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SOX9 Gene

protein-coding   GIFtS: 65

GC17P067628
SRY (sex determining region Y)-box 9
(Previous names: campomelic dysplasia, autosomal sex-reversal )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CMD1, CMPD1)
Services    

Aliases &
Descriptions
for SOX9

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CMD1 2, 5
CMPD1 2
SRA1 1, 2, 5
Descriptions
SRY (sex determining region Y)-box 9 2
SRY (sex determining region Y)-box 9 (campomelic dysplasia,
autosomal sex-reversal) 2
SRY (sex-determining region Y)-box 9 (campomelic dysplasia,
autosomal sex-reversal) 2
SRY (sex-determining region Y)-box 9 protein 2
campomelic dysplasia, autosomal sex-reversal 1, 2
transcription factor SOX9 2
External Ids
HGNC: 112041
Entrez Gene: 66622
UniProtKB: P484363
Ensembl: ENSG000001253987
Search outside databases for aliases for SOX9 gene

Previous GC identifers: GC17P069873 GC17P073111 GC17P070581 GC17P070714

Summaries
for SOX9

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for SOX9:
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the
HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with
steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene.
Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex
reversal. [provided by RefSeq]

UniProtKB/Swiss-Prot: SOX9_HUMAN, P48436
Function: Plays an important role in the normal skeletal development. May regulate the expression
of other genes involved in chondrogenesis by acting as a transcription factor for these genes

Gene Wiki entry for SOX9

Genomic Location
for SOX9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SOX9 gene  

Entrez Gene cytogenetic band: 17q24.3-q25.1   Ensembl cytogenetic band:  17q24.3   HGNC cytogenetic band: 17q23

SOX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P067628:     (about GC identifiers)

Start:
 67,628,756 bp from pter
End:
 67,634,156 bp from pter
Size:
 5,401 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  

Proteins
for SOX9

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SOX9_HUMAN, P48436 (See protein sequence)
Recommended Name: Transcription factor SOX-9  
Size: 509 amino acids; 56137 Da
Subcellular location: Nucleus (Potential)
PDB structure from and Proteopedia :
1S9M (3D)    1SX9 (3D)    

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000337.1  

    ENSEMBL proteins: 
    ENSP00000245479 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SOX9)
    Human Recombinant Proteins from Abnova (SOX9)
                  OriGene Purified Recombinant Human Protein: SOX9 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS10805756
    GO:0005730NOT nucleolus IDA18029348
    About this table

    Antibodies for SOX9: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of SOX9
    Sigma-Aldrich Antibodies for SOX9
    R&D Systems Antibodies for SOX9
    Antibodies from Abcam (SOX9), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SOX9)
    Novus Biologicals Antibodies for SOX9

    Assays for SOX9: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SOX9

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR000910 HMG_HMG1/HMG2


       GeneDecks  SOX9 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P48436

    ProtoNet protein and cluster: P48436

    UniProtKB/Swiss-Prot: SOX9_HUMAN, P48436
    Similarity: Contains 1 HMG box DNA-binding domain

    Gene Function
    for SOX9

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SOX9)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SOX9)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000346

                  Applied Biosystems Silencer® siRNAs for SOX9

                  Sigma-Aldrich siRNA for SOX9  
                         Sigma-Aldrich shRNA Panels and shRNA for SOX9  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SOX9
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000346
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000346
                                     untagged cDNA clone in CMV expression vector: NM_000346 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000346

    UniProtKB/Swiss-Prot: SOX9_HUMAN, P48436
    Function: Plays an important role in the normal skeletal development. May regulate the expression
    of other genes involved in chondrogenesis by acting as a transcription factor for these genes

    Genatlas biochemistry entry for SOX9:
    SRY related HMG box gene 9,expressed in the genital ridge of both sexes,in chondrocytes and in
    non-skeletal tissues,likely involved in the differentiation of Sertoli cells,potent activator of
    the chondrocyte-specific enhancer of COL2A1,required for cartilage formation,important mediator of
    the BMP2 and Indian hedgehog (IHH) sinaling pathways in osteogenic cells,modulator of LINE
    retroposons promoter activity

    15/17 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Sox9) (see all 17 ):

    craniofacialdigestive/alimentaryembryogenesisendocrine/exocrine gland
    growth/sizehearing/vestibular/earhomeostasis/metabolismlethality-postnatallethality-prenatal/perinatal
    limbs/digits/tailnervous systemnormalreproductive systemrespiratory system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003704 specific RNA polymerase II transcription factor activity TAS10805756
    GO:0005515 protein binding IEA--
    GO:0016563 transcription activator activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    Pathways & Interactions
    for SOX9

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for SOX9
     Selected targets of CREB1
     Selected targets of ESR1

       GeneDecks  SOX9 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SOX9  (Your Favorite Gene powered by Ingenuity) 
     Wnt/&beta

       GeneDecks  SOX9 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SOX9 


    5/87 Interacting proteins for SOX9 (ENSP000002454793) via UniProtKB, MINT, and/or STRING (see all 87 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMHENSP000002214963STRING (score=.989)
    MED12ENSP000003331253STRING (score=.987)
    NR5A1ENSP000003626903STRING (score=.982)
    WT1ENSP000003313273STRING (score=.982)
    COL2A1ENSP000003465113STRING (score=.972)
    About this table

    5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502 cartilage condensation IEA--
    GO:0001708 cell fate specification IEA--
    GO:0001837 epithelial to mesenchymal transition IEA--
    GO:0001942 hair follicle development IEA--
    GO:0006350 transcription IEA--
    About this table

    Drugs & Compounds
    for SOX9

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SOX9
    10/11 Novoseek chemical compound relationships for SOX9 gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dmrt 67.48 1 16868052 (1)
    glycosaminoglycan 60.29 11 15639641 (2), 18163512 (1), 19096623 (1), 18985688 (1) (see all 9)
    cmps 50.64 3 10213041 (1), 11076045 (1)
    chondroitin sulfate 22.27 8 18433381 (6)
    ribonucleic acid 17.46 2 17518710 (1), 11710435 (1)
    oxygen 0.00 5 17640365 (3), 15645446 (1)
    steroid 0.00 3 11008738 (1), 17234760 (1), 18190855 (1)
    zinc 0.00 1 10741423 (1)
    glyceraldehyde 3-phosphate 0.00 3 12923462 (2), 14563147 (1)
    cyclic amp 0.00 2 17289023 (1), 10980415 (1)
    About this table


    Transcripts
    for SOX9

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SOX9)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SOX9)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000346

                  Sigma-Aldrich siRNA for SOX9  
                         Sigma-Aldrich shRNA Panels and shRNA for SOX9  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000346  

    REFSEQ mRNAs for SOX9 gene: 

    NM_000346.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000346  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000346
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000346
                                     untagged cDNA clone in CMV expression vector: NM_000346 

    Additional cDNA sequence: 

    AK295455.1 BC007951.2 BC018276.1 BC056420.1 BT006875.1 Z46629.1 

    4 DOTS entries:

    DT.416519  DT.95288976  DT.40299601  DT.97818151 

    24/205 AceView cDNA sequences (see all 205 ):

    W95308 AI453423 AA400739 BC007951 AA975310 BU076661 BG056521 NM_000346 
    AW183687 BM762705 BM845551 W24710 AA778589 AI572187 AW080366 BQ045441 
    AA535677 AW005563 N92393 BQ182292 CA773589 CK300183 AA778708 BG697040 

    highest scoring ESTs for SOX9:

    Z46629 AA090808 AA322324 AA334252 AA375477 AA385905 AA400464 AA400739 AA420456 AA469215 

    Unigene Cluster for SOX9:

    SRY (sex determining region Y)-box 9
    Hs.647409  [show with all ESTs]
    Unigene Representative Sequence: NM_000346


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000245479  

    Expression
    for SOX9

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SOX9 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SOX9

    1 / 2 / 3

    5 probe-sets matching SOX9 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33436_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Z46629 1.00 1.00 1.00 1

    		202935_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI382146 0.60 0.75 0.68 1

    		202936_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000346 0.60 1.00 0.82 1

    		202935_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		202936_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SOX9 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGTCATCCAT

    SOURCE GeneReport for Unigene cluster: Hs.647409

    Expression variation in blood from EXPOLDB for SOX9

    Orthologs
    for SOX9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SOX9 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SOX91   -- SRY (sex determining region Y)-box 9 94.24(n)
    95.87(a)    		 403464  NM_001002978.1  NP_001002978.1 
    chimpanzee
    (Pan troglodytes)    		 SOX91   -- SRY (sex determining region Y)-box 9 99.87(n)
    99.8(a)    		 450101  NM_001009029.1  NP_001009029.1 
    mouse
    (Mus musculus)    		 Sox91, 5 11 (69.50 cM)5
    		 SRY-box containing gene 91, 5 91.45(n)1
    97.24(a)1    		 206821  NM_011448.31  NP_035578.21 
     AF4218785  AK0085355  (see all 18)
    chicken
    (Gallus gallus)    		 SOX91   -- SRY (sex determining region Y)-box 9 86.4(n)
    90.06(a)    		 374148  NM_204281.1  NP_989612.1 
    zebrafish
    (Danio rerio)    		 sox9a2   -- SRY-box containing gene 9a 80.59(n) 60641  AF277096.1 
    About this table        Species with no ortholog for SOX9

    ENSEMBL Gene Tree for SOX9

    Paralogs
    for SOX9

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SOX9 gene
    SRY2  SOX102  SOX82  

    SNPs/Variants
    for SOX9

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/36 NCBI SNPs in SOX9 are shown (see all 36 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs10426671,2
    		C,F,H,O67632146(+) GGCGAA/CGATGG 1 -- ut316Minor allele frequency- C:0.41MN EU EA WA NA 2002
    rs10426781,2
    		A,C,F67633703(+) TCTCTG/ACATCT 1 -- ut3110Minor allele frequency- A:0.33NS MN NA EA 644
    --
    rs10426731,2
    		A,C,F67632934(+) TTATCA/GTATAT 1 -- ut311Minor allele frequency- G:0.42MN 184
    rs99108641,2
    		A,C67634623(+) GAAAAA/TCAGTG 1 -- ng310--------
    rs22299891,2
    		C,F,H67630530(+) GACCAC/TCCGGA 1 H/H syn1 ese35Minor allele frequency- T:0.10MN EU EA WA 482
    --
    rs129509661,2
    		F,H67630840(+) CCCGTC/GCCGCT 1 -- int14Minor allele frequency- G:0.34EU EA WA 412
    --
    rs711521711,2
    		--67634112(-) TATAC-/AAAAAA 1 -- ut310--------
    --
    rs115553931,2
    		--67633432(-) TTTAAA/TAATAA 1 -- ut310--------
    --
    rs289402821,2
    		--67630516(+) TGCAGC/TACAAG 1 H/Y mis1 ese30--------
    --
    rs723206961,2
    		--67633298(+) TTTTT-/TTTTTT 1 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for SOX9 (up to first 250kb)

    Disorders & Mutations
    for SOX9

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 608160   disorders: 114290  114290  114290  

    UniProtKB/Swiss-Prot: SOX9_HUMAN, P48436

  • Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare,
    often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with
    male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of
    the newborn characterized by congenital bowing and angulation of long bones, unusually small
    scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft
    palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often
    evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after
    birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial
    cartilage and small thoracic cage

    • 10/28 Novoseek disease relationships for SOX9 gene (see all 28 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    campomelic dysplasia 97.24 78 10072439 (3), 8894698 (2), 10364523 (2), 16467253 (2) (see all 50)
    swyer syndrome 58.86 2 9002675 (1)
    skeletal dysplasia 54.21 2 9119111 (1)
    osteochondrodysplasias 52.77 1 11008738 (1)
    virilization 51.33 1 9452059 (1)
    achondroplasia 46.56 1 10980415 (1)
    dwarfism 42.95 2 8782821 (1), 11430871 (1)
    micrognathia 42.48 1 17551083 (1)
    hypertrophy 39.32 2 15979579 (1), 18692165 (1)
    pierre robin sequence 37.76 2 17551083 (2)
    About this table

    GeneTests: SOX9
    Campomelic Dysplasia

    Human Gene Mutation Database: SOX9
    Genetic Association Database: SOX9
    Human Genome Epidemiology Navigator: SOX9 (1 document)

    Medical News
    for SOX9

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SOX9

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/344 PubMed articles for SOX9 gene (see all 344 ):

    Search for SOX9

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SOX9

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6662 HGNC: 11204 AceView: SOX9 Ensembl:ENSG00000125398 euGenes: HUgn6662
    ECgene: SOX9 H-InvDB: SOX9

    Other Databases showing SOX9

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SOX9

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=SOX9

    Licensable Technologies
    for SOX9

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SOX9

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SOX9:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SOX9-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SOX9 Antibodies for SOX9
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SOX9 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (SOX9)
     Antibodies (SOX9)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for SOX9




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SOX9

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