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Aliases for SOX21 Gene

Aliases for SOX21 Gene

  • SRY-Box 21 2 3 5
  • SRY (Sex Determining Region Y)-Box 21 2 3
  • SRY Box 21 2 3
  • SOX-A 3 4
  • SOX25 3 4
  • SOXA 4

External Ids for SOX21 Gene

Previous GeneCards Identifiers for SOX21 Gene

  • GC13M093723
  • GC13M089750
  • GC13M094200
  • GC13M093061
  • GC13M094159
  • GC13M095361
  • GC13M075959

Summaries for SOX21 Gene

Entrez Gene Summary for SOX21 Gene

  • SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

GeneCards Summary for SOX21 Gene

SOX21 (SRY-Box 21) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX21 Gene

  • May play a role as an activator of transcription of OPRM1.

Gene Wiki entry for SOX21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX21 Gene

Genomics for SOX21 Gene

Regulatory Elements for SOX21 Gene

Enhancers for SOX21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOX21 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOX21 Gene

94,709,622 bp from pter
94,712,543 bp from pter
2,922 bases
Minus strand

Genomic View for SOX21 Gene

Genes around SOX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX21 Gene

Proteins for SOX21 Gene

  • Protein details for SOX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-21
    Protein Accession:
    Secondary Accessions:
    • P35715
    • Q15504
    • Q5TBS1

    Protein attributes for SOX21 Gene

    276 amino acids
    Molecular mass:
    28580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX21 Gene

Proteomics data for SOX21 Gene at MOPED

Post-translational modifications for SOX21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX21 Gene

Domains & Families for SOX21 Gene

Gene Families for SOX21 Gene

Protein Domains for SOX21 Gene


Suggested Antigen Peptide Sequences for SOX21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX21: view

Function for SOX21 Gene

Molecular function for SOX21 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 221,involved in embryonic CNS development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
May play a role as an activator of transcription of OPRM1.

Gene Ontology (GO) - Molecular Function for SOX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 10441749
genes like me logo Genes that share ontologies with SOX21: view
genes like me logo Genes that share phenotypes with SOX21: view

Animal Models for SOX21 Gene

MGI Knock Outs for SOX21:

Animal Model Products

miRNA for SOX21 Gene

miRTarBase miRNAs that target SOX21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX21 Gene

Localization for SOX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX21 Gene

Subcellular locations from

Jensen Localization Image for SOX21 Gene COMPARTMENTS Subcellular localization image for SOX21 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SOX21 Gene

Pathways & Interactions for SOX21 Gene

SuperPathways for SOX21 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX21: view

Pathways by source for SOX21 Gene

1 Qiagen pathway for SOX21 Gene

Interacting Proteins for SOX21 Gene

Gene Ontology (GO) - Biological Process for SOX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,ISS --
GO:0042633 hair cycle IEA --
GO:0043588 skin development IEA --
genes like me logo Genes that share ontologies with SOX21: view

No data available for SIGNOR curated interactions for SOX21 Gene

Drugs & Compounds for SOX21 Gene

No Compound Related Data Available

Transcripts for SOX21 Gene

mRNA/cDNA for SOX21 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX21 Gene

SRY (sex determining region Y)-box 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX21 Gene

No ASD Table

Relevant External Links for SOX21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX21 Gene

mRNA expression in normal human tissues for SOX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX21 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6), Skin - Not Sun Exposed (Suprapubic) (x5.4), Brain - Amygdala (x4.4), Esophagus - Mucosa (x4.2), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SOX21 Gene

This gene is overexpressed in Fetal gut (36.1), Fetal Brain (18.9), and Tlymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX21 Gene

SOURCE GeneReport for Unigene cluster for SOX21 Gene Hs.187577

genes like me logo Genes that share expression patterns with SOX21: view

Protein tissue co-expression partners for SOX21 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SOX21 Gene

Orthologs for SOX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX21 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Sox21 35
  • 93.36 (n)
  • 99.64 (a)
Sox21 16
Sox21 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sox21 35
  • 95.93 (n)
  • 100 (a)
(Bos Taurus)
Mammalia SOX21 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SOX21 36
  • 97 (a)
(Anolis carolinensis)
Reptilia SOX21 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sox21 35
  • 74.03 (n)
  • 86.05 (a)
(Danio rerio)
Actinopterygii sox21b 35
  • 71.33 (n)
  • 80.93 (a)
sox21a 36
  • 60 (a)
sox21b 36
  • 84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3288 35
fruit fly
(Drosophila melanogaster)
Insecta D 37
  • 87 (a)
Sox21a 37
  • 91 (a)
Sox21b 37
  • 91 (a)
Sox21a 36
  • 25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010922 35
  • 77.54 (n)
  • 82.61 (a)
(Caenorhabditis elegans)
Secernentea sox-3 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for SOX21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX21 Gene

Gene Tree for SOX21 (if available)
Gene Tree for SOX21 (if available)

Paralogs for SOX21 Gene

(10) SIMAP similar genes for SOX21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX21: view

Variants for SOX21 Gene

Sequence variations from dbSNP and Humsavar for SOX21 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_049562 -
rs35383846 -- 94,710,654(+) AAACA(-/G)GGGAG utr-variant-3-prime
rs189144824 -- 94,710,546(+) CGTGA(A/T)CATCT utr-variant-3-prime
rs536039267 -- 94,710,618(+) CTTGA(C/G)AGAAC utr-variant-3-prime
rs570200640 -- 94,710,603(+) TGGTT(C/G)GGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOX21 Gene

Variant ID Type Subtype PubMed ID
esv34004 CNV Loss 18971310
nsv832686 CNV Gain 17160897
nsv826750 CNV Gain 20364138
esv28079 CNV Loss 19812545

Variation tolerance for SOX21 Gene

Gene Damage Index Score: 0.32; 7.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SOX21 Gene

Disorders for SOX21 Gene

Relevant External Links for SOX21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SOX21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX21 Gene

Publications for SOX21 Gene

  1. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PMID: 10441749) Malas S. … Episkopou V. (Mamm. Genome 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A panel of genes methylated with high frequency in colorectal cancer. (PMID: 24485021) Mitchell S.M. … Molloy P.L. (BMC Cancer 2014) 3
  4. Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation. (PMID: 23463365) Caglayan D. … Ferletta M. (Int. J. Cancer 2013) 3
  5. Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. (PMID: 20824710) Ferletta M. … Westermark B. (Int. J. Cancer 2011) 3

Products for SOX21 Gene

Sources for SOX21 Gene