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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP4 Gene

protein-coding   GIFtS: 54
GCID: GC07P021434

Sp4 transcription factor
 Explore 12 diseases affiliated with
SP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SP4    

Aliases
for SP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sp4 Transcription Factor1 2
SPR-11 2 3
HF1B1 2
MGC1300081
MGC1300091
Transcription Factor Sp42

External Ids:    HGNC: 112091   Entrez Gene: 66712   Ensembl: ENSG000001058667   OMIM: 6005405   UniProtKB: Q024463   

Export aliases for SP4 gene to outside databases

Previous GC identifers: GC07P021112 GC07P021177 GC07P021212 GC07P021240


Summaries
for SP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SP4_HUMAN, Q02446
Function: Binds to GT and GC boxes promoters elements. Probable transcriptional activator

Gene Wiki entry for SP4 (Sp4 transcription factor)


Genomic Views
for SP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP4 gene promoter:
         NF-1/L   NF-1   S8   STAT3   IRF-7A   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15

SP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P021434:  view genomic region     (about GC identifiers)

Start:
 21,467,652 bp from pter      End:
 21,554,440 bp from pter
Size:
 86,789 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 21,519,001-21,605,471     

Proteins
for SP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SP4_HUMAN, Q02446 (See protein sequence)
Recommended Name: Transcription factor Sp4  
Size: 784 amino acids; 81985 Da
Subcellular location: Nucleus
Secondary accessions: O60402 Q32M52

Explore the universe of human proteins at neXtProt for SP4: NX_Q02446

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02446

    • SP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003103.2  
    ENSEMBL proteins: 
     ENSP00000222584   ENSP00000393623   ENSP00000390817  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SP4
    OriGene Custom Protein Services for SP4 
    GenScript Custom Purified and Recombinant Proteins Services for SP4
    Novus Biologicals SP4 Protein
    Novus Biologicals SP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SP4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SP4 for ontologies           About GeneDecksing



    SP4 Antibody Products: 
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    Uscn Antibodies for SP4
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    Uscn ELISAs and CLIAs for SP4

    Protein Domains /
    Families
    for SP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SP4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02446

    ProtoNet protein and cluster: Q02446

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: SP4_HUMAN, Q02446
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for SP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SP4_HUMAN, Q02446
    Function: Binds to GT and GC boxes promoters elements. Probable transcriptional activator

         Genatlas biochemistry entry for SP4:
    transcription factor SP4,GT box binding protein

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SP4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP4
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate SP4 (see all 70):
    hsa-miR-549 hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-30d hsa-miR-219-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: SP4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP4 (see all 7)
    OriGene shRNA RFP: SP4
    OriGene siRNA: SP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SP4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP4 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SP4 (NM_033306)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SP4
    Search LifeMap BioReagents cell lines for SP4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS7559627
    GO:0008270zinc ion binding IEA--


    SP4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SP4:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for SP4: Sp4tm3Krc Sp4tm2.1Krc Sp4tm1Ssp
         10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Sp4):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  reproductive system 

    SP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for SP4 (Q024463 ENSP000002225844) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    NKX3-1Q998013, ENSP000003702534I2D: score=1 STRING: ENSP00000370253
    CRXO431863, ENSP000002219964I2D: score=1 STRING: ENSP00000221996
    SP1P080473, ENSP000003293574I2D: score=2 STRING: ENSP00000329357
    SP3Q024473, ENSP000003103014I2D: score=1 STRING: ENSP00000310301
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12560508
    GO:0008016regulation of heart contraction ----


    SP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP4
    1 Novoseek chemical compound relationship for SP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 17.6 1 15781457 (1)

    Search CenterWatch for drugs/clinical trials and news about SP4 

    Transcripts
    for SP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SP4 gene: 
    NM_003112.3  

    Unigene Cluster for SP4:

    Sp4 transcription factor
    Hs.88013  [show with all ESTs]
    Unigene Representative Sequence: NM_003112
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222584(uc003sva.3 uc003svb.3) ENST00000432066 ENST00000448246
    ENST00000440636

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SP4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP4
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate SP4 (see all 70):
    hsa-miR-549 hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-30d hsa-miR-219-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: SP4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP4 (see all 7)
    OriGene shRNA RFP: SP4
    OriGene siRNA: SP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SP4 (NM_033306)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP4

    Additional cDNA sequence: 

    AK289728.1 AK296749.1 BC015512.1 BC109300.1 BC109301.1 X68561.1 

    3 DOTS entries:

    DT.406281  DT.100722533  DT.406941 

    18 AceView cDNA sequences:

    BF516188 BQ639622 BX476564 AL711462 X68561 BX950998 BF698532 NM_003112 
    BF879752 AA772989 AW502401 CA394476 AW993165 AL712713 AW629668 BX470713 
    AI797744 AI907933 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SP4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:        -                           


    ECgene alternative splicing isoforms for SP4

    Expression
    for SP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACTAAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP4

    SOURCE GeneReport for Unigene cluster: Hs.88013

    UniProtKB/Swiss-Prot: SP4_HUMAN, Q02446
    Tissue specificity: Abundant in brain

        SABiosciences Custom PCR Arrays for SP4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP4

    Orthologs
    for SP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SP4 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SP41 Sp4 transcription factor 83.35(n)
    90.14(a)    		   420607  XM_418708.3  XP_418708.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SP46
    --
    		 --
    		 83(a)
    4(a)
    		 1 ↔ 1
    possible ortholog
    		 6(29757930-29776264)
    3(88021848-88042132)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC688272 hypothetical protein MGC68827 76.15(n)    BC060494.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sp42 sp4 transcription factor 73.08(n)   387291  BC053313.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta EP22373 transcriptional activator 67(a)
    (best of 4)    		   21C6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y40B1A.43
    sptf-31    		 Zinc finger, C2H2 type3
    Protein SPTF-31    		 68(a)
    (best of 2)3
    50.05(n)1
    44.16(a)1    		   I(13368725-13372200)3
    1897831  NM_060952.31  NP_493353.31 


    ENSEMBL Gene Tree for SP4 (if available)
    TreeFam Gene Tree for SP4 (if available) 

    Paralogs
    for SP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP4 gene
    SP32  SP82  SP52  SP22  KLF172  SP12  SP62  SP92  
    SP72  
    18/26 SIMAP similar genes for SP4 using alignment to 5 protein entries:     SP4_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    Sp1    SP3    ZNF    KLF13    KLF9
    SP1    ZNF78L1    smap-7    DKFZp434J0650    SP9    ZNF72
    ZNF702P    DKFZp686M04222    ZFS-2    ZNF697    KLF6    SP2

    SP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SP4
    PGOHUM00000262202


    Genomic Variants
    for SP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1783 NCBI SNPs in SP4 are shown (see all 1783)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102653661,2
    		C,--21465696(+) AATCTA/GTGGTT 1 -- us2k10--------
    rs1424665481,2
    		--21465854(+) AAATGG/TAAGAA 1 -- us2k10--------
    rs1502190461,2
    		--21465911(+) TGTTCA/CGGGAT 1 -- us2k10--------
    rs20735341,2
    		C,F,H,--21465942(+) TGGGGT/CAGACA 1 -- us2k17Minor allele frequency- C:0.06NS EA 956
    rs1387437421,2
    		--21466050(+) TCAAGC/TTCAGC 1 -- us2k10--------
    rs20735351,2
    		C,F,H,--21466157(+) TGGCTT/CTGAGC 1 -- us2k16Minor allele frequency- C:0.06EA NS 2030
    rs1172190961,2
    		--21466175(+) GTAAGC/GATGCC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1175467321,2
    		F,--21466214(+) GGGTCA/GCTTCC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1493522221,2
    		--21466263(+) TGGCAC/TCATCC 1 -- us2k10--------
    rs1853269971,2
    		--21466274(+) TGACTG/TCAGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SP4 (21467652 - 21554440 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SP4
         1 CNV: 4527

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP4
    DNA2.0 Custom Variant and Variant Library Synthesis for SP4

    Disorders / Diseases
    for SP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SP4 for disorders           About GeneDecksing

    OMIM gene information: 600540    OMIM disorders: --

    12 diseases for SP4:    About MalaCards
    cone-rod dystrophy    major depressive disorder    bipolar disorder    alzheimer's disease
    colon cancer    pancreatic cancer    breast cancer    pancreatitis
    retinitis    schizophrenia    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: SP4 (7 documents)

    Export disorders for SP4 gene to outside databases

    Publications
    for SP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP4 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PubMed id 1454515)1, 2, 3 Hagen G.... Suske G. (1992)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    3. Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. (PubMed id 7559627)1, 9 Hagen G....Suske G. (1995)
    4. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. (PubMed id 15781457)1, 9 Lerner L.E....Farber D.B. (2005)
    5. Transcription factor SP4 is a susceptibility gene for bipolar disorder. (PubMed id 19401786)1, 9 Zhou X....Kelsoe J.R. (2009)
    6. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. (PubMed id 15345676)1, 9 Hong J....Safe S. (2004)
    7. Association of the Asn306Ser variant of the SP4 trans cription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PubMed id 17356515)1, 9 Gao Y.Q....Farber D.B. (2007)
    8. Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements. (PubMed id 11438531)1, 9 Lerner L.E....Farber D.B. (2001)
    9. Confirmed rare copy number variants implicate novel g enes in schizophrenia. (PubMed id 20298200)1, 9 Tam G.W....Grant S.G. (2010)
    10. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. (PubMed id 12560508)1, 9 Davis W....Tew K.D. (2003)

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    Genome Databases showing SP4 gene

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    Entrez Gene: 6671 HGNC: 11209 AceView: SP4 Ensembl:ENSG00000105866 euGenes: HUgn6671
    ECgene: SP4 H-InvDB: SP4

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