Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SOX7 Gene

protein-coding   GIFtS: 50
GCID: GC08M010581

SRY (Sex Determining Region Y)-Box 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SRY (Sex Determining Region Y)-Box 71 2
Transcription Factor SOX-72

External Ids:    HGNC: 181961   Entrez Gene: 835952   Ensembl: ENSG000001710567   OMIM: 6122025   UniProtKB: Q9BT813   

Export aliases for SOX7 gene to outside databases

Previous GC identifers: GC08M010645 GC08M010453 GC08M010618 GC08M009511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SOX7 Gene:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the
regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a
transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in
tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site
family (Wnt) pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX7 Gene:
SOX7 (SRY (sex determining region Y)-box 7) is a protein-coding gene. Diseases associated with SOX7 include barrett's adenocarcinoma, and prostate adenocarcinoma. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
Function: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes
expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity).
May be required for the survival of both hematopoietic and endothelial precursors during specification (By
similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses
Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA
sequence 5'-AACAAT-3'




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX7 gene promoter:
         RP58   RFX1   Lmo2   MyoD   FOXL1   AREB6   FAC1   FOXJ2 (long isoform)   FOXJ2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX7 promoter sequence
   Search Chromatin IP Primers for SOX7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p22

SOX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M010581:  view genomic region     (about GC identifiers)

Start:
10,581,278 bp from pter      End:
10,697,357 bp from pter
Size:
116,080 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81 (See protein sequence)
Recommended Name: Transcription factor SOX-7  
Size: 388 amino acids; 42197 Da
Subunit: Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active
CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription
Developmental stage: In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae
Secondary accessions: Q53YD0

Explore the universe of human proteins at neXtProt for SOX7: NX_Q9BT81

Explore proteomics data for SOX7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113627.1  
    ENSEMBL proteins: 
     ENSP00000301921   ENSP00000452017  

    SOX7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SOX7
    OriGene Protein Over-expression Lysate for SOX7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SOX7
    GenScript Custom Purified and Recombinant Proteins Services for SOX7
    Novus Biologicals SOX7 Protein
    Novus Biologicals SOX7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOX7

    SOX7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SOX7
    OriGene Antibodies for SOX7
    OriGene Custom Antibody Services for SOX7
    Novus Biologicals SOX7 Antibodies
    Abcam antibodies for SOX7
    Cloud-Clone Corp. Antibodies for SOX7
    ThermoFisher Antibodies for SOX7
    LSBio Antibodies in human, mouse, rat for SOX7

    SOX7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SOX7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOX7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOX7
    Cloud-Clone Corp. CLIAs for SOX7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR021934 Sox_C_TAD

    Graphical View of Domain Structure for InterPro Entry Q9BT81

    ProtoNet protein and cluster: Q9BT81

    UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
    Similarity: Contains 1 HMG box DNA-binding domain
    Similarity: Contains 1 Sox C-terminal domain


    SOX7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX7_HUMAN, Q9BT81
    Function: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes
    expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity).
    May be required for the survival of both hematopoietic and endothelial precursors during specification (By
    similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses
    Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA
    sequence 5'-AACAAT-3'

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19108950
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding ----
    GO:0044212transcription regulatory region DNA binding ISS--
         
    SOX7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOX7:
     Big cells 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sox7):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  no phenotypic analysis 

    SOX7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sox7tm1.1Dsco for SOX7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SOX7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX7 (see all 26):
    hsa-miR-3689b hsa-miR-485-3p hsa-miR-128 hsa-miR-410 hsa-miR-378b hsa-miR-378 hsa-miR-1252 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOX7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOX7
    Predesigned siRNA for gene silencing in human, mouse, rat SOX7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOX7

    Clone
    Products:
         
    OriGene clones in human, mouse for SOX7 (see all 6)
    OriGene ORF clones in mouse, rat for SOX7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX7 (NM_031439)
    Sino Biological Human cDNA Clone for SOX7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOX7
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOX7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SOX7_HUMAN, Q9BT81: Nucleus (By similarity). Cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18682240
    GO:0005737cytoplasm IDA18819930

    SOX7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SOX7 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX7
        Molecular Mechanisms of Cancer



        Pathway & Disease-focused RT2 Profiler PCR Array including SOX7: 
              Cell Lineage Identification in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SOX7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOX7 (Q9BT812, 3 ENSP000003019214) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD5Q997172, 3MINT-61824 I2D: score=3 
    SMAD7O151052, 3MINT-61812 I2D: score=3 
    DKC1ENSP000003585634STRING: ENSP00000358563
    TERF1ENSP000002766034STRING: ENSP00000276603
    MCRS1ENSP000003496404STRING: ENSP00000349640
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation IDA18682240
    GO:0006351transcription, DNA-templated IEA--
    GO:0008285negative regulation of cell proliferation IDA19108950
    GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA19108950
    GO:0045892negative regulation of transcription, DNA-templated IDA19108950

    SOX7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SOX7 gene: 
    NM_031439.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304501(uc003wtf.3 uc011kwz.2) ENST00000553390
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOX7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX7 (see all 26):
    hsa-miR-3689b hsa-miR-485-3p hsa-miR-128 hsa-miR-410 hsa-miR-378b hsa-miR-378 hsa-miR-1252 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOX7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOX7
    Predesigned siRNA for gene silencing in human, mouse, rat SOX7
    Clone
    Products:
         
    OriGene clones in human, mouse for SOX7 (see all 6)
    OriGene ORF clones in mouse, rat for SOX7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX7 (NM_031439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SOX7
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX7
      QuantiTect SYBR Green Assays in human, mouse, rat SOX7
      QuantiFast Probe-based Assays in human, mouse, rat SOX7

    Selected AceView cDNA sequences (see all 46):

    BT006693 AJ409320 NM_031439 BI771093 BC071947 AK055556 AI379326 AW051986 
    AA972681 T94425 BQ933022 AI160965 BU688398 BM450788 BI771765 BU187815 
    BI052457 BI224196 BE671627 AA035211 BU753665 BI052456 BX099602 BG740632 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SOX7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAATAAT
    SOX7 Expression
    About this image


    SOX7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 4 entries
             Hypoblast Cells Hypoblast
             Extraembryonic endoderm-like cells
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Interstitial Stroma Cells Interstitial Stroma
             S-shaped Body
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angioblasts Embryonic Blood Islands
             Human umbilical vein endothelial cells (HUVEC)
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 3 entries
             Primitive Streak Cells Primitive Streak
             Primitive streak-like cells
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 2 entries
             Visceral Endoderm Cells Visceral Endoderm
    SOX7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX7 Protein Expression

    UniProtKB/Swiss-Prot: SOX7_HUMAN, Q9BT81
    Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells
    in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal
    tumors due to promoter hypermethylation

        Pathway & Disease-focused RT2 Profiler PCR Array including SOX7: 
              Cell Lineage Identification in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SOX7
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX7
    QuantiTect SYBR Green Assays in human, mouse, rat SOX7
    QuantiFast Probe-based Assays in human, mouse, rat SOX7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SOX7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox71 , 5 SRY-box containing gene 75
    SRY (sex determining region Y)-box 71
    85.44(n)1
    89.21(a)1
      14 (33.34 cM)5
    206801  NM_011446.11  NP_035576.11 
     639437065 
    chicken
    (Gallus gallus)
    Aves SOX71 SRY (sex determining region Y)-box 7 72.83(n)
    71.2(a)
      771337  XM_001234627.3  XP_001234628.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia sox7-A2 SRY (sex determining region Y)-box 7, xSox7 protein 80.11(n)    D83649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sox72 SRY (sex determining region Y)-box 7 78.49(n)   394203  AY423014.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox153 DNA bending 39(a)   50E4   --


    ENSEMBL Gene Tree for SOX7 (if available)
    TreeFam Gene Tree for SOX7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SOX7 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX112  
    SOX82  SRY2  SOX102  
    9 SIMAP similar genes for SOX7 using alignment to 2 protein entries:     SOX7_HUMAN (see all proteins):
    PINX1    soxB    SOX10    SOX26    SOX17    SOX27
    SOX28    SOX25    SRY

    SOX7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SOX7 (see all 254)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69986341,2
    C,F--10580860(+) cgaaaG/Ccccgt 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs69986351,2
    C,F--10580861(+) gaaacA/Cccgtc 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs349435461,2
    C--10580895(+) AAAAA-/AATAGCT 1 -- ds50011Minor allele frequency- AA:0.00NA 2
    rs1852359501,2
    --10580924(+) GCAAAC/TGAGTA 1 -- ds50010--------
    rs1910224771,2
    --10580962(+) AGCCTC/TATAGT 1 -- ds50010--------
    rs125493711,2
    H--10581055(+) CATTGT/GCAATA 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs1493838841,2
    --10581280(+) CAGTCA/CTGGTA 1 -- ut310--------
    rs119848731,2
    C,F,H--10581349(+) AGTATG/CAGTTG 1 -- ut315Minor allele frequency- C:0.01NS EA WA 538
    rs1447433651,2
    C--10581377(+) AACAGC/TTTAGC 1 -- ut310--------
    rs1481309661,2
    --10581388(+) TTAATA/GTCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SOX7 (10581278 - 10697357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOX7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527184CNV Loss19592680

    Human Gene Mutation Database (HGMD): SOX7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOX7
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612202    OMIM disorders: --

    10 diseases for SOX7:    
    About MalaCards
    barrett's adenocarcinoma    prostate adenocarcinoma    myelodysplastic syndromes    endotheliitis
    adenocarcinoma    lung adenocarcinoma    colorectal cancer    prostatitis
    cerebritis    thyroiditis


    SOX7 for disorders           About GeneDecksing


    Export disorders for SOX7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SOX7 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SOX7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PubMed id 11691915)1, 2, 3, 9 Takash W....Berta P. (Nucleic Acids Res. 2001)
    2. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. (PubMed id 18819930)1, 2 Guo L.... Zhou W. (Mol. Cancer Res. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. SOX7 is down-regulated in lung cancer. (PubMed id 23557216)1 Hayano T....Koeffler H.P. (amp 2013)
    6. Methylation of the CpG island near SOX7 gene promoter is correlated with the poor prognosis of patients with myelodysplastic syndrome. (PubMed id 22706399)1 Fan R....Lin G.W. (Tohoku J. Exp. Med. 2012)
    7. Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer. (PubMed id 23295859)1 Chan D.W....Ngan H.Y. (Oncotarget 2012)
    8. Decreased expression of SOX7 is correlated with poor prognosis in lung adenocarcinoma patients. (PubMed id 22777918)1 Li B....Zhang Y. (Pathol. Oncol. Res. 2012)
    9. SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. (PubMed id 22171135)1 Zhou X....Zhang Y. (World J. Gastroenterol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83595 HGNC: 18196 AceView: SOX7 Ensembl:ENSG00000171056 euGenes: HUgn83595
    ECgene: SOX7 H-InvDB: SOX7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SOX7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOX7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SOX7 gene:
    Search GeneIP for patents involving SOX7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SOX7 (SOX7)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SOX7   OriGene RNAi products in human, mouse, rat for SOX7  
     OriGene qPCR primer pairs and template standards for SOX7   OriGene Protein Over-expression Lysate for SOX7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SOX7  
     OriGene qSTAR qPCR primer pairs in human, mouse for SOX7   OriGene Purified Protein for SOX7  
     OriGene ORF clones in mouse, rat for SOX7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SOX7   OriGene Custom Protein Services for SOX7  

     
     
     Block miRNA regulation of human, mouse, rat SOX7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SOX7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX7 Predesigned siRNA for gene silencing in human, mouse, rat SOX7
     QuantiFast Probe-based Assays in human, mouse, rat SOX7 QuantiTect SYBR Green Assays in human, mouse, rat SOX7
     PCR Arrays including human, mouse, rat SOX7 Search Chromatin IP Primers for SOX7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX7  Search GeneGlobe Interaction Network for SOX7
     Regulatory tfbs in SOX7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SOX7 GenScript cDNA clones with any tag delivered in your preferred vector for SOX7
     GenScript Custom Assay Services for SOX7 GenScript Custom overexpressing Cell Line Services for SOX7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SOX7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SOX7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SOX7 antibodies
     SOX7 proteins
     SOX7 lysates
     Antibodies for SOX7
     See all of Abcam's Antibodies, Kits and Proteins for SOX7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SOX7
     Antibodies for SOX7
     ELISAs for SOX7
     CLIAs for SOX7



     Browse ESI BIO Cell Lines and PureStem Progenitors for SOX7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX7
     SwitchGear 3'UTR luciferase reporter plasmids for SOX7
     SwitchGear Promoter luciferase reporter plasmids for SOX7
     ThermoFisher Antibodies for SOX7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX7
     LSBio Antibodies in human, mouse, rat for SOX7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SOX7 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4