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SOX12 Gene

protein-coding   GIFtS: 47
GCID: GC20P000306

SRY (Sex Determining Region Y)-Box 12

(Previous name: SRY (sex determining region Y)-box 22)
(Previous symbol: SOX22)
  Search for SOX12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRY (Sex Determining Region Y)-Box 121 2     SRY-Related HMG-Box Gene 222
SOX221 2 3 5     Transcription Factor SOX-122
SRY (Sex Determining Region Y)-Box 221     Protein SOX-223
SOX-22 Protein2     

External Ids:    HGNC: 111981   Entrez Gene: 66662   Ensembl: ENSG000001777327   OMIM: 6019475   UniProtKB: O153703   

Export aliases for SOX12 gene to outside databases

Previous GC identifers: GC20P000294 GC20P000301 GC20P000254


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOX12 Gene:
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high
mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of
the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of
developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early
development and have been proposed to act as target-specific transcription factors and/or as chromatin structure
regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved
domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several
cell types. (provided by RefSeq, Jan 2013)

GeneCards Summary for SOX12 Gene:
SOX12 (SRY (sex determining region Y)-box 12) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription coactivator activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370
Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

Gene Wiki entry for SOX12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX12 gene promoter:
         HFH-3   Spz1   Tal-1   GATA-1   E47   C/EBPalpha   CREB   CHOP-10   FOXI1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SOX12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX12 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P000306:  view genomic region     (about GC identifiers)

Start:
306,207 bp from pter      End:
310,868 bp from pter
Size:
4,662 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370 (See protein sequence)
Recommended Name: Transcription factor SOX-12  
Size: 315 amino acids; 34122 Da
Sequence caution: Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201;
Secondary accessions: Q5D038 Q9NUD4

Explore the universe of human proteins at neXtProt for SOX12: NX_O15370

Explore proteomics data for SOX12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008874.2  
    ENSEMBL proteins: 
     ENSP00000441671   ENSP00000347646  

    SOX12 Human Recombinant Protein Products:

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    Novus Biologicals SOX12 Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOX12

     
    Search eBioscience for Proteins for SOX12 

    SOX12 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SOX12

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    Search eBioscience for ELISAs for SOX12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR017386 SOX-12/11/4a

    Graphical View of Domain Structure for InterPro Entry O15370

    ProtoNet protein and cluster: O15370

    UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with SOX12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX12_HUMAN, O15370
    Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0001105RNA polymerase II transcription coactivator activity ISS--
    GO:0003677DNA binding NAS9215677
         
    Find genes that share ontologies with SOX12           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SOX12:
     Increased cell death HMECs cel 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sox12):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hematopoietic system 
     immune system  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     normal  reproductive system  skeleton 

    Find genes that share phenotypes with SOX12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sox12tm2.1Weg for SOX12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX12

    miRNA
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    Block miRNA regulation of human, mouse, rat SOX12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX12 (see all 122):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSOX12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOX12
    Predesigned siRNA for gene silencing in human, mouse, rat SOX12

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SOX12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOX12_HUMAN, O15370: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0032993protein-DNA complex IEA--

    Find genes that share ontologies with SOX12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOX12 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX12
        Molecular Mechanisms of Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOX12
    Interactions:

        Search GeneGlobe Interaction Network for SOX12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SOX12 (ENSP000003476464) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4ENSP000003415514STRING: ENSP00000341551
    SRMENSP000003661564STRING: ENSP00000366156
    CHTF18ENSP000002623154STRING: ENSP00000262315
    TAF2ENSP000003674064STRING: ENSP00000367406
    TAF8ENSP000003620684STRING: ENSP00000362068
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter NAS9215677
    GO:0021510spinal cord development ISS--
    GO:0045165cell fate commitment IEP9215677
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ISS--
    GO:0065004protein-DNA complex assembly IEA--

    Find genes that share ontologies with SOX12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOX12 gene: 
    NM_006943.3  

    Unigene Cluster for SOX12:

    SRY (sex determining region Y)-box 12
    Hs.43627  [show with all ESTs]
    Unigene Representative Sequence: NM_006943
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544632 ENST00000342665(uc002wdh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOX12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX12 (see all 122):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSOX12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOX12
    Predesigned siRNA for gene silencing in human, mouse, rat SOX12
    Clone
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    OriGene ORF clones in mouse, rat for SOX12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12
    Primer
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    OriGene qPCR primer pairs and template standards for SOX12
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX12
      QuantiTect SYBR Green Assays in human, mouse, rat SOX12
      QuantiFast Probe-based Assays in human, mouse, rat SOX12

    Additional mRNA sequence: BC067361.1 

    7 DOTS entries:

    DT.453042  DT.101964090  DT.86854650  DT.120814608  DT.97816664  DT.97841906  DT.97841908 

    Selected AceView cDNA sequences (see all 127):

    AA425701 AW105302 AW028670 AA128513 NM_006943 AI805407 BM670751 BU634219 
    AA428551 BF508404 D80910 BU860084 AI669236 BQ923317 BM699154 AI161357 
    BX477861 AI051187 AI560376 BQ639636 BU176133 BC028103 AW247052 AI081047 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOX12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTGAAGA
    SOX12 Expression
    About this image

    SOX12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43627

    UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370
    Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult
    heart, pancreas, testis and ovary. Other tissues were only weakly positive

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOX12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox121 , 5 SRY-box containing gene 125
    SRY (sex determining region Y)-box 121
    90.98(n)1
    95.22(a)1
      2 (74.94 cM)5
    206671  NM_011438.21  NP_035568.11 
     1523936115 
    chicken
    (Gallus gallus)
    Aves LOC7771791 transcription factor SOX-12-like 81.66(n)
    85.23(a)
      777179  XM_003642466.2  XP_003642514.2 
    lizard
    (Anolis carolinensis)
    Reptilia SOX126
    SRY (sex determining region Y)-box 12
    54(a)
    1 ↔ 1
    GL343346.1(1139219-1140190)
    zebrafish
    (Danio rerio)
    Actinopterygii sox126
    SRY (sex determining region Y)-box 12
    38(a)
    1 ↔ 1
    11(25123721-25125485) ENSDARG00000025847
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox146
    Sox box protein 14
    14(a)
    1 → many
    2R(19866744-19872700)
    worm
    (Caenorhabditis elegans)
    Secernentea sem-26
    Protein SEM-2 (sem-2) mRNA, complete cds
    20(a)
    1 → many
    I(5204664-5215218) WBGene00004771


    ENSEMBL Gene Tree for SOX12 (if available)
    TreeFam Gene Tree for SOX12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOX12 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX152  
    SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX112  SOX82  
    SRY2  SOX102  SOX72  
    5 SIMAP similar genes for SOX12 using alignment to 1 protein entry:     SOX12_HUMAN:
    SOX10    SRY    SOX15    SOX14    SOX11

    Find genes that share paralogs with SOX12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOX12 (see all 82)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146672181,2
    F--307938(+) GCCGGG/ATGGCA 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs1872916701,2
    --307949(+) ACGCAC/TGCGCC 1 -- ut310--------
    rs1394286941,2
    C--307966(+) GCCCCC/TCCCTT 1 -- ut310--------
    rs10475061,2
    C,F,A,H--308189(+) CTCCAG/CCCAAC 1 -- ut31 ese313Minor allele frequency- C:0.16MN NS EA NA WA CSA 841
    rs10475071,2
    C,F,A,H--308193(+) AGCCAA/GCGGGG 1 -- ut31 ese321Minor allele frequency- G:0.18MN NS EA NA WA CSA 2430
    rs1920630631,2
    --308195(+) CCAACG/TGGGCG 1 -- ut310--------
    rs1814509751,2
    C--308200(+) GGGGCA/GTCGCT 1 -- ut310--------
    rs1426996901,2
    --308321(+) CGGTCG/TCGTGG 1 -- ut310--------
    rs81251601,2
    C--308359(+) CTTTTC/TCCCCC 1 -- ut31 trp30--------
    rs356810371,2
    C--308402(+) GGAAAT/ACCAGC 1 -- ut313Minor allele frequency- A:0.06WA EA 240

    HapMap Linkage Disequilibrium report for SOX12 (306207 - 310868 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SOX12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOX12
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601947    OMIM disorders: --


    Find genes that share disorders with SOX12           About GenesLikeMe


    Export disorders for SOX12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOX12 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SOX12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PubMed id 9215677)1, 2, 3, 9 Jay P.... Berta P. (Hum. Mol. Genet. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. (PubMed id 18505825)1 Hoser M....Sock E. (Mol. Cell. Biol. 2008)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. (PubMed id 11222737)1 Weiss M.A. (Mol. Endocrinol. 2001)
    9. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. (PubMed id 11071752)1 Bowles J....Koopman P. (Dev. Biol. 2000)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6666 HGNC: 11198 AceView: SOX12 Ensembl:ENSG00000177732 euGenes: HUgn6666
    ECgene: SOX12 H-InvDB: SOX12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOX12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOX12 gene:
    Search GeneIP for patents involving SOX12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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