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Aliases for SP140L Gene

Aliases for SP140L Gene

  • SP140 Nuclear Body Protein-Like 2 3

External Ids for SP140L Gene

Previous GeneCards Identifiers for SP140L Gene

  • GC02P230900
  • GC02P231191
  • GC02P223032

Summaries for SP140L Gene

GeneCards Summary for SP140L Gene

SP140L (SP140 Nuclear Body Protein-Like) is a Protein Coding gene. An important paralog of this gene is SP100.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP140L Gene

Genomics for SP140L Gene

Regulatory Elements for SP140L Gene

Genomic Location for SP140L Gene

Start:
230,327,175 bp from pter
End:
230,403,732 bp from pter
Size:
76,558 bases
Orientation:
Plus strand

Genomic View for SP140L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP140L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP140L Gene

Proteins for SP140L Gene

  • Protein details for SP140L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H930-SP14L_HUMAN
    Recommended name:
    Nuclear body protein SP140-like protein
    Protein Accession:
    Q9H930
    Secondary Accessions:
    • Q2M375
    • Q4ZG65
    • Q9BSP3

    Protein attributes for SP140L Gene

    Size:
    580 amino acids
    Molecular mass:
    67005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14413.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SP140L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP140L Gene

Proteomics data for SP140L Gene at MOPED

Post-translational modifications for SP140L Gene

  • Ubiquitination at Lys207, Lys238, Lys389, and Lys414
  • Modification sites at PhosphoSitePlus

Other Protein References for SP140L Gene

No data available for DME Specific Peptides for SP140L Gene

Domains for SP140L Gene

Gene Families for SP140L Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for SP140L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H930

UniProtKB/Swiss-Prot:

SP14L_HUMAN :
  • Q9H930
Domain:
  • Contains 1 bromo domain.
  • Contains 1 HSR domain.
  • Contains 1 SAND domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with SP140L: view

Function for SP140L Gene

Gene Ontology (GO) - Molecular Function for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SP140L: view

Phenotypes for SP140L Gene

genes like me logo Genes that share phenotypes with SP140L: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SP140L Gene

Localization for SP140L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP140L Gene COMPARTMENTS Subcellular localization image for SP140L gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SP140L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SP140L Gene

Pathways for SP140L Gene

SuperPathways for SP140L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with SP140L: view

No data available for Pathways by source for SP140L Gene

Transcripts for SP140L Gene

mRNA/cDNA for SP140L Gene

(4) Additional mRNA sequences :
(14) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SP140L Gene

SP140 nuclear body protein-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SP140L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SP140L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP140L Gene

No ASD Table

Relevant External Links for SP140L Gene

GeneLoc Exon Structure for
SP140L
ECgene alternative splicing isoforms for
SP140L

Expression for SP140L Gene

mRNA expression in normal human tissues for SP140L Gene

mRNA differential expression in normal tissues according to GTEx for SP140L Gene

This gene is overexpressed in Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP140L Gene

SOURCE GeneReport for Unigene cluster for SP140L Gene Hs.589661

genes like me logo Genes that share expressions with SP140L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SP140L Gene

Orthologs for SP140L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SP140L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP140L 35
  • 98.85 (n)
  • 98.45 (a)
SP140L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia A630001G21Rik 36
  • 27 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX569789.2 36
  • 33 (a)
ManyToMany
BX569789.4 36
  • 21 (a)
ManyToMany
zgc:113411 36
  • 24 (a)
ManyToMany
Species with no ortholog for SP140L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP140L Gene

ENSEMBL:
Gene Tree for SP140L (if available)
TreeFam:
Gene Tree for SP140L (if available)

Paralogs for SP140L Gene

Paralogs for SP140L Gene

Selected SIMAP similar genes for SP140L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SP140L Gene

genes like me logo Genes that share paralogs with SP140L: view

Variants for SP140L Gene

Sequence variations from dbSNP and Humsavar for SP140L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs519696 -- 230,326,673(-) GACAT(G/T)GGGAC upstream-variant-2KB
rs520473 -- 230,326,616(-) AGTGT(G/T)CTTAG upstream-variant-2KB
rs521518 -- 230,326,481(-) GGGCC(A/G)CCTTG upstream-variant-2KB
rs521564 -- 230,326,463(-) CAGGG(A/G)TGAAG upstream-variant-2KB
rs665577 -- 230,326,330(-) TCTCT(G/T)CCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SP140L Gene

Variant ID Type Subtype PubMed ID
esv29172 CNV Loss 19812545
esv2721594 CNV Deletion 23290073
dgv4444n71 CNV Gain 21882294
esv2751844 CNV Gain 17911159
nsv875947 CNV Loss 21882294
nsv508889 CNV Insertion 20534489
esv2721596 CNV Deletion 23290073
esv2673997 CNV Deletion 23128226
nsv819175 CNV Loss 19587683
esv2625322 CNV Deletion 19546169
esv993570 CNV Loss 20482838
nsv521344 CNV Gain 19592680

Relevant External Links for SP140L Gene

HapMap Linkage Disequilibrium report
SP140L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP140L Gene

Disorders for SP140L Gene

Relevant External Links for SP140L

Genetic Association Database (GAD)
SP140L
Human Genome Epidemiology (HuGE) Navigator
SP140L
genes like me logo Genes that share disorders with SP140L: view

No data available for UniProtKB/Swiss-Prot for SP140L Gene

Publications for SP140L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SP140L Gene

Sources for SP140L Gene

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