SOX6 Gene

Aliases
for SOX6 gene

Previous GC identifers: GC11M017086 GC11M016740 GC11M016032 GC11M015957 GC11M015673

Summaries
for SOX6 gene

Genomic Views
for SOX6 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_009237.18  

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOX6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX6

SOX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M015949:  view genomic region     (about GC identifiers)

Proteins
for SOX6 gene

Explore the universe of human proteins at neXtProt for SOX6: NX_P35712

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SOX6 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SOX6
	GenScript Custom Purified and Recombinant Proteins Services for SOX6
	Novus Biologicals SOX6 Protein Novus Biologicals SOX6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOX6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SOX6
	R&D Systems Antibodies for SOX6
	Browse OriGene Antibodies OriGene Custom Antibody Services for SOX6
	GenScript Custom Superior Antibodies Services for SOX6
	Novus Biologicals SOX6 Antibodies
	Search for Antibodies for SOX6 at Abcam
	Uscn Antibodies for SOX6
	ThermoFisher Antibodies for SOX6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOX6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOX6

Protein Domains /
Families
for SOX6 gene

ProtoNet protein and cluster: P35712

Function
for SOX6 gene

miRNA Products:		miRTarBase miRNAs that target SOX6: hsa-mir-1 (MIRT003203), hsa-mir-499-5p (MIRT004658)
		OriGene 3'-UTR Clone (see all 4): SOX6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX6
		8/147 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX6 (see all 147):
		hsa-miR-576-3p hsa-miR-100* hsa-miR-520f hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-342-3p hsa-miR-208b hsa-miR-200b
		SwitchGear 3'UTR luciferase reporter plasmid: SOX6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX6 (see all 6) OriGene siRNA: SOX6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SOX6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX6 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX6 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SOX6 (NM_033326)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOX6
		Search LifeMap BioReagents cell lines for SOX6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 3 alleles) (MGI details for Sox6)

Pathways & Interactions
for SOX6 gene

	Super-pathway	contained gene-specific pathways
1	Endochondral Ossification	Endochondral Ossification 1.00
2	Rho Family GTPases	Molecular Mechanisms of Cancer 0.51

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX6

Molecular Mechanisms of Cancer

1 BioSystems Pathway for SOX6

Endochondral Ossification

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

Drugs & Compounds
for SOX6 gene

Transcripts
for SOX6 gene

Expression
for SOX6 gene

SOX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATCTTTGG

10/33 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 33)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneAutopod Epiphyseal EndChondrocytes			Bone, Cartilage
	BoneAutopod Epiphyseal EndPrechondrocytes			Bone, Cartilage
	BoneCervical VertebraeChondrocytes			Bone, Cartilage
	BoneCervical VertebraePrechondrocytes			Bone, Cartilage
	BoneLumbar VertebraeChondrocytes			Bone, Cartilage
	BoneLumbar VertebraePrechondrocytes			Bone, Cartilage
	BoneSacral VertebraeChondrocytes			Bone, Cartilage
	BoneSacral VertebraePrechondrocytes			Bone, Cartilage
	BoneStylopod Epiphyseal EndChondrocytes			Bone, Cartilage
	BoneStylopod Epiphyseal EndPrechondrocytes			Bone, Cartilage
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Sclerotome cells (Primary Cell)			Bone, Cartilage, Somite
	Chondrocyte-like cells (Direct differentiati...)			Bone, Cartilage
	Mesoderm-like cells (Direct differentiati...)			Mesoderm

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOX6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX6

Orthologs
for SOX6 gene

Paralogs
for SOX6 gene

Paralogs for SOX6 gene

SOX13²  SOX2²  SOX4²  SOX1²  SOX14²  SOX3²  SOX9²  SOX12²  

SOX15²  SOX18²  SOX5²  ENSG00000258724²  SOX21²  SOX17²  SOX11²  SOX8²  

SRY²  SOX10²  SOX7²  

10 SIMAP similar genes for SOX6 using alignment to 6 protein entries:     SOX6_HUMAN (see all proteins):

SOX5P    SOX17    SRY    soxB    SOX25    SOX27

SOX26    SOX28    SOX5    SOX10

SOX6 for paralogs           About GeneDecksing

Genomic Variants
for SOX6 gene

10/6959 NCBI SNPs in SOX6 are shown (see all 6959)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs754511461,2	F,	--	15672927(+)	TCAGGT/CAAAGA	4	--	ds5001		3		CSA WA	122
rs118234671,2	C,H	--	15674953(+)	AATGAT/CGCAAG	4	--	ut31		5		NS EA NA	426
rs734170041,2	C,F,	--	15675142(+)	GCTGCA/GTTTCT	4	--	ut31		3		WA CSA	122
rs753827231,2		--	15675393(+)	ACTCCG/AAAGAA	4	--	ut31		1		WA	118
rs110238021,2	C,F,H,	--	15675650(+)	AAACCG/AAGGTG	4	--	ut31		5		NS NA	586
rs47568401,2	C,H	--	15676507(+)	AATTAG/CAAAAA	4	--	ut31		4		NS EA	418
rs1131347971,2		--	15676747(+)	AGAACG/ATGGCT	4	--	ut31		1		CSA	2
rs1132341361,2		--	15677304(+)	GGAGAG/AGTATA	4	--	ut31		1		CSA	2
rs747046751,2	C,F,	--	15678515(+)	CACTAT/CGTACA	4	--	ut31		1		WA	118
rs782436331,2	C,	--	15678543(+)	AAGGAC/TGGAAA	4	--	ut31		2		CSA WA	119

HapMap Linkage Disequilibrium report for SOX6 (15987995 - 16237995 bp, first 250kb of SOX6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SOX6
     3 CNVs: 23106 101145 101146
     1 Indel: 60036
Human Gene Mutation Database (HGMD): SOX6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX6

DNA2.0 Custom Variant and Variant Library Synthesis for SOX6

Disorders / Diseases
for SOX6 gene

13 diseases for SOX6

1 Novoseek disease relationship for SOX6 gene    About this table

Publications
for SOX6 gene

PubMed articles for SOX6 gene, integrated from 9 sources (see all 56): (articles sorted by number of sources associating them with SOX6)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, characterization and chromosome mapping of the human SOX6 gene. (PubMed id 11255018)^{1, 2, 3, 9} Cohen-Barak O.... Brilliant M.H. (2001)
2. Repression of SOX6 transcriptional activity by SUMO modification. (PubMed id 16442531)^{1, 2} Fernandez-Lloris R.... Ventura F. (2006)
3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
4. A conserved family of genes related to the testis determining gene, SRY. (PubMed id 1614875)^{1, 2} Denny P.... Ashworth A. (1992)
5. Powerful bivariate genome-wide association analyses s uggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in ma les. (PubMed id 19714249)^{1, 9} Liu Y.Z....Deng H.W. (2009)
6. Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. (PubMed id 10760285)^{1, 9} Hagiwara N....Brilliant M.H. (2000)
7. Identification of novel germline polymorphisms governi ng capecitabine sensitivity. (PubMed id 22864933)¹ O'Donnell P.H....Dolan M.E. (2012)
8. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. (PubMed id 22547066)¹ Yamashita S....Asahara H. (2012)
9. Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations. (PubMed id 21625884)¹ Yang T.L....Deng H.W. (2012)
10. SHOX interacts with the chondrogenic transcription fa ctors SOX5 and SOX6 to activate the aggrecan enhancer. (PubMed id 21262861)¹ Aza-Carmona M....Heath K.E. (2011)

External Searches for SOX6 gene

Genome Databases showing SOX6 gene

Other Databases showing SOX6 gene

Specialized Databases showing SOX6 gene

Products
for SOX6 gene