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Aliases for SOX7 Gene

Aliases for SOX7 Gene

  • SRY-Box 7 2 3 5
  • SRY (Sex Determining Region Y)-Box 7 2
  • SRY Box 7 2

External Ids for SOX7 Gene

Previous GeneCards Identifiers for SOX7 Gene

  • GC08M010645
  • GC08M010453
  • GC08M010618
  • GC08M009511
  • GC08M010581

Summaries for SOX7 Gene

Entrez Gene Summary for SOX7 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX7 Gene

SOX7 (SRY-Box 7) is a Protein Coding gene. Diseases associated with SOX7 include Uterine Body Mixed Cancer. Among its related pathways are Signaling by Wnt and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ENSG00000258724.

UniProtKB/Swiss-Prot for SOX7 Gene

  • Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Additional gene information for SOX7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX7 Gene

Genomics for SOX7 Gene

Regulatory Elements for SOX7 Gene

Enhancers for SOX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H010812 1 ENCODE dbSUPER 17.1 -83.3 -83330 2 CTCF ZNF197 ETV1 ZNF175 USF2 REST ELF1 RAD21 GABPA FOSL1 SOX7 RP1L1 PINX1 LOC101929229 ENSG00000269918 GC08M010803 MIR1322
GH08H010775 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -46.7 -46669 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 CAVIN1 RP1L1 SOX7 ENSG00000255310 ENSG00000269918 GC08M010757 GC08M010803
GH08H010798 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -69.9 -69873 4 PKNOX1 ATF1 ARNT ARID4B FEZF1 YY1 TCF12 ATF7 FOS DEK RP1L1 C8orf74 LOC102723313 ENSG00000269918 SOX7 ENSG00000255310 GC08M010803 GC08M010757
GH08H010714 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +14.3 14334 3 HDAC1 TBP ATF1 RB1 KLF17 RAD21 TCF12 EGR1 ETV6 ATF7 C8orf74 ENSG00000269918 SOX7 RP1L1 LOC102723313
GH08H010787 1.3 Ensembl ENCODE dbSUPER 8.7 -58.5 -58498 3 CTCF TAL1 JUN BATF RAD21 MTA3 CTBP1 EED FOS ETV6 ENSG00000255310 SOX7 RP1L1 ENSG00000269918 GC08M010803 GC08M010757
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOX7 on UCSC Golden Path with GeneCards custom track

Promoters for SOX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220988 274 1001 SUZ12 MAX ZIC2 E2F1 POLR2A ZBTB48 PATZ1 ZNF143 ZNF391 ZBTB20

Genomic Location for SOX7 Gene

Chromosome:
8
Start:
10,723,768 bp from pter
End:
10,730,574 bp from pter
Size:
6,807 bases
Orientation:
Minus strand

Genomic View for SOX7 Gene

Genes around SOX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX7 Gene

Proteins for SOX7 Gene

  • Protein details for SOX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT81-SOX7_HUMAN
    Recommended name:
    Transcription factor SOX-7
    Protein Accession:
    Q9BT81
    Secondary Accessions:
    • B4DKV0
    • Q53YD0

    Protein attributes for SOX7 Gene

    Size:
    388 amino acids
    Molecular mass:
    42197 Da
    Quaternary structure:
    • Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.

    Alternative splice isoforms for SOX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX7 Gene

Post-translational modifications for SOX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX7 Gene

Domains & Families for SOX7 Gene

Gene Families for SOX7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOX7 Gene

Suggested Antigen Peptide Sequences for SOX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX7: view

No data available for UniProtKB/Swiss-Prot for SOX7 Gene

Function for SOX7 Gene

Molecular function for SOX7 Gene

UniProtKB/Swiss-Prot Function:
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Phenotypes From GWAS Catalog for SOX7 Gene

Gene Ontology (GO) - Molecular Function for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 19108950
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with SOX7: view
genes like me logo Genes that share phenotypes with SOX7: view

Animal Models for SOX7 Gene

MGI Knock Outs for SOX7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SOX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX7 Gene

Localization for SOX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18682240
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 18819930
genes like me logo Genes that share ontologies with SOX7: view

Pathways & Interactions for SOX7 Gene

genes like me logo Genes that share pathways with SOX7: view

Interacting Proteins for SOX7 Gene

Gene Ontology (GO) - Biological Process for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001706 endoderm formation IDA 18682240
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation IDA 19108950
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 19108950
genes like me logo Genes that share ontologies with SOX7: view

No data available for SIGNOR curated interactions for SOX7 Gene

Drugs & Compounds for SOX7 Gene

No Compound Related Data Available

Transcripts for SOX7 Gene

mRNA/cDNA for SOX7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX7 Gene

SRY (sex determining region Y)-box 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SOX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SOX7 Gene

No ASD Table

Relevant External Links for SOX7 Gene

GeneLoc Exon Structure for
SOX7
ECgene alternative splicing isoforms for
SOX7

Expression for SOX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX7 Gene

This gene is overexpressed in Vagina (x8.0) and Cervix - Ectocervix (x6.9).

NURSA nuclear receptor signaling pathways regulating expression of SOX7 Gene:

SOX7

SOURCE GeneReport for Unigene cluster for SOX7 Gene:

Hs.709543

mRNA Expression by UniProt/SwissProt for SOX7 Gene:

Q9BT81-SOX7_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.

Evidence on tissue expression from TISSUES for SOX7 Gene

  • Lung(4.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with SOX7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX7 Gene

Orthologs for SOX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX7 33
  • 93.33 (n)
dog
(Canis familiaris)
Mammalia SOX7 33
  • 91.26 (n)
cow
(Bos Taurus)
Mammalia SOX7 33
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Sox7 33 16 34
  • 85.44 (n)
rat
(Rattus norvegicus)
Mammalia Sox7 33
  • 84.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves SOX7 33
  • 72.83 (n)
-- 34
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sox7 33
  • 67.41 (n)
Str.1804 33
African clawed frog
(Xenopus laevis)
Amphibia sox7-A 33
zebrafish
(Danio rerio)
Actinopterygii sox7 33 34
  • 65.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sox15 35 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToMany
Species where no ortholog for SOX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOX7 Gene

ENSEMBL:
Gene Tree for SOX7 (if available)
TreeFam:
Gene Tree for SOX7 (if available)

Paralogs for SOX7 Gene

(9) SIMAP similar genes for SOX7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOX7: view

Variants for SOX7 Gene

Sequence variations from dbSNP and Humsavar for SOX7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs879255423 Uncertain significance 10,726,113(-) GGCCA(C/G)TCCCC reference, missense
rs1000177021 -- 10,730,449(+) GGGTC(A/G)CCTCG intron-variant, utr-variant-5-prime
rs1000250441 -- 10,730,558(+) GGCGG(C/T)CGCGT intron-variant, utr-variant-5-prime
rs1000259362 -- 10,725,414(+) TGTCC(C/T)CCCAT utr-variant-3-prime
rs1000636595 -- 10,724,605(+) GAGTT(A/G)GCAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOX7 Gene

Variant ID Type Subtype PubMed ID
nsv1032725 CNV loss 25217958
nsv527184 CNV loss 19592680

Variation tolerance for SOX7 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX7 Gene

Human Gene Mutation Database (HGMD)
SOX7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX7 Gene

Disorders for SOX7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOX7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
uterine body mixed cancer
  • malignant mixed tumor of corpus uteri
- elite association - COSMIC cancer census association via MalaCards
Search SOX7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOX7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX7
genes like me logo Genes that share disorders with SOX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOX7 Gene

Publications for SOX7 Gene

  1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PMID: 11691915) Takash W … Berta P (Nucleic acids research 2001) 2 3 4 22 60
  2. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. (PMID: 18819930) Guo L … Zhou W (Molecular cancer research : MCR 2008) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7. (PMID: 26515813) Bao Y … Chen J (Clinical and experimental medicine 2017) 3 60

Products for SOX7 Gene

Sources for SOX7 Gene

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