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Aliases for SP2 Gene

Aliases for SP2 Gene

  • Sp2 Transcription Factor 2 3
  • KIAA0048 4

External Ids for SP2 Gene

Previous GeneCards Identifiers for SP2 Gene

  • GC17P045680
  • GC17P048454
  • GC17P046315
  • GC17P046449
  • GC17P046448
  • GC17P043328
  • GC17P045973
  • GC17P041342

Summaries for SP2 Gene

Entrez Gene Summary for SP2 Gene

  • This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

GeneCards Summary for SP2 Gene

SP2 (Sp2 Transcription Factor) is a Protein Coding gene. Diseases associated with SP2 include brain cancer. GO annotations related to this gene include histone deacetylase binding. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP2 Gene

  • Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Gene Wiki entry for SP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP2 Gene

Genomics for SP2 Gene

Regulatory Elements for SP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SP2 Gene

Start:
47,896,150 bp from pter
End:
47,932,271 bp from pter
Size:
36,122 bases
Orientation:
Plus strand

Genomic View for SP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP2 Gene

Proteins for SP2 Gene

  • Protein details for SP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02086-SP2_HUMAN
    Recommended name:
    Transcription factor Sp2
    Protein Accession:
    Q02086
    Secondary Accessions:
    • A6NK74

    Protein attributes for SP2 Gene

    Size:
    613 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16680.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33814.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA05923.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP2 Gene

Proteomics data for SP2 Gene at MOPED

Post-translational modifications for SP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP2 Gene

Domains for SP2 Gene

Gene Families for SP2 Gene

HGNC:
  • SP :Specificity protein transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SP2 Gene

Suggested Antigen Peptide Sequences for SP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02086

UniProtKB/Swiss-Prot:

SP2_HUMAN :
  • Q02086
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP2: view

Function for SP2 Gene

Molecular function for SP2 Gene

GENATLAS Biochemistry:
transcription factor SP2,linked to RARA and HOXb genes
UniProtKB/Swiss-Prot Function:
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Gene Ontology (GO) - Molecular Function for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0042826 histone deacetylase binding IPI 17827154
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP2: view
genes like me logo Genes that share phenotypes with SP2: view

Animal Models for SP2 Gene

MGI Knock Outs for SP2:

Animal Model Products

miRNA for SP2 Gene

miRTarBase miRNAs that target SP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SP2 Gene

Localization for SP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP2 Gene COMPARTMENTS Subcellular localization image for SP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SP2: view

Pathways for SP2 Gene

SuperPathways for SP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1341900
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0006955 immune response TAS 1341900
genes like me logo Genes that share ontologies with SP2: view

No data available for Pathways by source for SP2 Gene

Transcripts for SP2 Gene

Unigene Clusters for SP2 Gene

Sp2 transcription factor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for SP2 Gene

GeneLoc Exon Structure for
SP2
ECgene alternative splicing isoforms for
SP2

Expression for SP2 Gene

mRNA expression in normal human tissues for SP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SP2 Gene

This gene is overexpressed in Blymphocyte (16.0), CD8 Tcells (10.1), Peripheral blood mononuclear cells (9.3), Pancreas (7.4), and Retina (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP2 Gene

SOURCE GeneReport for Unigene cluster for SP2 Gene Hs.514276

genes like me logo Genes that share expressions with SP2: view

Expression partners for SP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SP2 Gene

Orthologs for SP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SP2 35
  • 92.01 (n)
  • 96.41 (a)
SP2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP2 35
  • 92.85 (n)
  • 97.36 (a)
SP2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp2 35
  • 89.16 (n)
  • 93.95 (a)
Sp2 16
Sp2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SP2 35
  • 99.51 (n)
  • 99.84 (a)
SP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp2 35
  • 90.18 (n)
  • 95.3 (a)
oppossum
(Monodelphis domestica)
Mammalia SP2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SP2 35
  • 77.14 (n)
  • 84.03 (a)
SP2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp2 35
  • 65.7 (n)
  • 68.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13441 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537519 35
  • 63.79 (n)
  • 65 (a)
sp2 36
  • 61 (a)
OneToMany
sp2 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5669 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea T22C8.5 37
  • 57 (a)
sptf-2 36
  • 47 (a)
ManyToMany
Species with no ortholog for SP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP2 Gene

ENSEMBL:
Gene Tree for SP2 (if available)
TreeFam:
Gene Tree for SP2 (if available)

Paralogs for SP2 Gene

genes like me logo Genes that share paralogs with SP2: view

Variants for SP2 Gene

Sequence variations from dbSNP and Humsavar for SP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs36045974 -- 47,897,864(+) GTGTT(-/A)CCAGT intron-variant, utr-variant-5-prime
rs563282871 -- 47,897,832(+) TCAGA(C/T)AACCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SP2 Gene

Variant ID Type Subtype PubMed ID
nsv518892 CNV Loss 19592680
nsv908575 CNV Loss 21882294
nsv2072 CNV Loss 18451855

Relevant External Links for SP2 Gene

HapMap Linkage Disequilibrium report
SP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP2 Gene

Disorders for SP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SP2 Gene in MalaCards »

(1) Diseases for SP2 Gene including...

Relevant External Links for SP2

Genetic Association Database (GAD)
SP2
Human Genome Epidemiology (HuGE) Navigator
SP2
genes like me logo Genes that share disorders with SP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SP2 Gene

Publications for SP2 Gene

  1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C. … Winoto A. (Mol. Cell. Biol. 1992) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization. (PMID: 9730617) Scohy S. … Szpirer J. (Cytogenet. Cell Genet. 1998) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 48

Products for SP2 Gene

Sources for SP2 Gene

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