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Aliases for SOX12 Gene

Aliases for SOX12 Gene

  • SRY (Sex Determining Region Y)-Box 12 2 3
  • SOX22 3 4 6
  • SRY (Sex Determining Region Y)-Box 22 2
  • SRY-Related HMG-Box Gene 22 3
  • Transcription Factor SOX-12 3
  • SOX-22 Protein 3
  • Protein SOX-22 4

External Ids for SOX12 Gene

Previous Symbols for SOX12 Gene

  • SOX22

Summaries for SOX12 Gene

Entrez Gene Summary for SOX12 Gene

  • Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]

GeneCards Summary for SOX12 Gene

SOX12 (SRY (Sex Determining Region Y)-Box 12) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II transcription coactivator activity. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX12 Gene

  • Binds to the sequence 5-AACAAT-3.

Gene Wiki entry for SOX12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX12 Gene

Genomics for SOX12 Gene

Genomic Location for SOX12 Gene

Start:
325,401 bp from pter
End:
330,228 bp from pter
Size:
4,828 bases
Orientation:
Plus strand

Genomic View for SOX12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX12 Gene

Regulatory Elements for SOX12 Gene

Proteins for SOX12 Gene

  • Protein details for SOX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15370-SOX12_HUMAN
    Recommended name:
    Transcription factor SOX-12
    Protein Accession:
    O15370
    Secondary Accessions:
    • Q5D038
    • Q9NUD4

    Protein attributes for SOX12 Gene

    Size:
    315 amino acids
    Molecular mass:
    34122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201; Evidence={ECO:0000305};

neXtProt entry for SOX12 Gene

Proteomics data for SOX12 Gene at MOPED

Post-translational modifications for SOX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX12 Gene

Domains for SOX12 Gene

Gene Families for SOX12 Gene

HGNC:
  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX12 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SOX12_HUMAN
Domain:
  • Contains 1 HMG box DNA-binding domain.:
    • O15370
genes like me logo Genes that share domains with SOX12: view

Function for SOX12 Gene

Molecular function for SOX12 Gene

UniProtKB/Swiss-Prot Function: Binds to the sequence 5-AACAAT-3.

Gene Ontology (GO) - Molecular Function for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS --
GO:0001105 RNA polymerase II transcription coactivator activity ISS --
GO:0003677 DNA binding NAS 9215677
genes like me logo Genes that share ontologies with SOX12: view
genes like me logo Genes that share phenotypes with SOX12: view

Animal Models for SOX12 Gene

MGI Knock Outs for SOX12:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SOX12 Gene

Localization for SOX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX12 Gene COMPARTMENTS Subcellular localization image for SOX12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0032993 protein-DNA complex IEA --
genes like me logo Genes that share ontologies with SOX12: view

Pathways for SOX12 Gene

SuperPathways for SOX12 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX12: view

Pathways by source for SOX12 Gene

1 Qiagen pathway for SOX12 Gene

Interacting Proteins for SOX12 Gene

Gene Ontology (GO) - Biological Process for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter NAS 9215677
GO:0021510 spinal cord development ISS --
GO:0045165 cell fate commitment IEP 9215677
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with SOX12: view

Transcripts for SOX12 Gene

mRNA/cDNA for SOX12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX12 Gene

SRY (sex determining region Y)-box 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX12 Gene

No ASD Table

Relevant External Links for SOX12 Gene

GeneLoc Exon Structure for
SOX12
ECgene alternative splicing isoforms for
SOX12

Expression for SOX12 Gene

mRNA expression in normal human tissues for SOX12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOX12 Gene

SOURCE GeneReport for Unigene cluster for SOX12 Gene Hs.43627

mRNA Expression by UniProt/SwissProt for SOX12 Gene

O15370-SOX12_HUMAN
Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.
genes like me logo Genes that share expressions with SOX12: view

Orthologs for SOX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX12 36
  • 96.4 (n)
  • 95.24 (a)
SOX12 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOX12 36
  • 94.9 (n)
  • 97.45 (a)
SOX12 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sox12 36
  • 90.98 (n)
  • 95.22 (a)
Sox12 16
Sox12 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOX12 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sox12 36
  • 91.3 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves LOC777179 36
  • 81.66 (n)
  • 85.23 (a)
lizard
(Anolis carolinensis)
Reptilia SOX12 37
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sox12 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sox14 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-2 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROX1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10865 37
  • 18 (a)
OneToMany
Species with no ortholog for SOX12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX12 Gene

ENSEMBL:
Gene Tree for SOX12 (if available)
TreeFam:
Gene Tree for SOX12 (if available)

Paralogs for SOX12 Gene

Selected SIMAP similar genes for SOX12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX12: view

Variants for SOX12 Gene

Sequence variations from dbSNP and Humsavar for SOX12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs742608 -- 330,646(-) TCCCA(A/G)TACAG downstream-variant-500B
rs742609 -- 330,724(-) CTCCC(C/T)GACCT downstream-variant-500B
rs742610 -- 330,725(-) TCTCC(C/G)CGACC downstream-variant-500B
rs1047506 -- 327,545(+) CTCCA(C/G)CCAAC utr-variant-3-prime
rs1047507 -- 327,549(+) AGCCA(A/G)CGGGG utr-variant-3-prime

Relevant External Links for SOX12 Gene

HapMap Linkage Disequilibrium report
SOX12

No data available for Structural Variations from Database of Genomic Variants (DGV) for SOX12 Gene

Disorders for SOX12 Gene

No disorders were found for SOX12 Gene.

No data available for UniProtKB/Swiss-Prot for SOX12 Gene

Publications for SOX12 Gene

  1. SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PMID: 9215677) Jay P. … Berta P. (Hum. Mol. Genet. 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. (PMID: 18505825) Hoser M. … Sock E. (Mol. Cell. Biol. 2008) 3

Products for SOX12 Gene

Sources for SOX12 Gene

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