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Aliases for SP1 Gene

Aliases for SP1 Gene

  • Sp1 Transcription Factor 2 3 5
  • Specificity Protein 1 2
  • TSFP1 4

External Ids for SP1 Gene

Previous GeneCards Identifiers for SP1 Gene

  • GC12P053801
  • GC12P053490
  • GC12P052060
  • GC12P050814
  • GC12P053773

Summaries for SP1 Gene

Entrez Gene Summary for SP1 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for SP1 Gene

SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include breast cancer and pancreatic cancer. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SP3.

UniProtKB/Swiss-Prot for SP1 Gene

  • Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for SP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP1 Gene

Genomics for SP1 Gene

Regulatory Elements for SP1 Gene

Promoters for SP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SP1 Gene

Chromosome:
12
Start:
53,380,176 bp from pter
End:
53,416,446 bp from pter
Size:
36,271 bases
Orientation:
Plus strand

Genomic View for SP1 Gene

Genes around SP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP1 Gene

Proteins for SP1 Gene

  • Protein details for SP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08047-SP1_HUMAN
    Recommended name:
    Transcription factor Sp1
    Protein Accession:
    P08047
    Secondary Accessions:
    • E4Z9M7
    • G5E9M8
    • Q86TN8
    • Q9H3Q5
    • Q9NR51
    • Q9NY21
    • Q9NYE7

    Protein attributes for SP1 Gene

    Size:
    785 amino acids
    Molecular mass:
    80693 Da
    Quaternary structure:
    • Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1 (By similarity). Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1.
    Miscellaneous:
    • In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.
    SequenceCaution:
    • Sequence=AAH43224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SP1 Gene

    Alternative splice isoforms for SP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP1 Gene

Proteomics data for SP1 Gene at MOPED

Post-translational modifications for SP1 Gene

  • Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter.
  • O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1 phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma).
  • Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues.
  • Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is susceptible to degradation.
  • Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation.
  • Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by phosphorylation.
  • Glycosylation at Ser 491, Ser 612, Thr 640, Ser 641, Ser 698, and Ser 702
  • Modification sites at PhosphoSitePlus

Other Protein References for SP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SP1 (SP1)

No data available for DME Specific Peptides for SP1 Gene

Domains & Families for SP1 Gene

Protein Domains for SP1 Gene

Suggested Antigen Peptide Sequences for SP1 Gene

Graphical View of Domain Structure for InterPro Entry

P08047

UniProtKB/Swiss-Prot:

SP1_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP1: view

Function for SP1 Gene

Molecular function for SP1 Gene

GENATLAS Biochemistry:
transcription factor Sp-1,GT box binding protein
UniProtKB/Swiss-Prot Function:
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.
UniProtKB/Swiss-Prot Induction:
By insulin.

Gene Ontology (GO) - Molecular Function for SP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 14979875
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 21659522
GO:0003677 DNA binding IDA 12560508
GO:0003690 double-stranded DNA binding IDA 20371611
genes like me logo Genes that share ontologies with SP1: view
genes like me logo Genes that share phenotypes with SP1: view

Animal Models for SP1 Gene

MGI Knock Outs for SP1:

Animal Model Products

miRNA for SP1 Gene

miRTarBase miRNAs that target SP1

Transcription Factor Targets for SP1 Gene

Selected GeneGlobe predicted Target genes for SP1
Targeted motifs for SP1 Gene
HOMER Transcription Factor Regulatory Elements motif SP1
  • Consensus sequence: GGCCCCGCCCCC Submotif: canonical Cell Type: NA

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for SP1 Gene

Localization for SP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP1 Gene

Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP1 Gene COMPARTMENTS Subcellular localization image for SP1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SP1 Gene

Pathways & Interactions for SP1 Gene

genes like me logo Genes that share pathways with SP1: view

SIGNOR curated interactions for SP1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 12169688
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 12771217
genes like me logo Genes that share ontologies with SP1: view

Drugs & Compounds for SP1 Gene

(70) Drugs for SP1 Gene - From: Novoseek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1645
Serotonin Pharma 3147

(60) Additional Compounds for SP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SP1: view

Transcripts for SP1 Gene

Unigene Clusters for SP1 Gene

Sp1 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SP1 Gene

GeneLoc Exon Structure for
SP1
ECgene alternative splicing isoforms for
SP1

Expression for SP1 Gene

mRNA expression in normal human tissues for SP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP1 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for SP1 Gene

This gene is overexpressed in CD8 Tcells (15.8), Lung (9.8), and Fetal gut (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP1 Gene



SOURCE GeneReport for Unigene cluster for SP1 Gene Hs.649191

mRNA Expression by UniProt/SwissProt for SP1 Gene

P08047-SP1_HUMAN
Tissue specificity: Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
genes like me logo Genes that share expression patterns with SP1: view

Protein tissue co-expression partners for SP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP1 35
  • 99.7 (n)
  • 100 (a)
SP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP1 36
  • 97 (a)
OneToOne
SP1 35
  • 94.1 (n)
  • 95.92 (a)
dog
(Canis familiaris)
Mammalia SP1 35
  • 94.09 (n)
  • 96.94 (a)
SP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp1 16
Sp1 36
  • 96 (a)
OneToOne
Sp1 35
  • 92.34 (n)
  • 95.64 (a)
rat
(Rattus norvegicus)
Mammalia Sp1 35
  • 92.77 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves SP1 35
  • 74.69 (n)
  • 81.96 (a)
SP1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76006 35
sp1 35
  • 68.28 (n)
  • 71.57 (a)
zebrafish
(Danio rerio)
Actinopterygii sp1 36
  • 49 (a)
OneToOne
sp1 35
  • 65.15 (n)
  • 65.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spps 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sptf-3 36
  • 32 (a)
OneToMany
Species with no ortholog for SP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP1 Gene

ENSEMBL:
Gene Tree for SP1 (if available)
TreeFam:
Gene Tree for SP1 (if available)

Paralogs for SP1 Gene

Paralogs for SP1 Gene

genes like me logo Genes that share paralogs with SP1: view

Variants for SP1 Gene

Sequence variations from dbSNP and Humsavar for SP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs784880 -- 53,380,985(+) tcgct(C/G)ttgtt intron-variant, upstream-variant-2KB
rs784881 -- 53,406,070(+) ctttt(C/T)ttttt intron-variant
rs784882 -- 53,406,111(+) ctgtc(A/G)cccag intron-variant
rs784883 -- 53,406,348(+) acagg(C/T)gtgaa intron-variant
rs2446066 -- 53,384,866(+) TATGG(G/T)CCCAG intron-variant

Variation tolerance for SP1 Gene

Residual Variation Intolerance Score: 6.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP1 Gene

HapMap Linkage Disequilibrium report
SP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SP1 Gene

Disorders for SP1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
pancreatic cancer
  • pancreatic carcinoma, somatic
prostate cancer
  • prostate cancer, hereditary, 5
dengue disease
  • dengue hemorrhagic fever
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SP1

Genetic Association Database (GAD)
SP1
Human Genome Epidemiology (HuGE) Navigator
SP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP1
genes like me logo Genes that share disorders with SP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP1 Gene

Publications for SP1 Gene

  1. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. (PMID: 18199680) Chuang J.-Y. … Hung J.-J. (Mol. Biol. Cell 2008) 3 4 23 67
  2. The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7. (PMID: 1662663) Szpirer J. … DeLuca H.F. (Genomics 1991) 2 3 23
  3. Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. (PMID: 19621387) Lu S. … Archer M.C. (Int. J. Cancer 2010) 3 23
  4. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. (PMID: 20086170) Jia Z. … Xie K. (Cancer Res. 2010) 3 23
  5. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu C.T. … Wu W.S. (FEBS J. 2010) 3 23

Products for SP1 Gene

Sources for SP1 Gene

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