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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOX11 Gene

protein-coding   GIFtS: 56
GCID: GC02P005842

SRY (sex determining region Y)-box 11
 Explore 13 diseases affiliated with
SOX11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SOX11    

Aliases
for SOX11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SRY (Sex Determining Region Y)-Box 111 2
SRY (Sex-Determining Region Y)-Box 112
SRY-Related HMG-Box Gene 112
Transcription Factor SOX-112

External Ids:    HGNC: 111911   Entrez Gene: 66642   Ensembl: ENSG000001768877   OMIM: 6008985   UniProtKB: P357163   

Export aliases for SOX11 gene to outside databases

Previous GC identifers: GC02P005617 GC02P005884 GC02P005854 GC02P005783 GC02P005834


Summaries
for SOX11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SOX11:
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the
regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a
transcriptional regulator after forming a protein complex with other proteins. The protein may function in the
developing nervous system and play a role in tumorigenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
development

Gene Wiki entry for SOX11


Genomic Views
for SOX11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOX11 gene promoter:
         Sp1   AP-2gamma   NF-AT   HEN1   NF-AT4   NF-AT2   AP-2beta   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOX11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOX11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25

SOX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P005842:  view genomic region     (about GC identifiers)

Start:
 5,832,799 bp from pter      End:
 5,841,517 bp from pter
Size:
 8,719 bases      Orientation:
 plus strand

Proteins
for SOX11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716 (See protein sequence)
Recommended Name: Transcription factor SOX-11  
Size: 441 amino acids; 46679 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4ZFV8

Explore the universe of human proteins at neXtProt for SOX11: NX_P35716

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35716

    • SOX11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003099.1  
    ENSEMBL proteins: 
     ENSP00000322568  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: SOX11
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    Novus Biologicals SOX11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SOX11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17934069
    GO:0005737cytoplasm IDA17934069


    SOX11 for ontologies           About GeneDecksing



    SOX11 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOX11
    R&D Systems Antibodies for SOX11
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    Abcam antibodies for SOX11 
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    ThermoFisher Antibodies for SOX11

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    Uscn ELISAs and CLIAs for SOX11

    Protein Domains /
    Families
    for SOX11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SOX11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009071 HMG_superfamily
     IPR017386 SOX-12/11/4a

    Graphical View of Domain Structure for InterPro Entry P35716

    ProtoNet protein and cluster: P35716

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Similarity: Contains 1 HMG box DNA-binding domain


    Function
    for SOX11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
    development

         Genatlas biochemistry entry for SOX11:
    SRY related HMG box gene 11,expressed in the developing central and peripheral nervous system,somites,developing
    limbs,facial mesenchyme,kidney,lung,specific postmitotic neuronal subpopulation,modulator of LINE retroposons promoter
    activity

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX11
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX11 (see all 7)
    OriGene shRNA RFP: SOX11
    OriGene siRNA: SOX11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SOX11

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOX11 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SOX11
    Search LifeMap BioReagents cell lines for SOX11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA--
    GO:0001071nucleic acid binding transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0001105RNA polymerase II transcription coactivator activity ISS--


    SOX11 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Sox11tm2.2Weg for SOX11
         15/18 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sox11) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  normal 

    SOX11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SOX11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    2Rho Family GTPases
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SOX11
        Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX11
        Molecular Mechanisms of Cancer



    SOX11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOX11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SOX11 (P357163 ENSP000003225684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU3F2P202653, ENSP000003291704I2D: score=1 STRING: ENSP00000329170
    POU3F3P202643, ENSP000003550014I2D: score=1 STRING: ENSP00000355001
    About this table

    Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19808959
    GO:0001501skeletal system development ISS--
    GO:0001822kidney development IEA--
    GO:0001841neural tube formation ISS--
    GO:0002089lens morphogenesis in camera-type eye ISS--


    SOX11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SOX11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOX11
    Search CenterWatch for drugs/clinical trials and news about SOX11 

    Transcripts
    for SOX11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SOX11 gene: 
    NM_003108.3  

    Unigene Cluster for SOX11:

    SRY (sex determining region Y)-box 11
    Hs.432638  [show with all ESTs]
    Unigene Representative Sequence: AB028641
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322002(uc002qyj.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SOX11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX11
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOX11 (see all 7)
    OriGene shRNA RFP: SOX11
    OriGene siRNA: SOX11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX11
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOX11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOX11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOX11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX11

    Additional cDNA sequence: 

    AB028641.1 BC025789.1 BC127200.1 BC127201.1 U23752.1 

    4 DOTS entries:

    DT.434667  DT.92414003  DT.121028601  DT.102828070 

    24/96 AceView cDNA sequences (see all 96):

    AW157202 AW236986 BM722157 AA897354 AI362665 AI418677 BM729190 AI423179 
    F11451 BC025789 AW275020 BI524334 BI524024 AI470073 AI374754 AI699997 
    AA975478 AW090162 AW163178 AI360875 BE328685 CR622054 CA445903 AI214294 

    GeneLoc Exon Structure


    Expression
    for SOX11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOX11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGTGTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SOX11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    BrainHypothalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)

    See SOX11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOX11

    SOURCE GeneReport for Unigene cluster: Hs.432638

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Tissue specificity: Expressed mainly in the nervous system

        SABiosciences Custom PCR Arrays for SOX11
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX11
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11

    Orthologs
    for SOX11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SOX11 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SOX111 SRY (sex determining region Y)-box 11 81.09(n)
    80.41(a)    		   396104  NM_205187.1  NP_990518.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SOX116
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343240.1(2101117-2102346)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.8912 Xenopus laevis mRNA for XLS13A protein, complete cds 82.74(n)    D87209.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AJ237812.12   -- 80.78(n)   30602  AJ237812.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sox146
    		 Sox box protein 14
    		 12(a)
    		 1 → many
    		 2R(19866744-19872700)
    worm
    (Caenorhabditis elegans)    		 Secernentea sem-26
    sox-46
    		 Protein SOX-4
    		 20(a)
    19(a)
    		 1 ↔ many
    possible ortholog
    		 I(5205106-5215221)
    X(3505427-3506378)


    ENSEMBL Gene Tree for SOX11 (if available)
    TreeFam Gene Tree for SOX11 (if available) 

    Paralogs
    for SOX11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOX11 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX212  SOX62  SOX172  SOX82  
    SRY2  SOX102  SOX72  
    15 SIMAP similar genes for SOX11 using alignment to 3 protein entries:     SOX11_HUMAN (see all proteins):
    SOX14    SOX17    SOX28    SOX26    SOX25    SOX27
    soxB    SOX5    SRY    SOX10    SOX15    SOX30
    SOX4    SOX21    SOX12

    SOX11 for paralogs           About GeneDecksing



    Genomic Variants
    for SOX11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/147 NCBI SNPs in SOX11 are shown (see all 147)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1931690061,2
    		--5830835(+) TTATCC/GCAATG 1 -- us2k10--------
    rs2021429731,2
    		C--5830845(-) AAATTA/CCCGCC 1 -- us2k10--------
    rs173627721,2
    		C,F,H,--5830918(+) ATCCAA/GTACTT 1 -- us2k113Minor allele frequency- G:0.04NA NS EA 1104
    rs1850532701,2
    		--5830921(+) CAATAC/GTTAAG 1 -- us2k10--------
    rs1486223561,2
    		--5830972(+) AGATTC/TGGATA 1 -- us2k10--------
    rs1894276331,2
    		--5831024(+) TCCGGG/TCAGTG 1 -- us2k10--------
    rs1818233771,2
    		--5831151(+) CCGTAA/GAGGTA 1 -- us2k10--------
    rs1852189451,2
    		--5831216(+) TCCGCC/GGCTGC 1 -- us2k10--------
    rs1456570001,2
    		--5831251(+) GTCGCA/GGCTCC 1 -- us2k10--------
    rs1881519411,2
    		--5831318(+) GTGCAC/TCTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOX11 (5832799 - 5841517 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SOX11
         1 CNV: 4273

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOX11
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX11

    Disorders / Diseases
    for SOX11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SOX11 for disorders           About GeneDecksing

    OMIM gene information: 600898    OMIM disorders: --

    13 diseases for SOX11:    About MalaCards
    sex reversal    burkitt's lymphoma    mantle cell lymphoma    malignant glioma
    male infertility    epithelial ovarian cancer    ovarian cancer    infertility
    kidney disease    medulloblastoma    twinning    retinitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SOX11:
    Mantle cell lymphoma

    3 Novoseek disease relationships for SOX11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 65 1 19880779 (1)
    malignant glioma 53.5 2 15583815 (1), 16504379 (1)
    lymphoma 20.8 2 17934069 (1), 19880778 (1), 19880779 (1)


    Export disorders for SOX11 gene to outside databases

    Publications
    for SOX11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOX11 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SOX11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. (PubMed id 8666406)1, 2, 3, 9 Jay P.... Berta P. (1995)
    2. Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. (PubMed id 12637543)1, 3 Wiebe M.S....Rizzino A. (2003)
    3. Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. (PubMed id 10574465)1, 2 Azuma T....Muramatsu M. (1999)
    4. Partial cloning of SOX-11 and SOX-12, two new human SOX genes. (PubMed id 8332506)1, 2 Goze C.... Berta P. (1993)
    5. Strong lymphoid nuclear expression of SOX11 transcrip tion factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (PubMed id 19880779)1, 9 Dictor M....Borrebaeck C. (2009)
    6. SOX11 expression is highly specific for mantle cell l ymphoma and identifies the cyclin D1-negative subtype. (PubMed id 19880778)1, 9 Mozos A....Campo E. (2009)
    7. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. (PubMed id 17934069)1, 9 Ek S....Borrebaeck C.A. (2008)
    8. Members of the SRY family regulate the human LINE retrotransposons. (PubMed id 10606637)1, 9 Tchenio T....Heidmann T. (2000)
    9. A highly sensitive and specific qPCR assay for quantif ication of the biomarker SOX11 in mantle cell lymphoma. (PubMed id 22827557)1 Hamborg K.H....Nyvold C.G. (2012)
    10. The expression of SOX11, cyclin D1, cyclin D2, and cyc lin D3 in B-cell lymphocytic proliferative diseases. (PubMed id 21479697)1 Cao X....Li J.Y. (2012)

    External Searches for SOX11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SOX11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6664 HGNC: 11191 AceView: SOX11 Ensembl:ENSG00000176887 euGenes: HUgn6664
    ECgene: SOX11 H-InvDB: SOX11

    Other Databases showing SOX11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SOX11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOX11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOX11 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SOX11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SOX11 gene:
    Search GeneIP for patents involving SOX11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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