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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP3 Gene

protein-coding   GIFtS: 59
GCID: GC02M174771

Sp3 transcription factor
 Explore 44 diseases affiliated with
SP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SP3    

Aliases
for SP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sp3 Transcription Factor1 2
SPR-21 3
SPR22
GC-Binding Transcription Factor Sp32
Specificity Protein 32
Transcription Factor Sp32

External Ids:    HGNC: 112081   Entrez Gene: 66702   Ensembl: ENSG000001728457   OMIM: 6018045   UniProtKB: Q024473   

Export aliases for SP3 gene to outside databases

Previous GC identifers: GC02M172825 GC02M173434 GC02M174737 GC02M174975 GC02M174598 GC02M174481 GC02M166650


Summaries
for SP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SP3:
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by
binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger
DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional
transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants
encoding different isoforms have been described for this gene, and one has been reported to initiate translation from
a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation
initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. (provided by
RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as
cell-cycle regulation, hormone-induction and house-keeping

Gene Wiki entry for SP3 (Sp3 transcription factor)


Genomic Views
for SP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

SP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M174771:  view genomic region     (about GC identifiers)

Start:
 174,771,187 bp from pter      End:
 174,830,430 bp from pter
Size:
 59,244 bases      Orientation:
 minus strand

Proteins
for SP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447 (See protein sequence)
Recommended Name: Transcription factor Sp3  
Size: 781 amino acids; 81925 Da
Subunit: Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts
with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2
(preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity.
Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a
Subcellular location: Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when
sumoylated. Some localization in PML nuclear bodies
Secondary accessions: A0AVL9 B4E2B7 Q69B26 Q69B27 Q8TD56 Q8WWU4 Q9BQR1
Alternative splicing, Alternative initiation: 6 isoforms:  Q02447-1   Q02447-2   Q02447-3   Q02447-4   Q02447-5   Q02447-6   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for SP3: NX_Q02447

Post-translational modifications:

  • Not glycosylated1
  • Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate
    • transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at
    Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through
    altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the
    interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter1
  • Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at
    • this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on
    Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on
    transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02447

    • SP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017371.3  NP_001166183.1  NP_003102.1  

    ENSEMBL proteins: 
     ENSP00000310301   ENSP00000406140   ENSP00000413665   ENSP00000388903  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for SP3
    OriGene Purified Protein: SP3
    OriGene Protein Over-expression Lysate (see all 2): SP3
    OriGene Custom Protein Services for SP3 
    GenScript Custom Purified and Recombinant Proteins Services for SP3
    Novus Biologicals SP3 Protein
    Novus Biologicals SP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SP3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC12560508
    GO:0016605PML body IEA--
    GO:0017053transcriptional repressor complex IEA--


    SP3 for ontologies           About GeneDecksing



    SP3 Antibody Products: 
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    Uscn Antibodies for SP3
    ThermoFisher Antibodies for SP3

    Assay Products for SP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SP3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SP3

    Protein Domains /
    Families
    for SP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SP3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02447

    ProtoNet protein and cluster: Q02447

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for SP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or
    post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box
    promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as
    cell-cycle regulation, hormone-induction and house-keeping

         Genatlas biochemistry entry for SP3:
    transcription factor SP-3,activator,GT box binding protein

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP3
    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmid: SP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP3 (see all 4)
    OriGene shRNA RFP: SP3
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SP3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP3 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SP3
    Search LifeMap BioReagents cell lines for SP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--


    SP3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SP3:
     Increased HPV18 LCR reporter a 

    Animal Models:
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sp3) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  no phenotypic analysis  respiratory system  skeleton 

    SP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Proteolysis Putative SUMO-1 pathway
    		Proteolysis Putative SUMO-1 pathway1.00
    		Proteolysis_Putative SUMO-1 pathway0.97
    2Development VEGF signaling via VEGFR2 - generic cascades
    		Development VEGF signaling and activation0.75
    		Development_VEGF signaling and activation0.75
    3Development_Ligand-dependent activation of the ESR1/AP-1 pathway
    		Transcription Ligand-dependent activation of the ESR1/SP pathway0.37
    		Transcription_Ligand-dependent activation of the ESR1/SP pathway0.37
    4G-protein signaling Regulation of RAC1 activity
    		G-protein signaling Rac2 regulation pathway0.16
    		G-protein signaling_Rac2 regulation pathway0.16
    5Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for SP3
        Development VEGF signaling and activation
    G-protein signaling Rac2 regulation pathway
    Proteolysis Putative SUMO-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SP3
        Signaling in Gap Junctions

    5 GeneGo (Thomson Reuters) Pathways for SP3
        Proteolysis Putative SUMO-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    G-protein signaling Rac2 regulation pathway
    Development VEGF signaling and activation

    3 BioSystems Pathways for SP3 
        Selenium Metabolism and Selenoproteins
    SIDS Susceptibility Pathways
    Regulation of Telomerase



    SP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for SP3 (Q024471, 2, 3 ENSP000003103014) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABPAQ065462, 3, ENSP000003468864MINT-49853 MINT-49854 I2D: score=4 STRING: ENSP00000346886
    STK19P498422, 3, ENSP000003644824MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000364482
    ESR1P033721, 3, ENSP000002062494EBI-348158,EBI-78473 I2D: score=3 STRING: ENSP00000206249
    E2F1Q010943, ENSP000003455714I2D: score=3 STRING: ENSP00000345571
    PIAS1O759253, ENSP000002496364I2D: score=3 STRING: ENSP00000249636
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001701in utero embryonic development ----
    GO:0001779natural killer cell differentiation IEA--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001889liver development IEA--


    SP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP3
    10/36 Novoseek chemical compound relationships for SP3 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mithramycin 88.7 15 16734381 (1), 17142323 (1), 11261509 (1), 15708372 (1) (see all 11)
    butyrate 49.7 12 16456404 (3), 16732318 (2), 11517158 (2), 17540780 (1) (see all 6)
    oligonucleotide 45.8 17 10722737 (2), 10597223 (1), 8687178 (1), 15467729 (1) (see all 16)
    5-aza-2'deoxycytidine 43.6 3 16204032 (1), 15107420 (1), 18522535 (1)
    dimethyl sulfate 36.4 1 9494121 (1)
    zinc 29.3 15 15523672 (2), 12736330 (2), 1341900 (1), 8621476 (1) (see all 13)
    estrogen 26.6 21 18543253 (6), 15541729 (3), 15987735 (2), 20382698 (2) (see all 7)
    cytosine 19.1 2 17881752 (1), 15107420 (1)
    gsno 16.7 7 14766015 (4), 16877677 (1)
    vegf 14.7 11 15374992 (2), 9264407 (2), 10816575 (1), 17363604 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about SP3 

    Transcripts
    for SP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SP3 gene (3 alternative transcripts): 
    NM_001017371.4  NM_001172712.1  NM_003111.4  

    Unigene Cluster for SP3:

    Sp3 transcription factor
    Hs.531587  [show with all ESTs]
    Unigene Representative Sequence: NM_003111
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310015(uc002uie.3 uc002uig.3 uc010zel.2) ENST00000418194
    ENST00000416195 ENST00000465379 ENST00000462904 ENST00000483084 ENST00000490182
    ENST00000455789(uc002uif.3)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP3
    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SP3 (see all 161):
    hsa-miR-411* hsa-miR-579 hsa-miR-4305 hsa-miR-3653 hsa-miR-519a hsa-miR-4275 hsa-miR-1273d hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmid: SP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP3 (see all 4)
    OriGene shRNA RFP: SP3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SP3 (NM_004346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP3

    Additional cDNA sequence: 

    AB209334.1 AJ310752.1 AJ430844.1 AK021546.1 AK304199.1 AY070137.1 AY441957.1 AY441958.1 
    BC042945.2 BC126414.1 BC143928.1 BX648857.1 M97191.2 X68560.1 

    15 DOTS entries:

    DT.40308094  DT.91893190  DT.97817798  DT.100655969  DT.208017  DT.40314397  DT.92437077  DT.100677183 
    DT.100825714  DT.121008821  DT.121008826  DT.86855082  DT.91918438  DT.95374239  DT.97786239 

    24/244 AceView cDNA sequences (see all 244):

    AL700040 BE045347 BG401758 BQ051119 AI627700 AW138249 AI672309 BF968634 
    AI470526 AL045601 AA405050 AV647061 BI909132 BQ010796 AI474184 AW241801 
    NM_003111 BF593871 AI433324 BM480285 AW204666 AW295678 AW295574 AI560975 

    GeneLoc Exon Structure


    Expression
    for SP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATTACCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP3

    SOURCE GeneReport for Unigene cluster: Hs.531587

    UniProtKB/Swiss-Prot: SP3_HUMAN, Q02447
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including SP3: 
              Transcription Factors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP3

    Orthologs
    for SP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SP3 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SP31 Sp3 transcription factor 86.07(n)
    90.21(a)    		   395302  NM_204603.1  NP_989934.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 95(a)
    84(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 GL343316.1(493626-495338)
    GL343316.1(471848-493625)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.50362 Xenopus laevis transcribed sequence with moderate similarity more 78.1(n)    48054768 
    zebrafish
    (Danio rerio)    		 Actinopterygii sp3a1 sp3a transcription factor 60.62(n)
    63.69(a)    		   558652  NM_001089498.1  NP_001082967.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG56693   -- 74(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y40B1A.43 Zinc finger, C2H2 type 67(a)
    (best of 2)    		   I(13368725-13372200)   --


    ENSEMBL Gene Tree for SP3 (if available)
    TreeFam Gene Tree for SP3 (if available) 

    Paralogs
    for SP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP3 gene
    SP42  SP82  SP52  SP22  KLF172  SP12  SP62  SP92  
    SP72  
    18/41 SIMAP similar genes for SP3 using alignment to 8 protein entries:     SP3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    SP5    SP7    SP6    WT1    KLF13
    KLF9    SP9    SP4    KLF1    KLF6    ZNF56
    kr-znf3    DKFZp686N0199    GTF3A    DKFZp313F0536    KLF7    ZNF

    SP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SP3
    PGOHUM00000248458


    Genomic Variants
    for SP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1138 NCBI SNPs in SP3 are shown (see all 1138)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1407688651,2
    		--174770763(+) ATGAAC/TTTTTC 3 -- ds50010--------
    rs1447440731,2
    		--174770775(+) GGGGAA/GAAGGT 3 -- ds50010--------
    rs1838074021,2
    		--174770790(+) GATTCC/TAAAAA 3 -- ds50010--------
    rs1406093011,2
    		C,--174770884(+) AAAGT-/CCCCCATC 3 -- ds50010--------
    rs1885250271,2
    		--174771094(+) TGATTA/TCACAA 3 -- ds50010--------
    rs1478677261,2
    		--174771319(+) ATTTTA/GAAACC 3 -- ut310--------
    rs1489249891,2
    		--174771354(+) GCAACA/CACCCC 3 -- ut310--------
    rs739759071,2
    		C,F,--174771542(+) ACATAT/CACACT 3 -- ut314Minor allele frequency- C:0.18WA CSA 124
    rs1821407321,2
    		--174771590(+) CTACCA/GGGCCT 3 -- ut310--------
    rs1428225711,2
    		C,--174771842(+) CTCAAA/TCTATA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SP3 (174771187 - 174830430 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SP3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SP3

    Disorders / Diseases
    for SP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SP3 for disorders           About GeneDecksing

    OMIM gene information: 601804    OMIM disorders: --

    20/44 diseases for SP3 (see all 44):    About MalaCards
    human t-cell leukemia virus type 1    dna topoisomerase ii    adenomatous polyposis coli    cushing's syndrome
    cystic fibrosis    wolfram syndrome    acute lymphoblastic leukemia    multiple sclerosis
    lymphoblastic leukemia    acute myeloid leukemia    huntington's disease    myeloid leukemia
    fibrosarcoma    polyposis    t-cell leukemia    leukemia
    alzheimer's disease    colon cancer    retinoblastoma    fibrosis

    10/22 Novoseek disease relationships for SP3 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 27.2 1 11443124 (1)
    breast cancer 23.1 19 12176973 (3), 17511886 (2), 18543253 (2), 18006846 (2) (see all 10)
    retinoblastoma 21.9 3 11228546 (2), 15374992 (1)
    tumors 19.8 10 15317818 (1), 15857802 (1), 9371492 (1), 15247906 (1) (see all 9)
    cancer 14.6 6 15857802 (1), 12176973 (1), 16901903 (1), 19621387 (1) (see all 6)
    leukemia t-cell 11 2 16716116 (2)
    alzheimers disease 4.35 1 17934324 (1)
    fibrosarcoma 4.03 4 15857802 (2), 10452548 (1)
    astrocytoma 0 1 10506168 (1)
    necrosis 0 1 15706661 (1)


    Export disorders for SP3 gene to outside databases

    Publications
    for SP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP3 gene, integrated from 9 sources (see all 367):
    (articles sorted by number of sources associating them with SP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PubMed id 1341900)1, 2, 3, 9 Kingsley C. and Winoto A. (1992)
    2. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PubMed id 1454515)1, 2, 3 Hagen G.... Suske G. (1992)
    3. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. (PubMed id 17548428)1, 2, 9 Wooten-Blanks L.G....Ogretmen B. (2007)
    4. The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PubMed id 12176973)1, 2, 9 Sun J.M.... Davie J.R. (2002)
    5. Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. (PubMed id 9278495)1, 2, 9 Ihn H. and Trojanowska M. (1997)
    6. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis. (PubMed id 15474306)1, 2, 9 Moran K.M.... Richert J.R. (2004)
    7. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. (PubMed id 12419227)1, 2, 9 Ross S.... Gill G. (2002)
    8. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PubMed id 10391891)1, 2, 9 Ding H.... Belayew A. (1999)
    9. Complexity of translationally controlled transcription factor Sp3 isoform expression. (PubMed id 15247228)1, 2, 9 Sapetschnig A....Suske G. (2004)
    10. Acetylated SP3 is a transcriptional activator. (PubMed id 12837748)1, 2, 9 Ammanamanchi S.... Brattain M.G. (2003)

    External Searches for SP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6670 HGNC: 11208 AceView: SP3 Ensembl:ENSG00000172845 euGenes: HUgn6670
    ECgene: SP3 H-InvDB: SP3

    Other Databases showing SP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SP3 gene:
    Search GeneIP for patents involving SP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SP3 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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