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SP2 Gene

protein-coding   GIFtS: 54
GCID: GC17P045973

Sp2 Transcription Factor

  See SP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sp2 Transcription Factor1 2
Transcription Factor Sp22
KIAA00483

External Ids:    HGNC: 112071   Entrez Gene: 66682   Ensembl: ENSG000001671827   OMIM: 6018015   UniProtKB: Q020863   

Export aliases for SP2 gene to outside databases

Previous GC identifers: GC17P045680 GC17P048454 GC17P046315 GC17P046449 GC17P046448 GC17P043328 GC17P041342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SP2 Gene:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are
sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three
carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp
subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes
primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress
expression from different promoters. (provided by RefSeq, Jul 2008)

GeneCards Summary for SP2 Gene:
SP2 (Sp2 transcription factor) is a protein-coding gene. Diseases associated with SP2 include brain cancer. GO annotations related to this gene include histone deacetylase binding. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP2_HUMAN, Q02086
Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain
functional recognition sites

Gene Wiki entry for SP2 (Sp2 transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SP2 gene promoter:
         GR   p53   AP-1   GR-beta   ATF-2   LCR-F1   CREB   deltaCREB   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP2 promoter sequence
   Search Chromatin IP Primers for SP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.3-q22

SP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045973:  view genomic region     (about GC identifiers)

Start:
45,973,516 bp from pter      End:
46,006,323 bp from pter
Size:
32,808 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SP2_HUMAN, Q02086 (See protein sequence)
Recommended Name: Transcription factor Sp2  
Size: 613 amino acids; 64900 Da
Sequence caution: Sequence=AAH16680.1; Type=Erroneous initiation; Sequence=AAH33814.1; Type=Erroneous initiation;
Sequence=BAA05923.2; Type=Erroneous initiation;
Secondary accessions: A6NK74
Alternative splicing: 2 isoforms:  Q02086-1   Q02086-2   

Explore the universe of human proteins at neXtProt for SP2: NX_Q02086

Explore proteomics data for SP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003101.3  
    ENSEMBL proteins: 
     ENSP00000365931  

    SP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SP2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02086

    ProtoNet protein and cluster: Q02086

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: SP2_HUMAN, Q02086
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with SP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP2_HUMAN, Q02086
    Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain
    functional recognition sites

         Genatlas biochemistry entry for SP2:
    transcription factor SP2,linked to RARA and HOXb genes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0042826histone deacetylase binding IPI17827154
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SP2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sp2):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with SP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sp2tm1.2Sus for SP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP2

    miRNA
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    miRTarBase miRNAs that target SP2:
    hsa-mir-29a-3p (MIRT049983)

    Block miRNA regulation of human, mouse, rat SP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP2 (see all 47):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-4317 hsa-miR-4307 hsa-miR-300 hsa-miR-548k hsa-miR-875-5p hsa-miR-411
    SwitchGear 3'UTR luciferase reporter plasmidSP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SP2
    Predesigned siRNA for gene silencing in human, mouse, rat SP2

    Gene Editing
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    OriGene ORF clones in mouse, rat for SP2
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    GenScript Custom all cDNA clones Services for SP2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SP2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SP2_HUMAN, Q02086: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SP2
    Interactions:

        Search GeneGlobe Interaction Network for SP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SP2 (Q020863 ENSP000003659314) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010943, ENSP000003455714I2D: score=3 STRING: ENSP00000345571
    NKX3-1Q998013, ENSP000003702534I2D: score=1 STRING: ENSP00000370253
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    NR0B2Q154663, ENSP000002542274I2D: score=1 STRING: ENSP00000254227
    BANPQ8N9N53I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1341900
    GO:0006955immune response TAS1341900
    GO:0035264multicellular organism growth IEA--

    Find genes that share ontologies with SP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SP2 gene: 
    NM_003110.5  

    Unigene Cluster for SP2:

    Sp2 transcription factor
    Hs.514276  [show with all ESTs]
    Unigene Representative Sequence: D28588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376741(uc002imk.3 uc002iml.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat SP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP2 (see all 47):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-4317 hsa-miR-4307 hsa-miR-300 hsa-miR-548k hsa-miR-875-5p hsa-miR-411
    SwitchGear 3'UTR luciferase reporter plasmidSP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SP2
    Predesigned siRNA for gene silencing in human, mouse, rat SP2
    Clone
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    OriGene ORF clones in mouse, rat for SP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP2
    Primer
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    OriGene qPCR primer pairs and template standards for SP2
    OriGene qSTAR qPCR primer pairs in human, mouse for SP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP2
      QuantiTect SYBR Green Assays in human, mouse, rat SP2
      QuantiFast Probe-based Assays in human, mouse, rat SP2

    Additional mRNA sequence: 

    AK097532.1 BC005914.1 BC016680.2 BC033814.2 D28588.1 M97190.1 

    8 DOTS entries:

    DT.100745834  DT.100745833  DT.100024819  DT.95373196  DT.120990071  DT.120990078  DT.120990081  DT.95373199 

    Selected AceView cDNA sequences (see all 125):

    AA430659 AK097532 BE463643 BQ682212 BE674131 CK903944 BQ917889 BQ227715 
    AL044196 BQ880312 BQ216368 AI830153 AA323029 AI214583 BM757316 BQ637856 
    AL556794 AI359678 AI912031 BE072644 AA704703 BU070535 CD616293 BU955720 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                    -     -     -     -                                                                                 
    SP2:                                      -                                                                                 
    SP3:                    -     -           -                                                                                 
    SP4:                    -     -     -                                                                                       
    SP5:                    -     -     -     -                             -     -                                             


    ECgene alternative splicing isoforms for SP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAAAAACA
    SP2 Expression
    About this image


    SP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514276
        Custom PCR Arrays for SP2
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    QuantiFast Probe-based Assays in human, mouse, rat SP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp21 , 5 Sp2 transcription factor1, 5 89.16(n)1
    93.95(a)1
      11 (60.17 cM)5
    789121  NM_001080964.11  NP_001074433.11 
     969533415 
    chicken
    (Gallus gallus)
    Aves SP21 Sp2 transcription factor 77.14(n)
    84.03(a)
      425673  XM_423405.4  XP_423405.3 
    lizard
    (Anolis carolinensis)
    Reptilia SP26
    Sp2 transcription factor
    79(a)
    1 ↔ 1
    6(74714580-74744909)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134412 Xenopus laevis transcribed sequence with weak similarity more 74.69(n)    CB207942.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005375191 transcription factor Sp2-like 63.79(n)
    65(a)
      100537519  XM_003199449.2  XP_003199497.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C8.53 Zinc finger, C2H2 type (3 domains) 57(a)   II(8625475-8627495)   --


    ENSEMBL Gene Tree for SP2 (if available)
    TreeFam Gene Tree for SP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SP2 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for SP2 using alignment to 2 protein entries:     SP2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    DKFZp686N0199    ZFS-5    KLF16    ZNF323    KLF9
    ZNF697    ZNF    KLF13    kr-znf3    DKFZp434J0650    ZNF72
    ZFS-2    ZFS-6    ZNF78L1    smap-7    HZF16    SP4

    Find genes that share paralogs with SP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for SP2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832865441,2
    --45975185(+) GGGGGC/TGAATC 1 -- int10--------
    rs1874560571,2
    --45975506(+) GGCTCC/TGGGAG 1 -- int10--------
    rs1910888621,2
    --45975523(+) TTTGGC/TATCAC 1 -- int10--------
    rs1424592191,2
    --45975533(+) CTCTGG/TACAGC 1 -- int10--------
    rs360459741,2
    ----45975230(+) GTGTT-/ACCAGT 1 -- int10--------
    rs3755273101,2
    ----45975550(+) ACTGGC/TACTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SP2 (45973516 - 46006323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518892CNV Loss19592680
    nsv908575CNV Loss21882294
    nsv2072CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601801    OMIM disorders: --

    1 disease for SP2:    
    About MalaCards
    brain cancer


    Find genes that share disorders with SP2           About GenesLikeMe

    Genetic Association Database (GAD): SP2
    Human Genome Epidemiology (HuGE) Navigator: SP2 (3 documents)

    Export disorders for SP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SP2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PubMed id 1341900)1, 2, 3 Kingsley C. and Winoto A. (Mol. Cell. Biol. 1992)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31--&gt;q32.1 (Sp2), 3q24--&gt;q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3--&gt;q22 by in situ hybridization. (PubMed id 9730617)1, 3 Scohy S....Szpirer J. (Cytogenet. Cell Genet. 1998)
    5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    6. Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. (PubMed id 15953604)1, 9 Lee Y.C....Strott C.A. (FEBS Lett. 2005)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6668 HGNC: 11207 AceView: SP2 Ensembl:ENSG00000167182 euGenes: HUgn6668
    ECgene: SP2 H-InvDB: SP2

    (According to HUGE)
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    HUGE: KIAA0048

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SP2 gene:
    Search GeneIP for patents involving SP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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