Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP3 Gene

protein-coding   GIFtS: 62
GCID: GC02M174771

Sp3 Transcription Factor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sp3 Transcription Factor1 2
SPR22
GC-Binding Transcription Factor Sp32
Specificity Protein 32
Transcription Factor Sp32
SPR-23

External Ids:    HGNC: 112081   Entrez Gene: 66702   Ensembl: ENSG000001728457   OMIM: 6018045   UniProtKB: Q024473   

Export aliases for SP3 gene to outside databases

Previous GC identifers: GC02M172825 GC02M173434 GC02M174737 GC02M174975 GC02M174598 GC02M174481 GC02M166650


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SP3 Gene:
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription
by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger
DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional
transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants
encoding different isoforms have been described for this gene, and one has been reported to initiate translation
from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation
initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. (provided by
RefSeq, Feb 2010)

GeneCards Summary for SP3 Gene: 
SP3 (Sp3 transcription factor) is a protein-coding gene. Diseases associated with SP3 include wolfram syndrome, and cushing's syndrome, and among its related super-pathways are Development VEGF signaling via VEGFR2 - generic cascades and G-protein signaling Rac2 regulation pathway. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
promoters. Weak activator of transcription but can activate a number of genes involved in different processes
such as cell-cycle regulation, hormone-induction and house-keeping

Gene Wiki entry for SP3 (Sp3 transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

SP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M174771:  view genomic region     (about GC identifiers)

Start:
174,771,187 bp from pter      End:
174,830,430 bp from pter
Size:
59,244 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447 (See protein sequence)
Recommended Name: Transcription factor Sp3  
Size: 781 amino acids; 81925 Da
Subunit: Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF.
Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with
HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its
transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a
Subcellular location: Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when
sumoylated. Some localization in PML nuclear bodies
Secondary accessions: A0AVL9 B4E2B7 Q69B26 Q69B27 Q8TD56 Q8WWU4 Q9BQR1
Alternative splicing, Alternative initiation: 6 isoforms:  Q02447-1   Q02447-2   Q02447-3   Q02447-4   Q02447-5   Q02447-6   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for SP3: NX_Q02447

Explore proteomics data for SP3 at MOPED 

Post-translational modifications:

  • UniProtKB: Not glycosylated
  • UniProtKB: Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate
    transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at
    Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events
    through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase
    the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT
    promoter
  • UniProtKB: Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site.
    Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear
    bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3,
    which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control
    transcriptional activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02447

  • SP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SP3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001017371.3  NP_001166183.1  NP_003102.1  

    ENSEMBL proteins: 
     ENSP00000310301   ENSP00000406140   ENSP00000413665   ENSP00000388903  

    Human Recombinant Protein Products for SP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SP3
    OriGene Purified Protein for SP3
    OriGene Protein Over-expression Lysate for SP3
    OriGene MassSpec for SP3 
    OriGene Custom Protein Services for SP3
    GenScript Custom Purified and Recombinant Proteins Services for SP3
    Novus Biologicals SP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SP3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC12560508
    GO:0016605PML body IEA--
    GO:0017053transcriptional repressor complex IEA--

    SP3 for ontologies           About GeneDecksing



    SP3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SP3
    R&D Systems Antibodies for SP3
    OriGene Antibodies for SP3
    OriGene Custom Antibody Services for SP3
    GenScript Superior Antibodies for SP3
    Novus Biologicals SP3 Antibodies
    Abcam antibodies for SP3
    Cloud-Clone Corp. Antibodies for SP3 
    ThermoFisher Antibodies for SP3
    LSBio Antibodies in human, mouse, rat for SP3 

    Assay Products for SP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SP3 
    Cloud-Clone Corp. CLIAs for SP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02447

    ProtoNet protein and cluster: Q02447

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    SP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP3_HUMAN, Q02447
    Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
    post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
    promoters. Weak activator of transcription but can activate a number of genes involved in different processes
    such as cell-cycle regulation, hormone-induction and house-keeping

         Genatlas biochemistry entry for SP3:
    transcription factor SP-3,activator,GT box binding protein

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    SP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SP3:
     Increased HPV18 LCR reporter a 

         15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sp3) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  no phenotypic analysis  respiratory system  skeleton 

    SP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP3
    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SP3
    Sirion Biotech Customized adenovirus for overexpression of SP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SP3 (see all 18)
    OriGene ORF clones in mouse, rat for SP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    Sino Biological Human cDNA Clone for SP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3
    Sirion Biotech Customized lentivirus for stable overexpression of SP3 
                         Customized lentivirus expression plasmids for stable overexpression of SP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SP3
    Search LifeMap BioReagents cell lines for SP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SP3 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling and activation0.75
    2G-protein signaling Rac2 regulation pathway
    G-protein signaling Rac2 regulation pathway1.00
    3Development Ligand-dependent activation of the ESR1/AP-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway0.37
    4CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    5DNA damage Role of SUMO in p53 regulation
    Proteolysis Putative SUMO-1 pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for SP3
        Development VEGF signaling and activation
    G-protein signaling Rac2 regulation pathway
    Proteolysis Putative SUMO-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SP3
        Signaling in Gap Junctions

    5 GeneGo (Thomson Reuters) Pathways for SP3
        Proteolysis Putative SUMO-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    G-protein signaling Rac2 regulation pathway
    Development VEGF signaling and activation

    3 BioSystems Pathways for SP3
        Selenium Metabolism and Selenoproteins
    SIDS Susceptibility Pathways
    Regulation of Telomerase




    SP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for SP3 (Q024471, 2, 3 ENSP000003103014) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206342P498422, 3, ENSP000003728174MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000372817
    ENSG00000236250P498422, 3, ENSP000003917984MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000391798
    STK19P498422, 3, ENSP000003644824MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000364482
    ENSG00000226033P498422, 3MINT-62758 MINT-62584 MINT-62682 I2D: score=5 
    ENSG00000226257P498422, 3MINT-62758 MINT-62584 MINT-62682 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001701in utero embryonic development ----
    GO:0001779natural killer cell differentiation IEA--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001889liver development IEA--

    SP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP3

    10/36 Novoseek inferred chemical compound relationships for SP3 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mithramycin 88.7 15 16734381 (1), 17142323 (1), 11261509 (1), 15708372 (1) (see all 11)
    butyrate 49.7 12 16456404 (3), 16732318 (2), 11517158 (2), 17540780 (1) (see all 6)
    oligonucleotide 45.8 17 10722737 (2), 10597223 (1), 8687178 (1), 15467729 (1) (see all 16)
    5-aza-2'deoxycytidine 43.6 3 16204032 (1), 15107420 (1), 18522535 (1)
    dimethyl sulfate 36.4 1 9494121 (1)
    zinc 29.3 15 15523672 (2), 12736330 (2), 1341900 (1), 8621476 (1) (see all 13)
    estrogen 26.6 21 18543253 (6), 15541729 (3), 15987735 (2), 20382698 (2) (see all 7)
    cytosine 19.1 2 17881752 (1), 15107420 (1)
    gsno 16.7 7 14766015 (4), 16877677 (1)
    vegf 14.7 11 15374992 (2), 9264407 (2), 10816575 (1), 17363604 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about SP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SP3 gene (3 alternative transcripts): 
    NM_001017371.4  NM_001172712.1  NM_003111.4  

    Unigene Cluster for SP3:

    Sp3 transcription factor
    Hs.531587  [show with all ESTs]
    Unigene Representative Sequence: NM_003111
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310015(uc002uie.3 uc002uig.3 uc010zel.2) ENST00000418194
    ENST00000416195 ENST00000465379 ENST00000462904 ENST00000483084 ENST00000490182
    ENST00000455789(uc002uif.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP3
    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP3
    Clone
    Products:
         
    OriGene clones in human, mouse for SP3 (see all 18)
    OriGene ORF clones in mouse, rat for SP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3
    Sirion Biotech Customized lentivirus for stable overexpression of SP3 
                         Customized lentivirus expression plasmids for stable overexpression of SP3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP3

    Additional mRNA sequence: 

    AB209334.1 AJ310752.1 AJ430844.1 AK021546.1 AK304199.1 AY070137.1 AY441957.1 AY441958.1 
    BC042945.2 BC126414.1 BC143928.1 BX648857.1 M97191.2 X68560.1 

    15 DOTS entries:

    DT.40308094  DT.91893190  DT.97817798  DT.100655969  DT.208017  DT.40314397  DT.92437077  DT.100677183 
    DT.100825714  DT.121008821  DT.121008826  DT.86855082  DT.91918438  DT.95374239  DT.97786239 

    24/244 AceView cDNA sequences (see all 244):

    AI739310 BF593871 AA731372 AA640122 AI560975 AW471202 AV647061 AI990396 
    BQ214319 BF968634 BQ010796 AW510797 AI927326 BI909132 AI079680 AA768196 
    AU118442 BG029713 AW851556 NM_003111 AL045601 AI433324 BE045347 AA806044 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP3 expression in normal human tissues (normalized intensities)      SP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTACCA
    SP3 Expression
    About this image


    SP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             mouth   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Breast
             breast ; myoepithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; cells in endometrial stroma   

    See SP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP3

    SOURCE GeneReport for Unigene cluster: Hs.531587

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including SP3: 
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SP3 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp31 , 5 trans-acting transcription factor 31, 5 95.27(n)1
    97.42(a)1
      2 (43.35 cM)5
    206871  NM_001018042.31  NP_001018052.11 
     729364275 
    chicken
    (Gallus gallus)
    Aves SP31 Sp3 transcription factor 86.07(n)
    90.21(a)
      395302  NM_204603.1  NP_989934.1 
    lizard
    (Anolis carolinensis)
    Reptilia SP36
    Sp3 transcription factor
    80(a)
    1 ↔ 1
    GL343316.1(451728-496848)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50362 Xenopus laevis transcribed sequence with moderate similarity more 78.1(n)    48054768 
    zebrafish
    (Danio rerio)
    Actinopterygii sp3a1 sp3a transcription factor 60.62(n)
    63.69(a)
      558652  NM_001089498.1  NP_001082967.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56693   -- 74(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for SP3 (if available)
    TreeFam Gene Tree for SP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP3 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    18/36 SIMAP similar genes for SP3 using alignment to 8 protein entries:     SP3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    SP5    SP6    WT1    KLF13    KLF9
    SP9    SP4    KLF1    KLF6    ZNF56    kr-znf3
    DKFZp686N0199    GTF3A    KLF7    ZNF    Sp1    DKFZp434J0650

    SP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SP3
    PGOHUM00000248458


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1313 SNPs in SP3 are shown (see all 1313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407688651,2
    C--174165274(+) ATGAAC/TTTTTC 3 -- ds50010--------
    rs1447440731,2
    C--174165286(+) GGGGAA/GAAGGT 3 -- ds50010--------
    rs1838074021,2
    --174165301(+) GATTCC/TAAAAA 3 -- ds50010--------
    rs1406093011,2
    C--174165395(+) AAAGT-/CCCCCATC 3 -- ds50010--------
    rs1885250271,2
    --174165605(+) TGATTA/TCACAA 3 -- ds50010--------
    rs1478677261,2
    C--174165830(+) ATTTTA/GAAACC 3 -- ut310--------
    rs1489249891,2
    --174165865(+) GCAACA/CACCCC 3 -- ut310--------
    rs739759071,2
    C,F--174166053(+) ACATAT/CACACT 3 -- ut314Minor allele frequency- C:0.18WA CSA 124
    rs1821407321,2
    --174166101(+) CTACCA/GGGCCT 3 -- ut310--------
    rs1428225711,2
    C--174166353(+) CTCAAA/TCTATA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SP3 (174771187 - 174830430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673963CNV Deletion23128226
    esv2664144CNV Deletion23128226
    nsv821796CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601804    OMIM disorders: --

    20/37 diseases for SP3 (see all 37):    About MalaCards
    wolfram syndrome    cushing's syndrome    huntington's disease    fibrosarcoma
    human t-cell leukemia virus type 1    scleroderma    gout    retinoblastoma
    cystic fibrosis    multiple sclerosis    colon adenocarcinoma    pancreatic cancer
    choriocarcinoma    nasopharyngitis    t-cell leukemia    muscular dystrophy
    colon cancer    acute lymphoblastic leukemia    acute myeloid leukemia    alzheimer's disease


    SP3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/22 Novoseek inferred disease relationships for SP3 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 27.2 1 11443124 (1)
    breast cancer 23.1 19 12176973 (3), 17511886 (2), 18543253 (2), 18006846 (2) (see all 10)
    retinoblastoma 21.9 3 11228546 (2), 15374992 (1)
    tumors 19.8 10 15317818 (1), 15857802 (1), 9371492 (1), 15247906 (1) (see all 9)
    cancer 14.6 6 15857802 (1), 12176973 (1), 16901903 (1), 19621387 (1) (see all 6)
    leukemia t-cell 11 2 16716116 (2)
    alzheimers disease 4.35 1 17934324 (1)
    fibrosarcoma 4.03 4 15857802 (2), 10452548 (1)
    astrocytoma 0 1 10506168 (1)
    necrosis 0 1 15706661 (1)


    Export disorders for SP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP3 gene, integrated from 9 sources (see all 376):
    (articles sorted by number of sources associating them with SP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PubMed id 1341900)1, 2, 3, 9 Kingsley C. and Winoto A. (1992)
    2. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PubMed id 1454515)1, 2, 3 Hagen G.... Suske G. (1992)
    3. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. (PubMed id 17548428)1, 2, 9 Wooten-Blanks L.G....Ogretmen B. (2007)
    4. The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PubMed id 12176973)1, 2, 9 Sun J.M.... Davie J.R. (2002)
    5. Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. (PubMed id 9278495)1, 2, 9 Ihn H. and Trojanowska M. (1997)
    6. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis. (PubMed id 15474306)1, 2, 9 Moran K.M.... Richert J.R. (2004)
    7. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. (PubMed id 12419227)1, 2, 9 Ross S.... Gill G. (2002)
    8. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PubMed id 10391891)1, 2, 9 Ding H.... Belayew A. (1999)
    9. Complexity of translationally controlled transcription factor Sp3 isoform expression. (PubMed id 15247228)1, 2, 9 Sapetschnig A....Suske G. (2004)
    10. Acetylated SP3 is a transcriptional activator. (PubMed id 12837748)1, 2, 9 Ammanamanchi S.... Brattain M.G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6670 HGNC: 11208 AceView: SP3 Ensembl:ENSG00000172845 euGenes: HUgn6670
    ECgene: SP3 H-InvDB: SP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SP3 gene:
    Search GeneIP for patents involving SP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SP3
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SP3 (Sp3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SP3   OriGene RNAi products in human, mouse, rat for SP3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SP3  
     OriGene MassSpec something-or-other for SP3   OriGene clones in human, mouse for SP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SP3   OriGene Purified Protein for SP3  
     OriGene ORF clones in mouse, rat for SP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SP3   OriGene Custom Protein Services for SP3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP3
     QIAGEN SeqTarget long-range PCR primers for resequencing SP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP3
     GenScript Custom Purified and Recombinant Proteins Services for SP3 GenScript cDNA clones with any tag delivered in your preferred vector for SP3
     GenScript Custom Assay Services for SP3 GenScript Superior Antibodies for SP3
     GenScript Custom overexpressing Cell Line Services for SP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SP3 promoter
     Search Chromatin IP Primers for SP3
     RT2 qPCR Primer Assay in human, mouse, rat SP3
     GNC Network for SP3
     SABiosciences PCR Arrays including human, mouse, rat SP3
     Search Tocris compounds for SP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SP3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for SP3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SP3 antibodies
     SP3 lysates
     Antibodies for SP3
     See all of Abcam's Antibodies, Kits and Proteins for SP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SP3
     Antibodies for SP3
     ELISAs for SP3
     CLIAs for SP3
     Search LifeMap BioReagents cell lines for SP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3
     SwitchGear 3'UTR luciferase reporter plasmids for SP3
     SwitchGear Promoter luciferase reporter plasmids for SP3
     ThermoFisher Antibodies for SP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SP3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SP3
    Customized:
     lentivirus for stable overexpression of SP3
     lentivirus expression plasmids for stable overexpression of SP3
     adenovirus for overexpression of SP3
     LSBio Antibodies in human, mouse, rat for SP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SP3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4