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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SOX12 Gene

protein-coding GIFtS: 49
GCID: GC20P000306

SRY (sex determining region Y)-box 12

(Previous name: SRY (sex determining region Y)-box 22 )
(Previous symbol: SOX22)

Search for SOX12
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SRY (Sex Determining Region Y)-Box 12¹ ²		SRY-Related HMG-Box Gene 22²
SOX22¹ ² ³ ⁵		Transcription Factor SOX-12²
SRY (Sex Determining Region Y)-Box 22¹		Protein SOX-22³
SOX-22 Protein²

External Ids:	HGNC: 11198¹	Entrez Gene: 6666²	Ensembl: ENSG00000177732⁷	OMIM: 601947⁵	UniProtKB: O15370³

Export aliases for SOX12 gene to outside databases

Previous GC identifers: GC20P000294 GC20P000301 GC20P000254

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOX12:

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility

group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain

superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes.

SOX transcription factors have diverse tissue-specific expression patterns during early development and have been

proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The

protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in

various tissues suggests a role in both differentiation and maintenance of several cell types. (provided by RefSeq,

Jan 2013)

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

Gene Wiki entry for SOX12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SOX12 gene promoter:
HFH-3 Spz1 Tal-1 GATA-1 E47 C/EBPalpha CREB CHOP-10 FOXI1 deltaCREB
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SOX12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

SOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX12 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P000306: view genomic region (about GC identifiers)

Start:	306,207 bp from pter	End:	310,868 bp from pter
Size:	4,662 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370 (See protein sequence)

Recommended Name: Transcription factor SOX-12

Size: 315 amino acids; 34122 Da

Subcellular location: Nucleus

Sequence caution: Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201;

Secondary accessions: Q5D038 Q9NUD4

Explore the universe of human proteins at neXtProt for SOX12: NX_O15370

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15370

SOX12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_008874.2

ENSEMBL proteins:

ENSP00000441671 ENSP00000347646

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SOX12
	GenScript Custom Purified and Recombinant Proteins Services for SOX12
	Novus Biologicals SOX12 Proteins Novus Biologicals SOX12 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOX12

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0032993	protein-DNA complex	IEA	--

SOX12 for ontologies About GeneDecksing

SOX12 Antibody Products:

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	Novus Biologicals SOX12 Antibodies
	Search for Antibodies for SOX12 at Abcam
	Uscn Antibodies for SOX12
	ThermoFisher Antibodies for SOX12

Assay Products for SOX12:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOX12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOX12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SOX12 for domains About GeneDecksing

2 InterPro domains/families:

IPR009071 HMG_superfamily

IPR017386 SOX-12/11/4a

Graphical View of Domain Structure for InterPro Entry O15370

ProtoNet protein and cluster: O15370

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Similarity: Contains 1 HMG box DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SOX12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX12
		8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX12 (see all 122):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SOX12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX12 (see all 4) OriGene shRNA RFP: SOX12 OriGene siRNA: SOX12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SOX12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOX12
		Search LifeMap BioReagents cell lines for SOX12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	ISS	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISS	--
GO:0001105	RNA polymerase II transcription coactivator activity	ISS	--
GO:0003677	DNA binding	NAS	9215677

SOX12 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SOX12:

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Sox12^tm2.1Weg for SOX12
13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sox12):

cardiovascular system	craniofacial	embryogenesis	growth/size	hematopoietic system
immune system	limbs/digits/tail	mortality/aging	nervous system	no phenotypic analysis
normal	reproductive system	skeleton

SOX12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Rho Family GTPases

Molecular Mechanisms of Cancer

0.51

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX12

Molecular Mechanisms of Cancer

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SOX12

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for SOX12 (ENSP00000347646⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD4	ENSP00000341551⁴	STRING: ENSP00000341551
SRM	ENSP00000366156⁴	STRING: ENSP00000366156
--	ENSP00000379148⁴	STRING: ENSP00000379148

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	NAS	9215677
GO:0021510	spinal cord development	ISS	--
GO:0045165	cell fate commitment	IEP	9215677
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0065004	protein-DNA complex assembly	IEA	--

SOX12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOX12
Search CenterWatch for drugs/clinical trials and news about SOX12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOX12 gene:

NM_006943.3

Unigene Cluster for SOX12:

SRY (sex determining region Y)-box 12

Hs.43627 [show with all ESTs]

Unigene Representative Sequence: NM_006943

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000544632 ENST00000342665(uc002wdh.3)

miRNA Products:		OriGene 3'-UTR Clone: SOX12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX12
		8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX12 (see all 122):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SOX12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX12 (see all 4) OriGene shRNA RFP: SOX12 OriGene siRNA: SOX12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOX12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX12

Additional cDNA sequence:

BC028103.1 BC067361.1

9 DOTS entries:

DT.453042 DT.101964090 DT.97841906 DT.97816664 DT.120814608 DT.86854650 DT.97841908 DT.100750162

DT.97841909

24/127 AceView cDNA sequences (see all 127):

BM670751 AI161357 BU176133 BM699154 AI051187 NM_006943 AI805407 AA425701

BX477861 AW105302 BU860084 BU634219 AI685644 AW247052 AA128513 BQ923317

BF508404 AA428551 AW028670 AW196342 AI669236 BU179354 BU539596 BQ639636

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOX12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGTGAAGA

About this image
See SOX12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOX12

SOURCE GeneReport for Unigene cluster: Hs.43627

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart,

pancreas, testis and ovary. Other tissues were only weakly positive

SABiosciences Custom PCR Arrays for SOX12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOX12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOX12 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC777179¹	transcription factor SOX-12-like	78.26(n) 78.88(a)		777179 XM_003642466.1 XP_003642514.1
lizard (Anolis carolinensis)	Reptilia	SOX12⁶	--	47(a)	1 ↔ 1	GL343346.1(1139219-1140190)
zebrafish (Danio rerio)	Actinopterygii	sox12⁶	SRY (sex determining region Y)-box 12	23(a)	1 ↔ 1	11(25123721-25125485)
fruit fly (Drosophila melanogaster)	Insecta	Sox14⁶	Sox box protein 14	11(a)	1 → many	2R(19866744-19872700)
worm (Caenorhabditis elegans)	Secernentea	sox-4⁶ sem-2⁶	SEx Muscle abnormal family member (sem-2)	19(a) 16(a)	possible ortholog 1 ↔ many	X(3505427-3506378) I(5205106-5215221)

ENSEMBL Gene Tree for SOX12 (if available)
TreeFam Gene Tree for SOX12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SOX12 gene

SOX13² SOX2² SOX4² SOX1² SOX14² SOX3² SOX9² SOX15²

SOX18² SOX5² ENSG00000258724² SOX21² SOX6² SOX17² SOX11² SOX8²

SRY² SOX10² SOX7²

5 SIMAP similar genes for SOX12 using alignment to 1 protein entry: SOX12_HUMAN:

SRY SOX10 SOX15 SOX14 SOX11

SOX12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6036828^1,2	C,F,A,	--	255751(+)	`gcctgA/Gctcat`	1	--	int¹ tfbs³		1		WA	118
rs6106898^1,2		--	255786(+)	`aggttC/Tcacca`	1	--	int¹		0	--	--	--	--
rs79142767^1,2	F,	--	255913(+)	`AACATT/CGCCTA`	1	--	int¹		1		WA	118
rs6049762^1,2	C,F,A,H,	--	255966(+)	`AAAACC/AACCAT`	1	--	int¹		6		NS EA CSA WA	535
rs76063236^1,2	C,	--	256089(+)	`AAGGTT/GTTACA`	1	--	int¹		3		CSA WA	121
rs6049789^1,2	C,F,A,H,	--	256216(+)	`CTCCAA/GTTTCT`	1	--	int¹		14		NS NA EA WA	1750
rs2268434^1,2	C,F,	--	256236(+)	`CCACCC/TCCACC`	1	--	int¹		2		EA WA	1606
rs62191421^1,2		--	256617(+)	`CCACGC/ACCCCA`	1	--	int¹		1		NA	2
rs73574572^1,2	C,	--	256792(+)	`CAGCTC/GAGGAC`	1	--	int¹		2		WA	120
rs6138337^1,2	C	--	256823(+)	`GCCCCG/TCGGCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SOX12 (306207 - 310868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SOX12: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX12

DNA2.0 Custom Variant and Variant Library Synthesis for SOX12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SOX12 for disorders About MalaCards

SOX12 for disorders About GeneDecksing

OMIM gene information: 601947 OMIM disorders: --

Export disorders for SOX12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOX12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SOX12)

Utopia: connect your pdf to the dynamic
world of online information

SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PubMed id 9215677)^{1, 2, 3, 9} Jay P.... Berta P. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Sox12 deletion in the mouse reveals nonreciprocal red undancy with the related Sox4 and Sox11 transcription factors. (PubMed id 18505825)¹ Hoser M....Sock E. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. (PubMed id 11222737)¹ Weiss M.A. (2001)
Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. (PubMed id 11071752)¹ Bowles J....Koopman P. (2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)¹ Adams M.D....White O. (1995)
Studies on the effect of various agents on the maturat ion of thymus stem cells. (PubMed id 185058)¹ Singh U. and Owen J.J. (1975)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6666	HGNC: 11198	AceView: SOX12	Ensembl:ENSG00000177732	euGenes: HUgn6666
ECgene: SOX12	H-InvDB: SOX12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SOX12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SOX12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SOX12 gene:
Search GeneIP for patents involving SOX12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for SOX12
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOX12
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	GenScript Custom Purified and Recombinant Proteins Services for SOX12		GenScript cDNA clones with any tag delivered in your preferred vector for SOX12
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12

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ThermoFisher Antibodies for SOX12

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SOX12 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

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Export list of displayed genes

SOX12 Gene

SRY (sex determining region Y)-box 12

Aliases
for SOX12 gene

Summaries
for SOX12 gene

Genomic Views
for SOX12 gene

Proteins
for SOX12 gene

Protein Domains /
Families
for SOX12 gene

Function
for SOX12 gene

Pathways & Interactions
for SOX12 gene

Drugs & Compounds
for SOX12 gene

Transcripts
for SOX12 gene

Expression
for SOX12 gene

Orthologs
for SOX12 gene

Paralogs
for SOX12 gene

Genomic Variants
for SOX12 gene

Disorders / Diseases
for SOX12 gene

Publications
for SOX12 gene

External Searches for SOX12 gene

Genome Databases showing SOX12 gene

Other Databases showing SOX12 gene

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for SOX12 gene

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Export list of displayed genes

SOX12 Gene

SRY (sex determining region Y)-box 12

Aliasesfor SOX12 gene

Summariesfor SOX12 gene

Genomic Viewsfor SOX12 gene

Proteinsfor SOX12 gene

Protein Domains /Familiesfor SOX12 gene

Functionfor SOX12 gene

Pathways & Interactionsfor SOX12 gene

Drugs & Compoundsfor SOX12 gene

Transcriptsfor SOX12 gene

Expression for SOX12 gene

Orthologsfor SOX12 gene

Paralogsfor SOX12 gene

Genomic Variantsfor SOX12 gene

Disorders / Diseasesfor SOX12 gene

Publicationsfor SOX12 gene

External Searches for SOX12 gene

Genome Databases showing SOX12 gene

Other Databases showing SOX12 gene

Specialized Databases showing SOX12 gene

Intellectual Propertyfor SOX12 gene

Productsfor SOX12 gene

View Random Gene

Aliases
for SOX12 gene

Summaries
for SOX12 gene

Genomic Views
for SOX12 gene

Proteins
for SOX12 gene

Protein Domains /
Families
for SOX12 gene

Function
for SOX12 gene

Pathways & Interactions
for SOX12 gene

Drugs & Compounds
for SOX12 gene

Transcripts
for SOX12 gene

Expression
for SOX12 gene

Orthologs
for SOX12 gene

Paralogs
for SOX12 gene

Genomic Variants
for SOX12 gene

Disorders / Diseases
for SOX12 gene

Publications
for SOX12 gene

Intellectual Property
for SOX12 gene

Products
for SOX12 gene