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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SP100 Gene

protein-coding GIFtS: 61
GCID: GC02P231280

SP100 nuclear antigen

(Previous name: nuclear antigen Sp100 )

Explore 18 diseases affiliated with
SP100 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SP100 Nuclear Antigen¹ ²		Lysp100b³
Nuclear Dot-Associated Sp100 Protein² ³		Nuclear Autoantigen Sp-100²
Speckled 100 KDa² ³		SP100-HMG Nuclear Autoantigen²
Nuclear Antigen Sp100¹		Lysp100b³

External Ids:	HGNC: 11206¹	Entrez Gene: 6672²	Ensembl: ENSG00000067066⁷	OMIM: 604585⁵	UniProtKB: P23497³

Export aliases for SP100 gene to outside databases

Previous GC identifers: GC02P229341 GC02P230012 GC02P231245 GC02P231483 GC02P231106 GC02P230991 GC02P223121

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SP100:

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies.

PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body

interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis,

immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes

a high-mobility group protein. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: SP100_HUMAN, P23497

Function: May play a role in the control of gene expression

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SP100 gene promoter:
TBP GR HOXA3 AML1a GATA-1 Pax-3 POU2F1 POU2F1a TFIID GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SP100 promoter sequence

Search SABiosciences Chromatin IP Primers for SP100

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP100

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

SP100 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP100 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P231280: view genomic region (about GC identifiers)

Start:	231,280,657 bp from pter	End:	231,410,317 bp from pter
Size:	129,661 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SP100_HUMAN, P23497 (See protein sequence)

Recommended Name: Nuclear autoantigen Sp-100

Size: 879 amino acids; 100417 Da

Subunit: Homodimer. Splice variants heterodimerize. Interacts with members of the HP1 family of nonhistone chromosomal

protein, such as CBX5 and CBX3 via the PxVxL motif. Interacts with Epstein-Barr virus EBNA-LP. Interacts with human

cytomegalovirus/HHV-5 protein UL123

Subcellular location: Nucleus, PML body. Note=Found in the nuclear body, also known as nuclear domain 10 (ND10), PML

oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate

shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear

localization of the isoforms

Miscellaneous: The major isoform Sp100-A, has a calculated MW of 54 kDa, but exhibits aberrant electrophoretic

mobilities, with an apparent MW OF 100 kDa

1 PDB 3D structure from and Proteopedia for SP100:

1H5P (3D)

Secondary accessions: B4DDX5 B8ZZD8 E9PH61 F8WFE2 O75450 Q13343 Q8TE34 Q96F70 Q96T24 Q96T95 Q9NP33

Q9UE32

Alternative splicing: 7 isoforms: P23497-1 P23497-2 P23497-3 P23497-4 P23497-5 P23497-6 P23497-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SP100: NX_P23497

Post-translational modifications:

Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or

nuclear body targeting¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23497

SP100 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001073860.1 NP_001193630.1 NP_001193631.1 NP_001193632.1 NP_001193633.1 NP_003104.2

ENSEMBL proteins:

ENSP00000264052 ENSP00000391616 ENSP00000387311 ENSP00000386404 ENSP00000386427

ENSP00000343023 ENSP00000386998 ENSP00000400277 ENSP00000416563 ENSP00000393679

ENSP00000399389 ENSP00000342729

Reactome Protein details: P23497
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Enzo Life Sciences proteins for SP100
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SP100
	GenScript Custom Purified and Recombinant Proteins Services for SP100
	Novus Biologicals SP100 Proteins Novus Biologicals SP100 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SP100
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	nucleolus	IMP	11313457
GO:0005737	cytoplasm	IDA	9412458
GO:0016605	PML body	IDA	9636146

SP100 for ontologies About GeneDecksing

SP100 Antibody Products:

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	Novus Biologicals SP100 Antibodies
	Search for Antibodies for SP100 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for SP100

Assay Products for SP100:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SP100
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SP100 for domains About GeneDecksing

4 InterPro domains/families:

IPR009071 HMG_superfamily

IPR010919 SAND_dom-like

IPR004865 Sp100

IPR000770 SAND_dom

Graphical View of Domain Structure for InterPro Entry P23497

ProtoNet protein and cluster: P23497

4 Blocks protein families:

IPB000135 High mobility group proteins HMG1 and HMG2

IPB000770 SAND domain

IPB004865 Sp100 domain

IPB010919 SAND-like

UniProtKB/Swiss-Prot: SP100_HUMAN, P23497

Domain: The HSR domain is important for the nuclear body targeting as well as for the dimerization

Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains.

This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain

Similarity: Contains 2 HMG box DNA-binding domains

Similarity: Contains 1 HSR domain

Similarity: Contains 1 SAND domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SP100_HUMAN, P23497

Function: May play a role in the control of gene expression

Induction: By interferon

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SP100 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP100
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SP100 (see all 10):
		hsa-miR-505 hsa-miR-576-5p hsa-miR-875-3p hsa-miR-3065-5p hsa-miR-4263 hsa-miR-4261 hsa-miR-1243 hsa-miR-378*

		SwitchGear 3'UTR luciferase reporter plasmid: SP100 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP100 (see all 7) OriGene shRNA RFP: SP100 OriGene siRNA: SP100
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP100

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SP100

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP100 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP100 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SP100 (NM_003113)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP100
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP100

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SP100
		Search LifeMap BioReagents cell lines for SP100

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP100

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003713	transcription coactivator activity	IDA	14647468
GO:0003714	transcription corepressor activity	IDA	16873258
GO:0005515	protein binding	IPI	9636146
GO:0008134	transcription factor binding	IPI	11909962

SP100 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SP100:

Increased cell death in HCC-19

Synthetic lethal with imatinib

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Interferon gamma signaling

Interferon gamma signaling

1.00

Expression of IFNG-stimulated genes

0.72

Proteolysis Putative SUMO-1 pathway

Proteolysis Putative SUMO-1 pathway

1.00

Proteolysis_Putative SUMO-1 pathway

0.97

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

4-1BB Pathway

SUMO Pathway

0.30

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SP100

Proteolysis Putative SUMO-1 pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SP100

SUMO Pathway

1 GeneGo (Thomson Reuters) Pathway for SP100

Proteolysis Putative SUMO-1 pathway

5 Reactome Pathways for SP100

	Interferon gamma signaling
	Cytokine Signaling in Immune system
	Expression of IFNG-stimulated genes
	Interferon Signaling
	Immune System

SP100 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SP100

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/83 Interacting proteins for SP100 (P23497^{1, 2, 3} ENSP00000343023⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 83)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP8AP2	Q9UKL3²^,³	MINT-4298689 MINT-4298663 MINT-4298616 MINT-4298595 MINT-4298639 I2D: score=2
SUMO1	P63165²^,³, ENSP00000376076⁴	MINT-68030 I2D: score=6 STRING: ENSP00000376076
SNIP1	Q8TAD8²^,³	MINT-62168 I2D: score=3
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	15247905
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA	14647468
GO:0019048	virus-host interaction	IEA	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0032526	response to retinoic acid	IDA	11313457

SP100 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SP100 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SP100
2 Novoseek chemical compound relationships for SP100 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	2.42	1	11264371 (1)
zinc	0	1	12595897 (1)

Search CenterWatch for drugs/clinical trials and news about SP100

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SP100 gene (6 alternative transcripts):

NM_001080391.1 NM_001206701.1 NM_001206702.1 NM_001206703.1 NM_001206704.1 NM_003113.3

Unigene Cluster for SP100:

SP100 nuclear antigen

Hs.369056 [show with all ESTs]

Unigene Representative Sequence: NM_001080391

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000264052(uc010zmb.2 uc002vqt.3) ENST00000432979 ENST00000409824

ENST00000409341(uc002vqq.2) ENST00000409112(uc002vqs.3) ENST00000340126(uc002vqu.1)

ENST00000409897(uc002vqv.2) ENST00000470940 ENST00000466710 ENST00000413284

ENST00000452345 ENST00000462751 ENST00000494508 ENST00000492546 ENST00000459786

ENST00000431952(uc010fxp.1) ENST00000494901 ENST00000488180

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SP100 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP100
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SP100 (see all 10):
		hsa-miR-505 hsa-miR-576-5p hsa-miR-875-3p hsa-miR-3065-5p hsa-miR-4263 hsa-miR-4261 hsa-miR-1243 hsa-miR-378*

		SwitchGear 3'UTR luciferase reporter plasmid: SP100 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP100 (see all 7) OriGene shRNA RFP: SP100 OriGene siRNA: SP100
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP100

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP100 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP100 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SP100 (NM_003113)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP100
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP100

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP100 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SP100
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP100
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP100

Additional cDNA sequence:

AF056322.1 AF255565.1 AK091898.1 AK293373.1 AK304205.1 BC011562.1 CR749288.1 L79987.1

L79988.1 M60618.1 U36501.1

24/25 DOTS entries (see all 25):

DT.95201549 DT.100812010 DT.417890 DT.97759968 DT.99966858 DT.100812012 DT.92433977 DT.120949411

DT.95201551 DT.91942938 DT.417892 DT.92433973 DT.99936220 DT.100800332 DT.100812011 DT.95074494

DT.100812005 DT.100812009 DT.120949365 DT.120949413 DT.40132837 DT.91984281 DT.92003248 DT.409178

24/323 AceView cDNA sequences (see all 323):

BM922530 BM744037 AW590715 NM_003113 BQ581499 AL554153 CR749288 CA447975

CB851577 CR613678 BM905778 AI902667 CB216535 AF255565 CB164671 BF516261

CN482955 BM723015 AI902668 AI886092 BU507268 AI753406 BP342835 AA278237

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SP100 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:																															-
SP2:			-				-																								-
SP3:
SP4:
SP5:

ExUns:	24
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SP100

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SP100 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAACAGAA

About this image

SP100 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CD31, CD144 positive cells (Two-step protocol fo...)

See SP100 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SP100

SOURCE GeneReport for Unigene cluster: Hs.369056

UniProtKB/Swiss-Prot: SP100_HUMAN, P23497

Tissue specificity: Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some

T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines

SABiosciences Custom PCR Arrays for SP100

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP100 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SP100
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP100
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP100

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP100

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SP100 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sp100⁵	nuclear antigen Sp100	--		1 (43.60 cM) 85649988
zebrafish (Danio rerio)	Actinopterygii	BX569789.2⁶ BX569789.5⁶	--	35(a) 24(a)	many ↔ many many ↔ many	3(24837780-24845598) 3(24862707-24880269)

ENSEMBL Gene Tree for SP100 (if available)
TreeFam Gene Tree for SP100 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SP100 gene

SP110² SP140L² SP140²

14 SIMAP similar genes for SP100 using alignment to 11 protein entries: SP100_HUMAN (see all proteins):

FLJ00340 HMGB1P1 DKFZp686E07254 SP140L HMGB1 HMGB2

HMGB3 HMG1 SP110 HMGB4 DKFZp779G118 SP140

AIRE WUGSC

SP100 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SP100
PGOHUM00000236327

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143469446^1,2		--	231278913(+)	`AGCCAC/TGGAAA`	5	--	us2k¹		0	--	--	--	--
rs3754941^1,2	C,F,A,H,	--	231278929(+)	`CCAGGA/GGTTCC`	5	--	us2k¹		17		EA NS NA	3688
rs115170753^1,2	F,	--	231278942(+)	`TATTTC/TCTTCT`	5	--	us2k¹		1		NA	120
rs3754942^1,2	C,F,A,H,	--	231278979(+)	`ACATGT/ACTTCT`	5	--	us2k¹		25		NA NS EA WA CSA	2495
rs3754943^1,2	C,F,H,	--	231278996(+)	`GGTCCC/TGTCCC`	5	--	us2k¹ tfbs³		18		NA NS EA WA CSA	935
rs188199296^1,2		--	231279035(+)	`TTTTCC/TGGATC`	5	--	us2k¹		0	--	--	--	--
rs60304451^1,2		--	231279091(+)	`ACCAGC/TGGAGC`	5	--	us2k¹		4		NA WA EA	360
rs12694864^1,2	C,F,A,H,	--	231279221(+)	`GCCAGC/TCTGTG`	5	--	us2k¹		13		NA NS EA WA	922
rs12987948^1,2	C,F,H,	--	231279258(+)	`TGCTCT/ATAGTA`	5	--	us2k¹		15		NA NS EA WA CSA	812
rs147974550^1,2		--	231279361(+)	`GAGAAC/TGTGAA`	5	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SP100 (231280657 - 231410317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SP100
2 CNVs: 63325 98165
5 Indels: 26585 45959 40425 61889 42440
Human Gene Mutation Database (HGMD): SP100

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SP100 for disorders           About GeneDecksing

OMIM gene information: 604585    OMIM disorders: --

18 diseases for SP100:    About MalaCards

leukemia connective tissue disease primary biliary cirrhosis sclerosing cholangitis

herpes simplex mantle cell lymphoma cytomegalovirus infection cholangitis

lupus erythematosus autoimmune hepatitis laryngitis teratocarcinoma

influenza laryngeal cancer tonsillitis pneumonia

hepatitis neuronitis

2 diseases from the University of Copenhagen DISEASES database for SP100:

Primary biliary cirrhosis Autoimmune hepatitis

10/11 Novoseek disease relationships for SP100 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
promyelocytic leukemia	87.3	12	8681971 (3), 9362351 (2), 10525530 (1), 15778999 (1) (see all 9)
biliary cirrhosis primary	78.9	10	1281200 (2), 9362351 (2), 1384113 (1), 7631159 (1) (see all 8)
leukemia promyelocytic acute	68	1	9230084 (1)
herpes simplex	50.7	2	18160441 (1), 19279115 (1)
virus infection	37.8	4	15778999 (1), 10629941 (1), 9973607 (1), 19279115 (1)
autoimmunity	34.9	2	9973607 (1), 8681971 (1)
autoimmune response	31.3	2	9089912 (2)
autoimmune diseases	24.2	5	7631159 (1), 8537240 (1), 9089912 (1), 9268632 (1) (see all 5)
liver diseases	0	1	1281200 (1)
tumors	0	1	18984860 (1)

Human Genome Epidemiology (HuGE) Navigator: SP100 (4 documents)

Export disorders for SP100 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SP100 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with SP100)

Utopia: connect your pdf to the dynamic
world of online information

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. (PubMed id 8695863)^{1, 2, 3} Dent A.L....Staudt L.M. (1996)
Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. (PubMed id 2258622)^{1, 2, 3} Szostecki C.... Will H. (1990)
Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif. (PubMed id 9973607)^{1, 2, 9} Guldner H.H.... Sternsdorf T. (1999)
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. (PubMed id 9636146)^{1, 2, 9} Seeler J.-S.... Dejean A. (1998)
Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Alu insertion events. (PubMed id 11574059)^{1, 2, 9} Devor E.J. (2001)
Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. (PubMed id 11313457)^{1, 2, 9} Seeler J.-S.... Dejean A. (2001)
The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers. (PubMed id 10212234)^{1, 2, 9} Sternsdorf T.... Will H. (1999)
The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN- gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility. (PubMed id 8810287)^{1, 2, 9} Groetzinger T.... Will H. (1996)
Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression. (PubMed id 21880768)^{1, 2} Kim Y.E....Ahn J.H. (2011)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6672	HGNC: 11206	AceView: SP100	Ensembl:ENSG00000067066	euGenes: HUgn6672
ECgene: SP100	H-InvDB: SP100

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SP100	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SP100 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SP100 gene:
Search GeneIP for patents involving SP100

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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