 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP4 35 34
  • 95.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp4 34
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Sp4 16 35 34
  • 92.46 (n)
oppossum
(Monodelphis domestica)
Mammalia SP4 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SP4 35 34
  • 83.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP4 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp4 34
  • 76.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68827 34
zebrafish
(Danio rerio)
Actinopterygii sp4 35 34
  • 62.22 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EP2237 36
  • 67 (a)
CG5669 36
  • 62 (a)
btd 36
  • 57 (a)
CG3065 36
  • 57 (a)
Spps 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y40B1A.4 36
  • 68 (a)
T22C8.5 36
  • 53 (a)
sptf-3 35
  • 34 (a)
OneToMany
Species where no ortholog for SP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP4 Gene

ENSEMBL:
Gene Tree for SP4 (if available)
TreeFam:
Gene Tree for SP4 (if available)

Paralogs for SP4 Gene

Paralogs for SP4 Gene

genes like me logo Genes that share paralogs with SP4: view

Variants for SP4 Gene

Sequence variations from dbSNP and Humsavar for SP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs869025250 Uncertain significance 21,482,084(+) TCACA(C/T)GGAGT downstream-variant-500B, reference, missense
rs1000034310 -- 21,496,521(+) ATTGT(A/C)TTCCA intron-variant
rs1000040570 -- 21,439,413(+) GCGAA(A/G)GCAGG intron-variant
rs1000088740 -- 21,502,196(+) GTCCC(A/C)GTCCA intron-variant
rs1000093762 -- 21,491,787(+) TCAAA(A/C)CAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP4 Gene

Variant ID Type Subtype PubMed ID
dgv6305n100 CNV gain 25217958
esv2734112 CNV deletion 23290073
esv2734113 CNV deletion 23290073
esv3571692 CNV loss 25503493
esv3612505 CNV loss 21293372
nsv1074078 CNV deletion 25765185
nsv1144167 CNV deletion 24896259
nsv524775 CNV loss 19592680
nsv830921 CNV gain 17160897

Variation tolerance for SP4 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP4 Gene

Human Gene Mutation Database (HGMD)
SP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP4 Gene

Disorders for SP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • bipolar depression
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search SP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SP4

Genetic Association Database (GAD)
SP4
Human Genome Epidemiology (HuGE) Navigator
SP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP4
genes like me logo Genes that share disorders with SP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP4 Gene

Publications for SP4 Gene

  1. Transcription factor SP4 is a susceptibility gene for bipolar disorder. (PMID: 19401786) Zhou X. … Kelsoe J.R. (PLoS ONE 2009) 3 22 46 64
  2. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PMID: 17356515) Gao Y.Q. … Farber D.B. (Mol. Vis. 2007) 3 22 46 64
  3. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PMID: 1454515) Hagen G. … Suske G. (Nucleic Acids Res. 1992) 2 3 4 64
  4. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. (PMID: 20038947) Shyn S.I. … Hamilton S.P. (Mol. Psychiatry 2011) 3 46 64
  5. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 46 64

Products for SP4 Gene

Sources for SP4 Gene

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