SOX21 Gene

Aliases
for SOX21 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC13M093723 GC13M089750 GC13M094200 GC13M093061 GC13M094159 GC13M075959

Summaries
for SOX21 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for SOX21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000013.10  NC_018924.2  NT_009952.15  

SwitchGear Promoter luciferase reporter plasmid: SOX21 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX21

SOX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095361:  view genomic region     (about GC identifiers)

Proteins
for SOX21 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for SOX21: NX_Q9Y651

Explore proteomics data for SOX21 at MOPED


See SOX21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

SOX21 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SOX21 Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for SOX21
	GenScript Custom Purified and Recombinant Proteins Services for SOX21
	Novus Biologicals SOX21 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SOX21
	Search eBioscience for Proteins for SOX21
	antibodies-online proteins for SOX21 (5 products)
	antibodies-online peptides for SOX21

SOX21 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SOX21
	Browse OriGene Antibodies OriGene Custom Antibody Services for SOX21
	Novus Biologicals SOX21 Antibodies
	Abcam antibodies for SOX21
	Cloud-Clone Corp. Antibodies for SOX21
	Search ThermoFisher Antibodies for SOX21
	antibodies-online antibodies for SOX21 (21 products)

SOX21 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SOX21
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOX21
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SOX21 Cloud-Clone Corp. CLIAs for SOX21
	Search eBioscience for ELISAs for SOX21
	antibodies-online kits for SOX21 (6 products)

Domains /
Families
for SOX21 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9Y651

Find genes that share domains with SOX21           About GenesLikeMe

Function
for SOX21 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Sox21)

genOway: Develop your customized and physiologically relevant rodent model for SOX21

miRNA Products:		Block miRNA regulation of human, mouse, rat SOX21 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SOX21 (see all 49):
		hsa-miR-549 hsa-miR-19b-2* hsa-miR-578 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-3613-3p hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: SOX21 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SOX21
		Predesigned siRNA for gene silencing in human, mouse, rat SOX21

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SOX21

Clone Products:		OriGene clones in human, mouse for SOX21 (see all 6) OriGene ORF clones in mouse, rat for SOX21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX21 (NM_007084)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOX21
		Browse ESI BIO Cell Lines and PureStem Progenitors for SOX21

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

Localization
for SOX21 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	3
mitochondrion	1

About this image

Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for SOX21 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

SuperPaths for SOX21 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	ERK Signaling	Molecular Mechanisms of Cancer 0.51

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX21

Molecular Mechanisms of Cancer

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for SOX21 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Transcripts
for SOX21 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for SOX21 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOX21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATTTAGTTT

About this image

Epithelial Cells
Fetal Medulla Cells Hair Shaft
Hair (Integumentary System)    fully expand to see all 5 entries
Fetal Medulla Cells Hair Shaft
Brain (Nervous System)    fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier
Endothelium (Cardiovascular System)
Endothelial Cells Blood Brain Barrier
Neural Tube (Nervous System)
Telencephalon

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SOX21
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX21
		QuantiTect SYBR Green Assays in human, mouse, rat SOX21
		QuantiFast Probe-based Assays in human, mouse, rat SOX21

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

Orthologs
for SOX21 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for SOX21 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SOX21 gene

SOX13²  SOX2²  SOX4²  SOX1²  SOX14²  SOX3²  SOX9²  SOX12²  

SOX15²  SOX18²  SOX5²  ENSG00000258724²  SOX17²  SOX6²  SOX11²  SOX8²  

SRY²  SOX10²  SOX7²  

10 SIMAP similar genes for SOX21 using alignment to 1 protein entry:     SOX21_HUMAN:

soxB    SRY    SOX17    SOX15    SOX14    SOX10

SOX11    SOX3    SOX1    SOX2

Find genes that share paralogs with SOX21           About GenesLikeMe

Genomic Variants
for SOX21 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for SOX21 (see all 42)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1502824451,2		--	95361448(+)	AAGGAA/CTACCC	1	--	int1		0	--	--	--	--
rs1876603481,2		--	95361556(+)	AGAAAC/TTGGTG	1	--	int1		0	--	--	--	--
rs726384021,2		--	95361592(+)	TTCAAC/TGGGCT	1	--	int1		0	--	--	--	--
rs2006264041,2	C	--	95361621(+)	ATGCC-/TTTTTT	1	--	int1		0	--	--	--	--
rs1179189841,2	F	--	95361627(+)	TTTTTT/GTTGTT	1	--	int1		1		EA	120
rs726398031,2	C	--	95361659(+)	ACTTGC/GGCTTT	1	--	int1		0	--	--	--	--
rs1417704321,2		--	95361723(+)	GCTCTG/TAATAA	1	--	int1		0	--	--	--	--
rs1470816941,2	C	--	95361931(+)	ATGAAC/GAGAGT	1	--	ut31		0	--	--	--	--
rs1906854741,2		--	95361995(+)	AAGGTC/TACACT	1	--	ut31		0	--	--	--	--
rs735504791,2	C	--	95362035(+)	CCATAT/CTTAAA	1	--	ut31		3		WA CSA	121

HapMap Linkage Disequilibrium report for SOX21 (95361876 - 95364389 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SOX21:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv34004	CNV	Loss	18971310
esv28079	CNV	Loss	19812545
nsv826750	CNV	Gain	20364138
nsv832686	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SOX21

DNA2.0 Custom Variant and Variant Library Synthesis for SOX21

Disorders / Diseases
for SOX21 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

Publications
for SOX21 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOX21 gene, integrated from 10 sources (see all 16): (articles sorted by number of sources associating them with SOX21)

Utopia: connect your pdf to the dynamic world of online information

1. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PubMed id 10441749)^{1, 2, 3} Malas S.... Episkopou V. (Mamm. Genome 1999)
2. A conserved family of genes related to the testis determining gene, SRY. (PubMed id 1614875)^{1, 2} Denny P.... Ashworth A. (Nucleic Acids Res. 1992)
3. Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation. (PubMed id 23463365)¹ Caglayan D....Ferletta M. (Int. J. Cancer 2013)
4. Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. (PubMed id 20824710)¹ Ferletta M....Westermark B. (Int. J. Cancer 2011)
5. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H.... Kim N.S. (Mamm. Genome 2005)
6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (Nature 2004)
7. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. (PubMed id 12194848)¹ Schepers G.E....Koopman P. (Dev. Cell 2002)
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
9. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (Genome Res. 2000)
10. Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. (PubMed id 9827568)¹ Cremazy F.... Jay P. (FEBS Lett. 1998)

External Searches for SOX21 gene

Genome Databases showing SOX21 gene

Other Databases showing SOX21 gene

Specialized Databases showing SOX21 gene

Products
for SOX21 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section