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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SOX14 Gene

protein-coding GIFtS: 51
GCID: GC03P137483

SRY (sex determining region Y)-box 14

Explore 10 diseases affiliated with
SOX14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SRY (Sex Determining Region Y)-Box 14¹ ²
SOX28¹ ² ³
HMG Box Transcription Factor SOX-14²
SRY-Box 14²
Transcription Factor SOX-14²
Protein SOX-28³

External Ids:	HGNC: 11193¹	Entrez Gene: 8403²	Ensembl: ENSG00000168875⁷	OMIM: 604747⁵	UniProtKB: O95416³

Export aliases for SOX14 gene to outside databases

Previous GC identifers: GC03P134468 GC03P138275 GC03P138765 GC03P138804 GC03P138966 GC03P134858

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOX14:

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the

regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a

transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to

be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and

Mobius syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SOX14_HUMAN, O95416

Function: Acts as a negative regulator of transcription (By similarity)

Gene Wiki entry for SOX14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SOX14 gene promoter:
Max1 MEF-2 RelA NF-kappaB PPAR-alpha MEF-2A POU2F1 aMEF-2 NF-kappaB1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOX14 promoter sequence

Search SABiosciences Chromatin IP Primers for SOX14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22-q23 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22-q23

SOX14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX14 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P137483: view genomic region (about GC identifiers)

Start:	137,483,579 bp from pter	End:	137,484,396 bp from pter
Size:	818 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SOX14_HUMAN, O95416 (See protein sequence)

Recommended Name: Transcription factor SOX-14

Size: 240 amino acids; 26485 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: B2RAC0 Q3KPH7

Explore the universe of human proteins at neXtProt for SOX14: NX_O95416

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95416

SOX14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004180.1

ENSEMBL proteins:

ENSP00000305343

Human Recombinant Protein Products for SOX14:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SOX14 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOX14

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--

SOX14 for ontologies About GeneDecksing

SOX14 Antibody Products:

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Assay Products for SOX14:

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	Uscn ELISAs and CLIAs for SOX14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SOX14 for domains About GeneDecksing

2 InterPro domains/families:

IPR009071 HMG_superfamily

IPR022097 TF_SOX

Graphical View of Domain Structure for InterPro Entry O95416

ProtoNet protein and cluster: O95416

UniProtKB/Swiss-Prot: SOX14_HUMAN, O95416

Similarity: Contains 1 HMG box DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SOX14_HUMAN, O95416

Function: Acts as a negative regulator of transcription (By similarity)

Genatlas biochemistry entry for SOX14:

SRY related HMG box gene 14,predominantly expressed in fetal brain,spinal cord,thymus,potentially involved in

regulation of nervous system development,modulator of LINE retroposons promoter activity

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043565	sequence-specific DNA binding	ISS	--

SOX14 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for SOX14:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sox14):

no phenotypic analysis

SOX14 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SOX14

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX14
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX14 (see all 19):
		hsa-miR-548j hsa-miR-548i hsa-miR-24-1* hsa-miR-4272 hsa-miR-219-5p hsa-miR-500a hsa-miR-24-2* hsa-miR-511

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX14 (see all 4) OriGene shRNA RFP: SOX14 OriGene siRNA: SOX14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX14
		Sirion Biotech Custom design and validation of potent shRNA sequences against SOX14

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SOX14
			Sirion Biotech Customized adenovirus for overexpression of SOX14 Sirion Biotech Customized adenovirus for potent knockdown of SOX14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX14 (NM_004189)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX14

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOX14
		Search LifeMap BioReagents cell lines for SOX14
		Sirion Biotech Customized stable knockdown cell line services for SOX14 Sirion Biotech Customized inducible knockdown cell line services for SOX14 Sirion Biotech Customized stable overexpressing cell line services for SOX14 Sirion Biotech Customized inducible overexpressing cell line services for SOX14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX14

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Rho Family GTPases

Molecular Mechanisms of Cancer

0.51

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX14

Molecular Mechanisms of Cancer

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SOX14

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007399	nervous system development	TAS	9925951
GO:0045892	negative regulation of transcription, DNA-dependent	ISS	--

SOX14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOX14
Search CenterWatch for drugs/clinical trials and news about SOX14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOX14 gene:

NM_004189.3

Unigene Cluster for SOX14:

SRY (sex determining region Y)-box 14

Hs.248184 [show with all ESTs]

Unigene Representative Sequence: NM_004189

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000306087(uc003erm.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX14
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX14 (see all 19):
		hsa-miR-548j hsa-miR-548i hsa-miR-24-1* hsa-miR-4272 hsa-miR-219-5p hsa-miR-500a hsa-miR-24-2* hsa-miR-511

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX14 (see all 4) OriGene shRNA RFP: SOX14 OriGene siRNA: SOX14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX14
		Sirion Biotech Custom design and validation of potent shRNA sequences against SOX14

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX14 (NM_004189)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOX14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX14

Additional cDNA sequence:

AK314127.1 BC106729.1 BC106730.1

1 DOTS entry:

DT.91734375

5 AceView cDNA sequences:

NM_004189 BX416919 BX430903 BQ025639 BQ022364

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOX14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACCCCCAG

About this image

SOX14 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Brain

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SOX14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOX14

SOURCE GeneReport for Unigene cluster: Hs.248184

SABiosciences Custom PCR Arrays for SOX14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOX14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOX14 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SOX14¹	SRY (sex determining region Y)-box 14	84.44(n) 96.25(a)		395526 NM_204761.1 NP_990092.1
zebrafish (Danio rerio)	Actinopterygii	AF101266.1²	--	78.71(n)		30543 AF101266.1
fruit fly (Drosophila melanogaster)	Insecta	Sox21a³	transcription factor	90(a) (best of 3)		70D2 --
worm (Caenorhabditis elegans)	Secernentea	sox-3⁶ sox-4⁶	Protein SOX-4	39(a) 22(a)	possible ortholog possible ortholog	X(14690764-14692930) X(3505427-3506378)

ENSEMBL Gene Tree for SOX14 (if available)
TreeFam Gene Tree for SOX14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SOX14 gene

SOX13² SOX2² SOX4² SOX1² SOX3² SOX9² SOX12² SOX15²

SOX18² SOX5² ENSG00000258724² SOX21² SOX17² SOX6² SOX11² SOX8²

SRY² SOX10² SOX7²

13 SIMAP similar genes for SOX14 using alignment to 1 protein entry: SOX14_HUMAN:

SOX25 soxB SOX11 SOX10 SOX17 SRY

SOX5 SOX21 SOX15 SOX2 SOX12 SOX1

SOX8

SOX14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80147309^1,2	F	--	137481265(+)	`GCACCG/TCTGGT`	1	--	us2k¹		1		WA	118
rs182290003^1,2		--	137481290(+)	`GGTTGA/CCAGCG`	1	--	us2k¹		0	--	--	--	--
rs12636928^1,2	C,F,H	--	137481332(+)	`AAAGTG/ACGTTT`	1	--	us2k¹		10		NS EA NA WA	658
rs16847433^1,2	C,F,H	--	137481342(+)	`TGCTTC/TCTGAG`	1	--	us2k¹ tfbs³		25		NA NS EA WA	2788
rs140419310^1,2		--	137481390(+)	`GGTTAC/GAGGGC`	1	--	us2k¹		0	--	--	--	--
rs186616173^1,2		--	137481399(+)	`GCTGGA/TTGGAG`	1	--	us2k¹		0	--	--	--	--
rs145425414^1,2		--	137481423(+)	`GCCAGA/CGCTGG`	1	--	us2k¹		0	--	--	--	--
rs11717337^1,2	C,F,H	--	137481510(+)	`CGCAGG/AATCAG`	1	--	us2k¹		29		NA NS EA	3028
rs138029898^1,2		--	137481562(+)	`CCCAAC/TAGTCT`	1	--	us2k¹		0	--	--	--	--
rs192555207^1,2		--	137481574(+)	`ATCAGG/TTGTTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SOX14 (137483579 - 137484396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SOX14: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX14

DNA2.0 Custom Variant and Variant Library Synthesis for SOX14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SOX14 for disorders           About GeneDecksing

OMIM gene information: 604747    OMIM disorders: --

10 diseases for SOX14:    About MalaCards

blepharophimosis, ptosis, and epicanthus inversus syndrome mobius syndrome blepharophimosis ptosis

papillon-lefevre disease campomelic dysplasia anophthalmia hypopituitarism

hepatitis neuronitis

4 diseases from the University of Copenhagen DISEASES database for SOX14:

Mobius syndrome "blepharophimosis, ptosis, and epicanthus inversus syndrome" Papillon-Lefevre disease Blepharophimosis

Human Genome Epidemiology (HuGE) Navigator: SOX14 (1 document)

Export disorders for SOX14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOX14 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SOX14)

Utopia: connect your pdf to the dynamic
world of online information

Characterisation and mapping of the human SOX14 gene. (PubMed id 9925951)^{1, 2, 3} Arsic N.... Stevanovic M. (1998)
Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. (PubMed id 10830911)^{1, 2, 9} Hargrave M.... Koopman P. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PubMed id 10441749)^{1, 2} Malas S.... Episkopou V. (1999)
Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. (PubMed id 9827568)^{1, 2} Cremazy F.... Jay P. (1998)
Tissue-specific Forkhead protein FOXA2 up-regulates S OX14 gene expression. (PubMed id 20074681)¹ Popovic J....Stevanovic M. (2010)
Analysis of copy number variation in 8,842 Korean ind ividuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)¹ Kim H.Y....Kim H. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. (PubMed id 12100890)¹ Wilson M. and Koopman P. (2002)
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. (PubMed id 12194848)¹ Schepers G.E....Koopman P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8403	HGNC: 11193	AceView: SOX14	Ensembl:ENSG00000168875	euGenes: HUgn8403
ECgene: SOX14	H-InvDB: SOX14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SOX14	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SOX14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SOX14 gene:
Search GeneIP for patents involving SOX14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SOX14
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX14		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX14
	OriGene Protein Over-expression Lysate for SOX14		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SOX14		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX14
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOX14
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX14
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX14
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX14
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX14
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX14

	GenScript Custom Purified and Recombinant Proteins Services for SOX14		GenScript cDNA clones with any tag delivered in your preferred vector for SOX14
	GenScript Custom Assay Services for SOX14		GenScript Custom Superior Antibodies Services for SOX14
	GenScript Custom overexpressing Cell Line Services for SOX14		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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SOX14 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX14

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SOX14
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ThermoFisher Antibodies for SOX14

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX14

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SOX14

Sirion Biotech Customized:

	stable knockdown cell line services for SOX14
	inducible knockdown cell line services for SOX14
	design and validation of potent shRNA sequences against SOX14
	adenovirus for potent knockdown of SOX14
	adenovirus for overexpression of SOX14
	stable overexpressing cell line services for SOX14
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SOX14 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

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SOX14 Gene

SRY (sex determining region Y)-box 14

Aliases
for SOX14 gene

Summaries
for SOX14 gene

Genomic Views
for SOX14 gene

Proteins
for SOX14 gene

Protein Domains /
Families
for SOX14 gene

Function
for SOX14 gene

Pathways & Interactions
for SOX14 gene

Drugs & Compounds
for SOX14 gene

Transcripts
for SOX14 gene

Expression
for SOX14 gene

Orthologs
for SOX14 gene

Paralogs
for SOX14 gene

Genomic Variants
for SOX14 gene

Disorders / Diseases
for SOX14 gene

Publications
for SOX14 gene

External Searches for SOX14 gene

Genome Databases showing SOX14 gene

Other Databases showing SOX14 gene

Specialized Databases showing SOX14 gene

Intellectual Property
for SOX14 gene

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for SOX14 gene

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Export list of displayed genes

SOX14 Gene

SRY (sex determining region Y)-box 14

Aliasesfor SOX14 gene

Summariesfor SOX14 gene

Genomic Viewsfor SOX14 gene

Proteinsfor SOX14 gene

Protein Domains /Familiesfor SOX14 gene

Functionfor SOX14 gene

Pathways & Interactionsfor SOX14 gene

Drugs & Compoundsfor SOX14 gene

Transcriptsfor SOX14 gene

Expression for SOX14 gene

Orthologsfor SOX14 gene

Paralogsfor SOX14 gene

Genomic Variantsfor SOX14 gene

Disorders / Diseasesfor SOX14 gene

Publicationsfor SOX14 gene

External Searches for SOX14 gene

Genome Databases showing SOX14 gene

Other Databases showing SOX14 gene

Specialized Databases showing SOX14 gene

Intellectual Propertyfor SOX14 gene

Productsfor SOX14 gene

View Random Gene

Aliases
for SOX14 gene

Summaries
for SOX14 gene

Genomic Views
for SOX14 gene

Proteins
for SOX14 gene

Protein Domains /
Families
for SOX14 gene

Function
for SOX14 gene

Pathways & Interactions
for SOX14 gene

Drugs & Compounds
for SOX14 gene

Transcripts
for SOX14 gene

Expression
for SOX14 gene

Orthologs
for SOX14 gene

Paralogs
for SOX14 gene

Genomic Variants
for SOX14 gene

Disorders / Diseases
for SOX14 gene

Publications
for SOX14 gene

Intellectual Property
for SOX14 gene

Products
for SOX14 gene