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SP140 Gene

protein-coding   GIFtS: 52
GCID: GC02P231090

SP140 Nuclear Body Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SP140 Nuclear Body Protein1 2     LYSP100-A2
Lymphoid-Restricted Homolog Of Sp1002 3     LYSP100-B2
Nuclear Autoantigen Sp-1402 3     Lymphoid-Specific SP100 Homolog2
Speckled 140 KDa2 3     Nuclear Body Protein SP1402
LYSP1002 3     LYSp1003

External Ids:    HGNC: 171331   Entrez Gene: 112622   Ensembl: ENSG000000792637   OMIM: 6086025   UniProtKB: Q133423   

Export aliases for SP140 gene to outside databases

Previous GC identifers: GC02P229150 GC02P229822 GC02P231054 GC02P231292 GC02P230915 GC02P230798 GC02P222930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SP140 Gene:
SP140 (SP140 nuclear body protein) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SP100.

UniProtKB/Swiss-Prot: SP140_HUMAN, Q13342
Function: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May
be involved in the pathogenesis of acute promyelocytic leukemia and viral infection




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SP140 gene promoter:
         Nkx2-5   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP140 promoter sequence
   Search Chromatin IP Primers for SP140

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP140


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

SP140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP140 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P231090:  view genomic region     (about GC identifiers)

Start:
231,067,826 bp from pter      End:
231,223,762 bp from pter
Size:
155,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SP140_HUMAN, Q13342 (See protein sequence)
Recommended Name: Nuclear body protein SP140  
Size: 867 amino acids; 98223 Da
Miscellaneous: This antigen is recognized by autoantibodies from patients with primary biliary cirrhosis
Sequence caution: Sequence=AAB18617.1; Type=Frameshift; Positions=862; Sequence=AAX93282.1; Type=Erroneous gene
model prediction;
2 PDB 3D structures from and Proteopedia for SP140:
2MD7 (3D)        2MD8 (3D)    
Secondary accessions: Q13341 Q4ZG66 Q53TG1 Q6NSG4 Q92881 Q96TG3
Alternative splicing: 4 isoforms:  Q13342-1   Q13342-2   Q13342-3   Q13342-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SP140: NX_Q13342

Explore proteomics data for SP140 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys494, Lys676, Lys736
  • Modification sites at PhosphoSitePlus

  • See SP140 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001005176.1  NP_001265380.1  NP_001265381.1  NP_001265382.1  NP_009168.4  

    ENSEMBL proteins: 
     ENSP00000475284   ENSP00000375899   ENSP00000393618   ENSP00000342096   ENSP00000362749  
     ENSP00000440107   ENSP00000398210   ENSP00000345846  

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    Cloud-Clone Corp. Proteins for SP140

     
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    antibodies-online proteins for SP140 (4 products) 

     
    antibodies-online peptides for SP140

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 9):
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR001487 Bromodomain
     IPR010919 SAND_dom-like
     IPR004865 Sp100

    Graphical View of Domain Structure for InterPro Entry Q13342

    ProtoNet protein and cluster: Q13342

    5 Blocks protein domains:
    IPB000770 SAND domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like
    IPB004865 Sp100 domain
    IPB010919 SAND-like


    UniProtKB/Swiss-Prot: SP140_HUMAN, Q13342
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 HSR domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 SAND domain


    Find genes that share domains with SP140           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP140_HUMAN, Q13342
    Function: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May
    be involved in the pathogenesis of acute promyelocytic leukemia and viral infection
    Induction: By interferons

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8695863
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SP140           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SP140:
     Decreased viability  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SP140

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SP140_HUMAN, Q13342: Nucleus. Cytoplasm. Note=Localized to nuclear structures termed LANDS, for
    LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the
    nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may
    traffic between the cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8910577
    GO:0005635nuclear envelope TAS8695863
    GO:0005654nucleoplasm TAS8695863
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SP140           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SP140
    Interactions:

        GeneGlobe Interaction Network for SP140

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SP140 (Q133421, 3 ENSP000003758994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT2Q8IXJ63, ENSP000002493964I2D: score=1 STRING: ENSP00000249396
    PIN1Q135261EBI-2865100,EBI-714158
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS8695863
    GO:0006952defense response TAS8910577

    Find genes that share ontologies with SP140           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SP140



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SP140 gene (5 alternative transcripts): 
    NM_001005176.2  NM_001278451.1  NM_001278452.1  NM_001278453.1  NM_007237.4  

    Unigene Cluster for SP140:

    SP140 nuclear body protein
    Hs.632549  [show with all ESTs]
    Unigene Representative Sequence: U36500
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456542 ENST00000441657 ENST00000392045(uc002vqk.2 uc002vql.3 uc002vqm.3 uc010fxl.3)
    ENST00000417495 ENST00000343805 ENST00000543928 ENST00000373645(uc002vqj.3)
    ENST00000473711 ENST00000544128 ENST00000538494 ENST00000476126 ENST00000486750
    ENST00000479539 ENST00000486687(uc010zma.1) ENST00000420434 ENST00000350136(uc002vqn.3)

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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SP140
      QuantiTect SYBR Green Assays in human, mouse, rat SP140
      QuantiFast Probe-based Assays in human, mouse, rat SP140

    Additional mRNA sequence: 

    AK301267.1 AK301317.1 BC038091.1 BC054890.1 BC070160.1 BC105743.1 BC105744.1 BC105960.1 
    U36500.1 U63420.1 

    14 DOTS entries:

    DT.99986225  DT.99937546  DT.444052  DT.99993616  DT.40131632  DT.100777868  DT.100777869  DT.112371 
    DT.120949410  DT.91757377  DT.91984281  DT.95116766  DT.95311186  DT.95358561 

    Selected AceView cDNA sequences (see all 33):

    NM_001005176 AA741304 AI865439 BQ049232 BI019945 AI719324 BC070160 BC038091 
    AA404969 BC054890 BM809619 AA259138 BI021438 BX955263 CB112175 BI019815 
    AI435643 CD700509 CD685469 CD686065 BU603042 BG677021 BU537543 AA281823 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SP140 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                    -     -           -           -     -     -                                                                                             
    SP2:                    -     -           -           -     -     -                                                           -                                 
    SP3:                    -     -           -           -     -     -                       -           -           -     -                                       
    SP4:                                                                                                                                                            
    SP5:                    -     -           -           -                                                                                                         

    ExUns: 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
    SP1:              -                                                               
    SP2:              -                                                               
    SP3:              -                                                               
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for SP140

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SP140 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SP140 Expression
    About this image


    SP140 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    SP140 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SP140 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632549

    UniProtKB/Swiss-Prot: SP140_HUMAN, Q13342
    Tissue specificity: High levels in spleen and peripheral blood leukocytes, much lower levels in thymus, prostate,
    ovary, small intestine, and colon. Very low levels in heart, brain, placenta, lung, liver, skeletal muscle,
    kidney, and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP140

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SP140 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp1401 , 5 Sp140 nuclear body protein1, 5 69(n)1
    55.49(a)1
      1 (43.60 cM)5
    4344841  NM_001013817.21  NP_001013839.11 
     856003785 
    zebrafish
    (Danio rerio)
    Actinopterygii BX569789.26
    zgc:1134116
    (see all 3)
    zgc:113411
    (see all 3)
    33(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3(24837780-24845598) ENSDARG00000055359
    3(24932187-24941134) ENSDARG00000038133


    ENSEMBL Gene Tree for SP140 (if available)
    TreeFam Gene Tree for SP140 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SP140 gene
    SP1002  SP1102  SP140L2  
    6 SIMAP similar genes for SP140 using alignment to 11 protein entries:     SP140_HUMAN (see all proteins):
    SP140L    AIRE    FLJ00340    DKFZp686E07254    SP110    SP100

    Find genes that share paralogs with SP140           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SP140
    PGOHUM00000241131


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SP140 (see all 1866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602329291,2
    C,F--231092533(+) TGTTAG/AGCTGG 2 -- int17Minor allele frequency- A:0.36WA NA EA 366
    rs1815371371,2
    --231092755(+) ATGCAC/TTTAAT 2 -- int10--------
    rs1497858881,2
    --231092828(+) CCTTTC/TCATTT 2 -- int10--------
    rs1479425371,2
    --231092927(+) AGCTAC/TTTTTC 2 -- int10--------
    rs134048851,2
    C,F,H--231092953(+) gtttaT/Cggtct 2 -- int15Minor allele frequency- C:0.02NS EA WA 538
    rs75915821,2
    C,F,H--231093073(+) gcattC/Ttgcta 2 -- int19Minor allele frequency- T:0.09NS EA NA 666
    rs19464091,2
    C,F,A,H--231093168(-) cacagG/Ccagaa 2 -- int18Minor allele frequency- C:0.11NS EA NA WA 778
    rs1417381971,2
    --231093216(+) TCAATA/GATAGT 2 -- int10--------
    rs1471224231,2
    --231093336(+) TTGACA/CCTTTT 2 -- int10--------
    rs101971511,2
    C,F,H--231093485(+) aacctA/Gtctgt 2 -- int15Minor allele frequency- G:0.02NS EA WA 534

    HapMap Linkage Disequilibrium report for SP140 (231067826 - 231223762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SP140:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721594CNV Deletion23290073
    esv29172CNV Loss19812545
    dgv4444n71CNV Gain21882294
    nsv875944CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608602    OMIM disorders: --


    Find genes that share disorders with SP140           About GenesLikeMe

    Genetic Association Database (GAD): SP140
    Human Genome Epidemiology (HuGE) Navigator: SP140 (4 documents)

    Export disorders for SP140 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SP140 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SP140)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a leukocyte-specific component of the nuclear body. (PubMed id 8910577)1, 2, 3, 9 Bloch D.B.... Bloch K.D. (J. Biol. Chem. 1996)
    2. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. (PubMed id 8695863)1, 2, 3, 9 Dent A.L....Staudt L.M. (Blood 1996)
    3. Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1. (PubMed id 12368356)1, 3, 9 Madani N....Kabat D. (J. Virol. 2002)
    4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    5. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. (PubMed id 20731705)1, 4 Lan Q....Rothman N. (Eur. J. Haematol. 2010)
    6. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    7. Genetic susceptibility variants for chronic lymphocytic leukemia. (PubMed id 20332261)1, 4 Slager S.L....Cerhan J.R. (amp 2010)
    8. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PubMed id 18758461)1, 4 Di Bernardo M.C....Houlston R.S. (Nat. Genet. 2008)
    9. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PubMed id 23770605)1 Berndt S.I....Slager S.L. (Nat. Genet. 2013)
    10. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. (PubMed id 22700719)1 Slager S.L....Houlston R.S. (Blood 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11262 HGNC: 17133 AceView: SP140 Ensembl:ENSG00000079263 euGenes: HUgn11262
    ECgene: SP140 H-InvDB: SP140

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SP140 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SP140 gene:
    Search GeneIP for patents involving SP140

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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