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Aliases for SOX15 Gene

Aliases for SOX15 Gene

  • SRY (Sex Determining Region Y)-Box 15 2 3
  • SOX20 3 4 6
  • SRY (Sex Determining Region Y)-Box 20 2 3
  • SOX26 3 4
  • SOX27 3 4
  • Protein SOX-15 3
  • Protein SOX-12 4
  • Protein SOX-20 4
  • SOX12 4

External Ids for SOX15 Gene

Previous HGNC Symbols for SOX15 Gene

  • SOX20

Previous GeneCards Identifiers for SOX15 Gene

  • GC17M007905
  • GC17M008231
  • GC17M007434
  • GC17M007692
  • GC17M007433
  • GC17M007436
  • GC17M007491
  • GC17M007385

Summaries for SOX15 Gene

Entrez Gene Summary for SOX15 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX15 Gene

SOX15 (SRY (Sex Determining Region Y)-Box 15) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX15 Gene

  • Binds to the 5-AACAAT-3 sequence

Gene Wiki entry for SOX15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX15 Gene

Genomics for SOX15 Gene

Regulatory Elements for SOX15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOX15 Gene

Start:
7,588,178 bp from pter
End:
7,590,170 bp from pter
Size:
1,993 bases
Orientation:
Minus strand

Genomic View for SOX15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX15 Gene

Proteins for SOX15 Gene

  • Protein details for SOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60248-SOX15_HUMAN
    Recommended name:
    Protein SOX-15
    Protein Accession:
    O60248
    Secondary Accessions:
    • B4DWU7
    • D3DTQ0
    • P35717
    • Q9Y6W7

    Protein attributes for SOX15 Gene

    Size:
    233 amino acids
    Molecular mass:
    25251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX15 Gene

Proteomics data for SOX15 Gene at MOPED

Post-translational modifications for SOX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOX15 Gene

Domains for SOX15 Gene

Gene Families for SOX15 Gene

HGNC:
  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60248

UniProtKB/Swiss-Prot:

SOX15_HUMAN :
  • O60248
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX15: view

Function for SOX15 Gene

Molecular function for SOX15 Gene

UniProtKB/Swiss-Prot Function: Binds to the 5-AACAAT-3 sequence

Gene Ontology (GO) - Molecular Function for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0003677 DNA binding NAS 8332506
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8332506
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SOX15: view

Phenotypes for SOX15 Gene

MGI mutant phenotypes for SOX15:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with SOX15: view

Animal Models for SOX15 Gene

MGI Knock Outs for SOX15:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SOX15 Gene

Localization for SOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX15 Gene COMPARTMENTS Subcellular localization image for SOX15 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8332506
GO:0005737 cytoplasm IEA --
GO:0044798 nuclear transcription factor complex IEA --
genes like me logo Genes that share ontologies with SOX15: view

Pathways for SOX15 Gene

SuperPathways for SOX15 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX15: view

Pathways by source for SOX15 Gene

1 Qiagen pathway for SOX15 Gene

Gene Ontology (GO) - Biological Process for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 17363903
GO:0006325 chromatin organization NAS 8332506
GO:0006355 regulation of transcription, DNA-templated NAS 8332506
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9540826
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SOX15: view

Transcripts for SOX15 Gene

mRNA/cDNA for SOX15 Gene

(17) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX15 Gene

SRY (sex determining region Y)-box 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOX15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SOX15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX15 Gene

No ASD Table

Relevant External Links for SOX15 Gene

GeneLoc Exon Structure for
SOX15
ECgene alternative splicing isoforms for
SOX15

Expression for SOX15 Gene

mRNA expression in normal human tissues for SOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX15 Gene

This gene is overexpressed in Esophagus - Mucosa (10.9), Skin - Not Sun Exposed (Suprapubic) (5.1), and Skin - Sun Exposed (Lower leg) (4.2).

SOURCE GeneReport for Unigene cluster for SOX15 Gene Hs.95582

mRNA Expression by UniProt/SwissProt for SOX15 Gene

O60248-SOX15_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
genes like me logo Genes that share expressions with SOX15: view

In Situ Assay Products

No data available for Protein expression for SOX15 Gene

Orthologs for SOX15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX15 35
  • 99.57 (n)
  • 99.57 (a)
SOX15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOX15 35
  • 84.69 (n)
  • 81.12 (a)
SOX15 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOX15 35
  • 85.12 (n)
  • 84.55 (a)
SOX15 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sox15 35
  • 79.8 (n)
  • 74.46 (a)
Sox15 16
Sox15 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sox19a 36
  • 26 (a)
ManyToMany
sox19b 36
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SoxN 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sox-2 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for SOX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX15 Gene

ENSEMBL:
Gene Tree for SOX15 (if available)
TreeFam:
Gene Tree for SOX15 (if available)

Paralogs for SOX15 Gene

Selected SIMAP similar genes for SOX15 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SOX15 Gene

genes like me logo Genes that share paralogs with SOX15: view

Variants for SOX15 Gene

Sequence variations from dbSNP and Humsavar for SOX15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12944649 -- 7,588,910(+) CAGTC(A/G)CCTGA intron-variant
rs16956818 -- 7,589,751(+) TGGAA(A/G)GGTCT utr-variant-5-prime
rs34793392 -- 7,590,717(+) AGAGG(C/T)CTGTG upstream-variant-2KB
rs57903785 -- 7,590,598(+) CCCAA(-/CTCCA)GTCCC upstream-variant-2KB
rs59209949 -- 7,590,582(+) AGAAA(-/ACT)TAAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOX15 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Relevant External Links for SOX15 Gene

HapMap Linkage Disequilibrium report
SOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX15 Gene

Disorders for SOX15 Gene

Relevant External Links for SOX15

Genetic Association Database (GAD)
SOX15
genes like me logo Genes that share disorders with SOX15: view

No data available for UniProtKB/Swiss-Prot for SOX15 Gene

Publications for SOX15 Gene

  1. SOX20, a new member of the SOX gene family, is located on chromosome 17p13. (PMID: 8978787) Meyer J. … Scherer G. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. Isolation and expression of a human SRY-related cDNA hSOX20. (PMID: 9540826) Hiraoka Y. … Aiso S. (Biochim. Biophys. Acta 1998) 3 4
  3. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. (PMID: 9730625) Critcher R. … Farr C.J. (Cytogenet. Cell Genet. 1998) 2 3
  4. cDNA characterization and high resolution mapping of the human SOX20 gene. (PMID: 9880678) Vujic M. … Stevanovic M. (Mamm. Genome 1998) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SOX15 Gene

Sources for SOX15 Gene

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