Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SP1 Gene

protein-coding GIFtS: 64
GCID: GC12P053773

Sp1 transcription factor

Explore 139 diseases affiliated with
SP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sp1 Transcription Factor¹ ²
Specificity Protein 1²
Transcription Factor Sp1²
TSFP1³

External Ids:	HGNC: 11205¹	Entrez Gene: 6667²	Ensembl: ENSG00000185591⁷	OMIM: 189906⁵	UniProtKB: P08047³

Export aliases for SP1 gene to outside databases

Previous GC identifers: GC12P053801 GC12P053490 GC12P052060 GC12P050814

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SP1:

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters.

The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis,

immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as

phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this

protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047

Function: Transcription factor that can activate or repress transcription in response to physiological and pathological

stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved

in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by

post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).

Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage.

Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an

essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in

cancer cells by inducing TERT and TERC gene expression

Gene Wiki entry for SP1 (Sp1 transcription factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SP1 gene promoter:
STAT1 AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.1

SP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SP1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P053773: view genomic region (about GC identifiers)

Start:	53,773,960 bp from pter	End:	53,810,230 bp from pter
Size:	36,271 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047 (See protein sequence)

Recommended Name: Transcription factor Sp1

Size: 785 amino acids; 80693 Da

Subunit: Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62

protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40 VP2/3

proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2

proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of

HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and

JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction

is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1 (By similarity). Interacts with ATF7IP and TBP.

Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1

Subcellular location: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states.

Insulin promotes nuclear location, while glucagon favors cytoplasmic location

Miscellaneous: In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the

duplication of exons 2 and 3

Sequence caution: Sequence=AAH43224.1; Type=Erroneous initiation;

5 PDB 3D structures from and Proteopedia for SP1:

1SP1 (3D)

1SP2 (3D)

1VA1 (3D)

1VA2 (3D)

1VA3 (3D)

Secondary accessions: Q86TN8 Q9H3Q5 Q9NR51 Q9NY21 Q9NYE7

Explore the universe of human proteins at neXtProt for SP1: NX_P08047

Post-translational modifications:

Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and

proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances

ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on

transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but,

represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2.

Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the

ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation

on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107.

Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing

increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681

can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased

chromatin association during interphase and increases the transcriptional activity. On insulin stimulation,

sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues¹

Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the

expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter¹

Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by

phosphorylation¹

Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation

levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation¹

Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is

susceptible to degradation¹

O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1

phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially

deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction

with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter.

Inhibited by peroxisomome proliferator receptor gamma (PPARgamma)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08047

SP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001238754.1 NP_003100.1 NP_612482.2

ENSEMBL proteins:

ENSP00000457804 ENSP00000329357 ENSP00000404263 ENSP00000458133

Reactome Protein details: P08047
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for SP1
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SP1
	GenScript Custom Purified and Recombinant Proteins Services for SP1
	Novus Biologicals SP1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0032993	protein-DNA complex	IEA	--

SP1 for ontologies About GeneDecksing

SP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SP1
	OriGene Antibodies (see all 2): SP1 OriGene Custom Antibody Services for SP1
	GenScript Superior Antibodies for SP1
	Novus Biologicals SP1 Antibodies
	Abcam antibodies for SP1
	Browse Antibodies at Uscn
	ThermoFisher Antibody for SP1

Assay Products for SP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SP1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P08047

ProtoNet protein and cluster: P08047

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047

Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047

Function: Transcription factor that can activate or repress transcription in response to physiological and pathological

stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved

in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by

post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).

Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage.

Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an

essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in

cancer cells by inducing TERT and TERC gene expression

Induction: By insulin

Genatlas biochemistry entry for SP1:

transcription factor Sp-1,GT box binding protein

miRNA Products:		miRTarBase miRNAs that target SP1: hsa-mir-124 (MIRT002660), hsa-mir-29b (MIRT000445), hsa-mir-218 (MIRT004246)

		OriGene 3'-UTR Clone (see all 2): SP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP1
		8/196 QIAGEN miScript miRNA Assays for microRNAs that regulate SP1 (see all 196):
		hsa-miR-100* hsa-miR-520f hsa-miR-361-5p hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-877*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP1 (see all 7) OriGene shRNA RFP: SP1 OriGene siRNA: SP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SP1 (NM_170609)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SP1
		Search LifeMap BioReagents cell lines for SP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP1

Gene Ontology (GO): 5/20 molecular function terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISS	--
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	--
GO:0000987	core promoter proximal region sequence-specific DNA binding	--	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0001103	RNA polymerase II repressing transcription factor binding	ISS	--

SP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SP1:

Decreased viability with pacli

Animal Models:
13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sp1):

cardiovascular system	craniofacial	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	integument	limbs/digits/tail	liver/biliary system	mortality/aging
respiratory system	skeleton	vision/eye

SP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/62 super-pathways (see all 62) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Expression of Mevalonate Kinase (MVK)

Expression of Mevalonate Kinase (MVK)	1.00	Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)	0.75
Expression of 7-Dehydrocholesterol Reductase (DHCR7)	0.75	Expression of Phosphomevalonate Kinase (PMVK)	0.75
Expression of Lanosterol Demethylase (CYP51A1)	0.75	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)	0.75
Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	0.75	Expression of Fatty Acid Synthase (FASN)	0.62

Development_Prolactin receptor signaling

	Development_Prolactin receptor signaling	1.00			Leptin signaling pathway	0.32
	Development Prolactin receptor signaling	1.00

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 EMD Millipore Pathways for SP1 (see all 12)

	Dichloroethylene metabolism
	Cell cycle Regulation of G1/S transition (part 2)
	Development VEGF signaling and activation
	G-protein signaling Rac2 regulation pathway
	Cell cycle Regulation of G1/S transition (part 1)

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SP1 (see all 11)

	ErbB2-ErbB3 Heterodimers
	HMGB1 Pathway
	JAK-STAT Pathway
	Estrogen Pathway
	Signaling in Gap Junctions

2 Cell Signaling Technology (CST) Pathways for SP1

	Chromatin Regulation / Acetylation
	Wnt / Hedgehog / Notch

5/15 GeneGo (Thomson Reuters) Pathways for SP1 (see all 15)

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Development Endothelin-1/EDNRA transactivation of EGFR
	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	G-protein signaling Rac2 regulation pathway
	Development Role of Activin A in cell differentiation and proliferation

5/29 BioSystems Pathways for SP1 (see all 29)

	Integrated Breast Cancer Pathway
	SREBP signalling
	Estrogen signaling pathway
	SIDS Susceptibility Pathways
	Myometrial Relaxation and Contraction Pathways

5/22 Reactome Pathways for SP1 (see all 22)

	Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)
	Expression of Fatty Acid Synthase (FASN)
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Expression of Mevalonate Kinase (MVK)
	Metabolism

1 PharmGKB Pathway for SP1

EGFR Inhibitor Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for SP1):

	TGF-beta signaling pathway
	Huntington's disease

SP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/265 Interacting proteins for SP1 (P08047^{1, 2, 3} ENSP00000329357⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 265)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POU2F1	P14859¹^,²^,³, ENSP00000271411⁴	EBI-298336,EBI-624770 MINT-6803426 MINT-6803452 MINT-6803484 MINT-6803438 MINT-6803470 I2D: score=4 STRING: ENSP00000271411
HMGA1	P17096²^,³, ENSP00000308227⁴	MINT-49729 MINT-49730 MINT-49727 MINT-49728 I2D: score=4 STRING: ENSP00000308227
TP53	P04637²^,³, ENSP00000269305⁴	MINT-56525 MINT-56523 MINT-56524 I2D: score=6 STRING: ENSP00000269305
AATF	Q9NY61²^,³, ENSP00000225402⁴	MINT-49665 MINT-49666 I2D: score=4 STRING: ENSP00000225402
GABPA	Q06546²^,³, ENSP00000346886⁴	MINT-49851 MINT-49852 I2D: score=4 STRING: ENSP00000346886

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0001701	in utero embryonic development	--	--
GO:0001829	trophectodermal cell differentiation	IEA	--
GO:0001889	liver development	IEA	--
GO:0001892	embryonic placenta development	IEA	--

SP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SP1

1 HMDB Compound for SP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--

10/128 Novoseek chemical compound relationships for SP1 gene (see all 128) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mithramycin	91.2	153	20086170 (3), 17973266 (3), 15489892 (3), 17124180 (2) (see all 86)
wp631	81.3	10	10446226 (2), 16705627 (1), 11172687 (1), 12219017 (1) (see all 7)
5-aza-2'deoxycytidine	67.2	24	9632722 (6), 17203216 (2), 11507078 (2), 17260018 (1) (see all 7)
chloramphenicol	66.9	15	8344287 (1), 8910439 (1), 1423289 (1), 8245855 (1) (see all 13)
zinc	61.6	190	7685185 (4), 11395515 (4), 9586044 (3), 12565691 (3) (see all 99)
mal.4	60.2	3	7479972 (1), 12719007 (1)
oligonucleotide	58.1	89	10722737 (2), 8208618 (2), 9458359 (2), 8634093 (2) (see all 58)
dimethyl sulfate	58	3	12560236 (1), 9494121 (1), 9079666 (1)
estrogen	52.6	96	15541729 (4), 18543253 (3), 8195246 (3), 9328340 (3) (see all 60)
retinoic acid	46.4	55	15219855 (5), 17937658 (5), 10452548 (3), 8083995 (3) (see all 28)

Search CenterWatch for drugs/clinical trials and news about SP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SP1 gene (3 alternative transcripts):

NM_001251825.1 NM_003109.1 NM_138473.2

Unigene Cluster for SP1:

Sp1 transcription factor

Hs.649191 [show with all ESTs]

Unigene Representative Sequence: NM_138473

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000551969 ENST00000327443 ENST00000426431(uc021qyf.1 uc001scw.3 uc010sog.2)

ENST00000548560

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SP1
		8/196 QIAGEN miScript miRNA Assays for microRNAs that regulate SP1 (see all 196):
		hsa-miR-100* hsa-miR-520f hsa-miR-361-5p hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-877*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP1 (see all 7) OriGene shRNA RFP: SP1 OriGene siRNA: SP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SP1 (NM_170609)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP1

Additional cDNA sequence:

AB209678.1 AF252284.1 AF255682.1 AJ272134.1 AK311995.1 AL442093.1 BC012008.1 BC043224.1

BC062539.1 BC078158.1 FJ949572.1 FN908228.1 J03133.1

7 DOTS entries:

DT.446979 DT.100790645 DT.102841326 DT.121316782 DT.92030853 DT.92435550 DT.97859522

24/358 AceView cDNA sequences (see all 358):

AW847882 BP872136 BM714447 AI243266 AJ272134 BQ286204 AI431874 AF255682

AI183581 BU674208 BM974559 CA393369 BC043224 BP873002 AA075969 BQ718687

BQ184254 BF591132 AA730972 CB131820 BM930046 BM726055 AI862807 BF589344

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SP1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7
SP1:			-		-
SP2:					-
SP3:			-		-				-
SP4:

ECgene alternative splicing isoforms for SP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGATCTGCC

About this image

SP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SP1

SOURCE GeneReport for Unigene cluster: Hs.649191

UniProtKB/Swiss-Prot: SP1_HUMAN, P08047

Tissue specificity: Up-regulated in adenocarcinomas of the stomach (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including SP1 (see all 10):

Fibrosis in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Stem Cell Signaling in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Circadian Rhythms in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SP1 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SP1¹	Sp1 transcription factor	73.78(n) 80.67(a)		395303 NM_204604.1 NP_989935.1
lizard (Anolis carolinensis)	Reptilia	SP1⁶ --	--	74(a) 5(a)	1 ↔ 1 possible ortholog	2(73499280-73529749) 3(88021848-88042132)
tropical clawed frog (Xenopus tropicalis)	Amphibia	MGC76006²	transcription factor	79.67(n)		BC061414.1
zebrafish (Danio rerio)	Actinopterygii	sp1²	sp1 transcription factor	74.78(n)		324109 AI657942.1
fruit fly (Drosophila melanogaster)	Insecta	Spps¹	Sp1-like factor for pairing sensitive-silencing	42.74(n) 34.54(a)		42882 NM_142975.2 NP_651232.1
worm (Caenorhabditis elegans)	Secernentea	sptf-1⁶	Specificity Protein) Transcription Factor family m...	12(a)	possible ortholog	I(10366612-10371685)

ENSEMBL Gene Tree for SP1 (if available)
TreeFam Gene Tree for SP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SP1 gene

SP4² SP3² SP8² SP5² SP2² KLF17² SP6² SP9²

SP7²

18/68 SIMAP similar genes for SP1 using alignment to 8 protein entries: SP1_HUMAN (see all proteins) (see all similar genes):

Sp1 DHFRP2 PSG PSG3 PSG11 PSG7

WT1 PSG4 PSG5 PSG9 CEACAM4 PSG6

CEACAM3 CEACAM7 DKFZp686O1631 PSG2 PSG11s' CEACAM8

SP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140970253^1,2		--	53772217(+)	`CCATAA/GTGCTG`	2	--	us2k¹		0	--	--	--	--
rs74845657^1,2	F,	--	53772490(+)	`CAGCAA/GTCACT`	3	--	us2k¹		1		WA	118
rs192210146^1,2		--	53772692(+)	`CGGATA/GAAGAG`	3	--	us2k¹		0	--	--	--	--
rs184534663^1,2		--	53772837(+)	`CACTTC/TAGCCT`	3	--	us2k¹		0	--	--	--	--
rs73311395^1,2	C,	--	53772866(+)	`CCAGTC/TGTTTA`	3	--	us2k¹		1		WA	2
rs7131938^1,2	C,F,A,H,	--	53772927(+)	`AGTCTC/TACGGA`	3	--	us2k¹		20		NS EA NA WA CSA	2345
rs7131943^1,2	C,H,	--	53772952(+)	`GTCAGC/ATCAGT`	3	--	us2k¹ tfbs³		5		NS EA WA	538
rs189404261^1,2		--	53773029(+)	`CATTGA/TGGCAT`	3	--	us2k¹		0	--	--	--	--
rs192688895^1,2		--	53773119(+)	`CAAGTC/TCTAGT`	3	--	us2k¹		0	--	--	--	--
rs184499476^1,2		--	53773174(+)	`TTGAGA/CTGCAG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SP1 (53773960 - 53810230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP1

DNA2.0 Custom Variant and Variant Library Synthesis for SP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SP1 for disorders           About GeneDecksing

OMIM gene information: 189906    OMIM disorders: --

20/139 diseases for SP1 (see all 139):    About MalaCards

machado-joseph disease estrogen-receptor positive breast cancer hailey-hailey disease high blood pressure

human t-cell leukemia virus type 1 erythropoietic protoporphyria retinol binding protein cerebrotendinous xanthomatosis

dna topoisomerase ii hereditary hemorrhagic telangiectasia ectopic pregnancy erythema multiforme

myotonic dystrophy proliferative diabetic retinopathy multiple endocrine neoplasia autism spectrum disorder

xanthomatosis beta thalassemia primary biliary cirrhosis ovarian hyperstimulation syndrome

1 disease from the University of Copenhagen DISEASES database for SP1:

Cancer

10/93 Novoseek disease relationships for SP1 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	53.8	5	15998736 (1), 8463313 (1), 11304527 (1)
tumors	50.3	174	19772640 (4), 15818728 (4), 11844788 (3), 17510417 (3) (see all 98)
retinoblastoma	47.8	30	14653808 (3), 11228546 (2), 8007947 (2), 9242441 (2) (see all 20)
immunodeficiency	47.3	51	7690421 (2), 9525578 (2), 2072454 (2), 9584164 (2) (see all 43)
cancer	42.7	70	19621387 (4), 19588484 (3), 17656364 (3), 15263012 (2) (see all 44)
breast cancer	41.2	57	17927860 (6), 16143315 (4), 12176973 (3), 12052832 (3) (see all 27)
choriocarcinoma	34.3	6	10962555 (3), 10491299 (1), 9231796 (1), 17872376 (1)
colon cancer	32.3	5	15883203 (2), 19593667 (1), 17689681 (1), 20230799 (1)
prostate cancer	29	19	15708372 (2), 11336792 (2), 19017637 (2), 15895377 (1) (see all 15)
fibrosarcoma	27.1	14	15705902 (3), 15067326 (3), 15857802 (2), 10452548 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: SP1 (147 documents)

Export disorders for SP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SP1 gene, integrated from 9 sources (see all 2094):
(articles sorted by number of sources associating them with SP1)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. (PubMed id 18199680)^{1, 2, 9} Chuang J.-Y....Hung J.-J. (2008)
Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation. (PubMed id 18239466)^{1, 2, 9} Spengler M.L.... Brattain M.G. (2008)
Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene. (PubMed id 16943418)^{1, 2, 9} Zhang Y.... Dufau M.L. (2006)
Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. (PubMed id 18258854)^{1, 2, 9} Tan N.Y.... Khachigian L.M. (2008)
Snail associates with EGR-1 and SP-1 to upregulate tr anscriptional activation of p15INK4b. (PubMed id 20121949)^{1, 2, 9} Hu C.T....Wu W.S. (2010)
Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PubMed id 10391891)^{1, 2, 9} Ding H.... Belayew A. (1999)
O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PubMed id 19302979)^{1, 2, 9} Lim K. and Chang H.I. (2009)
Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. (PubMed id 16478997)^{1, 2, 9} Hung J.J....Chang W.C. (2006)
Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. (PubMed id 9065444)^{1, 2, 9} Narayan V.A.... Caradonna J.P. (1997)
The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7. (PubMed id 1662663)^{1, 3, 9} Szpirer J....DeLuca H.F. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6667	HGNC: 11205	AceView: SP1	Ensembl:ENSG00000185591	euGenes: HUgn6667
ECgene: SP1	Kegg: 6667	H-InvDB: SP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SP1 gene:
Search GeneIP for patents involving SP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SP1
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for SP1		OriGene shRNA RFP for SP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SP1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SP1		OriGene 3'-UTR Clone for SP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SP1		OriGene Custom Protein Services for SP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SP1

	GenScript Custom Purified and Recombinant Proteins Services for SP1		GenScript cDNA clones with any tag delivered in your preferred vector for SP1
	GenScript Custom Assay Services for SP1		GenScript Superior Antibodies for SP1
	GenScript Custom overexpressing Cell Line Services for SP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for SP1

	Regulatory tfbs in SP1 promoter
	Search Chromatin IP Primers for SP1
	RT² qPCR Primer Assay in human, mouse, rat SP1
	GNC Network for SP1
	SABiosciences PCR Arrays including human, mouse, rat SP1

Search Tocris compounds for SP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for SP1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SP1 antibodies
	SP1 proteins

	Antibodies for SP1
	See all of Abcam's Antibodies, Kits and Proteins for SP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for SP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SP1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SP1
	SwitchGear Promoter luciferase reporter plasmids for SP1

ThermoFisher Antibody for SP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SP1 Gene

Sp1 transcription factor

Aliases
for SP1 gene

Summaries
for SP1 gene

Genomic Views
for SP1 gene

Proteins
for SP1 gene

Protein Domains /
Families
for SP1 gene

Function
for SP1 gene

Pathways & Interactions
for SP1 gene

Drugs & Compounds
for SP1 gene

Transcripts
for SP1 gene

Expression
for SP1 gene

Orthologs
for SP1 gene

Paralogs
for SP1 gene

Genomic Variants
for SP1 gene

Disorders / Diseases
for SP1 gene

Publications
for SP1 gene

External Searches for SP1 gene

Genome Databases showing SP1 gene

Other Databases showing SP1 gene

Specialized Databases showing SP1 gene

Intellectual Property
for SP1 gene

Products
for SP1 gene

View Random Gene

Dementia
Leukemia T-Cell
Retinoblastoma
Erythroleukemia
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Teratocarcinoma
Liver diseases
Breast Cancer
NSCLC
primary tumor
Schizophrenia
AIDS
Keratoconus
Cancer
Rhabdomyosarcoma
Colorectal Carcinoma
somatic mutations
bone loss
Miscarriage
mammary tumor
Ovarian Cancer
Shock
Corneal Diseases
Colorectal Cancer
Inflammation
Tuberculosis
immunodeficiency
Hyperglycemia
Hepatitis B
Cervical Cancer
prostate cancer
Tumors
Mental Retardation
Trisomy
Metastasis
Fibrosarcoma
Necrosis
Lymphoblastic Leukemia Acute
Sarcoma
Acidosis
Glioblastoma
virus infection
Malignant Glioma
Huntington Disease
Senile Plaques
Glioblastoma Multiforme
Gastric Cancer
Myeloid Leukemia
Brain Tumors
BREAST CARCINOMA
Melanoma
Colon Cancer
promyelocytic leukemia
Parkinson Disease
Glioma
Hyperplasia
Venous Thrombosis
Liver Fibrosis
atherosclerotic plaque
Hodgkin Disease
Carcinoma
Astrocytoma
epithelial tumor
Leukemia
Osteosarcoma
Osteoporosis
Alcoholism
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
metastatic melanoma
Carcinoma Renal Cell
Pancreatic Cancer
Cancer Lung
HEART FAILURE
Myocardial Infarction
Wilms tumor
Machado-Joseph Disease
Adenoma
Bleeding
Keloid
OVARIAN CARCINOMA
Ewings sarcoma
solid tumor
Pregnancy Ectopic
Chromosomal Aberrations
Carcinoma Embryonal
Myotonic Dystrophy
Cholera
leukemogenesis
Arthritis
Choriocarcinoma

Advanced Search

Export list of displayed genes

SP1 Gene

Sp1 transcription factor

Aliasesfor SP1 gene

Summariesfor SP1 gene

Genomic Viewsfor SP1 gene

Proteinsfor SP1 gene

Protein Domains /Familiesfor SP1 gene

Functionfor SP1 gene

Pathways & Interactionsfor SP1 gene

Drugs & Compoundsfor SP1 gene

Transcriptsfor SP1 gene

Expression for SP1 gene

Orthologsfor SP1 gene

Paralogsfor SP1 gene

Genomic Variantsfor SP1 gene

Disorders / Diseasesfor SP1 gene

Publicationsfor SP1 gene

External Searches for SP1 gene

Genome Databases showing SP1 gene

Other Databases showing SP1 gene

Specialized Databases showing SP1 gene

Intellectual Propertyfor SP1 gene

Productsfor SP1 gene

View Random Gene

Aliases
for SP1 gene

Summaries
for SP1 gene

Genomic Views
for SP1 gene

Proteins
for SP1 gene

Protein Domains /
Families
for SP1 gene

Function
for SP1 gene

Pathways & Interactions
for SP1 gene

Drugs & Compounds
for SP1 gene

Transcripts
for SP1 gene

Expression
for SP1 gene

Orthologs
for SP1 gene

Paralogs
for SP1 gene

Genomic Variants
for SP1 gene

Disorders / Diseases
for SP1 gene

Publications
for SP1 gene

Intellectual Property
for SP1 gene

Products
for SP1 gene