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Aliases for SP140L Gene

Aliases for SP140L Gene

  • SP140 Nuclear Body Protein Like 2 3 5
  • SP140 Nuclear Body Protein-Like 2

External Ids for SP140L Gene

Previous GeneCards Identifiers for SP140L Gene

  • GC02P230900
  • GC02P231191
  • GC02P223032

Summaries for SP140L Gene

GeneCards Summary for SP140L Gene

SP140L (SP140 Nuclear Body Protein Like) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is SP140.

Additional gene information for SP140L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP140L Gene

Genomics for SP140L Gene

Regulatory Elements for SP140L Gene

Enhancers for SP140L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H230456 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +130.5 130501 1 POLR2A MAX RUNX3 MYC SPI1 SP140L SP100 SP110 HTR2B SP140 CAB39 GC02M230465
GH02H230408 1.1 Ensembl ENCODE dbSUPER 17.5 +81.8 81841 1 STAT1 JUND JUN STAT3 RAD21 NR2F2 GABPA SP140L ENSG00000279964 LOC105373925
GH02H230395 0.6 dbSUPER 27.4 +72.5 72506 7 MTA2 TAL1 MNT DPF2 CHAMP1 CC2D1A TCF12 NCOR1 TRIM24 SP140L RN7SL834P LOC105373925
GH02H230439 1.2 Ensembl ENCODE dbSUPER 13.1 +112.6 112570 1 HDAC1 SMARCE1 SOX6 JUN ELF1 DPF2 FOSL1 TCF12 SMARCA4 MLLT1 SP140L SP100 GC02M230465
GH02H230410 1.2 ENCODE dbSUPER 12.9 +84.8 84798 2 PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 SP140L ENSG00000279964 LOC105373925
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SP140L on UCSC Golden Path with GeneCards custom track

Promoters for SP140L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131658 434 1601 SIN3A ARID4B DMAP1 YY1 ELK1 FOS ATF7 RUNX3 MXD4 NFYC

Genomic Location for SP140L Gene

Chromosome:
2
Start:
230,327,166 bp from pter
End:
230,403,732 bp from pter
Size:
76,567 bases
Orientation:
Plus strand

Genomic View for SP140L Gene

Genes around SP140L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP140L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP140L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP140L Gene

Proteins for SP140L Gene

  • Protein details for SP140L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H930-SP14L_HUMAN
    Recommended name:
    Nuclear body protein SP140-like protein
    Protein Accession:
    Q9H930
    Secondary Accessions:
    • Q2M375
    • Q4ZG65
    • Q9BSP3

    Protein attributes for SP140L Gene

    Size:
    580 amino acids
    Molecular mass:
    67005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14413.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SP140L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP140L Gene

Post-translational modifications for SP140L Gene

  • Ubiquitination at Lys238
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SP140L Gene

Domains & Families for SP140L Gene

Gene Families for SP140L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for SP140L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SP140L: view

No data available for UniProtKB/Swiss-Prot for SP140L Gene

Function for SP140L Gene

Phenotypes From GWAS Catalog for SP140L Gene

Gene Ontology (GO) - Molecular Function for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP140L: view
genes like me logo Genes that share phenotypes with SP140L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SP140L Gene

Localization for SP140L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP140L gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SP140L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with SP140L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SP140L Gene

Pathways & Interactions for SP140L Gene

SuperPathways for SP140L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP140L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SP140L Gene

Drugs & Compounds for SP140L Gene

No Compound Related Data Available

Transcripts for SP140L Gene

Unigene Clusters for SP140L Gene

SP140 nuclear body protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP140L Gene

No ASD Table

Relevant External Links for SP140L Gene

GeneLoc Exon Structure for
SP140L
ECgene alternative splicing isoforms for
SP140L

Expression for SP140L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SP140L Gene

mRNA differential expression in normal tissues according to GTEx for SP140L Gene

This gene is overexpressed in Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SP140L Gene

This gene is overexpressed in Plasma (24.4), Peripheral blood mononuclear cells (21.2), Fetal testis (11.4), and Blymphocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SP140L Gene



Protein tissue co-expression partners for SP140L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SP140L Gene:

SP140L

SOURCE GeneReport for Unigene cluster for SP140L Gene:

Hs.589661

Evidence on tissue expression from TISSUES for SP140L Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SP140L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP140L Gene

Orthologs for SP140L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SP140L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP140L 34 33
  • 98.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 70 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia A630001G21Rik 34
  • 27 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX569789.2 34
  • 33 (a)
ManyToMany
zgc:113411 34
  • 24 (a)
ManyToMany
BX569789.4 34
  • 21 (a)
ManyToMany
Species where no ortholog for SP140L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP140L Gene

ENSEMBL:
Gene Tree for SP140L (if available)
TreeFam:
Gene Tree for SP140L (if available)

Paralogs for SP140L Gene

Paralogs for SP140L Gene

(6) SIMAP similar genes for SP140L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SP140L Gene

genes like me logo Genes that share paralogs with SP140L: view

Variants for SP140L Gene

Sequence variations from dbSNP and Humsavar for SP140L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000015595 -- 230,358,164(+) CGGAA(A/G)CAGCT intron-variant
rs1000089777 -- 230,327,969(+) TCCCA(A/G)GATGG intron-variant
rs1000141924 -- 230,383,327(+) CCAAG(A/C/G)CTCAT intron-variant
rs1000155154 -- 230,347,452(+) GCTGC(A/C)AGCTG intron-variant
rs1000191555 -- 230,342,515(+) CTCCC(A/G)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP140L Gene

Variant ID Type Subtype PubMed ID
dgv4180n100 CNV loss 25217958
dgv7334n54 CNV gain 21841781
esv2625322 CNV deletion 19546169
esv2673997 CNV deletion 23128226
esv2721594 CNV deletion 23290073
esv2721596 CNV deletion 23290073
esv2751844 CNV gain 17911159
esv29172 CNV loss 19812545
esv3397627 CNV insertion 20981092
esv3561132 CNV deletion 23714750
esv3594600 CNV loss 21293372
esv3594601 CNV loss 21293372
esv3893565 CNV gain+loss 25118596
esv993570 CNV loss 20482838
nsv1001929 CNV gain+loss 25217958
nsv1006206 CNV gain 25217958
nsv1109334 CNV deletion 24896259
nsv480569 CNV novel sequence insertion 20440878
nsv508889 CNV insertion 20534489
nsv521344 CNV gain 19592680
nsv584667 CNV loss 21841781
nsv819175 CNV loss 19587683
nsv979180 CNV duplication 23825009

Variation tolerance for SP140L Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP140L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP140L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP140L Gene

Disorders for SP140L Gene

Relevant External Links for SP140L

Genetic Association Database (GAD)
SP140L
Human Genome Epidemiology (HuGE) Navigator
SP140L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP140L

No disorders were found for SP140L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP140L Gene

Publications for SP140L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for SP140L Gene

Sources for SP140L Gene

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