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SOX15 Gene

protein-coding   GIFtS: 50
GCID: GC17M007491

SRY (Sex Determining Region Y)-Box 15

(Previous name: SRY (sex determining region Y)-box 20)
(Previous symbol: SOX20)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRY (Sex Determining Region Y)-Box 151 2     Protein SOX-152
SOX201 2 3 5     SOX123
SRY (Sex Determining Region Y)-Box 201 2     Protein SOX-123
SOX262 3     Protein SOX-203
SOX272 3     

External Ids:    HGNC: 111961   Entrez Gene: 66652   Ensembl: ENSG000001291947   OMIM: 6012975   UniProtKB: O602483   

Export aliases for SOX15 gene to outside databases

Previous GC identifers: GC17M007905 GC17M008231 GC17M007434 GC17M007692 GC17M007433 GC17M007436 GC17M007385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOX15 Gene:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the
regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a
transcriptional regulator after forming a protein complex with other proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX15 Gene:
SOX15 (SRY (sex determining region Y)-box 15) is a protein-coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX15_HUMAN, O60248
Function: Binds to the 5'-AACAAT-3' sequence

Gene Wiki entry for SOX15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX15 gene promoter:
         E2F-4   E2F-3a   E2F-5   C/EBPbeta   E2F-2   C/EBPalpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX15 promoter sequence
   Search Chromatin IP Primers for SOX15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12.3   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p12.3

SOX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007491:  view genomic region     (about GC identifiers)

Start:
7,491,496 bp from pter      End:
7,493,488 bp from pter
Size:
1,993 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOX15_HUMAN, O60248 (See protein sequence)
Recommended Name: Protein SOX-15  
Size: 233 amino acids; 25251 Da
Secondary accessions: D3DTQ0 P35717 Q9Y6W7

Explore the universe of human proteins at neXtProt for SOX15: NX_O60248

Explore proteomics data for SOX15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008873.1  
    ENSEMBL proteins: 
     ENSP00000439311   ENSP00000355354   ENSP00000458286  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry O60248

    ProtoNet protein and cluster: O60248

    UniProtKB/Swiss-Prot: SOX15_HUMAN, O60248
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with SOX15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX15_HUMAN, O60248
    Function: Binds to the 5'-AACAAT-3' sequence

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8332506
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8332506
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SOX15           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sox15):
     muscle  normal 

    Find genes that share phenotypes with SOX15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SOX15: Sox15tm1Imad Sox15tm1Yam

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX15
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX15
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    6 qRT-PCR Assays for microRNAs that regulate SOX15:
    hsa-miR-548a-3p hsa-miR-548g hsa-miR-661 hsa-miR-1323 hsa-miR-548e hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidSOX15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOX15

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOX15_HUMAN, O60248: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8332506
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SOX15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOX15 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX15
        Molecular Mechanisms of Cancer



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOX15
    Interactions:

        Search GeneGlobe Interaction Network for SOX15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for SOX15 (O602483 ENSP000003553544) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603, ENSP000003730164I2D: score=1 STRING: ENSP00000373016
    ENSG00000229094Q018603, ENSP000003888424I2D: score=1 STRING: ENSP00000388842
    ENSG00000230336Q018603, ENSP000004000474I2D: score=1 STRING: ENSP00000400047
    ENSG00000233911Q018603, ENSP000003928774I2D: score=1 STRING: ENSP00000392877
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
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    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS17363903
    GO:0006325chromatin organization NAS8332506
    GO:0006355regulation of transcription, DNA-templated NAS8332506
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9540826
    GO:0008584male gonad development TAS9540826

    Find genes that share ontologies with SOX15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX15



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOX15 gene: 
    NM_006942.1  

    Unigene Cluster for SOX15:

    SRY (sex determining region Y)-box 15
    Hs.95582  [show with all ESTs]
    Unigene Representative Sequence: AB006867
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538513(uc002ghy.1) ENST00000250055(uc002ghz.1) ENST00000570788

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SOX15:
    hsa-miR-548a-3p hsa-miR-548g hsa-miR-661 hsa-miR-1323 hsa-miR-548e hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidSOX15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOX15
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX15
      QuantiTect SYBR Green Assays in human, mouse, rat SOX15
      QuantiFast Probe-based Assays in human, mouse, rat SOX15

    Additional mRNA sequence: 

    AB006867.1 AJ006222.1 AK301687.1 BC000985.2 BC072003.1 

    3 DOTS entries:

    DT.110658  DT.91757171  DT.95109491 

    17 AceView cDNA sequences:

    NM_006942 BC072003 AB006867 T28489 BC000985 BX116598 BM563304 BG480459 
    BG480327 BM673169 BG714725 AI652276 BF514324 AJ006222 BM665592 AI921963 
    AA460735 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOX15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGCCAGGG
    SOX15 Expression
    About this image


    SOX15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Gonad
             Secondary Oocyte Antral Follicle
    SOX15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.95582

    UniProtKB/Swiss-Prot: SOX15_HUMAN, O60248
    Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord
    and adult brain and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOX15 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox151 , 5 SRY-box containing gene 155
    SRY (sex determining region Y)-box 151
    79.8(n)1
    74.46(a)1
      11 (42.86 cM)5
    206701  NM_009235.21  NP_033261.11 
     696553145 
    zebrafish
    (Danio rerio)
    Actinopterygii sox19b6
    sox19a6
    SRY-box containing gene 19a
    32(a)
    26(a)
    many ↔ many
    many ↔ many
    7(27620451-27623815) ENSDARG00000040266
    5(25868115-25870372) ENSDARG00000010770
    fruit fly
    (Drosophila melanogaster)
    Insecta SoxN6
    SoxNeuro
    17(a)
    1 → many
    2L(8825625-8829670)
    worm
    (Caenorhabditis elegans)
    Secernentea sox-26
    Protein SOX-2, isoform a
    29(a)
    1 → many
    X(7458293-7463736) WBGene00004949


    ENSEMBL Gene Tree for SOX15 (if available)
    TreeFam Gene Tree for SOX15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOX15 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX112  SOX82  
    SRY2  SOX102  SOX72  
    17 SIMAP similar genes for SOX15 using alignment to 2 protein entries:     SOX15_HUMAN (see all proteins):
    SOX27    SOX26    SOX25    SOX28    soxB    SOX10
    SRY    SOX21    SOX11    SOX17    SOX14    SOX5
    SOX12    SOX2    SOX3    SOX30    SOX8

    Find genes that share paralogs with SOX15           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SOX15
    PGOHUM00000262189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOX15 (see all 42)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465834491,2
    --7492085(+) TCTTGA/GGGAGT 1 -- int10--------
    rs1888629571,2
    --7492178(+) AGCAGC/GGGGGA 1 -- int10--------
    rs1491551381,2
    C--7492202(+) ACTAGG/TACACA 1 -- int10--------
    rs129446491,2
    C,F--7492228(+) CAGTCA/GCCTGA 1 -- int19Minor allele frequency- G:0.21NA CSA WA EA 370
    rs1173721431,2
    C,F--7492388(+) CTCCGG/ACATCC 1 -- int12Minor allele frequency- A:0.08NA EA 240
    rs1812721501,2
    C--7492432(+) GGCCTC/TCGTCT 1 -- int10--------
    rs1853427931,2
    --7492478(+) AGGCAA/GGTAGG 2 L syn10--------
    rs1998576061,2
    --7492498(+) AGCTGA/GGGGGT 2 P L mis10--------
    rs2022261611,2
    --7492566(+) CCGCCG/TCTGGC 2 R S mis10--------
    rs2007836501,2
    --7492626(+) TTGGCC/TTTGCG 2 K syn10--------

    HapMap Linkage Disequilibrium report for SOX15 (7491496 - 7493488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SOX15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SOX15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601297    OMIM disorders: --


    Find genes that share disorders with SOX15           About GenesLikeMe

    Genetic Association Database (GAD): SOX15

    Export disorders for SOX15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOX15 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SOX15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SOX20, a new member of the SOX gene family, is located on chromosome 17p13. (PubMed id 8978787)1, 2, 3 Meyer J.... Scherer G. (Cytogenet. Cell Genet. 1996)
    2. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PubMed id 22197929)1, 4 Yu X.Q....Liu J.J. (Nat. Genet. 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Isolation and expression of a human SRY-related cDNA hSOX20. (PubMed id 9540826)1, 2 Hiraoka Y.... Aiso S. (Biochim. Biophys. Acta 1998)
    5. cDNA characterization and high resolution mapping of the human SOX20 gene. (PubMed id 9880678)1, 2 Vujic M.... Stevanovic M. (Mamm. Genome 1998)
    6. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. (PubMed id 9730625)1, 3 Critcher R....Farr C.J. (Cytogenet. Cell Genet. 1998)
    7. Partial cloning of SOX-11 and SOX-12, two new human SOX genes. (PubMed id 8332506)1, 2 Goze C.... Berta P. (Nucleic Acids Res. 1993)
    8. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/I^-catenin signaling. (PubMed id 23318427)1 Thu K.L....Tsao M.S. (Oncogene 2014)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6665 HGNC: 11196 AceView: SOX15 Ensembl:ENSG00000129194 euGenes: HUgn6665
    ECgene: SOX15 H-InvDB: SOX15

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOX15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOX15 gene:
    Search GeneIP for patents involving SOX15

    GeneCards and IP:
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