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Aliases for SP3 Gene

Aliases for SP3 Gene

  • Sp3 Transcription Factor 2 3 5
  • GC-Binding Transcription Factor Sp3 3
  • Specificity Protein 3 3
  • SPR-2 4
  • SPR2 3

External Ids for SP3 Gene

Previous GeneCards Identifiers for SP3 Gene

  • GC02M172825
  • GC02M173434
  • GC02M174737
  • GC02M174975
  • GC02M174598
  • GC02M174481
  • GC02M174771
  • GC02M166650

Summaries for SP3 Gene

Entrez Gene Summary for SP3 Gene

  • This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

GeneCards Summary for SP3 Gene

SP3 (Sp3 Transcription Factor) is a Protein Coding gene. Diseases associated with SP3 include gastroesophageal junction adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. GO annotations related to this gene include chromatin binding and double-stranded DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP3 Gene

  • Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Gene Wiki entry for SP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP3 Gene

Genomics for SP3 Gene

Regulatory Elements for SP3 Gene

Promoters for SP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SP3 Gene

Chromosome:
2
Start:
173,906,459 bp from pter
End:
173,965,702 bp from pter
Size:
59,244 bases
Orientation:
Minus strand

Genomic View for SP3 Gene

Genes around SP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP3 Gene

Proteins for SP3 Gene

  • Protein details for SP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02447-SP3_HUMAN
    Recommended name:
    Transcription factor Sp3
    Protein Accession:
    Q02447
    Secondary Accessions:
    • A0AVL9
    • B4E2B7
    • Q69B26
    • Q69B27
    • Q8TD56
    • Q8WWU4
    • Q9BQR1

    Protein attributes for SP3 Gene

    Size:
    781 amino acids
    Molecular mass:
    81925 Da
    Quaternary structure:
    • Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.

    Alternative splice isoforms for SP3 Gene

neXtProt entry for SP3 Gene

Proteomics data for SP3 Gene at MOPED

Post-translational modifications for SP3 Gene

  • Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter.
  • Not glycosylated.
  • Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.
  • Ubiquitination at Lys 593
  • Modification sites at PhosphoSitePlus

Other Protein References for SP3 Gene

Antibody Products

No data available for DME Specific Peptides for SP3 Gene

Domains & Families for SP3 Gene

Protein Domains for SP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q02447

UniProtKB/Swiss-Prot:

SP3_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP3: view

Function for SP3 Gene

Molecular function for SP3 Gene

GENATLAS Biochemistry:
transcription factor SP-3,activator,GT box binding protein
UniProtKB/Swiss-Prot Function:
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Gene Ontology (GO) - Molecular Function for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with SP3: view
genes like me logo Genes that share phenotypes with SP3: view

Animal Models for SP3 Gene

MGI Knock Outs for SP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP3 Gene

Localization for SP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP3 Gene

Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP3 Gene COMPARTMENTS Subcellular localization image for SP3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with SP3: view

Pathways & Interactions for SP3 Gene

genes like me logo Genes that share pathways with SP3: view

SIGNOR curated interactions for SP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001503 ossification IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with SP3: view

Drugs & Compounds for SP3 Gene

(19) Drugs for SP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(17) Additional Compounds for SP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SP3: view

Transcripts for SP3 Gene

Unigene Clusters for SP3 Gene

Sp3 transcription factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP3 Gene

No ASD Table

Relevant External Links for SP3 Gene

GeneLoc Exon Structure for
SP3
ECgene alternative splicing isoforms for
SP3

Expression for SP3 Gene

mRNA expression in normal human tissues for SP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SP3 Gene

This gene is overexpressed in CD8 Tcells (15.9), Lymph node (13.3), CD4 Tcells (10.2), and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP3 Gene



SOURCE GeneReport for Unigene cluster for SP3 Gene Hs.531587

mRNA Expression by UniProt/SwissProt for SP3 Gene

Q02447-SP3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SP3: view

Protein tissue co-expression partners for SP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SP3 Gene

Orthologs for SP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP3 36
  • 98 (a)
OneToOne
SP3 35
  • 96.9 (n)
  • 98.11 (a)
dog
(Canis familiaris)
Mammalia SP3 35
  • 96.83 (n)
  • 98.23 (a)
SP3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp3 36
  • 96 (a)
OneToOne
Sp3 16
Sp3 35
  • 94.89 (n)
  • 96.78 (a)
oppossum
(Monodelphis domestica)
Mammalia SP3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SP3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp3 35
  • 94.47 (n)
  • 96.15 (a)
chicken
(Gallus gallus)
Aves SP3 35
  • 85.34 (n)
  • 89.16 (a)
SP3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP3 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5036 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sp3 35
  • 75.29 (n)
  • 76.22 (a)
Str.4059 35
zebrafish
(Danio rerio)
Actinopterygii sp3a 35
  • 60.95 (n)
  • 64.3 (a)
sp3a 36
  • 60 (a)
OneToMany
sp3b 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spps 36
  • 22 (a)
OneToMany
btd 37
  • 62 (a)
CG5669 37
  • 74 (a)
EP2237 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea sptf-3 36
  • 32 (a)
OneToMany
T22C8.5 37
  • 56 (a)
Y40B1A.4 37
  • 67 (a)
Species with no ortholog for SP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP3 Gene

ENSEMBL:
Gene Tree for SP3 (if available)
TreeFam:
Gene Tree for SP3 (if available)

Paralogs for SP3 Gene

Paralogs for SP3 Gene

Pseudogenes.org Pseudogenes for SP3 Gene

genes like me logo Genes that share paralogs with SP3: view

Variants for SP3 Gene

Sequence variations from dbSNP and Humsavar for SP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1047640 - 173,956,022(-) ATGGT(A/G)CAGTG reference, missense
rs1446572 -- 173,938,986(+) TCTAG(C/T)GGGTA intron-variant
rs1446573 -- 173,958,748(+) TATGC(C/T)AAAAC intron-variant
rs3754813 -- 173,956,172(+) TGTGG(C/T)TGACA reference, missense
rs3754814 -- 173,956,452(+) AAAAA(A/G)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP3 Gene

Variant ID Type Subtype PubMed ID
esv2664144 CNV Deletion 23128226
esv2673963 CNV Deletion 23128226
nsv821796 CNV Gain 20364138

Variation tolerance for SP3 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP3 Gene

HapMap Linkage Disequilibrium report
SP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP3 Gene

Disorders for SP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
- elite association - COSMIC cancer census association via MalaCards
Search SP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP3
genes like me logo Genes that share disorders with SP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP3 Gene

Publications for SP3 Gene

  1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C. … Winoto A. (Mol. Cell. Biol. 1992) 2 3 4 23 67
  2. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells. (PMID: 18496767) Petrovic I. … Stevanovic M. (Mol. Biol. Rep. 2009) 3 23
  3. Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness. (PMID: 19212434) Essafi-Benkhadir K. … PagA"s G. (PLoS ONE 2009) 3 23
  4. The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells. (PMID: 17906119) Enya K. … Onozaki K. (J. Leukoc. Biol. 2008) 3 23
  5. Transcriptional regulation of the 5'-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F. (PMID: 18342022) Tapias A. … NoAc V. (Biochim. Biophys. Acta 2008) 3 23

Products for SP3 Gene

Sources for SP3 Gene

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