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SOX12 Gene

protein-coding GIFtS: 47
GCID: GC20P000306

SRY (Sex Determining Region Y)-Box 12

(Previous name: SRY (sex determining region Y)-box 22)
(Previous symbol: SOX22)

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SRY (Sex Determining Region Y)-Box 12¹ ²		SRY-Related HMG-Box Gene 22²
SOX22¹ ² ³ ⁵		Transcription Factor SOX-12²
SRY (Sex Determining Region Y)-Box 22¹		Protein SOX-22³
SOX-22 Protein²

External Ids:	HGNC: 11198¹	Entrez Gene: 6666²	Ensembl: ENSG00000177732⁷	OMIM: 601947⁵	UniProtKB: O15370³

Export aliases for SOX12 gene to outside databases

Previous GC identifers: GC20P000294 GC20P000301 GC20P000254

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOX12 Gene:

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high

mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of

the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of

developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early

development and have been proposed to act as target-specific transcription factors and/or as chromatin structure

regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved

domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several

cell types. (provided by RefSeq, Jan 2013)

GeneCards Summary for SOX12 Gene:

SOX12 (SRY (sex determining region Y)-box 12) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription coactivator activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

Gene Wiki entry for SOX12 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000020.10 NC_018931.2 NT_011387.9

Regulatory elements:

Regulatory transcription factor binding sites in the SOX12 gene promoter:
HFH-3 Spz1 Tal-1 GATA-1 E47 C/EBPalpha CREB CHOP-10 FOXI1 deltaCREB
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for SOX12

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

SOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX12 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P000306: view genomic region (about GC identifiers)

Start:	306,207 bp from pter	End:	310,868 bp from pter
Size:	4,662 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370 (See protein sequence)

Recommended Name: Transcription factor SOX-12

Size: 315 amino acids; 34122 Da

Sequence caution: Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201;

Secondary accessions: Q5D038 Q9NUD4

Explore the universe of human proteins at neXtProt for SOX12: NX_O15370

Explore proteomics data for SOX12 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SOX12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008874.2

ENSEMBL proteins:

ENSP00000441671 ENSP00000347646

SOX12 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for SOX12
	Search eBioscience for Proteins for SOX12
	Search GeneTex for Proteins for SOX12
	antibodies-online proteins for SOX12 (4 products)
	antibodies-online peptides for SOX12

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	antibodies-online antibodies for SOX12 (37 products)

SOX12 Assay Products:

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	Cloud-Clone Corp. ELISAs for SOX12 Cloud-Clone Corp. CLIAs for SOX12
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	antibodies-online kits for SOX12 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

SOX: SRY (sex determining region Y)-boxes

2 InterPro protein domains:

IPR009071 HMG_box_dom

IPR017386 SOX-12/11/4a

Graphical View of Domain Structure for InterPro Entry O15370

ProtoNet protein and cluster: O15370

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Similarity: Contains 1 HMG box DNA-binding domain

Find genes that share domains with SOX12 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SOX12_HUMAN, O15370

Function: Binds to the sequence 5'-AACAAT-3' (By similarity)

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	ISS	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISS	--
GO:0001105	RNA polymerase II transcription coactivator activity	ISS	--
GO:0003677	DNA binding	NAS	9215677

Find genes that share ontologies with SOX12 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for SOX12:

Increased cell death HMECs cel

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sox12):

cardiovascular system	craniofacial	embryogenesis	growth/size/body	hematopoietic system
immune system	limbs/digits/tail	mortality/aging	nervous system	no phenotypic analysis
normal	reproductive system	skeleton

Find genes that share phenotypes with SOX12 About GenesLikeMe

Animal Models:
MGI mouse knock-out Sox12^tm2.1Weg for SOX12

genOway: Develop your customized and physiologically relevant rodent model for SOX12

miRNA Products:		Block miRNA regulation of human, mouse, rat SOX12 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SOX12 (see all 122):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SOX12 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SOX12
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

SOX12_HUMAN, O15370: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0032993	protein-DNA complex	IEA	--

Find genes that share ontologies with SOX12 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for SOX12 About

See pathways by source

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SuperPath

Contained pathways About

ERK Signaling

Molecular Mechanisms of Cancer

0.51

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX12

Molecular Mechanisms of Cancer

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SOX12
Interactions:

Search GeneGlobe Interaction Network for SOX12

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for SOX12 (ENSP00000347646⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD4	ENSP00000341551⁴	STRING: ENSP00000341551
SRM	ENSP00000366156⁴	STRING: ENSP00000366156
CHTF18	ENSP00000262315⁴	STRING: ENSP00000262315
TAF2	ENSP00000367406⁴	STRING: ENSP00000367406
TAF8	ENSP00000362068⁴	STRING: ENSP00000362068

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	NAS	9215677
GO:0021510	spinal cord development	ISS	--
GO:0045165	cell fate commitment	IEP	9215677
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0065004	protein-DNA complex assembly	IEA	--

Find genes that share ontologies with SOX12 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SOX12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for SOX12 gene:

NM_006943.3

Unigene Cluster for SOX12:

SRY (sex determining region Y)-box 12

Hs.43627 [show with all ESTs]

Unigene Representative Sequence: NM_006943

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000544632 ENST00000342665(uc002wdh.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat SOX12 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SOX12 (see all 122):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-1914* hsa-miR-1260b hsa-miR-578 hsa-miR-632 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SOX12 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SOX12
		Predesigned siRNA for gene silencing in human, mouse, rat SOX12

Clone Products:		OriGene clones in human, mouse for SOX12 (see all 7) OriGene ORF clones in mouse, rat for SOX12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOX12 (NM_006943)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX12

Primer Products:		OriGene qPCR primer pairs and template standards for SOX12 OriGene qSTAR qPCR primer pairs in human, mouse for SOX12
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SOX12
		QuantiTect SYBR Green Assays in human, mouse, rat SOX12
		QuantiFast Probe-based Assays in human, mouse, rat SOX12

Additional mRNA sequence: BC067361.1

7 DOTS entries:

DT.453042 DT.101964090 DT.86854650 DT.120814608 DT.97816664 DT.97841906 DT.97841908

Selected AceView cDNA sequences (see all 127):

AA425701 AW105302 AW028670 AA128513 NM_006943 AI805407 BM670751 BU634219

AA428551 BF508404 D80910 BU860084 AI669236 BQ923317 BM699154 AI161357

BX477861 AI051187 AI560376 BQ639636 BU176133 BC028103 AW247052 AI081047

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOX12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAGTGAAGA

About this image

SOX12 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SOX12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.43627

UniProtKB/Swiss-Prot: SOX12_HUMAN, O15370

Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult

heart, pancreas, testis and ovary. Other tissues were only weakly positive

Custom PCR Arrays for SOX12

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOX12 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sox12^{1 , 5}	SRY-box containing gene 12⁵ SRY (sex determining region Y)-box 12¹	90.98(n)¹ 95.22(a)¹		2 (74.94 cM)⁵ 20667¹ NM_011438.2¹ NP_035568.1¹ 152393611⁵
chicken (Gallus gallus)	Aves	LOC777179¹	transcription factor SOX-12-like	81.66(n) 85.23(a)		777179 XM_003642466.2 XP_003642514.2
lizard (Anolis carolinensis)	Reptilia	SOX12⁶	SRY (sex determining region Y)-box 12	54(a)	1 ↔ 1	GL343346.1(1139219-1140190)
zebrafish (Danio rerio)	Actinopterygii	sox12⁶	SRY (sex determining region Y)-box 12	38(a)	1 ↔ 1	11(25123721-25125485) ENSDARG00000025847
fruit fly (Drosophila melanogaster)	Insecta	Sox14⁶	Sox box protein 14	14(a)	1 → many	2R(19866744-19872700)
worm (Caenorhabditis elegans)	Secernentea	sem-2⁶	Protein SEM-2 (sem-2) mRNA, complete cds	20(a)	1 → many	I(5204664-5215218) WBGene00004771

ENSEMBL Gene Tree for SOX12 (if available)
TreeFam Gene Tree for SOX12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SOX12 gene

SOX13² SOX2² SOX4² SOX1² SOX14² SOX3² SOX9² SOX15²

SOX18² SOX5² ENSG00000258724² SOX21² SOX17² SOX6² SOX11² SOX8²

SRY² SOX10² SOX7²

5 SIMAP similar genes for SOX12 using alignment to 1 protein entry: SOX12_HUMAN:

SOX10 SRY SOX15 SOX14 SOX11

Find genes that share paralogs with SOX12 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114667218^1,2	F	--	307938(+)	`GCCGGG/ATGGCA`	1	--	ut3¹		1		WA	118
rs187291670^1,2		--	307949(+)	`ACGCAC/TGCGCC`	1	--	ut3¹		0	--	--	--	--
rs139428694^1,2	C	--	307966(+)	`GCCCCC/TCCCTT`	1	--	ut3¹		0	--	--	--	--
rs1047506^1,2	C,F,A,H	--	308189(+)	`CTCCAG/CCCAAC`	1	--	ut3¹ ese³		13		MN NS EA NA WA CSA	841
rs1047507^1,2	C,F,A,H	--	308193(+)	`AGCCAA/GCGGGG`	1	--	ut3¹ ese³		21		MN NS EA NA WA CSA	2430
rs192063063^1,2		--	308195(+)	`CCAACG/TGGGCG`	1	--	ut3¹		0	--	--	--	--
rs181450975^1,2	C	--	308200(+)	`GGGGCA/GTCGCT`	1	--	ut3¹		0	--	--	--	--
rs142699690^1,2		--	308321(+)	`CGGTCG/TCGTGG`	1	--	ut3¹		0	--	--	--	--
rs8125160^1,2	C	--	308359(+)	`CTTTTC/TCCCCC`	1	--	ut3¹ trp³		0	--	--	--	--
rs35681037^1,2	C	--	308402(+)	`GGAAAT/ACCAGC`	1	--	ut3¹		3		WA EA	240

HapMap Linkage Disequilibrium report for SOX12 (306207 - 310868 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SOX12: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SOX12

DNA2.0 Custom Variant and Variant Library Synthesis for SOX12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 601947 OMIM disorders: --

Find genes that share disorders with SOX12 About GenesLikeMe

Export disorders for SOX12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOX12 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with SOX12)

SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PubMed id 9215677)^{1, 2, 3, 9} Jay P.... Berta P. (Hum. Mol. Genet. 1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. (PubMed id 18505825)¹ Hoser M....Sock E. (Mol. Cell. Biol. 2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. (PubMed id 11222737)¹ Weiss M.A. (Mol. Endocrinol. 2001)
Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. (PubMed id 11071752)¹ Bowles J....Koopman P. (Dev. Biol. 2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6666	HGNC: 11198	AceView: SOX12	Ensembl:ENSG00000177732	euGenes: HUgn6666
ECgene: SOX12	H-InvDB: SOX12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SOX12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SOX12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SOX12 gene:
Search GeneIP for patents involving SOX12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


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SOX12 Gene

SRY (Sex Determining Region Y)-Box 12

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SOX12 Gene

SRY (Sex Determining Region Y)-Box 12

Aliasesfor SOX12 gene

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SOX12 Human Recombinant Protein Products:

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Genomic Variantsfor SOX12 gene

Disorders / Diseasesfor SOX12 gene

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Genome Databases showing SOX12 gene

Other Databases showing SOX12 gene

Specialized Databases showing SOX12 gene

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for SOX12 gene

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for SOX12 gene

Genomic Views
for SOX12 gene

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for SOX12 gene

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Families
for SOX12 gene

Function
for SOX12 gene

Localization
for SOX12 gene

Pathways & Interactions
for SOX12 gene

Drugs & Compounds
for SOX12 gene

Transcripts
for SOX12 gene

Expression
for SOX12 gene

Orthologs
for SOX12 gene

Paralogs
for SOX12 gene

Genomic Variants
for SOX12 gene

Disorders / Diseases
for SOX12 gene

Publications
for SOX12 gene

Intellectual Property
for SOX12 gene

Products
for SOX12 gene