Aliases for SP110 Gene
External Ids for SP110 Gene
Previous HGNC Symbols for SP110 Gene
Previous GeneCards Identifiers for SP110 Gene
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for SP110 Gene
SP110 (SP110 Nuclear Body Protein) is a Protein Coding gene. Diseases associated with SP110 include hepatic venoocclusive disease with immunodeficiency and hepatic veno-occlusive disease. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is SP140L.
UniProtKB/Swiss-Prot for SP110 Gene
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).