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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SP110 Gene

protein-coding   GIFtS: 59
GCID: GC02M230997

SP110 Nuclear Body Protein

(Previous names: interferon-induced protein 41, 30kD)
(Previous symbols: IFI41, IFI75)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SP110 Nuclear Body Protein1 2     Transcriptional Coactivator Sp1102 3
IFI411 2 5     VODI2 5
IFI751 2 5     IPR12
Interferon-Induced Protein 41, 30kD1 2     Interferon-Induced Protein 75, 52kD2
Interferon-Induced Protein 41/752 3     Phosphoprotein 412
Speckled 110 KDa2 3     Phosphoprotein 752

External Ids:    HGNC: 54011   Entrez Gene: 34312   Ensembl: ENSG000001358997   OMIM: 6044575   UniProtKB: Q9HB583   

Export aliases for SP110 gene to outside databases

Previous GC identifers: GC02M229093 GC02M229765 GC02M231236 GC02M230859 GC02M230741 GC02M222874


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SP110 Gene:
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene
is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body
component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone
receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis
and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and
three transcript variants, encoding distinct isoforms, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for SP110 Gene: 
SP110 (SP110 nuclear body protein) is a protein-coding gene. Diseases associated with SP110 include hepatic veno-occlusive disease with immunodeficiency, and lymph node tuberculosis. GO annotations related to this gene include DNA binding and signal transducer activity. An important paralog of this gene is SP100.

UniProtKB/Swiss-Prot: SP110_HUMAN, Q9HB58
Function: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes
with retinoic acid response elements (RARE)

Gene Wiki entry for SP110 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SP110 gene promoter:
         Nkx2-5   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSP110 promoter sequence
   Search SABiosciences Chromatin IP Primers for SP110

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP110


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

SP110 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP110 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M230997:  view genomic region     (about GC identifiers)

Start:
231,032,009 bp from pter      End:
231,090,444 bp from pter
Size:
58,436 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SP110_HUMAN, Q9HB58 (See protein sequence)
Recommended Name: Sp110 nuclear body protein  
Size: 689 amino acids; 78396 Da
Subunit: Isoform 3 interacts with HCV core protein
Subcellular location: Nucleus. Note=Found in the nuclear body
Sequence caution: Sequence=AAF99318.1; Type=Frameshift; Positions=Several; Sequence=AAG09826.1; Type=Frameshift;
Positions=141, 143; Sequence=AK026488; Type=Frameshift; Positions=296, 542, 567;
Secondary accessions: B4DVI4 F5H1M1 Q14976 Q14977 Q53TG2 Q8WUZ6 Q9HCT8
Alternative splicing: 7 isoforms:  Q9HB58-1   Q9HB58-2   Q9HB58-3   Q9HB58-4   Q9HB58-5   Q9HB58-6   Q9HB58-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SP110: NX_Q9HB58

Explore proteomics data for SP110 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (isoform 2)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HB58

  • SP110 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SP110 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001171944.1  NP_004500.3  NP_004501.3  NP_536349.2  

    ENSEMBL proteins: 
     ENSP00000258381   ENSP00000351488   ENSP00000375902   ENSP00000258382   ENSP00000387172  
     ENSP00000393992   ENSP00000399978   ENSP00000439558   ENSP00000344049  

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    Novus Biologicals SP110 Proteins
    Novus Biologicals SP110 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    SP110 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR001487 Bromodomain
     IPR010919 SAND_dom-like
     IPR004865 Sp100

    Graphical View of Domain Structure for InterPro Entry Q9HB58

    ProtoNet protein and cluster: Q9HB58

    4 Blocks protein domains:
    IPB000770 SAND domain
    IPB001965 Zn-finger-like
    IPB004865 Sp100 domain
    IPB010919 SAND-like


    UniProtKB/Swiss-Prot: SP110_HUMAN, Q9HB58
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 HSR domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 SAND domain


    SP110 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP110_HUMAN, Q9HB58
    Function: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes
    with retinoic acid response elements (RARE)
    Induction: By IFNG/IFN-gamma and all-trans retinoic acid (ATRA)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004871signal transducer activity TAS7693701
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    SP110 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SP110:
     Decreased Tat-dependent transc  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SP110 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP110


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SP110

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/13 Interacting proteins for SP110 (Q9HB582, 3 ENSP000002583814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFV2P194042, 3, ENSP000003272684MINT-63536 I2D: score=5 STRING: ENSP00000327268
    SMN1Q166372, 3MINT-8271542 I2D: score=2 
    SMN2Q166372, 3MINT-8271542 I2D: score=2 
    ANXA7P200732, 3MINT-8248735 I2D: score=2 
    CDKN1AP389362, 3MINT-8252246 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007165signal transduction TAS7693701
    GO:0019048modulation by virus of host morphology or physiology IEA--

    SP110 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SP110

    Search CenterWatch for drugs/clinical trials and news about SP110

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SP110 gene (4 alternative transcripts): 
    NM_001185015.1  NM_004509.3  NM_004510.3  NM_080424.2  

    Unigene Cluster for SP110:

    SP110 nuclear body protein
    Hs.145150  [show with all ESTs]
    Unigene Representative Sequence: AK128274
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477068 ENST00000480916 ENST00000258381(uc002vqg.3 uc002vqh.3)
    ENST00000483067 ENST00000358662 ENST00000463022 ENST00000392048(uc010fxj.3)
    ENST00000258382(uc002vqi.4 uc010fxk.3) ENST00000489597 ENST00000490880
    ENST00000486146 ENST00000409815 ENST00000455674 ENST00000462232 ENST00000416610
    ENST00000540870(uc021vxx.1) ENST00000338556
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSP110 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP110
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP110
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP110

    Additional mRNA sequence: 

    AF280094.1 AF280095.1 AK026488.1 AK128274.1 AK301097.1 AL832300.1 BC012447.2 BC019059.2 
    L22343.1 

    18 DOTS entries:

    DT.97844819  DT.100784503  DT.315250  DT.100784505  DT.87016829  DT.315249  DT.120949401  DT.97787522 
    DT.120949492  DT.92423845  DT.120949304  DT.87008738  DT.91704797  DT.100704880  DT.120949368  DT.120949382 
    DT.121015844  DT.40295425 

    24/174 AceView cDNA sequences (see all 174):

    CB529938 AW137571 AA780399 AA504832 AI168372 AL557996 BU174698 AI540791 
    AA907317 AI077443 AA443705 AW469400 AA926890 AA831048 AA252779 AI807423 
    AA074714 AW204185 AA744811 CR625933 BF223153 CB963887 AA699881 BU943434 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SP110 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                              -     -                       -               
    SP2:                                                                                                              -     -                 -     -               
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:              -     -                                                                                                                                       

    ExUns: 20b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SP110

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SP110 expression in normal human tissues (normalized intensities)      SP110 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SP110 Expression
    About this image


    SP110 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             leukocytes   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See SP110 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SP110

    SOURCE GeneReport for Unigene cluster: Hs.145150

    UniProtKB/Swiss-Prot: SP110_HUMAN, Q9HB58
    Tissue specificity: Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in
    thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung,
    liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including SP110: 
              Interferons & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP110

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SP110 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sp1101 , 5 Sp110 nuclear body protein1, 5 67.14(n)1
    52.36(a)1
      1 (43.60 cM)5
    1090321  NM_030194.11  NP_084470.11 
     855768995 
    zebrafish
    (Danio rerio)
    Actinopterygii BX569789.26
    zgc:1134116
    (see all 3)
    zgc:113411
    (see all 3)
    30(a)
    19(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(24837780-24845598)
    3(24932187-24941134)


    ENSEMBL Gene Tree for SP110 (if available)
    TreeFam Gene Tree for SP110 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SP110 gene
    SP1002  SP1402  SP140L2  
    10 SIMAP similar genes for SP110 using alignment to 12 protein entries:     SP110_HUMAN (see all proteins):
    TRIM66    CHD4    CHD5    TRIM33    SP140L    AIRE
    SP100    SP140    DKFZp686E07254    FLJ00340

    SP110 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1586 SNPs in SP110 are shown (see all 1586)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360304
    A breast cancer sample4--see VAR_0360302 G S mis40--------
    VAR_0360294
    A breast cancer sample4--see VAR_0360292 M T mis40--------
    rs39484641,2,4
    C,F,A,Hother1230420956(-) CAGATC/TGAAAG 6 S L mis149Minor allele frequency- T:0.14NS EA CSA NA WA EU 12118
    rs356347931,2
    C--222884399(+) GGTGA-/CTCTGGA 4 -- int11Minor allele frequency- CT:0.00CSA 2
    rs769014231,2
    F--222895255(-) CAGAAT/AGGGAG 4 -- int11Minor allele frequency- A:0.50NA 4
    rs776939351,2
    C--222895283(-) AAACTT/ATCATC 4 -- int11Minor allele frequency- A:0.00NA 2
    rs783696291,2
    C--222895292(-) GCAAAA/GGAAAC 4 -- int12Minor allele frequency- G:0.00NA 4
    rs361269401,2
    C--222895497(+) TATAAA/GGTGTA 4 -- int12Minor allele frequency- G:0.25NA 4
    rs58393641,2
    C,F--222923662(+) TGAATA/-ATACG 4 -- int13Minor allele frequency- -:0.50NA CSA 6
    rs1886720281,2
    --230403387(+) ATTTTA/GCAACC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SP110 (231032009 - 231090444 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SP110:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29172CNV Loss19812545


    Human Gene Mutation Database (HGMD): SP110

    Locus Specific Mutation Databases (LSDB): SP110
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SP110
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604457   
    OMIM disorders: 235550  607948  
    UniProtKB/Swiss-Prot: SP110_HUMAN, Q9HB58
  • Hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]: Autosomal recessive primary
    immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized
    by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and
    absent tissue plasma cells. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for SP110:    About MalaCards
    hepatic veno-occlusive disease with immunodeficiency    lymph node tuberculosis    charcot-marie-tooth neuropathy type 1a    charcot-marie-tooth neuropathy type 1e
    hereditary neuropathy with liability to pressure palsies    extrapulmonary tuberculosis    charcot-marie-tooth neuropathy type 1    tuberculosis
    pulmonary tuberculosis    hepatitis    chronic lymphocytic leukemia    hepatitis c
    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SP110:
    Tuberculosis

    SP110 for disorders           About GeneDecksing

    GeneTests: SP110
    GeneReviews: SP110
    Genetic Association Database (GAD): SP110
    Human Genome Epidemiology (HuGE) Navigator: SP110 (28 documents)

    Export disorders for SP110 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SP110 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with SP110)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No associations of human pulmonary tuberculosis with Sp110 variants. (PubMed id 16816019)1, 2, 4 Thye T....Meyer C.G. (2006)
    2. Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. (PubMed id 7693701)1, 2, 3 Kadereit S.... Meurs E.F. (1993)
    3. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. (PubMed id 10913195)1, 2, 9 Bloch D.B.... Bloch K.D. (2000)
    4. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogenei c hematopoietic cell transplantation. (PubMed id 20353833)1, 4 Larsen M.E....Vindelov L. (2010)
    5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    6. Polymorphisms in IL-1beta, vitamin D receptor Fok1, a nd Toll-like receptor 2 are associated with extrapulmonary tuberculosis. (PubMed id 20196868)1, 4 Motsinger-Reif A.A....Sterling T.R. (2010)
    7. Genetic susceptibility variants for chronic lymphocyt ic leukemia. (PubMed id 20332261)1, 4 Slager S.L....Cerhan J.R. (2010)
    8. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PubMed id 18758461)1, 4 Di Bernardo M.C....Houlston R.S. (2008)
    9. SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. (PubMed id 17287948)1, 4 Babb C....Hoal E.G. (2007)
    10. Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. (PubMed id 17149599)1, 4 Szeszko J.S....Nejentsev S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3431 HGNC: 5401 AceView: SP110 Ensembl:ENSG00000135899 euGenes: HUgn3431
    ECgene: SP110 H-InvDB: SP110

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SP110 Pharmacogenomics, SNPs, Pathways
    SP110basehttp://bioinf.uta.fi/SP110base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SP110

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SP110 gene:
    Search GeneIP for patents involving SP110

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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