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SP3 Gene

protein-coding   GIFtS: 63
GCID: GC02M174771

Sp3 Transcription Factor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sp3 Transcription Factor1 2
SPR22
GC-Binding Transcription Factor Sp32
Specificity Protein 32
Transcription Factor Sp32
SPR-23

External Ids:    HGNC: 112081   Entrez Gene: 66702   Ensembl: ENSG000001728457   OMIM: 6018045   UniProtKB: Q024473   

Export aliases for SP3 gene to outside databases

Previous GC identifers: GC02M172825 GC02M173434 GC02M174737 GC02M174975 GC02M174598 GC02M174481 GC02M166650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SP3 Gene:
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription
by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger
DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional
transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants
encoding different isoforms have been described for this gene, and one has been reported to initiate translation
from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation
initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. (provided by
RefSeq, Feb 2010)

GeneCards Summary for SP3 Gene:
SP3 (Sp3 transcription factor) is a protein-coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
promoters. Weak activator of transcription but can activate a number of genes involved in different processes
such as cell-cycle regulation, hormone-induction and house-keeping

Gene Wiki entry for SP3 (Sp3 transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SP3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP3 promoter sequence
   Search Chromatin IP Primers for SP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

SP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M174771:  view genomic region     (about GC identifiers)

Start:
174,771,187 bp from pter      End:
174,830,430 bp from pter
Size:
59,244 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447 (See protein sequence)
Recommended Name: Transcription factor Sp3  
Size: 781 amino acids; 81925 Da
Subunit: Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF.
Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with
HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its
transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a
Secondary accessions: A0AVL9 B4E2B7 Q69B26 Q69B27 Q8TD56 Q8WWU4 Q9BQR1
Alternative splicing, Alternative initiation: 6 isoforms:  Q02447-1   Q02447-2   Q02447-3   Q02447-4   Q02447-5   Q02447-6   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for SP3: NX_Q02447

Explore proteomics data for SP3 at MOPED

Post-translational modifications: 

  • Not glycosylated1
  • Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate
    transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at
    Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events
    through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase
    the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT
    promoter1
  • Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site.
    Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear
    bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3,
    which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control
    transcriptional activity1
  • Ubiquitination2 at Lys593
  • Modification sites at PhosphoSitePlus

  • See SP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017371.3  NP_001166183.1  NP_003102.1  

    ENSEMBL proteins: 
     ENSP00000310301   ENSP00000406140   ENSP00000413665   ENSP00000388903  

    SP3 Human Recombinant Protein Products:

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    Novus Biologicals SP3 Lysates
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    Cloud-Clone Corp. Proteins for SP3

     
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    antibodies-online proteins for SP3 

     
    antibodies-online peptides for SP3

    SP3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SP3
    R&D Systems Antibodies for SP3
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    OriGene Custom Antibody Services for SP3
    Novus Biologicals SP3 Antibodies
    Abcam antibodies for SP3 (Q69B26, Q8WWU4, Q69B27)
    Cloud-Clone Corp. Antibodies for SP3
    ThermoFisher Antibodies for SP3
    antibodies-online antibodies for SP3 (14 products) 

    SP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SP3
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    antibodies-online kits for SP3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02447

    ProtoNet protein and cluster: Q02447

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with SP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP3_HUMAN, Q02447
    Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
    post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
    promoters. Weak activator of transcription but can activate a number of genes involved in different processes
    such as cell-cycle regulation, hormone-induction and house-keeping

         Genatlas biochemistry entry for SP3:
    transcription factor SP-3,activator,GT box binding protein

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    Find genes that share ontologies with SP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SP3:
     Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sp3) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  no phenotypic analysis  respiratory system  skeleton 

    Find genes that share phenotypes with SP3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SP3:
    hsa-mir-484 (MIRT042140), hsa-mir-27a-3p (MIRT002402), hsa-mir-124-3p (MIRT022933), hsa-mir-1260b (MIRT052769), hsa-mir-223-3p (MIRT006249)

    Block miRNA regulation of human, mouse, rat SP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SP3
    Predesigned siRNA for gene silencing in human, mouse, rat SP3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SP3
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    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    Sino Biological Human cDNA Clone for SP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3
    Addgene plasmids for SP3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SP3_HUMAN, Q02447: Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when
    sumoylated. Some localization in PML nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC12560508
    GO:0016605PML body IEA--
    GO:0017053transcriptional repressor complex IEA--

    Find genes that share ontologies with SP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SP3 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    2Transcription Ligand dependent activation of the ESR1 SP pathway
    Transcription Ligand dependent activation of the ESR1 SP pathway0.37
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    4Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33
    5Signaling in Gap Junctions
    Signaling in Gap Junctions0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SP3
        Signaling in Gap Junctions

    5 GeneGo (Thomson Reuters) Pathways for SP3
        Proteolysis Putative SUMO-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    G-protein signaling Rac2 regulation pathway
    Development VEGF signaling and activation

    3 BioSystems Pathways for SP3
        Selenium Metabolism and Selenoproteins
    SIDS Susceptibility Pathways
    Regulation of Telomerase



        Pathway & Disease-focused RT2 Profiler PCR Array including SP3: 
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SP3 (Q024471, 2, 3 ENSP000003103014) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206342P498422, 3, ENSP000003728174MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000372817
    ENSG00000236250P498422, 3, ENSP000003917984MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000391798
    STK19P498422, 3, ENSP000003644824MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000364482
    ENSG00000226033P498422, 3MINT-62758 MINT-62584 MINT-62682 I2D: score=5 
    ENSG00000226257P498422, 3MINT-62758 MINT-62584 MINT-62682 I2D: score=5 
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    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001701in utero embryonic development ----
    GO:0001779natural killer cell differentiation IEA--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001889liver development IEA--

    Find genes that share ontologies with SP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SP3

    Selected Novoseek inferred chemical compound relationships for SP3 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mithramycin 88.7 15 16734381 (1), 17142323 (1), 11261509 (1), 15708372 (1) (see all 11)
    butyrate 49.7 12 16456404 (3), 16732318 (2), 11517158 (2), 17540780 (1) (see all 6)
    oligonucleotide 45.8 17 10722737 (2), 10597223 (1), 8687178 (1), 15467729 (1) (see all 16)
    5-aza-2'deoxycytidine 43.6 3 16204032 (1), 15107420 (1), 18522535 (1)
    dimethyl sulfate 36.4 1 9494121 (1)
    zinc 29.3 15 15523672 (2), 12736330 (2), 1341900 (1), 8621476 (1) (see all 13)
    estrogen 26.6 21 18543253 (6), 15541729 (3), 15987735 (2), 20382698 (2) (see all 7)
    cytosine 19.1 2 17881752 (1), 15107420 (1)
    gsno 16.7 7 14766015 (4), 16877677 (1)
    vegf 14.7 11 15374992 (2), 9264407 (2), 10816575 (1), 17363604 (1) (see all 8)



    Find genes that share compounds with SP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SP3 gene (3 alternative transcripts): 
    NM_001017371.4  NM_001172712.1  NM_003111.4  

    Unigene Cluster for SP3:

    Sp3 transcription factor
    Hs.531587  [show with all ESTs]
    Unigene Representative Sequence: NM_003111
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310015(uc002uie.3 uc002uig.3 uc010zel.2) ENST00000418194
    ENST00000416195 ENST00000465379 ENST00000462904 ENST00000483084 ENST00000490182
    ENST00000455789(uc002uif.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSP3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3
    Addgene plasmids for SP3 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP3
      QuantiTect SYBR Green Assays in human, mouse, rat SP3
      QuantiFast Probe-based Assays in human, mouse, rat SP3

    Additional mRNA sequence: 

    AB209334.1 AJ310752.1 AJ430844.1 AK021546.1 AK304199.1 AY070137.1 AY441957.1 AY441958.1 
    BC042945.2 BC126414.1 BC143928.1 BX648857.1 M97191.2 X68560.1 

    15 DOTS entries:

    DT.40308094  DT.91893190  DT.97817798  DT.100655969  DT.208017  DT.40314397  DT.92437077  DT.100677183 
    DT.100825714  DT.121008821  DT.121008826  DT.86855082  DT.91918438  DT.95374239  DT.97786239 

    Selected AceView cDNA sequences (see all 244):

    BE045347 AV647061 AL700040 BG401758 AA731372 BQ010796 AW295574 AW851556 
    AA884900 AW173024 BG029713 AI352194 AW204666 AW471202 AA806044 BM449786 
    AI079680 AW138249 AA970388 AI739310 AI927326 BE041569 BQ214319 AI627700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTACCA
    SP3 Expression
    About this image


    SP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531587

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including SP3: 
              Transcription Factors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP3
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    QuantiFast Probe-based Assays in human, mouse, rat SP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp31 , 5 trans-acting transcription factor 31, 5 94.89(n)1
    96.78(a)1
      2 (43.35 cM)5
    206871  NM_001018042.31  NP_001018052.11 
     729364275 
    chicken
    (Gallus gallus)
    Aves SP31 Sp3 transcription factor 85.34(n)
    89.16(a)
      395302  NM_204603.1  NP_989934.1 
    lizard
    (Anolis carolinensis)
    Reptilia SP36
    Sp3 transcription factor
    84(a)
    1 ↔ 1
    GL343316.1(451728-496848)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50362 Xenopus laevis transcribed sequence with moderate similarity more 78.1(n)    48054768 
    zebrafish
    (Danio rerio)
    Actinopterygii sp3a1 sp3a transcription factor 60.95(n)
    64.3(a)
      558652  NM_001089498.1  NP_001082967.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56693   -- 74(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y40B1A.43 Zinc finger, C2H2 type 67(a)
    (best of 2)
      I(13368725-13372200)   --


    ENSEMBL Gene Tree for SP3 (if available)
    TreeFam Gene Tree for SP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SP3 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for SP3 using alignment to 8 protein entries:     SP3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    SP5    SP6    WT1    KLF13    KLF9
    SP9    SP4    KLF1    KLF6    ZNF56    kr-znf3
    DKFZp686N0199    GTF3A    KLF7    ZNF    Sp1    DKFZp434J0650

    Find genes that share paralogs with SP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SP3
    PGOHUM00000248458


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SP3 (see all 1313)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407688651,2
    C--174165274(+) ATGAAC/TTTTTC 3 -- ds50010--------
    rs1447440731,2
    C--174165286(+) GGGGAA/GAAGGT 3 -- ds50010--------
    rs1838074021,2
    --174165301(+) GATTCC/TAAAAA 3 -- ds50010--------
    rs1406093011,2
    C--174165395(+) AAAGT-/CCCCCATC 3 -- ds50010--------
    rs1885250271,2
    --174165605(+) TGATTA/TCACAA 3 -- ds50010--------
    rs1478677261,2
    C--174165830(+) ATTTTA/GAAACC 3 -- ut310--------
    rs1489249891,2
    --174165865(+) GCAACA/CACCCC 3 -- ut310--------
    rs739759071,2
    C,F--174166053(+) ACATAT/CACACT 3 -- ut314Minor allele frequency- C:0.18WA CSA 124
    rs1821407321,2
    --174166101(+) CTACCA/GGGCCT 3 -- ut310--------
    rs1428225711,2
    C--174166353(+) CTCAAA/TCTATA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SP3 (174771187 - 174830430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673963CNV Deletion23128226
    esv2664144CNV Deletion23128226
    nsv821796CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601804    OMIM disorders: --


    Find genes that share disorders with SP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SP3 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 27.2 1 11443124 (1)
    breast cancer 23.1 19 12176973 (3), 17511886 (2), 18543253 (2), 18006846 (2) (see all 10)
    retinoblastoma 21.9 3 11228546 (2), 15374992 (1)
    tumors 19.8 10 15317818 (1), 15857802 (1), 9371492 (1), 15247906 (1) (see all 9)
    cancer 14.6 6 15857802 (1), 12176973 (1), 16901903 (1), 19621387 (1) (see all 6)
    leukemia t-cell 11 2 16716116 (2)
    alzheimers disease 4.35 1 17934324 (1)
    fibrosarcoma 4.03 4 15857802 (2), 10452548 (1)
    astrocytoma 0 1 10506168 (1)
    necrosis 0 1 15706661 (1)


    Export disorders for SP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SP3 gene, integrated from 10 sources (see all 379):
    (articles sorted by number of sources associating them with SP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PubMed id 1341900)1, 2, 3, 9 Kingsley C. and Winoto A. (Mol. Cell. Biol. 1992)
    2. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PubMed id 1454515)1, 2, 3 Hagen G.... Suske G. (Nucleic Acids Res. 1992)
    3. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. (PubMed id 17548428)1, 2, 9 Wooten-Blanks L.G.... Ogretmen B. (FASEB J. 2007)
    4. The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PubMed id 12176973)1, 2, 9 Sun J.M.... Davie J.R. (J. Biol. Chem. 2002)
    5. Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. (PubMed id 9278495)1, 2, 9 Ihn H. and Trojanowska M. (Nucleic Acids Res. 1997)
    6. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis. (PubMed id 15474306)1, 2, 9 Moran K.M.... Richert J.R. (Gene 2004)
    7. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. (PubMed id 12419227)1, 2, 9 Ross S.... Gill G. (Mol. Cell 2002)
    8. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PubMed id 10391891)1, 2, 9 Ding H.... Belayew A. (J. Biol. Chem. 1999)
    9. Complexity of translationally controlled transcription factor Sp3 isoform expression. (PubMed id 15247228)1, 2, 9 Sapetschnig A.... Suske G. (J. Biol. Chem. 2004)
    10. Acetylated SP3 is a transcriptional activator. (PubMed id 12837748)1, 2, 9 Ammanamanchi S.... Brattain M.G. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6670 HGNC: 11208 AceView: SP3 Ensembl:ENSG00000172845 euGenes: HUgn6670
    ECgene: SP3 H-InvDB: SP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SP3 gene:
    Search GeneIP for patents involving SP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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