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Aliases for SOX7 Gene

Aliases for SOX7 Gene

  • SRY-Box 7 2 3 5
  • SRY (Sex Determining Region Y)-Box 7 2
  • SRY Box 7 2

External Ids for SOX7 Gene

Previous GeneCards Identifiers for SOX7 Gene

  • GC08M010645
  • GC08M010453
  • GC08M010618
  • GC08M009511
  • GC08M010581

Summaries for SOX7 Gene

Entrez Gene Summary for SOX7 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX7 Gene

SOX7 (SRY-Box 7) is a Protein Coding gene. Diseases associated with SOX7 include Uterine Body Mixed Cancer and Uterine Corpus Cancer. Among its related pathways are ERK Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX7 Gene

  • Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX7 Gene

Genomics for SOX7 Gene

Regulatory Elements for SOX7 Gene

Enhancers for SOX7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOX7 on UCSC Golden Path with GeneCards custom track

Promoters for SOX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOX7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOX7 Gene

Chromosome:
8
Start:
10,723,768 bp from pter
End:
10,730,574 bp from pter
Size:
6,807 bases
Orientation:
Minus strand

Genomic View for SOX7 Gene

Genes around SOX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX7 Gene

Proteins for SOX7 Gene

  • Protein details for SOX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT81-SOX7_HUMAN
    Recommended name:
    Transcription factor SOX-7
    Protein Accession:
    Q9BT81
    Secondary Accessions:
    • B4DKV0
    • Q53YD0

    Protein attributes for SOX7 Gene

    Size:
    388 amino acids
    Molecular mass:
    42197 Da
    Quaternary structure:
    • Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.

    Alternative splice isoforms for SOX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX7 Gene

Proteomics data for SOX7 Gene at MOPED

Post-translational modifications for SOX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SOX7

No data available for DME Specific Peptides for SOX7 Gene

Domains & Families for SOX7 Gene

Gene Families for SOX7 Gene

Protein Domains for SOX7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT81

UniProtKB/Swiss-Prot:

SOX7_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 Sox C-terminal domain.
genes like me logo Genes that share domains with SOX7: view

Function for SOX7 Gene

Molecular function for SOX7 Gene

UniProtKB/Swiss-Prot Function:
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Gene Ontology (GO) - Molecular Function for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with SOX7: view
genes like me logo Genes that share phenotypes with SOX7: view

Animal Models for SOX7 Gene

MGI Knock Outs for SOX7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX7 Gene

Localization for SOX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX7 Gene COMPARTMENTS Subcellular localization image for SOX7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SOX7 Gene

Pathways & Interactions for SOX7 Gene

genes like me logo Genes that share pathways with SOX7: view

Interacting Proteins for SOX7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301921%0d%0a9606.ENSP00000330836%0d%0a
Selected Interacting proteins: Q9BT81-SOX7_HUMAN ENSP00000301921 for SOX7 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 19108950
GO:0045892 negative regulation of transcription, DNA-templated IDA 19108950
GO:0060828 regulation of canonical Wnt signaling pathway IDA 19108950
genes like me logo Genes that share ontologies with SOX7: view

No data available for SIGNOR curated interactions for SOX7 Gene

Drugs & Compounds for SOX7 Gene

No Compound Related Data Available

Transcripts for SOX7 Gene

mRNA/cDNA for SOX7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX7 Gene

SRY (sex determining region Y)-box 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX7 Gene

No ASD Table

Relevant External Links for SOX7 Gene

GeneLoc Exon Structure for
SOX7
ECgene alternative splicing isoforms for
SOX7

Expression for SOX7 Gene

mRNA expression in normal human tissues for SOX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX7 Gene

This gene is overexpressed in Vagina (x8.0) and Cervix - Ectocervix (x6.9).

SOURCE GeneReport for Unigene cluster for SOX7 Gene Hs.709543

mRNA Expression by UniProt/SwissProt for SOX7 Gene

Q9BT81-SOX7_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
genes like me logo Genes that share expression patterns with SOX7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SOX7 Gene

Orthologs for SOX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOX7 35
  • 87.82 (n)
  • 88.83 (a)
dog
(Canis familiaris)
Mammalia SOX7 35
  • 91.26 (n)
  • 94.17 (a)
mouse
(Mus musculus)
Mammalia Sox7 35
  • 85.44 (n)
  • 89.21 (a)
Sox7 16
Sox7 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SOX7 35
  • 93.33 (n)
  • 91.3 (a)
rat
(Rattus norvegicus)
Mammalia Sox7 35
  • 84.77 (n)
  • 89.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves SOX7 35
  • 72.83 (n)
  • 71.2 (a)
-- 36
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sox7 35
  • 67.41 (n)
  • 70.36 (a)
Str.1804 35
African clawed frog
(Xenopus laevis)
Amphibia sox7-A 35
zebrafish
(Danio rerio)
Actinopterygii sox7 35
  • 65.1 (n)
  • 63.16 (a)
sox7 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sox15 37
  • 39 (a)
Sox15 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for SOX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOX7 Gene

ENSEMBL:
Gene Tree for SOX7 (if available)
TreeFam:
Gene Tree for SOX7 (if available)

Paralogs for SOX7 Gene

(9) SIMAP similar genes for SOX7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOX7: view

Variants for SOX7 Gene

Sequence variations from dbSNP and Humsavar for SOX7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10110624 -- 10,725,693(+) GCACA(A/G)GAAGG utr-variant-3-prime
rs11250064 -- 10,724,372(+) TTGGG(A/C)TAAGT utr-variant-3-prime
rs11984873 -- 10,723,839(+) AGTAT(C/G)AGTTG utr-variant-3-prime
rs4841432 -- 10,725,996(+) GGGGA(A/G)AGCTG reference, synonymous-codon
rs12548959 -- 10,724,074(+) ACATA(A/C)GATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOX7 Gene

Variant ID Type Subtype PubMed ID
nsv527184 CNV Loss 19592680

Variation tolerance for SOX7 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX7 Gene

Human Gene Mutation Database (HGMD)
SOX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX7 Gene

Disorders for SOX7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SOX7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uterine body mixed cancer
  • malignant mixed tumor of corpus uteri
uterine corpus cancer
  • corpus uteri cancer
- elite association - COSMIC cancer census association via MalaCards
Search SOX7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOX7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX7
genes like me logo Genes that share disorders with SOX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOX7 Gene

Publications for SOX7 Gene

  1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PMID: 11691915) Takash W. … Berta P. (Nucleic Acids Res. 2001) 2 3 4 23 67
  2. Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia. (PMID: 25940713) Man C.H. … Leung A.Y. (Blood 2015) 3
  3. Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma. (PMID: 24558429) Wu G.G. … Zeng X.C. (PLoS ONE 2014) 3
  4. Decreased expression of Sox7 correlates with the upregulation of the Wnt/I^-catenin signaling pathway and the poor survival of gastric cancer patients. (PMID: 24788044) Cui J. … Chen L. (Int. J. Mol. Med. 2014) 3
  5. The suppressive role of SOX7 in hepatocarcinogenesis. (PMID: 24816720) Wang C. … Min Z. (PLoS ONE 2014) 3

Products for SOX7 Gene

Sources for SOX7 Gene

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