SP140L Gene
protein-coding GIFtS: 43
GCID: GC02P231191
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SP140 nuclear body protein-like
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Aliases
for SP140L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SP140 Nuclear Body Protein-Like1 2 | | Nuclear Body Protein SP140-Like Protein2 |
Export aliases for SP140L gene to outside databasesPrevious GC identifers: GC02P230900 GC02P223032 |
Summaries
for SP140L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SP140L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SP140L gene promoter:
GR AML1a Tal-1beta HNF-3beta GATA-1 Pax-3 POU2F1 POU2F1a GR-alpha Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SP140L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP140L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1SP140L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P231191: view genomic region
(about GC identifiers)
Start:
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231,191,894 bp from pter |
End:
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231,268,447 bp from pter |
Size:
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76,554 bases |
Orientation:
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plus strand |
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Proteins
for SP140L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LY10L_HUMAN, Q9H930 (See
protein sequence)Recommended Name: Nuclear body protein SP140-like protein Size: 580 amino acids; 67005 Da
Sequence caution: Sequence=AAX88869.1; Type=Erroneous gene model prediction; Sequence=BAB14413.1; Type=Erroneousinitiation; Note=Translation N-terminally extended;
Secondary accessions: Q2M375 Q4ZG65 Q9BSP3Alternative splicing: 4 isoforms: Q9H930-4 Q9H930-1 Q9H930-2 Q9H930-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SP140L: NX_Q9H930
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H930
SP140L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612411.4
ENSEMBL proteins: ENSP00000395195 ENSP00000397911 ENSP00000395223 ENSP00000243810 ENSP00000379811
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SP140L for ontologies About GeneDecksing
SP140L Antibody Products:
Assay Products for SP140L: |
Protein
Domains /
Families
for SP140L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SP140L for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9H930ProtoNet protein and cluster: Q9H930 2 Blocks protein families: IPB000770 SAND domain IPB010919 SAND-like
UniProtKB/Swiss-Prot: LY10L_HUMAN, Q9H930Similarity: Contains 1 bromo domainSimilarity: Contains 1 HSR domainSimilarity: Contains 1 PHD-type zinc fingerSimilarity: Contains 1 SAND domain |
Function
for SP140L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SP140L (NM_138402) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SP140L | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP140L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP140L |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SP140L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SP140L:
|
Pathways & Interactions
for SP140L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP140L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SP140L (ENSP000003979114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SP140L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SP140L
Search CenterWatch for drugs/clinical trials and news about SP140L / LY10L
|
Transcripts
for SP140L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SP140L gene: NM_138402.4 Unigene Cluster for SP140L: SP140 nuclear body protein-like Hs.589661 [show with all ESTs]Unigene Representative Sequence: NM_13840210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444636 ENST00000415673(uc010fxm.1) ENST00000458341(uc010fxn.2)
ENST00000483728 ENST00000462156 ENST00000496870 ENST00000466656 ENST00000497212
ENST00000243810 ENST00000396563(uc010fxo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SP140L (NM_138402) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SP140L | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP140L |
Additional cDNA sequence: AK093187.1 BC004921.2 BC105007.1 BC143624.1 14 DOTS entries: DT.97840172 DT.91715161 DT.40131632 DT.100740297 DT.75164811 DT.95201549 DT.95215254 DT.120949411 DT.91984281 DT.99986225 DT.100777867 DT.40306918 DT.95116766 DT.95311186 9 AceView cDNA sequences: AI810978 AA688226 BF002973 AI810878 BC004921 BG335937 BX480665 BG335812 BE278323
GeneLoc Exon Structure
|
Expression
for SP140L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SP140L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCGCCCGC
About this image
See SP140L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SP140L
SOURCE GeneReport for Unigene cluster: Hs.589661
SABiosciences Custom PCR Arrays for SP140L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP140L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SP140L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP140L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP140L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP140L |
Orthologs
for SP140L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SP140L gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
BX569789.26BX569789.56 |
-- |
32(a)22(a) |
many ↔ manymany ↔ many |
3(24837780-24845598) 3(24862707-24880269) |
ENSEMBL Gene Tree for SP140L (if available)
TreeFam Gene Tree for SP140L (if available) |
Paralogs
for SP140L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SP140L gene
- SP1002 SP1102 SP1402
6 SIMAP similar genes for SP140L using alignment to 2 protein entries: LY10L_HUMAN (see all proteins):SP100 SP140 AIRE FLJ00340 SP110 DKFZp686E07254
SP140L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SP140L
PGOHUM00000240546
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Genomic Variants
for SP140L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SP140L (231191894 - 231268447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SP140L
4 CNVs: 63325 8397 98164 58971 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP140L |
|
Disorders
/ Diseases
for SP140L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SP140L for disorders About MalaCards
SP140L for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SP140L (2 documents)
Export disorders for SP140L gene to outside databases
|
Publications
for SP140L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SP140L gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SP140L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for SP140L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SP140L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SP140L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SP140L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SP140L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SP140L gene:
Search GeneIP for patents involving SP140L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SP140L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SP140L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP140L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP140L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SP140L | | OriGene 3'-UTR Clone for SP140L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP140L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP140L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP140L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP140L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP140L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP140L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP140L |
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 | | | SP140L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP140L |
|  |  |  | | | | Search ThermoFisher Antibodies for SP140L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SP140L |
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