Aliases for SP3 Gene
External Ids for SP3 Gene
Previous GeneCards Identifiers for SP3 Gene
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
GeneCards Summary for SP3 Gene
SP3 (Sp3 Transcription Factor) is a Protein Coding gene. Diseases associated with SP3 include Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Regulation of Telomerase. GO annotations related to this gene include chromatin binding and double-stranded DNA binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot for SP3 Gene
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.