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Aliases for SP3 Gene

Aliases for SP3 Gene

  • Sp3 Transcription Factor 2 3 5
  • GC-Binding Transcription Factor Sp3 3
  • Transcription Factor Sp3 3
  • Specificity Protein 3 3
  • SPR-2 4
  • SPR2 3

External Ids for SP3 Gene

Previous GeneCards Identifiers for SP3 Gene

  • GC02M172825
  • GC02M173434
  • GC02M174737
  • GC02M174975
  • GC02M174598
  • GC02M174481
  • GC02M174771
  • GC02M166650

Summaries for SP3 Gene

Entrez Gene Summary for SP3 Gene

  • This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

GeneCards Summary for SP3 Gene

SP3 (Sp3 Transcription Factor) is a Protein Coding gene. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and SUMOylation. GO annotations related to this gene include chromatin binding and double-stranded DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP3 Gene

  • Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Gene Wiki entry for SP3 Gene

Additional gene information for SP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP3 Gene

Genomics for SP3 Gene

Regulatory Elements for SP3 Gene

Enhancers for SP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H174038 2 FANTOM5 Ensembl ENCODE dbSUPER 14 -73.9 -73851 2 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS DEK SP3 MAP3K20 RPSAP24 LINC01960
GH02H174020 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -59.0 -58970 7 PKNOX1 FOXA2 FEZF1 BATF YY1 ZNF143 FOS ATF7 RUNX3 CREM ENSG00000273258 SP3 LINC01960
GH02H174030 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -66.6 -66554 3 HDAC1 PKNOX1 ATF1 PTBP1 FOS RUNX3 CREM EGR2 SMARCA5 CBFB SP3 ENSG00000273258 LINC01960 RPSAP24
GH02H173988 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -25.0 -25002 4 CTCF TAF1 MAX REST BATF RAD21 RELA YY1 JUND POLR2A SP3 ENSG00000273258 CIR1 ENSG00000271151
GH02H174035 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.7 -71.0 -71006 2 HDAC1 CTCF LEF1 RNF2 JUN CEBPB JUNB ELF1 BATF CC2D1A SP3 RPSAP24 LINC01960
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SP3 on UCSC Golden Path with GeneCards custom track

Promoters for SP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126521 1602 4601 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for SP3 Gene

Chromosome:
2
Start:
173,906,459 bp from pter
End:
173,965,702 bp from pter
Size:
59,244 bases
Orientation:
Minus strand

Genomic View for SP3 Gene

Genes around SP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP3 Gene

Proteins for SP3 Gene

  • Protein details for SP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02447-SP3_HUMAN
    Recommended name:
    Transcription factor Sp3
    Protein Accession:
    Q02447
    Secondary Accessions:
    • A0AVL9
    • B4E2B7
    • Q69B26
    • Q69B27
    • Q8TD56
    • Q8WWU4
    • Q9BQR1

    Protein attributes for SP3 Gene

    Size:
    781 amino acids
    Molecular mass:
    81925 Da
    Quaternary structure:
    • Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.

    Alternative splice isoforms for SP3 Gene

neXtProt entry for SP3 Gene

Post-translational modifications for SP3 Gene

  • Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter.
  • Not glycosylated.
  • Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.
  • Ubiquitination at posLast=593593
  • Modification sites at PhosphoSitePlus

Other Protein References for SP3 Gene

Antibody Products

  • Abcam antibodies for SP3

No data available for DME Specific Peptides for SP3 Gene

Domains & Families for SP3 Gene

Gene Families for SP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SP3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q02447

UniProtKB/Swiss-Prot:

SP3_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP3: view

Function for SP3 Gene

Molecular function for SP3 Gene

GENATLAS Biochemistry:
transcription factor SP-3,activator,GT box binding protein
UniProtKB/Swiss-Prot Function:
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Phenotypes From GWAS Catalog for SP3 Gene

Gene Ontology (GO) - Molecular Function for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 14979875
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0000987 core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with SP3: view
genes like me logo Genes that share phenotypes with SP3: view

Animal Models for SP3 Gene

MGI Knock Outs for SP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SP3
  • Applied Biological Materials Clones for SP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP3 Gene

Localization for SP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP3 Gene

Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP3 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
golgi apparatus 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IBA 12560508
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IEA --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with SP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SP3 Gene

Pathways & Interactions for SP3 Gene

genes like me logo Genes that share pathways with SP3: view

SIGNOR curated interactions for SP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001503 ossification IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with SP3: view

Drugs & Compounds for SP3 Gene

(20) Drugs for SP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for SP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SP3: view

Transcripts for SP3 Gene

Unigene Clusters for SP3 Gene

Sp3 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SP3
  • Applied Biological Materials Clones for SP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SP3 Gene

No ASD Table

Relevant External Links for SP3 Gene

GeneLoc Exon Structure for
SP3
ECgene alternative splicing isoforms for
SP3

Expression for SP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SP3 Gene

This gene is overexpressed in CD8 Tcells (15.9), Lymph node (13.3), CD4 Tcells (10.2), and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SP3 Gene



Protein tissue co-expression partners for SP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SP3 Gene:

SP3

SOURCE GeneReport for Unigene cluster for SP3 Gene:

Hs.531587

mRNA Expression by UniProt/SwissProt for SP3 Gene:

Q02447-SP3_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SP3 Gene

  • Blood(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(3.1)
  • Skin(2.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with SP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP3 Gene

Orthologs for SP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP3 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP3 33 34
  • 96.9 (n)
dog
(Canis familiaris)
Mammalia SP3 33 34
  • 96.83 (n)
mouse
(Mus musculus)
Mammalia Sp3 33 16 34
  • 94.89 (n)
rat
(Rattus norvegicus)
Mammalia Sp3 33
  • 94.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SP3 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SP3 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SP3 33 34
  • 85.34 (n)
lizard
(Anolis carolinensis)
Reptilia SP3 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp3 33
  • 75.29 (n)
Str.4059 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5036 33
zebrafish
(Danio rerio)
Actinopterygii sp3a 33 34
  • 60.95 (n)
sp3b 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5669 35
  • 74 (a)
EP2237 35
  • 65 (a)
btd 35
  • 62 (a)
Spps 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y40B1A.4 35
  • 67 (a)
T22C8.5 35
  • 56 (a)
sptf-3 34
  • 32 (a)
OneToMany
Species where no ortholog for SP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP3 Gene

ENSEMBL:
Gene Tree for SP3 (if available)
TreeFam:
Gene Tree for SP3 (if available)

Paralogs for SP3 Gene

Variants for SP3 Gene

Sequence variations from dbSNP and Humsavar for SP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000051077 -- 173,966,377(+) GTTGT(A/G)TTTTA upstream-variant-2KB
rs1000059857 -- 173,930,197(+) CATAA(C/T)CCTGA intron-variant
rs1000110143 -- 173,930,461(+) AAATT(C/T)CCAAA intron-variant
rs1000248411 -- 173,931,473(+) CGAGT(A/G)GCTAG intron-variant
rs1000253099 -- 173,935,440(+) TGAGT(A/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP3 Gene

Variant ID Type Subtype PubMed ID
dgv751e214 CNV loss 21293372
esv2664144 CNV deletion 23128226
esv2673963 CNV deletion 23128226
esv3593394 CNV gain 21293372
esv3593395 CNV loss 21293372
esv3593396 CNV loss 21293372
nsv1112775 CNV deletion 24896259
nsv1118887 CNV deletion 24896259
nsv1152346 CNV insertion 26484159
nsv821796 CNV gain 20364138
nsv953518 CNV duplication 24416366
nsv953519 CNV deletion 24416366

Variation tolerance for SP3 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP3 Gene

Disorders for SP3 Gene

Relevant External Links for SP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP3

No disorders were found for SP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP3 Gene

Publications for SP3 Gene

  1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C … Winoto A (Molecular and cellular biology 1992) 2 3 4 22 60
  2. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. (PMID: 17548428) Wooten-Blanks LG … Ogretmen B (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007) 3 4 22 60
  3. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis. (PMID: 15474306) Moran KM … Richert JR (Gene 2004) 3 4 22 60
  4. Complexity of translationally controlled transcription factor Sp3 isoform expression. (PMID: 15247228) Sapetschnig A … Suske G (The Journal of biological chemistry 2004) 3 4 22 60
  5. Acetylated sp3 is a transcriptional activator. (PMID: 12837748) Ammanamanchi S … Brattain MG (The Journal of biological chemistry 2003) 3 4 22 60

Products for SP3 Gene

  • Addgene plasmids for SP3

Sources for SP3 Gene

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