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Aliases for SOX4 Gene

Aliases for SOX4 Gene

  • SRY-Box 4 2 3 5
  • SRY (Sex Determining Region Y)-Box 4 2 3
  • SRY Box 4 2 3
  • Ecotropic Viral Integration Site 16 3
  • SRY-Related HMG-Box Gene 4 3
  • EVI16 3

External Ids for SOX4 Gene

Previous GeneCards Identifiers for SOX4 Gene

  • GC06P021651
  • GC06P021701

Summaries for SOX4 Gene

Entrez Gene Summary for SOX4 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX4 Gene

SOX4 (SRY-Box 4) is a Protein Coding gene. Diseases associated with SOX4 include Pediatric Ependymoma. Among its related pathways are ERK Signaling and IL-5 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX4 Gene

  • Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5-AACAAAG-3 motif.

Gene Wiki entry for SOX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX4 Gene

Genomics for SOX4 Gene

Regulatory Elements for SOX4 Gene

Enhancers for SOX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOX4 Gene

21,592,769 bp from pter
21,598,619 bp from pter
5,851 bases
Plus strand

Genomic View for SOX4 Gene

Genes around SOX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX4 Gene

Proteins for SOX4 Gene

  • Protein details for SOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-4
    Protein Accession:

    Protein attributes for SOX4 Gene

    474 amino acids
    Molecular mass:
    47263 Da
    Quaternary structure:
    • Interacts with UBE2I.

neXtProt entry for SOX4 Gene

Proteomics data for SOX4 Gene at MOPED

Post-translational modifications for SOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX4 Gene

Domains & Families for SOX4 Gene

Gene Families for SOX4 Gene

Protein Domains for SOX4 Gene


Suggested Antigen Peptide Sequences for SOX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX4: view

Function for SOX4 Gene

Molecular function for SOX4 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 4,transcriptional activator in embryonic heart,developing CNS,lung,tooth-bud,mesonephros,genitalia,pre B and T cells,controlled by progesterone,expressed in normal breast and in breast cancer cells,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5-AACAAAG-3 motif.

Gene Ontology (GO) - Molecular Function for SOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IEA,IDA 20049565
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 7706298
genes like me logo Genes that share ontologies with SOX4: view
genes like me logo Genes that share phenotypes with SOX4: view

Animal Models for SOX4 Gene

MGI Knock Outs for SOX4:

Animal Model Products

miRNA for SOX4 Gene

miRTarBase miRNAs that target SOX4
Targeted motifs for SOX4 Gene
HOMER Transcription Factor Regulatory Elements motif SOX4
  • Consensus sequence: YCTTTGTTCC Submotif: canonical Cell Type: proB GEO ID: GSE50066

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for SOX4 Gene

Localization for SOX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX4 Gene

Subcellular locations from

Jensen Localization Image for SOX4 Gene COMPARTMENTS Subcellular localization image for SOX4 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for SOX4 Gene

Pathways & Interactions for SOX4 Gene

genes like me logo Genes that share pathways with SOX4: view

Pathways by source for SOX4 Gene

1 KEGG pathway for SOX4 Gene
1 Qiagen pathway for SOX4 Gene

Gene Ontology (GO) - Biological Process for SOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001841 neural tube formation IEA,ISS --
GO:0002328 pro-B cell differentiation IEA,ISS --
GO:0003183 mitral valve morphogenesis IEA,ISS --
GO:0003211 cardiac ventricle formation IEA,ISS --
GO:0003289 atrial septum primum morphogenesis IEA,ISS --
genes like me logo Genes that share ontologies with SOX4: view

No data available for SIGNOR curated interactions for SOX4 Gene

Drugs & Compounds for SOX4 Gene

(2) Drugs for SOX4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SOX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOX4: view

Transcripts for SOX4 Gene

mRNA/cDNA for SOX4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(531) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX4 Gene

SRY (sex determining region Y)-box 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX4 Gene

No ASD Table

Relevant External Links for SOX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX4 Gene

mRNA expression in normal human tissues for SOX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX4 Gene

This gene is overexpressed in Ovary (x4.9).

Protein differential expression in normal tissues from HIPED for SOX4 Gene

This gene is overexpressed in Brain (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX4 Gene

SOURCE GeneReport for Unigene cluster for SOX4 Gene Hs.643910

mRNA Expression by UniProt/SwissProt for SOX4 Gene

Tissue specificity: Testis, brain, and heart.
genes like me logo Genes that share expression patterns with SOX4: view

Protein tissue co-expression partners for SOX4 Gene

- Elite partner

Primer Products

Orthologs for SOX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOX4 35
  • 87.98 (n)
  • 87.55 (a)
SOX4 36
  • 95 (a)
(Canis familiaris)
Mammalia SOX4 35
  • 91.45 (n)
  • 91.55 (a)
SOX4 36
  • 92 (a)
(Mus musculus)
Mammalia Sox4 35
  • 80 (n)
  • 78.41 (a)
Sox4 16
Sox4 36
  • 88 (a)
(Pan troglodytes)
Mammalia SOX4 35
  • 99.58 (n)
  • 100 (a)
SOX4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sox4 35
  • 79.7 (n)
  • 78.18 (a)
(Monodelphis domestica)
Mammalia SOX4 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SOX4 36
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sox4 35
  • 84.18 (n)
  • 94.89 (a)
Str.9180 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68880 35
(Danio rerio)
Actinopterygii -- 35
sox4b 35
  • 81.92 (n)
  • 81.92 (a)
sox4a 36
  • 60 (a)
sox4b 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sox14 37
  • 40 (a)
Sox14 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea sem-2 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10865 36
  • 20 (a)
Species with no ortholog for SOX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX4 Gene

Gene Tree for SOX4 (if available)
Gene Tree for SOX4 (if available)

Paralogs for SOX4 Gene

(2) SIMAP similar genes for SOX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX4: view

Variants for SOX4 Gene

Sequence variations from dbSNP and Humsavar for SOX4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1051048 -- 21,596,063(+) aaagg(A/G)aaaaa utr-variant-3-prime
rs1051049 -- 21,596,092(+) GGGCT(C/G)GCTTC utr-variant-3-prime
rs1051079 -- 21,596,021(+) GAAAA(A/G)AAGAA utr-variant-3-prime
rs1052050 -- 21,598,474(+) AGGCC(A/C)CAAAA utr-variant-3-prime
rs14256 -- 21,594,406(+) AGGGG(C/T)CAGTT utr-variant-5-prime

Variation tolerance for SOX4 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOX4 Gene

Disorders for SOX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOX4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pediatric ependymoma
  • familial ependymoma
- elite association - COSMIC cancer census association via MalaCards
Search SOX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SOX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOX4 Gene

Publications for SOX4 Gene

  1. Characterization and mapping of the human SOX4 gene. (PMID: 8268656) Farr C.J. … Goodfellow P.N. (Mamm. Genome 1993) 2 3 4 67
  2. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. (PMID: 9730625) Critcher R. … Farr C.J. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4. (PMID: 20049565) Iqbal M.S. … Kawano M.M. (Int. J. Hematol. 2010) 3 23
  4. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. (PMID: 20080751) Ragvin A. … Becker T.S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer. (PMID: 20331975) Shen R. … Cheng S. (Biochem. Biophys. Res. Commun. 2010) 3 23

Products for SOX4 Gene

Sources for SOX4 Gene