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Aliases for SOX12 Gene

Aliases for SOX12 Gene

  • SRY-Box 12 2 3 5
  • SRY (Sex Determining Region Y)-Box 12 2 3
  • SOX22 3 4
  • SRY (Sex Determining Region Y)-Box 22 2
  • SRY-Related HMG-Box Gene 22 3
  • Transcription Factor SOX-12 3
  • SOX-22 Protein 3
  • Protein SOX-22 4
  • SRY Box 12 2

External Ids for SOX12 Gene

Previous HGNC Symbols for SOX12 Gene

  • SOX22

Previous GeneCards Identifiers for SOX12 Gene

  • GC20P000294
  • GC20P000301
  • GC20P000254

Summaries for SOX12 Gene

Entrez Gene Summary for SOX12 Gene

  • Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]

GeneCards Summary for SOX12 Gene

SOX12 (SRY-Box 12) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is SOX4.

UniProtKB/Swiss-Prot for SOX12 Gene

  • Binds to the sequence 5-AACAAT-3.

Gene Wiki entry for SOX12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX12 Gene

Genomics for SOX12 Gene

Regulatory Elements for SOX12 Gene

Enhancers for SOX12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G000399 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +76.1 76085 4.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 TBC1D20 ACTG1P3 NRSN2 RBCK1 ENSG00000229728 SOX12 TRIB3 ZCCHC3 CSNK2A1 GC20P000386
GH20G000377 1.4 ENCODE dbSUPER 10.8 +55.5 55495 6.5 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 TRIB3 TBC1D20 RBCK1 NRSN2-AS1 NRSN2 ENSG00000229728 SOX12 ACTG1P3 GC20P000385 GC20P000387
GH20G000674 1.3 Ensembl ENCODE 10.9 +350.3 350261 1.9 ARID4B SIN3A ZNF48 ZNF766 ZNF143 JUNB ZHX2 MXD4 MIER2 REST NRSN2 SOX12 ENSG00000270299 SCRT2
GH20G000541 1.1 ENCODE 10.9 +217.8 217775 2.9 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NRSN2 SOX12 TBC1D20 ACTG1P3 CSNK2A1 PIR56447 GC20M000488 GC20M000487
GH20G000727 1.5 Ensembl ENCODE dbSUPER 5.5 +402.9 402914 1.3 ATF1 ARID4B ZNF48 GLIS2 CBX5 ZNF143 ZNF263 SP5 MIER2 REST SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 SOX12 GC20P000743 PIR59185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOX12 on UCSC Golden Path with GeneCards custom track

Promoters for SOX12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133399 329 3801 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for SOX12 Gene

Chromosome:
20
Start:
325,571 bp from pter
End:
330,228 bp from pter
Size:
4,658 bases
Orientation:
Plus strand

Genomic View for SOX12 Gene

Genes around SOX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX12 Gene

Proteins for SOX12 Gene

  • Protein details for SOX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15370-SOX12_HUMAN
    Recommended name:
    Transcription factor SOX-12
    Protein Accession:
    O15370
    Secondary Accessions:
    • Q5D038
    • Q9NUD4

    Protein attributes for SOX12 Gene

    Size:
    315 amino acids
    Molecular mass:
    34122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201; Evidence={ECO:0000305};

neXtProt entry for SOX12 Gene

Post-translational modifications for SOX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX12 Gene

Domains & Families for SOX12 Gene

Gene Families for SOX12 Gene

Protein Domains for SOX12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX12: view

No data available for UniProtKB/Swiss-Prot for SOX12 Gene

Function for SOX12 Gene

Molecular function for SOX12 Gene

UniProtKB/Swiss-Prot Function:
Binds to the sequence 5-AACAAT-3.

Gene Ontology (GO) - Molecular Function for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA,ISS --
GO:0001105 RNA polymerase II transcription coactivator activity ISS --
GO:0003677 DNA binding NAS 9215677
genes like me logo Genes that share ontologies with SOX12: view
genes like me logo Genes that share phenotypes with SOX12: view

Animal Models for SOX12 Gene

MGI Knock Outs for SOX12:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX12 Gene

Localization for SOX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0032993 protein-DNA complex IEA --
genes like me logo Genes that share ontologies with SOX12: view

Pathways & Interactions for SOX12 Gene

SuperPathways for SOX12 Gene

SuperPathway Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX12: view

Pathways by source for SOX12 Gene

1 Qiagen pathway for SOX12 Gene

Interacting Proteins for SOX12 Gene

Gene Ontology (GO) - Biological Process for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter NAS 9215677
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0021510 spinal cord development IEA,ISS --
genes like me logo Genes that share ontologies with SOX12: view

No data available for SIGNOR curated interactions for SOX12 Gene

Transcripts for SOX12 Gene

mRNA/cDNA for SOX12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX12 Gene

SRY (sex determining region Y)-box 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX12 Gene

No ASD Table

Relevant External Links for SOX12 Gene

GeneLoc Exon Structure for
SOX12
ECgene alternative splicing isoforms for
SOX12

Expression for SOX12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX12 Gene

Protein differential expression in normal tissues from HIPED for SOX12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOX12 Gene



Protein tissue co-expression partners for SOX12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOX12 Gene:

SOX12

SOURCE GeneReport for Unigene cluster for SOX12 Gene:

Hs.43627

mRNA Expression by UniProt/SwissProt for SOX12 Gene:

O15370-SOX12_HUMAN
Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.

Evidence on tissue expression from TISSUES for SOX12 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SOX12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX12 Gene

Orthologs for SOX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX12 34 35
  • 96.4 (n)
dog
(Canis familiaris)
Mammalia SOX12 34 35
  • 94.9 (n)
rat
(Rattus norvegicus)
Mammalia Sox12 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Sox12 34 16 35
  • 90.98 (n)
oppossum
(Monodelphis domestica)
Mammalia SOX12 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777179 34
  • 81.66 (n)
lizard
(Anolis carolinensis)
Reptilia SOX12 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sox12 35
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sox14 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-2 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROX1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10865 35
  • 18 (a)
OneToMany
Species where no ortholog for SOX12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX12 Gene

ENSEMBL:
Gene Tree for SOX12 (if available)
TreeFam:
Gene Tree for SOX12 (if available)

Paralogs for SOX12 Gene

(5) SIMAP similar genes for SOX12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX12: view

Variants for SOX12 Gene

Sequence variations from dbSNP and Humsavar for SOX12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000287490 -- 326,462(+) TGGTC(C/G)AGACC upstream-variant-2KB, reference, missense
rs1000716575 -- 330,513(+) AAGCA(C/G)GTGGG downstream-variant-500B
rs1000771318 -- 327,071(+) ACCCC(C/T)TCCCC upstream-variant-2KB, utr-variant-3-prime
rs1000835030 -- 329,257(+) CACCC(A/G)TGTGA utr-variant-3-prime
rs1000896166 -- 325,407(+) CGGCG(A/C)CCGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOX12 Gene

Variant ID Type Subtype PubMed ID
dgv4219n100 CNV gain 25217958
esv3893263 CNV loss 25118596
nsv1133498 CNV deletion 24896259

Variation tolerance for SOX12 Gene

Gene Damage Index Score: 2.38; 42.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOX12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX12 Gene

Disorders for SOX12 Gene

Relevant External Links for SOX12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX12

No disorders were found for SOX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX12 Gene

Publications for SOX12 Gene

  1. SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PMID: 9215677) Jay P. … Berta P. (Hum. Mol. Genet. 1997) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma. (PMID: 26998831) Roisman A. … Slavutsky I. (Genes Chromosomes Cancer 2016) 3 64
  5. Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1. (PMID: 25704764) Huang W. … Xia L. (Hepatology 2015) 3 64

Products for SOX12 Gene

Sources for SOX12 Gene

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