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Set Analyses:

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SOX21 Gene

protein-coding GIFtS: 50
GCID: GC13M095361

SRY (Sex Determining Region Y)-Box 21

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
SRY (Sex Determining Region Y)-Box 21¹ ²
SRY-Box 21¹ ²
SOX-A² ³
SOX25² ³
Transcription Factor SOX-21²
SOXA³

External Ids:	HGNC: 11197¹	Entrez Gene: 11166²	Ensembl: ENSG00000125285⁷	OMIM: 604974⁵	UniProtKB: Q9Y651³

Export aliases for SOX21 gene to outside databases

Previous GC identifers: GC13M093723 GC13M089750 GC13M094200 GC13M093061 GC13M094159 GC13M075959

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOX21 Gene:

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high

mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein

(MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the

HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).(supplied by OMIM, Apr

2004)

GeneCards Summary for SOX21 Gene:

SOX21 (SRY (sex determining region Y)-box 21) is a protein-coding gene. Diseases associated with SOX21 include lambert-eaton myasthenic syndrome, and campomelic dysplasia. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651

Function: May play a role as an activator of transcription of OPRM1 (By similarity)

Gene Wiki entry for SOX21 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000013.11 NC_018924.2 NT_009952.15

Regulatory elements:

Regulatory transcription factor binding sites in the SOX21 gene promoter:
Sox5 Sp1 COMP1 Chx10 IRF-7A CUTL1 POU6F1 (c2) Egr-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOX21 promoter sequence

Search Chromatin IP Primers for SOX21

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31-q32 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q31-q32

SOX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX21 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M095361: view genomic region (about GC identifiers)

Start:	95,361,876 bp from pter	End:	95,364,389 bp from pter
Size:	2,514 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651 (See protein sequence)

Recommended Name: Transcription factor SOX-21

Size: 276 amino acids; 28580 Da

Secondary accessions: P35715 Q15504 Q5TBS1

Explore the universe of human proteins at neXtProt for SOX21: NX_Q9Y651

Explore proteomics data for SOX21 at MOPED

See SOX21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009015.1

ENSEMBL proteins:

ENSP00000366144

SOX21 Human Recombinant Protein Products:

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SOX21 Antibody Products:

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	LSBio Antibodies in human, mouse, rat for SOX21

SOX21 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SOX21 Cloud-Clone Corp. CLIAs for SOX21

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SOX: SRY (sex determining region Y)-boxes

2 InterPro protein domains:

IPR009071 HMG_box_dom

IPR022097 TF_SOX

Graphical View of Domain Structure for InterPro Entry Q9Y651

ProtoNet protein and cluster: Q9Y651

UniProtKB/Swiss-Prot: SOX21_HUMAN, Q9Y651

Similarity: Contains 1 HMG box DNA-binding domain

SOX21 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SOX21_HUMAN, Q9Y651

Function: May play a role as an activator of transcription of OPRM1 (By similarity)

Genatlas biochemistry entry for SOX21:

SRY related HMG box gene 221,involved in embryonic CNS development,modulator of LINE retroposons promoter activity

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	NAS	10441749
GO:0003677	DNA binding	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	ISS	--

SOX21 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sox21):

endocrine/exocrine gland

integument

SOX21 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX21

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX21

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX21

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX21

miRNA Products:		Block miRNA regulation of human, mouse, rat SOX21 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SOX21 (see all 49):
		hsa-miR-549 hsa-miR-19b-2* hsa-miR-578 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-3613-3p hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SOX21 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SOX21
		Predesigned siRNA for gene silencing in human, mouse, rat SOX21

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SOX21

Clone Products:		OriGene clones in human, mouse for SOX21 (see all 6) OriGene ORF clones in mouse, rat for SOX21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX21 (NM_007084)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOX21
		Browse ESI BIO Cell Lines and PureStem Progenitors for SOX21

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SOX21_HUMAN, Q9Y651: Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
mitochondrion	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--

SOX21 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SOX21 About

See pathways by source

SuperPath

Contained pathways About

ERK Signaling

Molecular Mechanisms of Cancer

0.51

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX21

Molecular Mechanisms of Cancer

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SOX21
Interactions:

Search GeneGlobe Interaction Network for SOX21

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SOX21 (ENSP00000366144⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHTF18	ENSP00000262315⁴	STRING: ENSP00000262315
TAF2	ENSP00000367406⁴	STRING: ENSP00000367406
TAF8	ENSP00000362068⁴	STRING: ENSP00000362068
MSH2	ENSP00000233146⁴	STRING: ENSP00000233146

About this table

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001942	hair follicle development	IEA	--
GO:0006355	regulation of transcription, DNA-templated	ISS	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	NAS	10441749
GO:0006366	transcription from RNA polymerase II promoter	NAS	10441749
GO:0042633	hair cycle	--	--

SOX21 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SOX21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SOX21 gene:

NM_007084.2

Unigene Cluster for SOX21:

SRY (sex determining region Y)-box 21

Hs.187577 [show with all ESTs]

Unigene Representative Sequence: NM_007084

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000376945(uc001vma.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat SOX21 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SOX21 (see all 49):
		hsa-miR-549 hsa-miR-19b-2* hsa-miR-578 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-3613-3p hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SOX21 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SOX21
		Predesigned siRNA for gene silencing in human, mouse, rat SOX21

Clone Products:		OriGene clones in human, mouse for SOX21 (see all 6) OriGene ORF clones in mouse, rat for SOX21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX21 (NM_007084)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX21

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SOX21
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SOX21
		QuantiTect SYBR Green Assays in human, mouse, rat SOX21
		QuantiFast Probe-based Assays in human, mouse, rat SOX21

Additional mRNA sequence:

X65666.1 X71136.1

1 DOTS entry:

DT.40299601

12 AceView cDNA sequences:

AI201812 BM783159 NM_007084 AI884987 X71136 AI816765 X65666 AI569726

AI418194 BF940869 AI869218 AA040785

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SOX21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATTTAGTTT

About this image

SOX21 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Epithelial Cells
Fetal Medulla Cells Hair Shaft

Hair (Integumentary System) fully expand to see all 5 entries
Fetal Medulla Cells Hair Shaft

Brain (Nervous System) fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier

Endothelium (Cardiovascular System)
Endothelial Cells Blood Brain Barrier

Neural Tube (Nervous System)
Telencephalon

SOX21 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SOX21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.187577

Custom PCR Arrays for SOX21

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SOX21
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SOX21
		QuantiTect SYBR Green Assays in human, mouse, rat SOX21
		QuantiFast Probe-based Assays in human, mouse, rat SOX21

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SOX21 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sox21^{1 , 5}	SRY-box containing gene 21⁵ SRY (sex determining region Y)-box 21¹	93.36(n)¹ 99.64(a)¹		14 (61.92 cM)⁵ 223227¹ NM_177753.3¹ NP_808421.1¹ 118233232⁵
lizard (Anolis carolinensis)	Reptilia	SOX21⁶	SRY (sex determining region Y)-box 21	75(a)	1 ↔ 1	3(84855418-84856257)
tropical clawed frog (Xenopus tropicalis)	Amphibia	sox21¹	SRY (sex determining region Y)-box 21	74.03(n) 86.05(a)		100038091 XM_002939280.2 XP_002939326.1
zebrafish (Danio rerio)	Actinopterygii	sox21b¹	SRY-box containing gene 21 b	71.33(n) 80.93(a)		406246 NM_001009888.2 NP_001009888.1
fruit fly (Drosophila melanogaster)	Insecta	Sox21a³	transcription factor	91(a) (best of 3)		70D2 --
worm (Caenorhabditis elegans)	Secernentea	sox-3⁶	Protein SOX-3 (sox-3) mRNA, complete cds	42(a)	1 → many	X(14690833-14692999) WBGene00004950

ENSEMBL Gene Tree for SOX21 (if available)
TreeFam Gene Tree for SOX21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SOX21 gene

SOX13² SOX2² SOX4² SOX1² SOX14² SOX3² SOX9² SOX12²

SOX15² SOX18² SOX5² ENSG00000258724² SOX17² SOX6² SOX11² SOX8²

SRY² SOX10² SOX7²

10 SIMAP similar genes for SOX21 using alignment to 1 protein entry: SOX21_HUMAN:

soxB SRY SOX17 SOX15 SOX14 SOX10

SOX11 SOX3 SOX1 SOX2

SOX21 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150282445^1,2		--	95361448(+)	`AAGGAA/CTACCC`	1	--	int¹		0	--	--	--	--
rs187660348^1,2		--	95361556(+)	`AGAAAC/TTGGTG`	1	--	int¹		0	--	--	--	--
rs72638402^1,2		--	95361592(+)	`TTCAAC/TGGGCT`	1	--	int¹		0	--	--	--	--
rs200626404^1,2	C	--	95361621(+)	`ATGCC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs117918984^1,2	F	--	95361627(+)	`TTTTTT/GTTGTT`	1	--	int¹		1		EA	120
rs72639803^1,2	C	--	95361659(+)	`ACTTGC/GGCTTT`	1	--	int¹		0	--	--	--	--
rs141770432^1,2		--	95361723(+)	`GCTCTG/TAATAA`	1	--	int¹		0	--	--	--	--
rs147081694^1,2	C	--	95361931(+)	`ATGAAC/GAGAGT`	1	--	ut3¹		0	--	--	--	--
rs190685474^1,2		--	95361995(+)	`AAGGTC/TACACT`	1	--	ut3¹		0	--	--	--	--
rs73550479^1,2	C	--	95362035(+)	`CCATAT/CTTAAA`	1	--	ut3¹		3		WA CSA	121

HapMap Linkage Disequilibrium report for SOX21 (95361876 - 95364389 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SOX21: About this table

Variant ID	Type	Subtype	PubMed ID
esv34004	CNV	Loss	18971310
esv28079	CNV	Loss	19812545
nsv826750	CNV	Gain	20364138
nsv832686	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SOX21

DNA2.0 Custom Variant and Variant Library Synthesis for SOX21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604974 OMIM disorders: --

8 diseases for SOX21:
About MalaCards

lambert-eaton myasthenic syndrome campomelic dysplasia hypopituitarism lung cancer

malaria melanoma neuronitis endotheliitis

SOX21 for disorders About GeneDecksing

Export disorders for SOX21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SOX21 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with SOX21)

Utopia: connect your pdf to the dynamic
world of online information

The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PubMed id 10441749)^{1, 2, 3} Malas S.... Episkopou V. (Mamm. Genome 1999)
A conserved family of genes related to the testis determining gene, SRY. (PubMed id 1614875)^{1, 2} Denny P.... Ashworth A. (Nucleic Acids Res. 1992)
Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation. (PubMed id 23463365)¹ Caglayan D....Ferletta M. (Int. J. Cancer 2013)
Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. (PubMed id 20824710)¹ Ferletta M....Westermark B. (Int. J. Cancer 2011)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H.... Kim N.S. (Mamm. Genome 2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (Nature 2004)
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. (PubMed id 12194848)¹ Schepers G.E....Koopman P. (Dev. Cell 2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (Genome Res. 2000)
Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. (PubMed id 9827568)¹ Cremazy F.... Jay P. (FEBS Lett. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11166	HGNC: 11197	AceView: SOX21	Ensembl:ENSG00000125285	euGenes: HUgn11166
ECgene: SOX21	H-InvDB: SOX21

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SOX21	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SOX21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SOX21 gene:
Search GeneIP for patents involving SOX21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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SOX21 Gene

SRY (Sex Determining Region Y)-Box 21

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SOX21 Gene

SRY (Sex Determining Region Y)-Box 21

Aliasesfor SOX21 gene

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SOX21 Human Recombinant Protein Products:

SOX21 Antibody Products:

SOX21 Assay Products:

Domains /Familiesfor SOX21 gene

Functionfor SOX21 gene

Localizationfor SOX21 gene

Pathways & Interactionsfor SOX21 gene

Drugs & Compoundsfor SOX21 gene

Transcriptsfor SOX21 gene

Expression for SOX21 gene

Orthologsfor SOX21 gene

Paralogsfor SOX21 gene

Genomic Variantsfor SOX21 gene

Disorders / Diseasesfor SOX21 gene

Publicationsfor SOX21 gene

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Genome Databases showing SOX21 gene

Other Databases showing SOX21 gene

Specialized Databases showing SOX21 gene

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for SOX21 gene

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for SOX21 gene

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for SOX21 gene

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for SOX21 gene

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for SOX21 gene

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for SOX21 gene

Drugs & Compounds
for SOX21 gene

Transcripts
for SOX21 gene

Expression
for SOX21 gene

Orthologs
for SOX21 gene

Paralogs
for SOX21 gene

Genomic Variants
for SOX21 gene

Disorders / Diseases
for SOX21 gene

Publications
for SOX21 gene

Intellectual Property
for SOX21 gene

Products
for SOX21 gene