Aliases for SP110 Gene
External Ids for SP110 Gene
Previous HGNC Symbols for SP110 Gene
Previous GeneCards Identifiers for SP110 Gene
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for SP110 Gene
SP110 (SP110 Nuclear Body Protein) is a Protein Coding gene. Diseases associated with SP110 include Hepatic Venoocclusive Disease With Immunodeficiency and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is ENSG00000280755.
UniProtKB/Swiss-Prot for SP110 Gene
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).