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Aliases for SOX14 Gene

Aliases for SOX14 Gene

  • SRY-Box 14 2 3 2 5
  • SRY (Sex Determining Region Y)-Box 14 2 3
  • HMG Box Transcription Factor SOX-14 2 3
  • SRY Box 14 2 3
  • SOX28 3 4
  • Protein SOX-28 4

External Ids for SOX14 Gene

Previous GeneCards Identifiers for SOX14 Gene

  • GC03P134468
  • GC03P138275
  • GC03P138765
  • GC03P138804
  • GC03P138966
  • GC03P137483
  • GC03P134858

Summaries for SOX14 Gene

Entrez Gene Summary for SOX14 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX14 Gene

SOX14 (SRY-Box 14) is a Protein Coding gene. Diseases associated with SOX14 include Moebius Syndrome. Among its related pathways are ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX14 Gene

  • Acts as a negative regulator of transcription.

Gene Wiki entry for SOX14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX14 Gene

Genomics for SOX14 Gene

Regulatory Elements for SOX14 Gene

Enhancers for SOX14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOX14 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOX14 Gene

Chromosome:
3
Start:
137,764,284 bp from pter
End:
137,766,338 bp from pter
Size:
2,055 bases
Orientation:
Plus strand

Genomic View for SOX14 Gene

Genes around SOX14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX14 Gene

Proteins for SOX14 Gene

  • Protein details for SOX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95416-SOX14_HUMAN
    Recommended name:
    Transcription factor SOX-14
    Protein Accession:
    O95416
    Secondary Accessions:
    • B2RAC0
    • Q3KPH7

    Protein attributes for SOX14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26485 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX14 Gene

Proteomics data for SOX14 Gene at MOPED

Post-translational modifications for SOX14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX14 Gene

Domains & Families for SOX14 Gene

Gene Families for SOX14 Gene

Protein Domains for SOX14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95416

UniProtKB/Swiss-Prot:

SOX14_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX14: view

Function for SOX14 Gene

Molecular function for SOX14 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 14,predominantly expressed in fetal brain,spinal cord,thymus,potentially involved in regulation of nervous system development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of transcription.

Gene Ontology (GO) - Molecular Function for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with SOX14: view
genes like me logo Genes that share phenotypes with SOX14: view

Animal Models for SOX14 Gene

MGI Knock Outs for SOX14:

Animal Model Products

miRNA for SOX14 Gene

miRTarBase miRNAs that target SOX14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX14 Gene

Localization for SOX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX14 Gene COMPARTMENTS Subcellular localization image for SOX14 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for SOX14 Gene

Pathways & Interactions for SOX14 Gene

SuperPathways for SOX14 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX14: view

Pathways by source for SOX14 Gene

1 Qiagen pathway for SOX14 Gene

Interacting Proteins for SOX14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305343%0d%0a9606.ENSP00000362170%0d%0a9606.ENSP00000403397%0d%0a
Selected Interacting proteins: ENSP00000305343 O95416-SOX14_HUMAN for SOX14 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0007399 nervous system development TAS 9925951
GO:0007601 visual perception IEA --
genes like me logo Genes that share ontologies with SOX14: view

No data available for SIGNOR curated interactions for SOX14 Gene

Drugs & Compounds for SOX14 Gene

No Compound Related Data Available

Transcripts for SOX14 Gene

mRNA/cDNA for SOX14 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX14 Gene

SRY (sex determining region Y)-box 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX14 Gene

No ASD Table

Relevant External Links for SOX14 Gene

GeneLoc Exon Structure for
SOX14
ECgene alternative splicing isoforms for
SOX14

Expression for SOX14 Gene

mRNA expression in normal human tissues for SOX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX14 Gene

This gene is overexpressed in Brain - Hypothalamus (x23.7), Brain - Substantia nigra (x14.9), and Prostate (x8.2).

Protein differential expression in normal tissues from HIPED for SOX14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX14 Gene



SOURCE GeneReport for Unigene cluster for SOX14 Gene Hs.248184

genes like me logo Genes that share expression patterns with SOX14: view

Protein tissue co-expression partners for SOX14 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SOX14 Gene

Orthologs for SOX14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOX14 35
  • 96.67 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SOX14 35
  • 96.25 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Sox14 35
  • 95.42 (n)
  • 99.58 (a)
Sox14 16
Sox14 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOX14 35
  • 99.72 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Sox14 35
  • 95.42 (n)
  • 99.58 (a)
oppossum
(Monodelphis domestica)
Mammalia SOX14 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOX14 35
  • 84.44 (n)
  • 96.25 (a)
SOX14 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sox14 35
  • 77.13 (n)
  • 89.12 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
sox14 35
  • 77.73 (n)
  • 91.18 (a)
sox14 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta D 37
  • 87 (a)
Sox21a 37
  • 90 (a)
Sox21b 37
  • 88 (a)
Sox21a 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sox-3 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SOX14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX14 Gene

ENSEMBL:
Gene Tree for SOX14 (if available)
TreeFam:
Gene Tree for SOX14 (if available)

Paralogs for SOX14 Gene

(13) SIMAP similar genes for SOX14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX14: view

Variants for SOX14 Gene

Sequence variations from dbSNP and Humsavar for SOX14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs149863 -- 137,763,521(+) ATAAC(A/G)TAAAT upstream-variant-2KB
rs157281 -- 137,763,401(+) CCGCT(C/G)TAGGG upstream-variant-2KB
rs201718 -- 137,764,520(+) CTGGT(G/T)CCTGA utr-variant-5-prime
rs2016242 -- 137,766,653(-) TCGGC(C/T)TTTGA downstream-variant-500B
rs16847433 -- 137,762,500(+) TGCTT(C/T)CTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOX14 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914

Variation tolerance for SOX14 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SOX14 Gene

Disorders for SOX14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOX14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
moebius syndrome
  • mobius syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SOX14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOX14

Genetic Association Database (GAD)
SOX14
Human Genome Epidemiology (HuGE) Navigator
SOX14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX14
genes like me logo Genes that share disorders with SOX14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOX14 Gene

Publications for SOX14 Gene

  1. Characterisation and mapping of the human SOX14 gene. (PMID: 9925951) Arsic N. … Stevanovic M. (Cytogenet. Cell Genet. 1998) 2 3 4 67
  2. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. (PMID: 10830911) Hargrave M. … Koopman P. (Hum. Genet. 2000) 3 23
  3. SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/I^-catenin pathway. (PMID: 25973056) Li F. … Tang S. (Int J Clin Exp Pathol 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for SOX14 Gene

Sources for SOX14 Gene

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