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SOX2 Gene

protein-coding GIFtS: 62

GC03P182912

SRY (sex determining region Y)-box 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ANOP3 ^²
MCOPS3 ^², ⁵
MGC2413 ^²

Descriptions
SRY (sex determining region Y)-box 2 ^²
SRY-related HMG-box gene 2 ^²
sex-determining region Y-box 2 ^²
transcription factor SOX2 ^²

External Ids
HGNC: 11195¹
Entrez Gene: 6657²
UniProtKB: P48431³
Ensembl: ENSG00000181449⁷

Search outside databases for aliases for SOX2 gene

Previous GC identifers: GC03P178128 GC03P182273 GC03P182831 GC03P182750

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SOX2:

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription

factors involved in the regulation of embryonic development and in the determination of cell fate.

The product of this gene is required for stem-cell maintenance in the central nervous system, and

also regulates gene expression in the stomach. Mutations in this gene have been associated with

optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye

malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript

(SOX2OT). [provided by RefSeq]

UniProtKB/Swiss-Prot: SOX2_HUMAN, P48431

Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the

expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and

ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity)

Gene Wiki entry for SOX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SOX2 gene

Entrez Gene cytogenetic band: 3q26.3-q27 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q26.3-q27

SOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P182912: (about GC identifiers)

Start:	182,912,416 bp from pter
End:	182,914,918 bp from pter
Size:	2,503 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SOX2_HUMAN, P48431 (See protein sequence)

Recommended Name: Transcription factor SOX-2

Size: 317 amino acids; 34310 Da

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1O4X (3D)

Secondary accessions: Q14537

Post-translational modifications:

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003097.1

ENSEMBL proteins:

ENSP00000323588

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SOX2 Protein
	Sigma-Aldrich AQUA Peptides for SOX2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SOX2)
	Human Recombinant Proteins from Abnova (SOX2)

OriGene Purified Recombinant Human Protein: SOX2

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	7849401
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for SOX2:

	Invitrogen Antibodies for SOX2
	Millipore Mono- and Polyclonal Antibodies for the study of SOX2
	Sigma-Aldrich Antibodies for SOX2
	R&D Systems Antibodies for SOX2
	Cell Signaling Technology (CST) Antibodies for SOX2
	Antibodies from Abcam (SOX2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SOX2)
	Novus Biologicals Antibodies for SOX2

Assays for SOX2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P48431

ProtoNet protein and cluster: P48431

UniProtKB/Swiss-Prot: SOX2_HUMAN, P48431

Similarity: Contains 1 HMG box DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SOX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SOX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003106

Applied Biosystems Silencer® siRNAs for SOX2

Sigma-Aldrich siRNA for SOX2

Sigma-Aldrich shRNA for SOX2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SOX2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003106
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003106
untagged cDNA clone in CMV expression vector: NM_003106

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC013923

UniProtKB/Swiss-Prot: SOX2_HUMAN, P48431

Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the

expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and

ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity)

Genatlas biochemistry entry for SOX2:

SRY related HMG box gene 2,expressed in inner cell mass,primitive ectoderm,developing

CNS,lens,induced by chordin,repressed by BMP4,activating FGF4,repressing osteopontin,inducing beta

and delta crystallin expression,modulator of LINE retroposons promoter activity

15/22 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Sox2) (see all 22 ):

behavior/neurological	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	nervous system	no phenotypic analysis	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0003700	transcription factor activity	NAS	7849401
GO:0005515	protein binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for SOX2 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta
Human Embryonic Stem Cell Pluripotency
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks SOX2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SOX2

5/56 Interacting proteins for SOX2 (ENSP00000323588³) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POU5F1	ENSP00000259915³	STRING (score=.997)
NANOGP8	ENSP00000229307³	STRING (score=.994)
PAX6	ENSP00000368424³	STRING (score=.992)
POU2F1	ENSP00000356836³	STRING (score=.981)
FGF4	ENSP00000168712³	STRING (score=.971)

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5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001708	cell fate specification	IEA	--
GO:0002052	positive regulation of neuroblast proliferation	IEA	--
GO:0006325	establishment or maintenance of chromatin architecture	NAS	7849401
GO:0006350	transcription	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SOX2
1 Novoseek chemical compound relationship for SOX2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	0.00	2	8641144 (1), 9435279 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SOX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SOX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003106

Sigma-Aldrich siRNA for SOX2

Sigma-Aldrich shRNA for SOX2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003106

REFSEQ mRNAs for SOX2 gene:

NM_003106.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003106

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003106
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003106
                                 untagged cDNA clone in CMV expression vector: NM_003106

Additional cDNA sequence:

AK312595.1 BC013923.2 CR592780.1 L07335.1 Z31560.1

9 DOTS entries:

DT.110032 DT.100779994 DT.91685066 DT.100649253 DT.120898896 DT.100025773 DT.100770335 DT.100643943

DT.91704238

24/138 AceView cDNA sequences (see all 138 ):

AI566840 BM719524 BF433292 BM718943 BU733331 AI364474 AI073494 BQ045260

AI360261 BM978785 BM700202 BM929439 AI573288 AU117840 CR592780 BF057693

Z31560 AW163619 AI936860 BM682840 BE792833 BE795592 AI933292 BC013923

highest scoring ESTs for SOX2:

AI669815 AW006202 AW007161 L07335 AA079711 AA115853 AA121979 AA133334 AA133407 AA451892

Unigene Cluster for SOX2:

SRY (sex determining region Y)-box 2

Hs.518438 [show with all ESTs]

Unigene Representative Sequence: NM_003106

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000325404

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SOX2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SOX2

¹ / ² / ³

11 probe-sets matching SOX2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89217_at²^{, 3}	U95-E	1	1.00	1.00	0.17	1.16	AW007161	1.00	1.00	1.00	1
33109_f_at²^{, 3}	U95-A	1	1.00	1.00	0.10	0.89	L07335	1.00	1.00	1.00	1
43431_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.09	AW006202	1.00	1.00	1.00	1
57685_at²^{, 3}	U95-B	1	1.00	1.00	0.96	1.00	AI669815	1.00	1.00	1.00	1
33108_i_at²^{, 3}	U95-A	1	1.00	1.00	0.16	0.09	L07335	1.00	1.00	1.00	1
213721_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L07335	1.00	1.00	1.00	1
228038_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI669815	1.00	1.00	1.00	1
213722_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AW007161	1.00	1.00	1.00	1
213721_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228038_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213722_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks SOX2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGAAAACCC

SOURCE GeneReport for Unigene cluster: Hs.518438
Expression variation in blood from EXPOLDB for SOX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SOX2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SOX2¹	--	SRY (sex determining region Y)-box 2	98(n) 100(a)	488092 XM_545216.2 XP_545216.2
chimpanzee (Pan troglodytes)	SOX2¹	--	SRY (sex determining region Y)-box 2	99.05(n) 98.74(a)	460869 XM_516895.2 XP_516895.2
cow (Bos taurus)	SOX2¹	--	SRY (sex determining region Y)-box 2	96.42(n) 100(a)	784383 XM_001252553.1 XP_001252554.1
rat (Rattus norvegicus)	Sox2¹	--	SRY (sex determining region Y)-box 2	94.85(n) 98.42(a)	499593 XM_574919.2 XP_574919.1
mouse (Mus musculus)	Sox2^{1, 5}	3 (15.00 cM)⁵	SRY-box containing gene 2^{1, 5}	94.53(n)¹ 98.42(a)¹	20674¹ NM_011443.3¹ NP_035573.3¹ AB108673⁵ AB221649⁵ (see all 15)

About this table Species with no ortholog for SOX2

ENSEMBL Gene Tree for SOX2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SOX2 gene

SOX3² SOX21² SOX15² SOX1² SOX14²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

9 NCBI SNPs in SOX2 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11915160^1,2	A,C,F,H	182914265(+)	`AGCAAC/ATTTTG`	1	--	ut3¹		4		EU EA WA	418
	rs7626501^1,2	F,H	182911300(+)	`CGGGGA/GAAATG`	1	--	ng5¹		4		EU EA WA	418
--	rs61335744^1,2	--	182911508(+)	`TCTTAC/TGGGGA`	1	--	ng5¹		0	--	--	--	--
--	rs55934172^1,2	--	182914089(+)	`GGGTGA/GGGAGG`	1	--	ut3¹		0	--	--	--	--
--	rs61651059^1,2	--	182910603(+)	`GGGGG-/GAGTGA`	1	--	ng5¹		0	--	--	--	--
--	rs56073304^1,2	--	182912812(+)	`GGCCGC/TCGGCG`	1	--	ut5¹		0	--	--	--	--
--	rs55956036^1,2	--	182914646(+)	`AGATAA/GAAAAA`	1	--	ut3¹		0	--	--	--	--
	rs35095647^1,2	--	182912000(+)	`GAGCCA/TCCCAC`	1	--	ng5¹		0	--	--	--	--
--	rs55683010^1,2	--	182913322(+)	`AGTTAC/TGCGCA`	1	Y/Y	syn¹		0	--	--	--	--

About this table
The following additional 17 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs9290727	rs34251173	rs6806029	rs4459940	rs6767575	rs4434184	rs10470352
rs6799574	rs12497248	rs13090842	rs9860562	rs9867181	rs12487748	rs12496378
rs35788479	rs4575941	rs7625466

HapMap Linkage Disequilibrium images for SOX2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 184429 disorders: 206900 206900

UniProtKB/Swiss-Prot: SOX2_HUMAN, P48431

Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900].

Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of

a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases,

microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular

abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or

bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula

10 Novoseek disease relationships for SOX2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anophthalmia	86.63	14	17522144 (5), 18385794 (2), 15503273 (2), 16892407 (1) (see all 6)
microphthalmia	76.95	9	17522144 (3), 18385794 (2), 16651659 (2), 18285410 (1)
eye abnormalities	71.00	1	18385794 (1)
carcinoma embryonal	58.88	3	9343393 (1), 9669521 (1), 17324942 (1)
metaplasia	37.12	6	14719100 (2), 15910596 (1), 14655050 (1), 18190713 (1)
hearing loss sensorineural	29.59	1	18407919 (1)
teratoma	19.69	10	17464316 (5)
small cell lung cancer	9.79	2	16077994 (1), 10760287 (1)
gastric cancer	5.94	7	18268498 (3), 15910596 (1), 17136346 (1)
tumors	0.00	1	15983380 (1)

About this table

GeneTests: SOX2

Anophthalmia/Microphthalmia

Human Gene Mutation Database: SOX2
Human Genome Epidemiology Navigator: SOX2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/135 PubMed articles for SOX2 gene (see all 135 ):

The cDNA sequence and chromosomal location of the human SOX2 gene. (PubMed id 7849401)^{2, 3, 4} Stevanovic M....Goodfellow P. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Mutations in SOX2 cause anophthalmia. (PubMed id 12612584)^{3, 4} Fantes J.... FitzPatrick D.R. (2003)
Expression of Sox2 in mature and immature teratomas of central nervous system. (PubMed id 17464316)^{1, 3} Phi J.H....Wang K.C. (2007)
Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. (PubMed id 18027866)^{1, 3} Park E.T....Kim Y.S. (2008)
SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. (PubMed id 18268498)^{1, 3} Otsubo T....Yuasa Y. (2008)
Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. (PubMed id 17136346)^{1, 3} Tani Y....Yuasa Y. (2007)
Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. (PubMed id 14719100)^{1, 3} Li X.L....Yuasa Y. (2004)
Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. (PubMed id 18366076)^{1, 3} Chakravarthy H....Rizzino A. (2008)
Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. (PubMed id 10801796)^{1, 3} Ambrosetti D.C....Basilico C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6657	HGNC: 11195	AceView: SOX2	Ensembl:ENSG00000181449	euGenes: HUgn6657
ECgene: SOX2	H-InvDB: SOX2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=SOX2
Wikipedia	http://en.wikipedia.org/wiki/Sox2

Licensable Technologies for SOX2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SOX2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SOX2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SOX2		Antibodies for SOX2
	Explore super-pooled esiRNAs		Proteins for SOX2
	Lentivirus-delivered shRNAs for SOX2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SOX2)
	Antibodies (SOX2)
	Chimera RNAi (SOX2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for SOX2

	Recombinant Proteins (SOX2)
	Antibodies (SOX2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for SOX2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SOX2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SOX2

Summaries
for SOX2

Genomic Location
for SOX2

Proteins
for SOX2

Protein Domains/
Families
for SOX2

Gene Function
for SOX2

Pathways & Interactions
for SOX2

Drugs & Compounds
for SOX2

Transcripts
for SOX2

Expression
for SOX2

Orthologs
for SOX2

Paralogs
for SOX2

SNPs/Variants
for SOX2

Disorders & Mutations
for SOX2

Medical News
for SOX2

Publications
for SOX2

Search for SOX2

Genome Databases showing SOX2

Other Databases showing SOX2

Specialized Databases showing SOX2

Licensable Technologies
for SOX2

Services
for SOX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SOX2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SOX2

Summariesfor SOX2

Genomic Locationfor SOX2

Proteinsfor SOX2

Protein Domains/Familiesfor SOX2

Gene Functionfor SOX2

Pathways & Interactionsfor SOX2

Drugs & Compoundsfor SOX2

Transcriptsfor SOX2

Expression for SOX2

Orthologsfor SOX2

Paralogsfor SOX2

SNPs/Variantsfor SOX2

Disorders & Mutationsfor SOX2

Medical Newsfor SOX2

Publicationsfor SOX2

Search for SOX2

Genome Databases showing SOX2

Other Databases showing SOX2

Specialized Databases showing SOX2

Licensable Technologiesfor SOX2

Servicesfor SOX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SOX2

Summaries
for SOX2

Genomic Location
for SOX2

Proteins
for SOX2

Protein Domains/
Families
for SOX2

Gene Function
for SOX2

Pathways & Interactions
for SOX2

Drugs & Compounds
for SOX2

Transcripts
for SOX2

Expression
for SOX2

Orthologs
for SOX2

Paralogs
for SOX2

SNPs/Variants
for SOX2

Disorders & Mutations
for SOX2

Medical News
for SOX2

Publications
for SOX2

Licensable Technologies
for SOX2

Services
for SOX2