Aliases for SOX21 Gene
Aliases for SOX21 Gene
External Ids for SOX21 Gene
- HGNC: 11197
- Entrez Gene: 11166
- Ensembl: ENSG00000125285
- OMIM: 604974
- UniProtKB: Q9Y651
Previous GeneCards Identifiers for SOX21 Gene
- GC13M093723
- GC13M089750
- GC13M094200
- GC13M093061
- GC13M094159
- GC13M095361
- GC13M075959
Summaries for SOX21 Gene
-
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]
GeneCards Summary for SOX21 Gene
SOX21 (SRY-Box 21) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SOX11.
UniProtKB/Swiss-Prot for SOX21 Gene
-
May play a role as an activator of transcription of OPRM1.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX21 Gene
Genomics for SOX21 Gene
Regulatory Elements for SOX21 Gene
Enhancers for SOX21 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SOX21 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SOX21 gene promoter:
Regulatory Element Products
Genomic Location for SOX21 Gene
- Chromosome:
- 13
- Start:
- 94,709,622 bp from pter
- End:
- 94,712,543 bp from pter
- Size:
- 2,922 bases
- Orientation:
- Minus strand
Genomic View for SOX21 Gene
Genes around SOX21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q32.1 by Ensembl
- 13q32.1 by Entrez Gene
- 13q32.1 by HGNC
SOX21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOX21 Gene
Proteins for SOX21 Gene
-
Protein details for SOX21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y651-SOX21_HUMAN
- Recommended name:
- Transcription factor SOX-21
- Protein Accession:
- Q9Y651
- P35715
- Q15504
- Q5TBS1
Protein attributes for SOX21 Gene
- Size:
- 276 amino acids
- Molecular mass:
- 28580 Da
- Quaternary structure:
- No Data Available
Protein Expression for SOX21 Gene
Post-translational modifications for SOX21 Gene
Other Protein References for SOX21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SOX21 (SOX21)
- Novus Biologicals Antibodies for SOX21
- Invitrogen Antibodies for SOX21
- antibodies-online Antibodies for SOX21: See all 35
- Search GeneTex for Antibodies for SOX21
-
Santa Cruz Biotechnology (SCBT) Antibodies for SOX21
Protein Products
-
OriGene Purified Proteins for SOX21
- Search Origene for MassSpec and Protein Over-expression Lysates for SOX21
- Origene Custom Protein Services for SOX21
- Novus Biologicals proteins for SOX21
- antibodies-online Proteins for SOX21: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SOX21
Assay Products
- antibodies-online Kits for SOX21: See all 9
No data available for DME Specific Peptides for SOX21 Gene
Domains & Families for SOX21 Gene
Gene Families for SOX21 Gene
Protein Domains for SOX21 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SOX21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y651- Domain:
-
- Contains 1 HMG box DNA-binding domain.
Function for SOX21 Gene
Molecular function for SOX21 Gene
- GENATLAS Biochemistry:
- SRY related HMG box gene 221,involved in embryonic CNS development,modulator of LINE retroposons promoter activity
- UniProtKB/Swiss-Prot Function:
- May play a role as an activator of transcription of OPRM1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 10441749 |
Phenotypes for SOX21 Gene
- MGI mutant phenotypes for SOX21:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SOX21:
Animal Models for SOX21 Gene
- MGI Knock Outs for SOX21:
-
- Sox21 tm1.1Ysa
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SOX21 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
- Search ViGene Biosciences for SOX21
CRISPR Products
-
OriGene CRISPR knockouts for SOX21
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOX21
- GenScript: Design CRISPR guide RNA sequences for SOX21
miRNA for SOX21 Gene
- miRTarBase miRNAs that target SOX21
miRNA Products
- Search ViGene Biosciences for SOX21
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for SOX21
- Browse OriGene Inhibitory RNA Products For SOX21
-
ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
Clone Products
- OriGene clones in human for SOX21
- OriGene ORF clones in human,mouse for SOX21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SOX21 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SOX21 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX21 Gene
Localization for SOX21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOX21 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 1 |
No data available for Gene Ontology (GO) - Cellular Components for SOX21 Gene
Pathways & Interactions for SOX21 Gene
More details on SuperPathways for SOX21| Superpath | Contained pathways | |
|---|---|---|
| 1 | ERK Signaling |
Pathways by source for SOX21 Gene
1 Qiagen pathway for SOX21 Gene
Interacting Proteins for SOX21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001942 | hair follicle development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,ISS | -- |
| GO:0042633 | hair cycle | IEA | -- |
| GO:0043588 | skin development | IEA | -- |
No data available for SIGNOR curated interactions for SOX21 Gene
Transcripts for SOX21 Gene
mRNA/cDNA for SOX21 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SOX21 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SOX21
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOX21
- GenScript: Design CRISPR guide RNA sequences for SOX21
miRNA Products
- Search ViGene Biosciences for SOX21
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for SOX21
- Browse OriGene Inhibitory RNA Products For SOX21
-
ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
Clone Products
- OriGene clones in human for SOX21
- OriGene ORF clones in human,mouse for SOX21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for SOX21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Induced pluripotent stem cell line 1
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Telencephalon
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
mRNA differential expression in normal tissues according to GTEx for SOX21 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6), Skin - Not Sun Exposed (Suprapubic) (x5.4), Brain - Amygdala (x4.4), Esophagus - Mucosa (x4.2), and Brain - Caudate (basal ganglia) (x4.1).
This gene is overexpressed in Fetal gut (36.1), Fetal Brain (18.9), and Tlymphocyte (13.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX21 Gene
SOURCE GeneReport for Unigene cluster for SOX21 Gene Hs.187577
Primer Products
-
OriGene qPCR primer pairs for SOX21
No data available for mRNA Expression by UniProt/SwissProt for SOX21 Gene
Orthologs for SOX21 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Sox21 35 |
|
||
| Sox21 16 |
|
||||
| Sox21 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Sox21 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SOX21 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SOX21 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SOX21 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sox21 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sox21b 35 |
|
||
| sox21a 36 |
|
ManyToMany | |||
| sox21b 36 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3288 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | D 37 |
|
|
|
| Sox21a 37 |
|
|
|||
| Sox21b 37 |
|
|
|||
| Sox21a 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010922 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sox-3 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for SOX21:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SOX21 Gene
Paralogs for SOX21 Gene
(10) SIMAP similar genes for SOX21 Gene using alignment to 1 proteins:
Variants for SOX21 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_049562 | - | ||||
| rs35383846 | -- | 94,710,654(+) | AAACA(-/G)GGGAG | utr-variant-3-prime | |
| rs189144824 | -- | 94,710,546(+) | CGTGA(A/T)CATCT | utr-variant-3-prime | |
| rs536039267 | -- | 94,710,618(+) | CTTGA(C/G)AGAAC | utr-variant-3-prime | |
| rs570200640 | -- | 94,710,603(+) | TGGTT(C/G)GGAGT | utr-variant-3-prime |
Gene Damage Index Score:
0.32;
7.18% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SOX21 Gene
Disorders for SOX21 Gene
Relevant External Links for SOX21
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SOX21
No disorders were found for SOX21 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX21 Gene
Publications for SOX21 Gene
- The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PMID: 10441749) Malas S. … Episkopou V. (Mamm. Genome 1999) 2 3 4 67
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A panel of genes methylated with high frequency in colorectal cancer. (PMID: 24485021) Mitchell S.M. … Molloy P.L. (BMC Cancer 2014) 3
- Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation. (PMID: 23463365) Caglayan D. … Ferletta M. (Int. J. Cancer 2013) 3
- Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. (PMID: 20824710) Ferletta M. … Westermark B. (Int. J. Cancer 2011) 3
Products for SOX21 Gene
- R&D Systems Antibodies for SOX21 (SOX21)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SOX21
- Search Origene for MassSpec and Protein Over-expression Lysates for SOX21
- Origene Custom Protein Services for SOX21
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for SOX21
- Browse OriGene Inhibitory RNA Products For SOX21
- OriGene qPCR primer pairs for SOX21
- OriGene CRISPR knockouts for SOX21
- OriGene clones in human for SOX21
- OriGene ORF clones in human,mouse for SOX21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SOX21
- GenScript Custom Assay Services for SOX21
- GenScript Custom overexpressing Cell Line Services for SOX21
- GenScript: Design CRISPR guide RNA sequences for SOX21
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SOX21
- Novus Biologicals Antibodies for SOX21
- Novus Biologicals proteins for SOX21
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for SOX21: See all 35
- antibodies-online Kits for SOX21: See all 9
- antibodies-online Proteins for SOX21: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for SOX21
- Search GeneTex for Proteins for SOX21
- ViGene Biosciences adenoviral particle packaged cDNA for SOX21 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SOX21 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SOX21 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SOX21 gene
- Search ViGene Biosciences for SOX21
- Search ViGene Biosciences for SOX21
- Santa Cruz Biotechnology (SCBT) Antibodies for SOX21
- Search Santa Cruz Biotechnology (SCBT) for SOX21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SOX21
Sources for SOX21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon