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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOX7 Gene

protein-coding   GIFtS: 54
GCID: GC08M010618

SRY (Sex Determining Region Y)-Box 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SRY (Sex Determining Region Y)-Box 71 2
Transcription Factor SOX-72

External Ids:    HGNC: 181961   Entrez Gene: 835952   Ensembl: ENSG000001710567   OMIM: 6122025   UniProtKB: Q9BT813   

Export aliases for SOX7 gene to outside databases

Previous GC identifers: GC08M010645 GC08M010453 GC08M009511


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOX7 Gene:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the
regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a
transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in
tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site
family (Wnt) pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX7 Gene: 
SOX7 (SRY (sex determining region Y)-box 7) is a protein-coding gene. Diseases associated with SOX7 include barrett's adenocarcinoma, and prostate adenocarcinoma, and among its related super-pathways are Rho Family GTPases. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
Function: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes
expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity).
May be required for the survival of both hematopoietic and endothelial precursors during specification (By
similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses
Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA
sequence 5'-AACAAT-3'




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_077531.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOX7 gene promoter:
         RP58   RFX1   Lmo2   MyoD   FOXL1   AREB6   FAC1   FOXJ2 (long isoform)   FOXJ2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOX7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p22

SOX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M010618:  view genomic region     (about GC identifiers)

Start:
10,581,278 bp from pter      End:
10,697,357 bp from pter
Size:
116,080 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81 (See protein sequence)
Recommended Name: Transcription factor SOX-7  
Size: 388 amino acids; 42197 Da
Subunit: Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active
CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription
Subcellular location: Nucleus (By similarity). Cytoplasm
Developmental stage: In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae
Secondary accessions: Q53YD0

Explore the universe of human proteins at neXtProt for SOX7: NX_Q9BT81

Explore proteomics data for SOX7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BT81

  • SOX7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOX7 Protein Expression
    REFSEQ proteins: NP_113627.1  
    ENSEMBL proteins: 
     ENSP00000301921   ENSP00000452017  

    Human Recombinant Protein Products for SOX7: 
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    OriGene Protein Over-expression Lysate for SOX7
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    OriGene Custom Protein Services for SOX7
    GenScript Custom Purified and Recombinant Proteins Services for SOX7
    Novus Biologicals SOX7 Protein
    Novus Biologicals SOX7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOX7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18682240
    GO:0005737cytoplasm IDA18819930

    SOX7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SOX7 
    Cloud-Clone Corp. CLIAs for SOX7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR021934 Sox_C_TAD

    Graphical View of Domain Structure for InterPro Entry Q9BT81

    ProtoNet protein and cluster: Q9BT81

    UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
    Similarity: Contains 1 HMG box DNA-binding domain
    Similarity: Contains 1 Sox C-terminal domain


    SOX7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX7_HUMAN, Q9BT81
    Function: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes
    expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity).
    May be required for the survival of both hematopoietic and endothelial precursors during specification (By
    similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses
    Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA
    sequence 5'-AACAAT-3'

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19108950
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding ISS--
         
    SOX7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOX7:
     Big cells 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sox7):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  no phenotypic analysis 

    SOX7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sox7tm1.1Dsco for SOX7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOX7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOX7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX7
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX7 (see all 26):
    hsa-miR-3689b hsa-miR-485-3p hsa-miR-128 hsa-miR-410 hsa-miR-378b hsa-miR-378 hsa-miR-1252 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOX7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for SOX7
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    Sino Biological Human cDNA Clone for SOX7
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                         Customized lentivirus expression plasmids for stable overexpression of SOX7 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOX7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho Family GTPases
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX7
        Molecular Mechanisms of Cancer



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOX7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for SOX7 (Q9BT812, 3 ENSP000003019214) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD5Q997172, 3MINT-61824 I2D: score=3 
    SMAD7O151052, 3MINT-61812 I2D: score=3 
    DKC1ENSP000003585634STRING: ENSP00000358563
    TERF1ENSP000002766034STRING: ENSP00000276603
    MCRS1ENSP000003496404STRING: ENSP00000349640
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation IDA18682240
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008285negative regulation of cell proliferation IDA19108950
    GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA19108950
    GO:0045892negative regulation of transcription, DNA-dependent IDA19108950

    SOX7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOX7

    Search CenterWatch for drugs/clinical trials and news about SOX7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOX7 gene: 
    NM_031439.3  

    Unigene Cluster for SOX7:

    SRY (sex determining region Y)-box 7
    Hs.709543  [show with all ESTs]
    Unigene Representative Sequence: NM_031439
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304501(uc003wtf.3 uc011kwz.2) ENST00000553390
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX7
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX7 (see all 26):
    hsa-miR-3689b hsa-miR-485-3p hsa-miR-128 hsa-miR-410 hsa-miR-378b hsa-miR-378 hsa-miR-1252 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOX7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOX7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX7
    Clone
    Products:
         
    OriGene clones in human, mouse for SOX7 (see all 7)
    OriGene ORF clones in mouse, rat for SOX7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX7 (NM_031439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX7
    Sirion Biotech Customized lentivirus for stable overexpression of SOX7 
                         Customized lentivirus expression plasmids for stable overexpression of SOX7 
    Primer
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    OriGene qPCR primer pairs and template standards for SOX7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX7

    Additional mRNA sequence: 

    AJ409320.1 AK055556.1 AK223574.1 BC071947.1 BT006693.1 

    4 DOTS entries:

    DT.220410  DT.121476709  DT.95302216  DT.97782023 

    24/46 AceView cDNA sequences (see all 46):

    BI771093 AW051986 BT006693 BC071947 T94425 AK055556 AA972681 BQ933022 
    AI379326 NM_031439 AJ409320 BI771765 BG291337 AI808807 BP350640 BI052457 
    BX099602 BI052456 AA035211 BE788436 BU753665 BI224196 BG740632 AI160965 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOX7 expression in normal human tissues (normalized intensities)      SOX7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAATAAT
    SOX7 Expression
    About this image


    SOX7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 23 entries
             Angioblasts Embryonic Capillary Plexus
             PureStem endothelial progenitor 30-SM2-1
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
             blood vessel   
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             S-shaped Body Cells S-shaped Body
             S-shaped Body
             Human Renal Glomerular Endothelial Cells (HRGEC)   
             visceral organ/metanephros/renal cortex   
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 5 entries
             Morula Cells Morula
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 5 entries
             Morula Cells Morula
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   

    See SOX7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOX7

    SOURCE GeneReport for Unigene cluster: Hs.709543

    UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
    Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells
    in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal
    tumors due to promoter hypermethylation

        SABiosciences Expression via Pathway-Focused PCR Array including SOX7: 
              Cell Lineage Identification in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SOX7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox71 , 5 SRY-box containing gene 71, 5 85.35(n)1
    89.21(a)1
      14 (33.34 cM)5
    206801  NM_011446.11  NP_035576.11 
     639437065 
    chicken
    (Gallus gallus)
    Aves SOX71 SRY (sex determining region Y)-box 7 72.83(n)
    71.2(a)
      771337  XM_001234627.2  XP_001234628.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia sox7-A2 SRY (sex determining region Y)-box 7, xSox7 protein 80.11(n)    D83649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sox72 SRY (sex determining region Y)-box 7 78.49(n)   394203  AY423014.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox153 DNA bending 39(a)   50E4   --


    ENSEMBL Gene Tree for SOX7 (if available)
    TreeFam Gene Tree for SOX7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOX7 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX112  
    SOX82  SRY2  SOX102  
    9 SIMAP similar genes for SOX7 using alignment to 2 protein entries:     SOX7_HUMAN (see all proteins):
    PINX1    soxB    SOX10    SOX26    SOX17    SOX27
    SOX28    SOX25    SRY

    SOX7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 SNPs in SOX7 are shown (see all 254)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69986341,2
    C,F--10580860(+) cgaaaG/Ccccgt 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs69986351,2
    C,F--10580861(+) gaaacA/Cccgtc 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs349435461,2
    C--10580895(+) AAAAA-/AATAGCT 1 -- ds50011Minor allele frequency- AA:0.00NA 2
    rs1852359501,2
    --10580924(+) GCAAAC/TGAGTA 1 -- ds50010--------
    rs1910224771,2
    --10580962(+) AGCCTC/TATAGT 1 -- ds50010--------
    rs125493711,2
    H--10581055(+) CATTGT/GCAATA 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs1493838841,2
    --10581280(+) CAGTCA/CTGGTA 1 -- ut310--------
    rs119848731,2
    C,F,H--10581349(+) AGTATG/CAGTTG 1 -- ut315Minor allele frequency- C:0.01NS EA WA 538
    rs1447433651,2
    C--10581377(+) AACAGC/TTTAGC 1 -- ut310--------
    rs1481309661,2
    --10581388(+) TTAATA/GTCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SOX7 (10581278 - 10697357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOX7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527184CNV Loss19592680


    Human Gene Mutation Database (HGMD): SOX7
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612202    OMIM disorders: --

    7 diseases for SOX7:    About MalaCards
    barrett's adenocarcinoma    prostate adenocarcinoma    myelodysplastic syndromes    colorectal cancer
    adenocarcinoma    endotheliitis    prostatitis


    SOX7 for disorders           About GeneDecksing


    Export disorders for SOX7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOX7 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SOX7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PubMed id 11691915)1, 2, 3, 9 Takash W....Berta P. (2001)
    2. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. (PubMed id 18819930)1, 2 Guo L....Zhou W. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Methylation of the CpG island near SOX7 gene promoter is correlated with the poor prognosis of patients with myelodysplastic syndrome. (PubMed id 22706399)1 Fan R....Lin G.W. (2012)
    6. Down-regulation of Sox7 is associated with aberrant ac tivation of Wnt/b-catenin signaling in endometrial cancer. (PubMed id 23295859)1 Chan D.W....Ngan H.Y. (2012)
    7. Decreased expression of SOX7 is correlated with poor p rognosis in lung adenocarcinoma patients. (PubMed id 22777918)1 Li B....Zhang Y. (2012)
    8. SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. (PubMed id 22171135)1 Zhou X....Zhang Y. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influe nce the microcirculation in vivo. (PubMed id 21060863)1 Ikram M.K....Wong T.Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83595 HGNC: 18196 AceView: SOX7 Ensembl:ENSG00000171056 euGenes: HUgn83595
    ECgene: SOX7 H-InvDB: SOX7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOX7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOX7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOX7 gene:
    Search GeneIP for patents involving SOX7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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