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Aliases for SOX7 Gene

Aliases for SOX7 Gene

  • SRY (Sex Determining Region Y)-Box 7 2 3

External Ids for SOX7 Gene

Summaries for SOX7 Gene

Entrez Gene Summary for SOX7 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX7 Gene

SOX7 (SRY (Sex Determining Region Y)-Box 7) is a Protein Coding gene. Diseases associated with SOX7 include barretts adenocarcinoma. Among its related pathways are ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX7 Gene

  • Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX7 Gene

Genomics for SOX7 Gene

Genomic Location for SOX7 Gene

Start:
10,723,768 bp from pter
End:
10,730,574 bp from pter
Size:
6,807 bases
Orientation:
Minus strand

Genomic View for SOX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX7 Gene

Regulatory Elements for SOX7 Gene

Proteins for SOX7 Gene

  • Protein details for SOX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT81-SOX7_HUMAN
    Recommended name:
    Transcription factor SOX-7
    Protein Accession:
    Q9BT81
    Secondary Accessions:
    • B4DKV0
    • Q53YD0

    Protein attributes for SOX7 Gene

    Size:
    388 amino acids
    Molecular mass:
    42197 Da
    Quaternary structure:
    • Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.

    Alternative splice isoforms for SOX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX7 Gene

Proteomics data for SOX7 Gene at MOPED

Post-translational modifications for SOX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX7 Gene

Domains for SOX7 Gene

Gene Families for SOX7 Gene

HGNC:
  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX7 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SOX7_HUMAN
Domain:
  • Contains 1 HMG box DNA-binding domain.:
    • Q9BT81
  • Contains 1 Sox C-terminal domain.:
    • Q9BT81
genes like me logo Genes that share domains with SOX7: view

Function for SOX7 Gene

Molecular function for SOX7 Gene

UniProtKB/Swiss-Prot Function: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Gene Ontology (GO) - Molecular Function for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 19108950
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with SOX7: view
genes like me logo Genes that share phenotypes with SOX7: view

Animal Models for SOX7 Gene

MGI Knock Outs for SOX7:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SOX7 Gene

Localization for SOX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX7 Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18682240
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18819930
genes like me logo Genes that share ontologies with SOX7: view

Pathways for SOX7 Gene

SuperPathways for SOX7 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX7: view

Pathways by source for SOX7 Gene

1 Qiagen pathway for SOX7 Gene

Interacting Proteins for SOX7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301921%0d%0a9606.ENSP00000330836%0d%0a
Selected Interacting proteins: Q9BT81-SOX7_HUMAN ENSP00000301921 for SOX7 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001706 endoderm formation IDA 18682240
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0008285 negative regulation of cell proliferation IDA 19108950
genes like me logo Genes that share ontologies with SOX7: view

Transcripts for SOX7 Gene

mRNA/cDNA for SOX7 Gene

Unigene Clusters for SOX7 Gene

SRY (sex determining region Y)-box 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX7 Gene

No ASD Table

Relevant External Links for SOX7 Gene

GeneLoc Exon Structure for
SOX7
ECgene alternative splicing isoforms for
SOX7

Expression for SOX7 Gene

mRNA expression in normal human tissues for SOX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX7 Gene

This gene is overexpressed in Vagina (8.0) and Cervix - Ectocervix (6.9).

SOURCE GeneReport for Unigene cluster for SOX7 Gene Hs.709543

mRNA Expression by UniProt/SwissProt for SOX7 Gene

Q9BT81-SOX7_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
genes like me logo Genes that share expressions with SOX7: view

Orthologs for SOX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX7 36
  • 93.33 (n)
  • 91.3 (a)
cow
(Bos Taurus)
Mammalia SOX7 36
  • 87.82 (n)
  • 88.83 (a)
dog
(Canis familiaris)
Mammalia SOX7 36
  • 91.26 (n)
  • 94.17 (a)
mouse
(Mus musculus)
Mammalia Sox7 36
  • 85.44 (n)
  • 89.21 (a)
Sox7 16
Sox7 37
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sox7 36
  • 84.77 (n)
  • 89.3 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
SOX7 36
  • 72.83 (n)
  • 71.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia sox7-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sox7 36
  • 67.41 (n)
  • 70.36 (a)
Str.1804 36
zebrafish
(Danio rerio)
Actinopterygii sox7 36
  • 65.1 (n)
  • 63.16 (a)
sox7 37
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sox15 37
  • 13 (a)
OneToMany
Sox15 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
OneToMany
Species with no ortholog for SOX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOX7 Gene

ENSEMBL:
Gene Tree for SOX7 (if available)
TreeFam:
Gene Tree for SOX7 (if available)

Paralogs for SOX7 Gene

Selected SIMAP similar genes for SOX7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOX7: view

Variants for SOX7 Gene

Sequence variations from dbSNP and Humsavar for SOX7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1139066 -- 10,724,756(-) AACAA(A/G)AGTGA utr-variant-3-prime
rs1139843 -- 10,724,587(+) TTGGT(C/G)ATTAG utr-variant-3-prime
rs4841432 -- 10,725,996(+) GGGGA(A/G)AGCTG synonymous-codon, reference
rs4841433 -- 10,726,399(+) GGGCA(C/G)TGCCG reference, missense
rs6998634 -- 10,723,350(+) cgaaa(C/G)cccgt downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SOX7 Gene

Variant ID Type Subtype PubMed ID
nsv527184 CNV Loss 19592680

Relevant External Links for SOX7 Gene

HapMap Linkage Disequilibrium report
SOX7
Human Gene Mutation Database (HGMD)
SOX7

Disorders for SOX7 Gene

(1) MalaCards Diseases for SOX7 Gene

Search for SOX7 Gene in MalaCards »
genes like me logo Genes that share disorders with SOX7: view

No data available for UniProtKB/Swiss-Prot for SOX7 Gene

Publications for SOX7 Gene

  1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PMID: 11691915) Takash W. … Berta P. (Nucleic Acids Res. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. (PMID: 18819930) Guo L. … Zhou W. (Mol. Cancer Res. 2008) 3 4
  5. Expandable endodermal progenitors: new tools to explore endoderm and its derivatives. (PMID: 18940723) Semb H. (Cell Stem Cell 2008) 3

Products for SOX7 Gene

Sources for SOX7 Gene

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