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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOX21 Gene

protein-coding   GIFtS: 50
GCID: GC13M095361

SRY (sex determining region Y)-box 21
 Explore 8 diseases affiliated with
SOX21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SOX21    

Aliases
for SOX21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SRY (Sex Determining Region Y)-Box 211 2
SOX251 2 3
SOX-A2 3
SRY-Box 212
Transcription Factor SOX-212
SOXA3

External Ids:    HGNC: 111971   Entrez Gene: 111662   Ensembl: ENSG000001252857   OMIM: 6049745   UniProtKB: Q9Y6513   

Export aliases for SOX21 gene to outside databases

Previous GC identifers: GC13M093723 GC13M089750 GC13M094200 GC13M093061 GC13M094159 GC13M075959


Summaries
for SOX21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SOX21:
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility
group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000).
SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For
additional background information on SOX genes, see SOX1 (MIM 602148).(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651
Function: May play a role as an activator of transcription of OPRM1 (By similarity)

Gene Wiki entry for SOX21


Genomic Views
for SOX21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOX21 gene promoter:
         Sox5   Sp1   COMP1   Chx10   IRF-7A   CUTL1   POU6F1 (c2)   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOX21 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOX21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31-q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31-q32

SOX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX21 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095361:  view genomic region     (about GC identifiers)

Start:
 95,361,876 bp from pter      End:
 95,364,389 bp from pter
Size:
 2,514 bases      Orientation:
 minus strand

Proteins
for SOX21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651 (See protein sequence)
Recommended Name: Transcription factor SOX-21  
Size: 276 amino acids; 28580 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: P35715 Q15504 Q5TBS1

Explore the universe of human proteins at neXtProt for SOX21: NX_Q9Y651

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y651

    • SOX21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009015.1  
    ENSEMBL proteins: 
     ENSP00000366144  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SOX21 
    GenScript Custom Purified and Recombinant Proteins Services for SOX21
    Novus Biologicals SOX21 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SOX21

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--


    SOX21 for ontologies           About GeneDecksing



    SOX21 Antibody Products: 
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    R&D Systems Antibodies for SOX21
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    Novus Biologicals SOX21 Antibodies
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    Uscn Antibodies for SOX21
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    Assay Products for SOX21: 
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    Uscn ELISAs and CLIAs for SOX21

    Protein Domains /
    Families
    for SOX21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SOX21 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009071 HMG_superfamily
     IPR022097 TF_SOX

    Graphical View of Domain Structure for InterPro Entry Q9Y651

    ProtoNet protein and cluster: Q9Y651

    UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651
    Similarity: Contains 1 HMG box DNA-binding domain


    Function
    for SOX21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651
    Function: May play a role as an activator of transcription of OPRM1 (By similarity)

         Genatlas biochemistry entry for SOX21:
    SRY related HMG box gene 221,involved in embryonic CNS development,modulator of LINE retroposons promoter activity

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SOX21
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX21
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX21 (see all 49):
    hsa-miR-549 hsa-miR-19b-2* hsa-miR-578 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: SOX21 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX21 (see all 4)
    OriGene shRNA RFP: SOX21
    OriGene siRNA: SOX21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX21

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SOX21

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX21 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX21
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOX21 (NM_007084)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SOX21
    Search LifeMap BioReagents cell lines for SOX21

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity NAS10441749
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--


    SOX21 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sox21):
     endocrine/exocrine gland  integument 

    SOX21 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SOX21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Rho Family GTPases
    		Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX21
        Molecular Mechanisms of Cancer


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOX21

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0006355regulation of transcription, DNA-dependent ISS--
    GO:0006357regulation of transcription from RNA polymerase II promoter NAS10441749
    GO:0006366transcription from RNA polymerase II promoter NAS10441749
    GO:0042633hair cycle ----


    SOX21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SOX21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOX21
    Search CenterWatch for drugs/clinical trials and news about SOX21 

    Transcripts
    for SOX21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SOX21 gene: 
    NM_007084.2  

    Unigene Cluster for SOX21:

    SRY (sex determining region Y)-box 21
    Hs.187577  [show with all ESTs]
    Unigene Representative Sequence: NM_007084
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376945(uc001vma.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SOX21
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX21
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX21 (see all 49):
    hsa-miR-549 hsa-miR-19b-2* hsa-miR-578 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: SOX21 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX21 (see all 4)
    OriGene shRNA RFP: SOX21
    OriGene siRNA: SOX21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX21
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX21 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX21
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOX21 (NM_007084)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX21
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOX21
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX21

    Additional cDNA sequence: 

    X65666.1 X71136.1 

    1 DOTS entry:

    DT.40299601 

    12 AceView cDNA sequences:

    BM783159 NM_007084 AI201812 AI418194 AI816765 X65666 AI569726 AI884987 
    X71136 BF940869 AI869218 AA040785 

    GeneLoc Exon Structure


    Expression
    for SOX21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOX21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SOX21 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SOX21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOX21

    SOURCE GeneReport for Unigene cluster: Hs.187577
        SABiosciences Custom PCR Arrays for SOX21
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX21
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOX21
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX21
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX21
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

    Orthologs
    for SOX21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SOX21 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SOX216
    SOX16
    		 --
    		 59(a)
    20(a)
    		 possible ortholog
    possible ortholog
    		 3(84855418-84856257)
    3(105298539-105299823)
    zebrafish
    (Danio rerio)    		 Actinopterygii sox21b1 SRY-box containing gene 21 b 73.2(n)
    84.9(a)    		   406246  NM_001009888.2  NP_001009888.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sox21a3 transcription factor 91(a)
    (best of 3)    		   70D2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea sox-46
    		 Protein SOX-4
    		 21(a)
    		 possible ortholog
    		 X(3505427-3506378)


    ENSEMBL Gene Tree for SOX21 (if available)
    TreeFam Gene Tree for SOX21 (if available) 

    Paralogs
    for SOX21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOX21 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX172  SOX62  SOX112  SOX82  
    SRY2  SOX102  SOX72  
    10 SIMAP similar genes for SOX21 using alignment to 1 protein entry:     SOX21_HUMAN:
    soxB    SRY    SOX17    SOX15    SOX14    SOX11
    SOX10    SOX3    SOX1    SOX2

    SOX21 for paralogs           About GeneDecksing



    Genomic Variants
    for SOX21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/44 NCBI SNPs in SOX21 are shown (see all 44)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1502824451,2
    		--95361448(+) AAGGAA/CTACCC 1 -- int10--------
    rs1876603481,2
    		--95361556(+) AGAAAC/TTGGTG 1 -- int10--------
    rs726384021,2
    		--95361592(+) TTCAAC/TGGGCT 1 -- int10--------
    rs2006264041,2
    		--95361621(+) ATGCC-/TTTTTT 1 -- int10--------
    rs1179189841,2
    		--95361627(+) TTTTTT/GTTGTT 1 -- int11Minor allele frequency- G:0.01EA 120
    rs726398031,2
    		C,--95361659(+) ACTTGC/GGCTTT 1 -- int10--------
    rs1417704321,2
    		--95361723(+) GCTCTG/TAATAA 1 -- int10--------
    rs1470816941,2
    		C,--95361931(+) ATGAAC/GAGAGT 1 -- ut310--------
    rs1906854741,2
    		--95361995(+) AAGGTC/TACACT 1 -- ut310--------
    rs735504791,2
    		C,--95362035(+) CCATAT/CTTAAA 1 -- ut313Minor allele frequency- C:0.12WA CSA 121

    HapMap Linkage Disequilibrium report for SOX21 (95361876 - 95364389 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SOX21
         2 CNVs: 71761 47869

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX21
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX21

    Disorders / Diseases
    for SOX21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SOX21 for disorders           About GeneDecksing

    OMIM gene information: 604974    OMIM disorders: --

    8 diseases for SOX21:    About MalaCards
    lambert-eaton myasthenic syndrome    campomelic dysplasia    myasthenic syndrome    anophthalmia
    hypopituitarism    lung cancer    melanoma    neuronitis


    Export disorders for SOX21 gene to outside databases

    Publications
    for SOX21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOX21 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SOX21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PubMed id 10441749)1, 2, 3 Malas S.... Episkopou V. (1999)
    2. A conserved family of genes related to the testis determining gene, SRY. (PubMed id 1614875)1, 2 Denny P.... Ashworth A. (1992)
    3. Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. (PubMed id 20824710)1 Ferletta M....Westermark B. (2011)
    4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    6. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. (PubMed id 12194848)1 Schepers G.E....Koopman P. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    9. Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. (PubMed id 9827568)1 Cremazy F.... Jay P. (1998)
    10. SOX3 is an X-linked gene related to SRY. (PubMed id 8111369)1 Stevanovic M.... Goodfellow P.N. (1993)

    External Searches for SOX21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SOX21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11166 HGNC: 11197 AceView: SOX21 Ensembl:ENSG00000125285 euGenes: HUgn11166
    ECgene: SOX21 H-InvDB: SOX21

    Other Databases showing SOX21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SOX21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOX21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SOX21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SOX21 gene:
    Search GeneIP for patents involving SOX21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SOX21 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOX21
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     Regulatory tfbs in SOX21 promoter
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     Novus Tissue Slides
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     Search for Antibodies for SOX21 at Abcam
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     SOX21 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SOX21
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21
     SwitchGear 3'UTR luciferase reporter plasmids for SOX21
     SwitchGear Promoter luciferase reporter plasmids for SOX21
     Search ThermoFisher Antibodies for SOX21
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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