Aliases for SOX17 Gene
External Ids for SOX17 Gene
Previous GeneCards Identifiers for SOX17 Gene
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOX17 Gene
SOX17 (SRY-Box 17) is a Protein Coding gene. Diseases associated with SOX17 include Vesicoureteral Reflux 3 and Familial Vesicoureteral Reflux. Among its related pathways are Mesodermal Commitment Pathway and Signaling by Wnt. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is SOX7.
UniProtKB/Swiss-Prot for SOX17 Gene
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5-AACAAT-3 or 5-AACAAAG-3. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).