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Aliases for SP2 Gene

Aliases for SP2 Gene

  • Sp2 Transcription Factor 2 3 5
  • KIAA0048 4

External Ids for SP2 Gene

Previous GeneCards Identifiers for SP2 Gene

  • GC17P045680
  • GC17P048454
  • GC17P046315
  • GC17P046449
  • GC17P046448
  • GC17P043328
  • GC17P045973
  • GC17P041342

Summaries for SP2 Gene

Entrez Gene Summary for SP2 Gene

  • This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

GeneCards Summary for SP2 Gene

SP2 (Sp2 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP2 Gene

  • Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Gene Wiki entry for SP2 Gene

Additional gene information for SP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP2 Gene

Genomics for SP2 Gene

Regulatory Elements for SP2 Gene

Enhancers for SP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H047941 1.4 ENCODE dbSUPER 81.3 +45.8 45803 2 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF416 SP3 NFYC SSRP1 ZNF610 MRPL45P2 UBE2Z EFCAB13 SP2 ENSG00000264701 CDK5RAP3 ENSG00000266601 RPS2P47 ENSG00000253347 SCRN2
GH17H048023 2 FANTOM5 Ensembl ENCODE dbSUPER 40.5 +129.3 129269 4.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SP2 ENSG00000266601 EFCAB13 ENSG00000253347 CBX1 MRPL45P2 SNX11 CDK5RAP3 COPZ2 SKAP1
GH17H048538 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 33.1 +677.1 677112 68.8 FEZF1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN NR2C1 KDM1A UBE2Z ENSG00000264701 HOXB2 CDK5RAP3 SP2 SKAP1 HOXB9 RN7SL125P GIP ENSG00000250838
GH17H048728 1.3 ENCODE dbSUPER 53.2 +832.8 832812 0.8 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 ZNF302 KLF7 SP3 REST UBE2Z SP2 ENSG00000264701 CDK5RAP3 SCRN2 ENSG00000266601 CBX1 ENSG00000263412 SUMO2P17 ENSG00000230532
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SP2 on UCSC Golden Path with GeneCards custom track

Promoters for SP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095234 146 2401 PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZBTB7B SLC30A9 ZNF207 ZNF143

Genomic Locations for SP2 Gene

Genomic Locations for SP2 Gene
36,218 bases
Plus strand

Genomic View for SP2 Gene

Genes around SP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP2 Gene

Proteins for SP2 Gene

  • Protein details for SP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor Sp2
    Protein Accession:
    Secondary Accessions:
    • A6NK74

    Protein attributes for SP2 Gene

    613 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16680.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33814.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA05923.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SP2 Gene


neXtProt entry for SP2 Gene

Post-translational modifications for SP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SP2 Gene

Domains & Families for SP2 Gene

Gene Families for SP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SP2 Gene

Suggested Antigen Peptide Sequences for SP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP2: view

Function for SP2 Gene

Molecular function for SP2 Gene

GENATLAS Biochemistry:
transcription factor SP2,linked to RARA and HOXb genes
UniProtKB/Swiss-Prot Function:
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Phenotypes From GWAS Catalog for SP2 Gene

Gene Ontology (GO) - Molecular Function for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10744779
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10744779
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SP2: view
genes like me logo Genes that share phenotypes with SP2: view

Animal Models for SP2 Gene

MGI Knock Outs for SP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP2 Gene

Localization for SP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SP2: view

Pathways & Interactions for SP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10744779
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1341900
GO:0006955 immune response TAS 1341900
genes like me logo Genes that share ontologies with SP2: view

No data available for Pathways by source and SIGNOR curated interactions for SP2 Gene

Drugs & Compounds for SP2 Gene

No Compound Related Data Available

Transcripts for SP2 Gene

Unigene Clusters for SP2 Gene

Sp2 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SP2

Alternative Splicing Database (ASD) splice patterns (SP) for SP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for SP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SP2 Gene

Protein differential expression in normal tissues from HIPED for SP2 Gene

This gene is overexpressed in Blymphocyte (16.0), CD8 Tcells (10.1), Peripheral blood mononuclear cells (9.3), Pancreas (7.4), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SP2 Gene

Protein tissue co-expression partners for SP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SP2 Gene:


SOURCE GeneReport for Unigene cluster for SP2 Gene:


Evidence on tissue expression from TISSUES for SP2 Gene

  • Spleen(4.5)
  • Bone marrow(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with SP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP2 Gene

Orthologs for SP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SP2 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia SP2 33 34
  • 92.85 (n)
(Bos Taurus)
Mammalia SP2 33 34
  • 92.01 (n)
(Rattus norvegicus)
Mammalia Sp2 33
  • 90.18 (n)
(Mus musculus)
Mammalia Sp2 33 16 34
  • 89.16 (n)
(Monodelphis domestica)
Mammalia SP2 34
  • 87 (a)
(Gallus gallus)
Aves SP2 33 34
  • 77.14 (n)
(Anolis carolinensis)
Reptilia SP2 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sp2 33
  • 65.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13441 33
(Danio rerio)
Actinopterygii LOC100537519 33
  • 63.79 (n)
sp2 34 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5669 35
  • 65 (a)
(Caenorhabditis elegans)
Secernentea T22C8.5 35
  • 57 (a)
sptf-2 34
  • 47 (a)
Species where no ortholog for SP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP2 Gene

Gene Tree for SP2 (if available)
Gene Tree for SP2 (if available)

Paralogs for SP2 Gene

Paralogs for SP2 Gene

genes like me logo Genes that share paralogs with SP2: view

Variants for SP2 Gene

Sequence variations from dbSNP and Humsavar for SP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000097487 -- 47,907,147(+) TCCTA(A/G)TGCTG intron-variant
rs1000160162 -- 47,928,874(+) CCTTT(A/G)TTAAC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000206700 -- 47,924,371(+) GCCCA(A/G)GCAAT intron-variant
rs1000243325 -- 47,907,140(+) GTGGA(A/T)GTCCT intron-variant
rs1000289321 -- 47,895,435(+) TAGGA(A/G)AGGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SP2 Gene

Variant ID Type Subtype PubMed ID
esv3640708 CNV loss 21293372
nsv2072 CNV deletion 18451855
nsv518892 CNV loss 19592680

Variation tolerance for SP2 Gene

Residual Variation Intolerance Score: 5.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP2 Gene

Disorders for SP2 Gene

Relevant External Links for SP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP2 Gene

Publications for SP2 Gene

  1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C … Winoto A (Molecular and cellular biology 1992) 2 3 4 60
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 45 60
  3. Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. (PMID: 15953604) Lee YC … Strott CA (FEBS letters 2005) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization. (PMID: 9730617) Scohy S … Szpirer J (Cytogenetics and cell genetics 1998) 2 3 60

Products for SP2 Gene

  • Addgene plasmids for SP2

Sources for SP2 Gene

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