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Aliases for SOX4 Gene

Aliases for SOX4 Gene

  • SRY (Sex Determining Region Y)-Box 4 2 3
  • Ecotropic Viral Integration Site 16 3
  • SRY-Related HMG-Box Gene 4 3
  • Transcription Factor SOX-4 3
  • EVI16 3

External Ids for SOX4 Gene

Previous GeneCards Identifiers for SOX4 Gene

  • GC06P021651
  • GC06P021701

Summaries for SOX4 Gene

Entrez Gene Summary for SOX4 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX4 Gene

SOX4 (SRY (Sex Determining Region Y)-Box 4) is a Protein Coding gene. Diseases associated with SOX4 include hepatocellular carcinoma. Among its related pathways are ERK Signaling and MicroRNAs in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX4 Gene

  • Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5-AACAAAG-3 motif

Gene Wiki entry for SOX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX4 Gene

Genomics for SOX4 Gene

Regulatory Elements for SOX4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOX4 Gene

Start:
21,592,769 bp from pter
End:
21,598,619 bp from pter
Size:
5,851 bases
Orientation:
Plus strand

Genomic View for SOX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX4 Gene

Proteins for SOX4 Gene

  • Protein details for SOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06945-SOX4_HUMAN
    Recommended name:
    Transcription factor SOX-4
    Protein Accession:
    Q06945
    Secondary Accessions:

    Protein attributes for SOX4 Gene

    Size:
    474 amino acids
    Molecular mass:
    47263 Da
    Quaternary structure:
    • Interacts with UBE2I.

neXtProt entry for SOX4 Gene

Proteomics data for SOX4 Gene at MOPED

Post-translational modifications for SOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOX4 Gene

Domains for SOX4 Gene

Gene Families for SOX4 Gene

HGNC:
  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06945

UniProtKB/Swiss-Prot:

SOX4_HUMAN :
  • Q06945
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX4: view

Function for SOX4 Gene

Molecular function for SOX4 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 4,transcriptional activator in embryonic heart,developing CNS,lung,tooth-bud,mesonephros,genitalia,pre B and T cells,controlled by progesterone,expressed in normal breast and in breast cancer cells,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5-AACAAAG-3 motif

Gene Ontology (GO) - Molecular Function for SOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0001046 core promoter sequence-specific DNA binding IDA 20049565
GO:0001071 nucleic acid binding transcription factor activity IMP 20049565
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 19147588
genes like me logo Genes that share ontologies with SOX4: view
genes like me logo Genes that share phenotypes with SOX4: view

Animal Models for SOX4 Gene

MGI Knock Outs for SOX4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOX4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SOX4 Gene

Localization for SOX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX4 Gene COMPARTMENTS Subcellular localization image for SOX4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16631117
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17875931
GO:0005739 mitochondrion IDA --
GO:0044798 nuclear transcription factor complex IEA --
genes like me logo Genes that share ontologies with SOX4: view

Pathways for SOX4 Gene

genes like me logo Genes that share pathways with SOX4: view

Pathways by source for SOX4 Gene

1 Qiagen pathway for SOX4 Gene
1 BioSystems pathway for SOX4 Gene
1 KEGG pathway for SOX4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0001841 neural tube formation ISS --
GO:0002328 pro-B cell differentiation ISS --
GO:0003183 mitral valve morphogenesis ISS --
GO:0003211 cardiac ventricle formation ISS --
genes like me logo Genes that share ontologies with SOX4: view

Compounds for SOX4 Gene

(4) Novoseek inferred chemical compound relationships for SOX4 Gene

Compound -log(P) Hits PubMed IDs
progestin 33 6
oligonucleotide 26.6 1
prostaglandin 8.44 1
progesterone 5.95 3
genes like me logo Genes that share compounds with SOX4: view

Transcripts for SOX4 Gene

mRNA/cDNA for SOX4 Gene

(531) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX4 Gene

SRY (sex determining region Y)-box 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOX4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX4 Gene

No ASD Table

Relevant External Links for SOX4 Gene

GeneLoc Exon Structure for
SOX4
ECgene alternative splicing isoforms for
SOX4

Expression for SOX4 Gene

mRNA expression in normal human tissues for SOX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX4 Gene

This gene is overexpressed in Ovary (4.9).

Protein differential expression in normal tissues for SOX4 Gene

This gene is overexpressed in Brain (63.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOX4 Gene

SOURCE GeneReport for Unigene cluster for SOX4 Gene Hs.643910

mRNA Expression by UniProt/SwissProt for SOX4 Gene

Q06945-SOX4_HUMAN
Tissue specificity: Testis, brain, and heart
genes like me logo Genes that share expressions with SOX4: view

Expression partners for SOX4 Gene

In Situ Assay Products

Orthologs for SOX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOX4 35
  • 87.98 (n)
  • 87.55 (a)
SOX4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOX4 35
  • 91.45 (n)
  • 91.55 (a)
SOX4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sox4 35
  • 80 (n)
  • 78.41 (a)
Sox4 16
Sox4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOX4 35
  • 99.58 (n)
  • 100 (a)
SOX4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sox4 35
  • 79.7 (n)
  • 78.18 (a)
oppossum
(Monodelphis domestica)
Mammalia SOX4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOX4 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sox4 35
  • 84.18 (n)
  • 94.89 (a)
Str.9180 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68880 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sox4b 35
  • 81.92 (n)
  • 81.92 (a)
sox4a 36
  • 60 (a)
OneToMany
sox4b 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sox14 37
  • 40 (a)
Sox14 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-2 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10865 36
  • 20 (a)
OneToMany
Species with no ortholog for SOX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX4 Gene

ENSEMBL:
Gene Tree for SOX4 (if available)
TreeFam:
Gene Tree for SOX4 (if available)

Paralogs for SOX4 Gene

Selected SIMAP similar genes for SOX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX4: view

Variants for SOX4 Gene

Sequence variations from dbSNP and Humsavar for SOX4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14256 -- 21,594,406(+) AGGGG(C/T)CAGTT utr-variant-5-prime
rs14547 -- 21,595,642(+) CGCCC(G/T)CCCCG reference, missense
rs1051048 -- 21,596,063(+) aaagg(A/G)aaaaa utr-variant-3-prime
rs1051049 -- 21,596,092(+) GGGCT(C/G)GCTTC utr-variant-3-prime
rs1051079 -- 21,596,021(+) GAAAA(A/G)AAGAA utr-variant-3-prime

Relevant External Links for SOX4 Gene

HapMap Linkage Disequilibrium report
SOX4
Human Gene Mutation Database (HGMD)
SOX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOX4 Gene

Disorders for SOX4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SOX4 Gene in MalaCards »

(1) Diseases for SOX4 Gene including...

(6) Novoseek inferred disease relationships for SOX4 Gene

Disease -log(P) Hits PubMed IDs
carcinoma adenoid cystic 36.8 1
adenocarcinoma 28.4 1
cancer 23.3 11
tumors 21.5 12
hepatocellular carcinoma 7.08 3

Relevant External Links for SOX4

Genetic Association Database (GAD)
SOX4
Human Genome Epidemiology (HuGE) Navigator
SOX4
genes like me logo Genes that share disorders with SOX4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SOX4 Gene

Publications for SOX4 Gene

  1. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. (PMID: 9730625) Critcher R. … Farr C.J. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Ubc9 interacts with SOX4 and represses its transcriptional activity. (PMID: 16631117) Pan X. … Zhang X. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Characterization and mapping of the human SOX4 gene. (PMID: 8268656) Farr C.J. … Goodfellow P.N. (Mamm. Genome 1993) 2 3 4
  4. CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4. (PMID: 20049565) Iqbal M.S. … Kawano M.M. (Int. J. Hematol. 2010) 3 23
  5. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. (PMID: 20080751) Ragvin A. … Becker T.S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23

Products for SOX4 Gene

  • Addgene plasmids for SOX4

Sources for SOX4 Gene

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