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Aliases for SP140L Gene

Aliases for SP140L Gene

  • SP140 Nuclear Body Protein Like 2 3 5
  • SP140 Nuclear Body Protein-Like 2

External Ids for SP140L Gene

Previous GeneCards Identifiers for SP140L Gene

  • GC02P230900
  • GC02P231191
  • GC02P223032

Summaries for SP140L Gene

GeneCards Summary for SP140L Gene

SP140L (SP140 Nuclear Body Protein Like) is a Protein Coding gene. Diseases associated with SP140L include Primary Biliary Cirrhosis. GO annotations related to this gene include chromatin binding. An important paralog of this gene is SP140.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP140L Gene

Genomics for SP140L Gene

Regulatory Elements for SP140L Gene

Enhancers for SP140L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SP140L on UCSC Golden Path with GeneCards custom track

Promoters for SP140L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SP140L Gene

230,327,166 bp from pter
230,403,732 bp from pter
76,567 bases
Plus strand

Genomic View for SP140L Gene

Genes around SP140L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP140L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP140L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP140L Gene

Proteins for SP140L Gene

  • Protein details for SP140L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear body protein SP140-like protein
    Protein Accession:
    Secondary Accessions:
    • Q2M375
    • Q4ZG65
    • Q9BSP3

    Protein attributes for SP140L Gene

    580 amino acids
    Molecular mass:
    67005 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX88869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14413.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SP140L Gene


neXtProt entry for SP140L Gene

Post-translational modifications for SP140L Gene

  • Ubiquitination at Lys 238
  • Modification sites at PhosphoSitePlus

Other Protein References for SP140L Gene

No data available for DME Specific Peptides for SP140L Gene

Domains & Families for SP140L Gene

Gene Families for SP140L Gene

Suggested Antigen Peptide Sequences for SP140L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bromo domain.
  • Contains 1 PHD-type zinc finger.
  • Contains 1 bromo domain.
  • Contains 1 HSR domain.
  • Contains 1 SAND domain.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with SP140L: view

Function for SP140L Gene

Gene Ontology (GO) - Molecular Function for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SP140L: view
genes like me logo Genes that share phenotypes with SP140L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SP140L Gene

Localization for SP140L Gene

Subcellular locations from

Jensen Localization Image for SP140L Gene COMPARTMENTS Subcellular localization image for SP140L gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SP140L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SP140L Gene

Pathways & Interactions for SP140L Gene

SuperPathways for SP140L Gene

No Data Available

Interacting Proteins for SP140L Gene

Gene Ontology (GO) - Biological Process for SP140L Gene


No data available for Pathways by source and SIGNOR curated interactions for SP140L Gene

Drugs & Compounds for SP140L Gene

No Compound Related Data Available

Transcripts for SP140L Gene

mRNA/cDNA for SP140L Gene

(16) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SP140L Gene

SP140 nuclear body protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP140L Gene

No ASD Table

Relevant External Links for SP140L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP140L Gene

mRNA expression in normal human tissues for SP140L Gene

mRNA differential expression in normal tissues according to GTEx for SP140L Gene

This gene is overexpressed in Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SP140L Gene

This gene is overexpressed in Plasma (24.4), Peripheral blood mononuclear cells (21.2), Fetal testis (11.4), and Blymphocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SP140L Gene

Protein tissue co-expression partners for SP140L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SP140L Gene:


SOURCE GeneReport for Unigene cluster for SP140L Gene:

genes like me logo Genes that share expression patterns with SP140L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SP140L Gene

Orthologs for SP140L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SP140L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SP140L 34
  • 98.85 (n)
  • 98.45 (a)
SP140L 35
  • 98 (a)
(Bos Taurus)
Mammalia -- 35
  • 70 (a)
-- 35
  • 26 (a)
(Canis familiaris)
Mammalia -- 35
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 19 (a)
(Mus musculus)
Mammalia A630001G21Rik 35
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
(Danio rerio)
Actinopterygii BX569789.2 35
  • 33 (a)
BX569789.4 35
  • 21 (a)
zgc:113411 35
  • 24 (a)
Species where no ortholog for SP140L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP140L Gene

Gene Tree for SP140L (if available)
Gene Tree for SP140L (if available)

Paralogs for SP140L Gene

Paralogs for SP140L Gene

(6) SIMAP similar genes for SP140L Gene using alignment to 5 proteins: Pseudogenes for SP140L Gene

genes like me logo Genes that share paralogs with SP140L: view

Variants for SP140L Gene

Sequence variations from dbSNP and Humsavar for SP140L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4973318 - 230,357,960(+) TAAAA(C/T)GTTTG nc-transcript-variant, reference, missense
rs28497362 - 230,383,546(+) GGGAA(C/T)GAGAA nc-transcript-variant, reference, missense
VAR_059146 -
rs1074886 -- 230,372,858(-) caatt(A/G)ttttc intron-variant
rs1107229 -- 230,325,951(-) GAGTC(C/T)TCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SP140L Gene

Variant ID Type Subtype PubMed ID
dgv4180n100 CNV loss 25217958
dgv7334n54 CNV gain 21841781
esv2625322 CNV deletion 19546169
esv2673997 CNV deletion 23128226
esv2721594 CNV deletion 23290073
esv2721596 CNV deletion 23290073
esv2751844 CNV gain 17911159
esv29172 CNV loss 19812545
esv3397627 CNV insertion 20981092
esv3561132 CNV deletion 23714750
esv3594600 CNV loss 21293372
esv3594601 CNV loss 21293372
esv3893565 CNV gain+loss 25118596
esv993570 CNV loss 20482838
nsv1001929 CNV gain+loss 25217958
nsv1006206 CNV gain 25217958
nsv1109334 CNV deletion 24896259
nsv480569 CNV novel sequence insertion 20440878
nsv508889 CNV insertion 20534489
nsv521344 CNV gain 19592680
nsv584667 CNV loss 21841781
nsv819175 CNV loss 19587683
nsv979180 CNV duplication 23825009

Variation tolerance for SP140L Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP140L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP140L Gene

Disorders for SP140L Gene

MalaCards: The human disease database

(1) MalaCards diseases for SP140L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • biliary liver cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SP140L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SP140L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP140L Gene

Publications for SP140L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. (PMID: 26347895) Saare M. … Peterson P. (J Immunol Res 2015) 3 65

Products for SP140L Gene

Sources for SP140L Gene

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