Aliases for SOX12 Gene
External Ids for SOX12 Gene
Previous HGNC Symbols for SOX12 Gene
Previous GeneCards Identifiers for SOX12 Gene
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
GeneCards Summary for SOX12 Gene
SOX12 (SRY (Sex Determining Region Y)-Box 12) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II transcription coactivator activity. An important paralog of this gene is SOX3.
UniProtKB/Swiss-Prot for SOX12 Gene
Binds to the sequence 5-AACAAT-3.