Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SOX13 Gene

protein-coding   GIFtS: 56
GCID: GC01P204043

SRY (Sex Determining Region Y)-Box 13

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SRY (Sex Determining Region Y)-Box 131 2 3     Type 1 Diabetes Autoantigen ICA122 3
Islet Cell Antibody 121 2     ICA122 5
SRY-Box 131 2     Type 1 Diabetes Autoantigen1
SRY-Related HMG-Box Gene 131 2     Sox-132
Islet Cell Antigen 122 3     Transcription Factor SOX-132

External Ids:    HGNC: 111921   Entrez Gene: 95802   Ensembl: ENSG000001438427   OMIM: 6047485   UniProtKB: Q9UN793   

Export aliases for SOX13 gene to outside databases

Previous GC identifers: GC01P201766 GC01P199503 GC01P200402 GC01P201259 GC01P201219 GC01P200774 GC01P202308 GC01P175207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SOX13 Gene:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the
regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a
transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be
a type-1 diabetes autoantigen, also known as islet cell antibody 12. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX13 Gene:
SOX13 (SRY (sex determining region Y)-box 13) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX2.

UniProtKB/Swiss-Prot: SOX13_HUMAN, Q9UN79
Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

Gene Wiki entry for SOX13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX13 gene promoter:
         GR   Sp1   RREB-1   SREBP-1c   GR-beta   SREBP-1b   SREBP-1a   IRF-7A   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX13 promoter sequence
   Search Chromatin IP Primers for SOX13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

SOX13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P204043:  view genomic region     (about GC identifiers)

Start:
204,042,243 bp from pter      End:
204,096,871 bp from pter
Size:
54,629 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SOX13_HUMAN, Q9UN79 (See protein sequence)
Recommended Name: Transcription factor SOX-13  
Size: 622 amino acids; 69228 Da
Sequence caution: Sequence=AAC83687.1; Type=Miscellaneous discrepancy; Note=Several frameshifts;
Sequence=AAF23875.1; Type=Erroneous initiation; Sequence=BAG65072.1; Type=Erroneous initiation;
Sequence=CAI16596.1; Type=Erroneous initiation;
Secondary accessions: B4E2B0 O95275 O95826 Q3KQV7 Q5SXX1 Q9UHW7

Explore the universe of human proteins at neXtProt for SOX13: NX_Q9UN79

Explore proteomics data for SOX13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005677.2  
    ENSEMBL proteins: 
     ENSP00000356172   ENSP00000433595   ENSP00000436297   ENSP00000434093  

    SOX13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SOX13
    OriGene Protein Over-expression Lysate for SOX13
    OriGene MassSpec for SOX13
    OriGene Custom Protein Services for SOX13
    GenScript Custom Purified and Recombinant Proteins Services for SOX13
    Novus Biologicals SOX13 Proteins
    Novus Biologicals SOX13 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOX13

     
    Search eBioscience for Proteins for SOX13 

     
    antibodies-online proteins for SOX13 (4 products) 

     
    antibodies-online peptides for SOX13

    SOX13 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOX13
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SOX13
    OriGene Custom Antibody Services for SOX13
    Novus Biologicals SOX13 Antibodies
    Abcam antibodies for SOX13
    Cloud-Clone Corp. Antibodies for SOX13
    ThermoFisher Antibodies for SOX13
    antibodies-online antibodies for SOX13 (43 products) 

    SOX13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SOX13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOX13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOX13
    Cloud-Clone Corp. CLIAs for SOX13
    Search eBioscience for ELISAs for SOX13 
    antibodies-online kits for SOX13 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UN79

    ProtoNet protein and cluster: Q9UN79

    UniProtKB/Swiss-Prot: SOX13_HUMAN, Q9UN79
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with SOX13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX13_HUMAN, Q9UN79
    Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

         Genatlas biochemistry entry for SOX13:
    SRY related HMB box gene 13,highly expressed in fetal kidney,lung,liver,with cow expression from thymus,spleen and
    muscle,modulator of LINE retroposons promoter activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10198172
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding ISS--
         
    Find genes that share ontologies with SOX13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SOX13:
     Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sox13):
     cardiovascular system  growth/size/body  hematopoietic system  immune system  limbs/digits/tail 
     skeleton 

    Find genes that share phenotypes with SOX13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sox13tm1Jskg for SOX13

       genOway: Develop your customized and physiologically relevant rodent model for SOX13

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOX13:
    hsa-let-7b-5p (MIRT052343), hsa-mir-335-5p (MIRT016882)

    Block miRNA regulation of human, mouse, rat SOX13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX13 (see all 46):
    hsa-miR-132* hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-3605-3p hsa-miR-624* hsa-miR-30d hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidSOX13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOX13
    Predesigned siRNA for gene silencing in human, mouse, rat SOX13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOX13

    Clone
    Products:
         
    OriGene clones in human, mouse for SOX13 (see all 7)
    OriGene ORF clones in mouse, rat for SOX13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX13 (NM_005686)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOX13
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOX13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SOX13_HUMAN, Q9UN79: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with SOX13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SOX13 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX13
        Molecular Mechanisms of Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOX13
    Interactions:

        Search GeneGlobe Interaction Network for SOX13

    2 Interacting proteins for SOX13 (Q9UN791, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD7O151052, 3MINT-61819 I2D: score=3 
    CTBP2P565451EBI-3928516,EBI-741533
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0009653anatomical structure morphogenesis TAS10198172

    Find genes that share ontologies with SOX13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX13

    1 Novoseek inferred chemical compound relationship for SOX13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 45.3 2 10854791 (1), 10871192 (1)



    Find genes that share compounds with SOX13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SOX13 gene: 
    NM_005686.2  

    Unigene Cluster for SOX13:

    SRY (sex determining region Y)-box 13
    Hs.201671  [show with all ESTs]
    Unigene Representative Sequence: NM_005686
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367203(uc001hal.3) ENST00000534185 ENST00000530882 ENST00000367204(uc001ham.3 uc010pqp.2 uc010pqq.2)
    ENST00000525442 ENST00000528591 ENST00000272193 ENST00000480326 ENST00000525258

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOX13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX13 (see all 46):
    hsa-miR-132* hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-3605-3p hsa-miR-624* hsa-miR-30d hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidSOX13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOX13
    Predesigned siRNA for gene silencing in human, mouse, rat SOX13
    Clone
    Products:
         
    OriGene clones in human, mouse for SOX13 (see all 7)
    OriGene ORF clones in mouse, rat for SOX13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX13 (NM_005686)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX13
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SOX13
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX13
      QuantiTect SYBR Green Assays in human, mouse, rat SOX13
      QuantiFast Probe-based Assays in human, mouse, rat SOX13

    Additional mRNA sequence: 

    AF083105.1 AF098915.1 AF116571.1 AK301782.1 AK304192.1 AK304801.1 AK314197.1 BC106038.1 

    8 DOTS entries:

    DT.86840746  DT.97790051  DT.91729986  DT.121390039  DT.121390060  DT.121390020  DT.121390059  DT.95084303 

    Selected AceView cDNA sequences (see all 100):

    BU189240 BE743449 CF456587 AV660473 BQ935858 AA524041 AF098915 AA316800 
    NM_005686 AL043036 AA346542 CN480970 BM013898 CD673803 BM727461 BM785423 
    AF083105 W81654 BF347258 AI270013 BM682414 BU740705 BM549374 BE727776 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SOX13    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                    -                       -                 -                                       
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for SOX13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SOX13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACAGGGT
    SOX13 Expression
    About this image


    SOX13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    SOX13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201671

    UniProtKB/Swiss-Prot: SOX13_HUMAN, Q9UN79
    Tissue specificity: Highly expressed in kidney, lung, and liver and low expression in thymus, brain, spleen, and
    muscle

        Custom PCR Arrays for SOX13
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SOX13
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX13
    QuantiTect SYBR Green Assays in human, mouse, rat SOX13
    QuantiFast Probe-based Assays in human, mouse, rat SOX13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SOX13 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox131 , 5 SRY-box containing gene 135
    SRY (sex determining region Y)-box 131
    87.77(n)1
    90.38(a)1
      1 (57.91 cM)5
    206681  NM_011439.21  NP_035569.21 
     1333823035 
    chicken
    (Gallus gallus)
    Aves SOX131 SRY (sex determining region Y)-box 13 77.58(n)
    77.74(a)
      419820  XM_004934895.1  XP_004934952.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOX136
    SRY (sex determining region Y)-box 13
    70(a)
    1 ↔ 1
    4(117913677-117950429)
    African clawed frog
    (Xenopus laevis)
    Amphibia xSox122 xSox12 protein 75.77(n)    D50552.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL929022.16
    Uncharacterized protein
    50(a)
    1 ↔ 1
    11(38969549-38994099) ENSDARG00000030297
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox102F3 transcription factor 75(a)   102C3   --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-133 Expression: pi lineage, gonad, head
    neurons, tail more
    69(a)   X(5703590-5708655)   --


    ENSEMBL Gene Tree for SOX13 (if available)
    TreeFam Gene Tree for SOX13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SOX13 gene
    SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  SOX152  
    SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX112  SOX82  
    SRY2  SOX102  SOX72  
    2 SIMAP similar genes for SOX13 using alignment to 4 protein entries:     SOX13_HUMAN (see all proteins):
    SOX10    SOX5

    Find genes that share paralogs with SOX13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SOX13 (see all 1193)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456808441,2
    C--204040308(+) CACTGC/TCATTG 1 -- us2k10--------
    rs66961871,2
    C,F,H--204040403(+) CCTTCC/TATCAA 1 -- us2k112Minor allele frequency- T:0.04NS EA NA WA 1452
    rs1903123331,2
    --204040485(+) TACATA/CCCTGC 1 -- us2k10--------
    rs1485102571,2
    --204040516(+) AGGGCG/TGAGAC 1 -- us2k10--------
    rs606040411,2
    C,F--204040539(+) GGTTAC/GCATAT 1 -- us2k12Minor allele frequency- G:0.08CSA WA 120
    rs1477509831,2
    --204040743(+) GAACAC/TATGCT 1 -- us2k10--------
    rs1425127791,2
    C--204040766(+) TGTGGA/GCATAG 1 -- us2k10--------
    rs1164809951,2
    F--204040812(+) TCTGCC/TCTACA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1468321521,2
    --204040891(+) GTGTCG/TTTGGT 1 -- us2k10--------
    rs1829111331,2
    --204040991(+) AGAAAA/GGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOX13 (204042243 - 204096871 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SOX13: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOX13
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604748    OMIM disorders: --


    Find genes that share disorders with SOX13           About GenesLikeMe

    Genetic Association Database (GAD): SOX13
    Human Genome Epidemiology (HuGE) Navigator: SOX13 (1 document)

    Export disorders for SOX13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SOX13 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SOX13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. (PubMed id 10198172)1, 3, 9 Roose J....Clevers H. (Genomics 1999)
    2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    3. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. (PubMed id 9421502)1, 2 Roose J.... Clevers H. (Nucleic Acids Res. 1998)
    4. Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. (PubMed id 10871192)1, 9 Kasimiotis H....Harley V.R. (Diabetes 2000)
    5. Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes. (PubMed id 11286511)1, 9 Argentaro A....Harley V.R. (Mol. Genet. Metab. 2001)
    6. Genomic characterisation and fine mapping of the human SOX13 gene. (PubMed id 10854791)1, 9 Argentaro A....Harley V.R. (Gene 2000)
    7. SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea. (PubMed id 14679071)1, 9 Park Y....Kim D. (Ann. N. Y. Acad. Sci. 2003)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9580 HGNC: 11192 AceView: SOX13 Ensembl:ENSG00000143842 euGenes: HUgn9580
    ECgene: SOX13 H-InvDB: SOX13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SOX13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SOX13 gene:
    Search GeneIP for patents involving SOX13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SOX13
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SOX13   OriGene RNAi products in human, mouse, rat for SOX13  
     OriGene qPCR primer pairs and template standards for SOX13   OriGene Protein Over-expression Lysate for SOX13  
     OriGene MassSpec for SOX13   OriGene clones in human, mouse for SOX13  
     OriGene qSTAR qPCR primer pairs in human, mouse for SOX13   OriGene Purified Protein for SOX13  
     OriGene ORF clones in mouse, rat for SOX13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SOX13   OriGene Custom Protein Services for SOX13  

     
     
     Block miRNA regulation of human, mouse, rat SOX13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SOX13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX13 Predesigned siRNA for gene silencing in human, mouse, rat SOX13
     QuantiFast Probe-based Assays in human, mouse, rat SOX13 QuantiTect SYBR Green Assays in human, mouse, rat SOX13
     Custom PCR Arrays for SOX13 Search Chromatin IP Primers for SOX13
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX13  Search GeneGlobe Interaction Network for SOX13
     Regulatory tfbs in SOX13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SOX13 GenScript cDNA clones with any tag delivered in your preferred vector for SOX13
     GenScript Custom Assay Services for SOX13 GenScript Custom overexpressing Cell Line Services for SOX13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SOX13
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SOX13 antibodies
     SOX13 proteins
     SOX13 lysates
     Antibodies for SOX13
     See all of Abcam's Antibodies, Kits and Proteins for SOX13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SOX13
     Antibodies for SOX13
     ELISAs for SOX13
     CLIAs for SOX13



     Browse ESI BIO Cell Lines and PureStem Progenitors for SOX13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX13
     SwitchGear 3'UTR luciferase reporter plasmids for SOX13
     SwitchGear Promoter luciferase reporter plasmids for SOX13
     ThermoFisher Antibodies for SOX13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX13
     Browse compounds at ApexBio
     Search Addgene for plasmids for SOX13
      Search eBioscience for proteins for SOX13
      Search eBioscience for elisas for SOX13
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SOX13
     antibodies-online antibodies for SOX13 (43 products)
     antibodies-online kits for SOX13 (4 products)
     antibodies-online peptides for SOX13
     antibodies-online proteins for SOX13 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SOX13 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4