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SP1 Gene

protein-coding   GIFtS: 67
GCID: GC12P053773

Sp1 Transcription Factor
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Aliases
for SP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sp1 Transcription Factor1 2
Specificity Protein 11 2
Transcription Factor Sp12
TSFP13

External Ids:    HGNC: 112051   Entrez Gene: 66672   Ensembl: ENSG000001855917   OMIM: 1899065   UniProtKB: P080473   

Export aliases for SP1 gene to outside databases

Previous GC identifers: GC12P053801 GC12P053490 GC12P052060 GC12P050814


Summaries
for SP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

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Entrez Gene summary for SP1 Gene:
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many
promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell
growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational
modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly
affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SP1 Gene:
SP1 (Sp1 transcription factor) is a protein-coding gene. Diseases associated with SP1 include accelerated tumor formation, and cerebrotendinous xanthomatosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047
Function: Transcription factor that can activate or repress transcription in response to physiological and
pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number
of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.
Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage,
glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the
cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of
SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex
with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression

Gene Wiki entry for SP1 (Sp1 transcription factor) Gene


Genomic Views
for SP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SP1 gene promoter:
         STAT1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SP1 promoter sequence
   Search Chromatin IP Primers for SP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

SP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053773:  view genomic region     (about GC identifiers)

Start:
 53,773,960 bp from pter      End:
 53,810,230 bp from pter
Size:
 36,271 bases      Orientation:
 plus strand

Proteins
for SP1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SP1_HUMAN, P08047 (See protein sequence)
Recommended Name: Transcription factor Sp1  
Size: 785 amino acids; 80693 Da
Subunit: Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus
IE62 protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40
VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between
the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional
activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts
with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with
NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1 (By similarity).
Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1
Miscellaneous: In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to
the duplication of exons 2 and 3
Sequence caution: Sequence=AAH43224.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for SP1:
1SP1 (3D)        1SP2 (3D)        1VA1 (3D)        1VA2 (3D)        1VA3 (3D)    
Secondary accessions: Q86TN8 Q9H3Q5 Q9NR51 Q9NY21 Q9NYE7

Explore the universe of human proteins at neXtProt for SP1: NX_P08047

Explore proteomics data for SP1 at MOPED

Post-translational modifications: 

  • Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination,
    sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation
    on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA
    damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739
    enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the
    repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1
    from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by
    calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene
    expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated
    by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is
    increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle
    interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases
    the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several
    C-terminal serine and threonine residues1
  • Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase
    in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter1
  • Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by
    phosphorylation1
  • Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation
    levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation1
  • Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved
    product is susceptible to degradation1
  • O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1
    phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially
    deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the
    interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the
    HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma)1
  • Glycosylation2 at Ser491, Ser612, Thr640, Ser641, Ser698, Ser702
  • Modification sites at PhosphoSitePlus

    • See SP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238754.1  NP_003100.1  NP_612482.2  

    ENSEMBL proteins: 
     ENSP00000457804   ENSP00000329357   ENSP00000404263   ENSP00000458133  
    Reactome Protein details: P08047

    SP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SP1
    OriGene Purified Protein for SP1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SP1
    GenScript Custom Purified and Recombinant Proteins Services for SP1
    Novus Biologicals SP1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SP1 
    OriGene Antibodies for SP1
    OriGene Custom Antibody Services for SP1
    Novus Biologicals SP1 Antibodies
    Abcam antibodies for SP1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SP1
    LSBio Antibodies in human, mouse, rat for SP1

    SP1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of SP1
    OriGene Custom Assay Services for SP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for SP1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SP: Specificity protein transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P08047

    ProtoNet protein and cluster: P08047

    UniProtKB/Swiss-Prot: SP1_HUMAN, P08047
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    SP1 for domains           About GeneDecksing


    Function
    for SP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP1_HUMAN, P08047
    Function: Transcription factor that can activate or repress transcription in response to physiological and
    pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number
    of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.
    Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage,
    glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the
    cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of
    SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex
    with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression
    Induction: By insulin

         Genatlas biochemistry entry for SP1:
    transcription factor Sp-1,GT box binding protein

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000987core promoter proximal region sequence-specific DNA binding ----
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001103RNA polymerase II repressing transcription factor binding ISS--
         
    SP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SP1:
     Decreased viability with pacli 

         13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sp1):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system  mortality/aging 
     respiratory system  skeleton  vision/eye 

    SP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SP1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGCCCCGCCCCC 

    miRNA
    Products:            		miRTarBase miRNAs that target SP1:
    hsa-mir-186-5p (MIRT045067), hsa-mir-1 (MIRT035536), hsa-let-7a-5p (MIRT052453), hsa-mir-16-5p (MIRT031577), hsa-let-7b-5p (MIRT052264), hsa-mir-29b-3p (MIRT000445), hsa-mir-22-3p (MIRT007329), hsa-mir-124-3p (MIRT002660), hsa-mir-335-5p (MIRT017513), hsa-let-7f-5p (MIRT051372), hsa-mir-218-5p (MIRT004246), hsa-mir-149-5p (MIRT007014), hsa-mir-99b-5p (MIRT044192), hsa-mir-21-5p (MIRT006236), hsa-mir-133a-3p (MIRT035537), hsa-mir-125a-5p (MIRT045732), hsa-mir-625-5p (MIRT039599), hsa-mir-27a-3p (MIRT002403)

    Block miRNA regulation of human, mouse, rat SP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SP1 (see all 196):
    hsa-miR-100* hsa-miR-520f hsa-miR-361-5p hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SP1
    Predesigned siRNA for gene silencing in human, mouse, rat SP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SP1

    Clone
    Products:             		 OriGene clones in human, mouse for SP1 (see all 12)
    OriGene ORF clones in mouse, rat for SP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SP1 (NM_170609)
    Sino Biological Human cDNA Clone for SP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SP1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP1


    Localization
    for SP1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    SP1_HUMAN, P08047: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states.
    Insulin promotes nuclear location, while glucagon favors cytoplasmic location
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0032993protein-DNA complex IEA--

    SP1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SP1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SP1 About   (see all 67)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    		Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    		SREBP signalling0.31
    		Activation of Gene Expression by SREBP (SREBF)0.75
    2IL-17 Family Signaling Pathways
    		IL17 signaling pathway0.51
    		Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3Prolactin Signaling Pathway
    		Development Prolactin receptor signaling0.39
    		Leptin signaling pathway0.35
    4Development Endothelin 1 EDNRA signaling
    		Development Endothelin 1 EDNRA transactivation of EGFR0.41
    		Estrogen signaling pathway0.34
    5Loss of Function of SMAD2/3 in Cancer
    		Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    		Signaling by TGF-beta Receptor Complex0.60
    		SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    		TGFBR1 KD Mutants in Cancer0.60
    		Loss of Function of SMAD2/3 in Cancer0.60
    		SMAD2/3 MH2 Domain Mutants in Cancer0.60
    		Loss of Function of SMAD4 in Cancer0.60
    		SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SP1 (see all 11)
        ErbB2-ErbB3 Heterodimers
    HMGB1 Pathway
    JAK-STAT Pathway
    Estrogen Pathway
    Signaling in Gap Junctions

    2 Cell Signaling Technology (CST) Pathways for SP1
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch

    Selected GeneGo (Thomson Reuters) Pathways for SP1 (see all 15)
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Endothelin-1/EDNRA transactivation of EGFR
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    G-protein signaling Rac2 regulation pathway
    Development Role of Activin A in cell differentiation and proliferation

    Selected BioSystems Pathways for SP1 (see all 32)
        Myometrial Relaxation and Contraction Pathways
    Mitochondrial Gene Expression
    EGFR1 Signaling Pathway
    Adipogenesis
    Selenium Metabolism and Selenoproteins


    4 Reactome Pathways for SP1
        PPARA activates gene expression
    Oncogene Induced Senescence
    Activation of gene expression by SREBF (SREBP)
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

    1 PharmGKB Pathway for SP1
        EGFR Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for SP1):
        TGF-beta signaling pathway
    Estrogen signaling pathway
    Huntington's disease
    Transcriptional misregulation in cancer


    SP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SP1 (see all 10): 
              Fibrosis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Stem Cell Signaling in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SP1 (P080471, 2, 3 ENSP000003293574) via UniProtKB, MINT, STRING, and/or I2D (see all 299)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU2F1P148591, 2, 3, ENSP000002714114EBI-298336,EBI-624770 MINT-6803426 MINT-6803452 MINT-6803484 MINT-6803438 MINT-6803470 I2D: score=4 STRING: ENSP00000271411
    EPAS1Q998141, 2, 3, ENSP000002637344EBI-298336,EBI-447470 MINT-3378498 MINT-3378477 I2D: score=1 STRING: ENSP00000263734
    HMGA1P170962, 3, ENSP000003082274MINT-49729 MINT-49730 MINT-49727 MINT-49728 I2D: score=4 STRING: ENSP00000308227
    TP53P046372, 3, ENSP000002693054MINT-56525 MINT-56523 MINT-56524 I2D: score=6 STRING: ENSP00000269305
    AATFQ9NY612, 3, ENSP000002254024MINT-49665 MINT-49666 I2D: score=4 STRING: ENSP00000225402
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001701in utero embryonic development ----
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001889liver development IEA--
    GO:0001892embryonic placenta development IEA--

    SP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SP1

    1 HMDB Compound for SP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    Selected Novoseek inferred chemical compound relationships for SP1 gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mithramycin 91.2 153 20086170 (3), 17973266 (3), 15489892 (3), 17124180 (2) (see all 86)
    wp631 81.3 10 10446226 (2), 16705627 (1), 11172687 (1), 12219017 (1) (see all 7)
    5-aza-2'deoxycytidine 67.2 24 9632722 (6), 17203216 (2), 11507078 (2), 17260018 (1) (see all 7)
    chloramphenicol 66.9 15 8344287 (1), 8910439 (1), 1423289 (1), 8245855 (1) (see all 13)
    zinc 61.6 190 7685185 (4), 11395515 (4), 9586044 (3), 12565691 (3) (see all 99)
    mal.4 60.2 3 7479972 (1), 12719007 (1)
    oligonucleotide 58.1 89 10722737 (2), 8208618 (2), 9458359 (2), 8634093 (2) (see all 58)
    dimethyl sulfate 58 3 12560236 (1), 9494121 (1), 9079666 (1)
    estrogen 52.6 96 15541729 (4), 18543253 (3), 8195246 (3), 9328340 (3) (see all 60)
    retinoic acid 46.4 55 15219855 (5), 17937658 (5), 10452548 (3), 8083995 (3) (see all 28)



    SP1 for compounds           About GeneDecksing



    Transcripts
    for SP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SP1 gene (3 alternative transcripts): 
    NM_001251825.1  NM_003109.1  NM_138473.2  

    Unigene Cluster for SP1:

    Sp1 transcription factor
    Hs.649191  [show with all ESTs]
    Unigene Representative Sequence: NM_138473
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551969 ENST00000327443 ENST00000426431(uc021qyf.1 uc001scw.3 uc010sog.2)
    ENST00000548560
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SP1 (see all 196):
    hsa-miR-100* hsa-miR-520f hsa-miR-361-5p hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): SP1 (NM_170609)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP1
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SP1

    Additional mRNA sequence: 

    AB209678.1 AF252284.1 AF255682.1 AJ272134.1 AK311995.1 AL442093.1 BC012008.1 BC043224.1 
    BC062539.1 BC078158.1 FJ949572.1 FN908228.1 J03133.1 

    7 DOTS entries:

    DT.446979  DT.100790645  DT.102841326  DT.121316782  DT.92030853  DT.92435550  DT.97859522 

    Selected AceView cDNA sequences (see all 358):

    CA429457 AU185499 BM966769 AA315541 NM_138473 AF255682 BQ423840 AI914615 
    AI673013 AI457440 C15268 CB162915 AI862807 BQ024629 BF085713 AW593793 
    AI243266 BU155908 W69188 AW207247 AI377742 AW505139 AW517875 BE899247 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7
    SP1:        -     -                                                   
    SP2:              -                                                   
    SP3:        -     -           -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for SP1

    Expression
    for SP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGATCTGCC
    SP1 Expression
    About this image


    SP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
     
     Epithelial Cells
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
     
     Fibroblasts
             Keratocytes Corneal Stroma
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Corneal Endothelium
     
     Skeletal Muscle (Muscoskeletal System)
             Mononuclear Myocytes Cervical Epaxial Myotome
    SP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.649191

    UniProtKB/Swiss-Prot: SP1_HUMAN, P08047
    Tissue specificity: Up-regulated in adenocarcinomas of the stomach (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SP1 (see all 10): 
              Fibrosis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Stem Cell Signaling in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for SP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sp11 , 5 trans-acting transcription factor 11, 5 92.34(n)1
    95.64(a)1    		   15 (57.55 cM)5
    206831  NM_013672.21  NP_038700.21 
     1024061435 
    chicken
    (Gallus gallus)    		 Aves SP11 Sp1 transcription factor 74.69(n)
    81.96(a)    		   395303  NM_204604.1  NP_989935.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SP16
    		 Sp1 transcription factor
    		 74(a)
    		 1 ↔ 1
    		 2(73497250-73536215)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC760062 transcription factor 79.67(n)    BC061414.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sp12 sp1 transcription factor 74.78(n)   324109  AI657942.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Spps6
    		 Sp1-like factor for pairing sensitive-silencing
    		 23(a)
    		 1 → many
    		 3R(20049167-20052656)
    worm
    (Caenorhabditis elegans)    		 Secernentea sptf-36
    		 Protein SPTF-3 (sptf-3) mRNA, complete cds
    		 32(a)
    		 1 → many
    		 I(13360675-13366888) WBGene00012735


    ENSEMBL Gene Tree for SP1 (if available)
    TreeFam Gene Tree for SP1 (if available)

    Paralogs
    for SP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SP1 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF102  KLF42  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for SP1 using alignment to 8 protein entries:     SP1_HUMAN (see all proteins) (see all similar genes):
    Sp1    DHFRP2    PSG    PSG3    PSG7    PSG6
    PSG11    WT1    PSG5    CEACAM4    PSG4    CEACAM3
    CEACAM7    DKFZp686O1631    PSG2    PSG11s'    PSG9    CEACAM8

    SP1 for paralogs           About GeneDecksing



    Genomic Variants
    for SP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SP1 (see all 863)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1409702531,2
    		--53606423(+) CCATAA/GTGCTG 2 -- us2k10--------
    rs748456571,2
    		F--53606696(+) CAGCAA/GTCACT 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1922101461,2
    		--53606898(+) CGGATA/GAAGAG 3 -- us2k10--------
    rs1845346631,2
    		--53607043(+) CACTTC/TAGCCT 3 -- us2k10--------
    rs733113951,2
    		C,F--53607072(+) CCAGTC/TGTTTA 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs71319381,2
    		C,F,A,H--53607133(+) AGTCTC/TACGGA 3 -- us2k120Minor allele frequency- T:0.23NS EA NA WA CSA 2345
    rs71319431,2
    		C,F,H--53607158(+) GTCAGC/ATCAGT 3 -- us2k1 tfbs35Minor allele frequency- A:0.00NS EA WA 538
    rs1894042611,2
    		--53607235(+) CATTGA/TGGCAT 3 -- us2k10--------
    rs1926888951,2
    		--53607325(+) CAAGTC/TCTAGT 3 -- us2k10--------
    rs1844994761,2
    		--53607380(+) TTGAGA/CTGCAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SP1 (53773960 - 53810230 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SP1

    Disorders / Diseases
    for SP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 189906    OMIM disorders: --

    Selected diseases for SP1 (see all 127):    
    About MalaCards
    accelerated tumor formation    cerebrotendinous xanthomatosis    dengue disease    erythropoietic protoporphyria
    corneal disease    osteoporotic fracture    machado-joseph disease    hailey-hailey disease
    hereditary hemorrhagic telangiectasia    erythema multiforme    xanthomatosis    keratoconus
    wolfram syndrome    keloids    ovarian epithelial cancer    otosclerosis
    cellulitis    ovarian hyperstimulation syndrome    glanders    osteomyelitis

    1 disease from the University of Copenhagen DISEASES database for SP1:
    Cancer

    SP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for SP1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 53.8 5 15998736 (1), 8463313 (1), 11304527 (1)
    tumors 50.3 174 19772640 (4), 15818728 (4), 11844788 (3), 17510417 (3) (see all 98)
    retinoblastoma 47.8 30 14653808 (3), 11228546 (2), 8007947 (2), 9242441 (2) (see all 20)
    immunodeficiency 47.3 51 7690421 (2), 9525578 (2), 2072454 (2), 9584164 (2) (see all 43)
    cancer 42.7 70 19621387 (4), 19588484 (3), 17656364 (3), 15263012 (2) (see all 44)
    breast cancer 41.2 57 17927860 (6), 16143315 (4), 12176973 (3), 12052832 (3) (see all 27)
    choriocarcinoma 34.3 6 10962555 (3), 10491299 (1), 9231796 (1), 17872376 (1)
    colon cancer 32.3 5 15883203 (2), 19593667 (1), 17689681 (1), 20230799 (1)
    prostate cancer 29 19 15708372 (2), 11336792 (2), 19017637 (2), 15895377 (1) (see all 15)
    fibrosarcoma 27.1 14 15705902 (3), 15067326 (3), 15857802 (2), 10452548 (1) (see all 5)

    Genetic Association Database (GAD): SP1
    Human Genome Epidemiology (HuGE) Navigator: SP1 (147 documents)

    Export disorders for SP1 gene to outside databases

    Publications
    for SP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SP1 gene, integrated from 10 sources (see all 2157):
    (articles sorted by number of sources associating them with SP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. (PubMed id 18199680)1, 2, 9 Chuang J.-Y....Hung J.-J. (Mol. Biol. Cell 2008)
    2. Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation. (PubMed id 18239466)1, 2, 9 Spengler M.L.... Brattain M.G. (Cell Cycle 2008)
    3. Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene. (PubMed id 16943418)1, 2, 9 Zhang Y.... Dufau M.L. (Mol. Cell. Biol. 2006)
    4. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. (PubMed id 18258854)1, 2, 9 Tan N.Y.... Khachigian L.M. (Circ. Res. 2008)
    5. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PubMed id 20121949)1, 2, 9 Hu C.T.... Wu W.S. (FEBS J. 2010)
    6. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PubMed id 10391891)1, 2, 9 Ding H.... Belayew A. (J. Biol. Chem. 1999)
    7. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PubMed id 19302979)1, 2, 9 Lim K. and Chang H.I. (Biochem. Biophys. Res. Commun. 2009)
    8. Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. (PubMed id 16478997)1, 2, 9 Hung J.J.... Chang W.C. (Mol. Cell. Biol. 2006)
    9. Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. (PubMed id 9065444)1, 2, 9 Narayan V.A.... Caradonna J.P. (J. Biol. Chem. 1997)
    10. The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7. (PubMed id 1662663)1, 3, 9 Szpirer J....DeLuca H.F. (Genomics 1991)

    External Searches for SP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6667 HGNC: 11205 AceView: SP1 Ensembl:ENSG00000185591 euGenes: HUgn6667
    ECgene: SP1 Kegg: 6667 H-InvDB: SP1

    Other Databases showing SP1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing SP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SP1 gene:
    Search GeneIP for patents involving SP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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