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SOX11 Gene

protein-coding   GIFtS: 56
GCID: GC02P005842

SRY (Sex Determining Region Y)-Box 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRY (Sex Determining Region Y)-Box 111 2
SRY-Related HMG-Box Gene 111 2
SRY (Sex-Determining Region Y)-Box 112
Transcription Factor SOX-112

External Ids:    HGNC: 111911   Entrez Gene: 66642   Ensembl: ENSG000001768877   OMIM: 6008985   UniProtKB: P357163   

Export aliases for SOX11 gene to outside databases

Previous GC identifers: GC02P005617 GC02P005884 GC02P005854 GC02P005783 GC02P005834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOX11 Gene:
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in
the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as
a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the
developing nervous system and play a role in tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX11 Gene:
SOX11 (SRY (sex determining region Y)-box 11) is a protein-coding gene. Diseases associated with SOX11 include mantle cell lymphoma, and malignant glioma. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
development

Gene Wiki entry for SOX11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX11 gene promoter:
         Sp1   AP-2gamma   NF-AT   HEN1   NF-AT4   NF-AT2   AP-2beta   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX11 promoter sequence
   Search Chromatin IP Primers for SOX11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25

SOX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P005842:  view genomic region     (about GC identifiers)

Start:
5,832,799 bp from pter      End:
5,841,517 bp from pter
Size:
8,719 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716 (See protein sequence)
Recommended Name: Transcription factor SOX-11  
Size: 441 amino acids; 46679 Da
Secondary accessions: Q4ZFV8

Explore the universe of human proteins at neXtProt for SOX11: NX_P35716

Explore proteomics data for SOX11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003099.1  
    ENSEMBL proteins: 
     ENSP00000322568  

    SOX11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SOX11

    SOX11 Antibody Products:

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    SOX11 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOX11
    Cloud-Clone Corp. CLIAs for SOX11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR017386 SOX-12/11/4a

    Graphical View of Domain Structure for InterPro Entry P35716

    ProtoNet protein and cluster: P35716

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Similarity: Contains 1 HMG box DNA-binding domain


    SOX11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX11_HUMAN, P35716
    Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
    development

         Genatlas biochemistry entry for SOX11:
    SRY related HMG box gene 11,expressed in the developing central and peripheral nervous system,somites,developing
    limbs,facial mesenchyme,kidney,lung,specific postmitotic neuronal subpopulation,modulator of LINE retroposons
    promoter activity

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA--
    GO:0001071nucleic acid binding transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0001105RNA polymerase II transcription coactivator activity ISS--
         
    SOX11 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sox11) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  normal 

    SOX11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SOX11: Sox11tm2.2Weg Sox11tm1.2Llei

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX11

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOX11:
    hsa-mir-128-3p (MIRT022064), hsa-mir-148b-3p (MIRT019474), hsa-mir-339-5p (MIRT042780)

    Block miRNA regulation of human, mouse, rat SOX11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOX11
    Predesigned siRNA for gene silencing in human, mouse, rat SOX11

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SOX11

    Clone
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    OriGene clones in human, mouse for SOX11 (see all 5)
    OriGene ORF clones in mouse, rat for SOX11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SOX11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOX11_HUMAN, P35716: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17934069
    GO:0005737cytoplasm IDA17934069

    SOX11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOX11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX11
        Molecular Mechanisms of Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOX11
    Interactions:

        Search GeneGlobe Interaction Network for SOX11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SOX11 (P357163 ENSP000003225684) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU3F2P202653, ENSP000003291704I2D: score=1 STRING: ENSP00000329170
    POU3F3P202643, ENSP000003550014I2D: score=1 STRING: ENSP00000355001
    HIST2H3DENSP000003332774STRING: ENSP00000333277
    CHTF18ENSP000002623154STRING: ENSP00000262315
    TAF2ENSP000003674064STRING: ENSP00000367406
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19808959
    GO:0001501skeletal system development ISS--
    GO:0001822kidney development IEA--
    GO:0001841neural tube formation ISS--
    GO:0002089lens morphogenesis in camera-type eye ISS--

    SOX11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SOX11 gene: 
    NM_003108.3  

    Unigene Cluster for SOX11:

    SRY (sex determining region Y)-box 11
    Hs.432638  [show with all ESTs]
    Unigene Representative Sequence: AB028641
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322002(uc002qyj.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOX11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOX11
    Predesigned siRNA for gene silencing in human, mouse, rat SOX11
    Clone
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    OriGene clones in human, mouse for SOX11 (see all 5)
    OriGene ORF clones in mouse, rat for SOX11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX11
      QuantiTect SYBR Green Assays in human, mouse, rat SOX11
      QuantiFast Probe-based Assays in human, mouse, rat SOX11

    Additional mRNA sequence: 

    AB028641.1 BC025789.1 BC127200.1 BC127201.1 U23752.1 

    4 DOTS entries:

    DT.434667  DT.92414003  DT.102828070  DT.121028601 

    Selected AceView cDNA sequences (see all 96):

    BM722157 AW163178 BQ892186 BI524024 AI418677 AI939636 AI362665 AW236986 
    BE350824 NM_003108 BE328685 BM682112 AI360875 AI374754 BI524334 F11451 
    CR622054 AA897354 CA445903 AI470073 AI214294 AI699997 AA975478 AI423179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOX11 expression in normal human tissues (normalized intensities)      SOX11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGTGTAG
    SOX11 Expression
    About this image


    SOX11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SOX11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432638

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Tissue specificity: Expressed mainly in the nervous system

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOX11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox111 , 5 SRY-box containing gene 115
    SRY (sex determining region Y)-box 111
    86.29(n)1
    84.77(a)1
      12 (9.95 cM)5
    206661  NM_009234.61  NP_033260.41 
     273342645 
    chicken
    (Gallus gallus)
    Aves SOX111 SRY (sex determining region Y)-box 11 78.4(n)
    75.7(a)
      396104  NM_205187.1  NP_990518.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOX116
    SRY (sex determining region Y)-box 11
    78(a)
    1 ↔ 1
    GL343240.1(2101117-2102346)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8912 Xenopus laevis mRNA for XLS13A protein, complete cds 82.74(n)    D87209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ237812.12   -- 80.78(n)   30602  AJ237812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox146
    Sox box protein 14
    17(a)
    1 → many
    2R(19866744-19872700)
    worm
    (Caenorhabditis elegans)
    Secernentea sem-26
    Protein SEM-2 (sem-2) mRNA, complete cds
    25(a)
    1 → many
    I(5204664-5215218) WBGene00004771


    ENSEMBL Gene Tree for SOX11 (if available)
    TreeFam Gene Tree for SOX11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOX11 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX82  
    SRY2  SOX102  SOX72  
    15 SIMAP similar genes for SOX11 using alignment to 3 protein entries:     SOX11_HUMAN (see all proteins):
    SOX14    SOX17    SOX28    SOX26    SOX25    SOX27
    soxB    SOX5    SRY    SOX10    SOX15    SOX30
    SOX4    SOX21    SOX12

    SOX11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOX11 (see all 188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931690061,2
    --5830835(+) TTATCC/GCAATG 1 -- us2k10--------
    rs2021429731,2
    C--5830845(-) AAATTA/CCCGCC 1 -- us2k10--------
    rs173627721,2
    C,F,H--5830918(+) ATCCAA/GTACTT 1 -- us2k113Minor allele frequency- G:0.04NA NS EA 1104
    rs1850532701,2
    --5830921(+) CAATAC/GTTAAG 1 -- us2k10--------
    rs1486223561,2
    C--5830972(+) AGATTC/TGGATA 1 -- us2k10--------
    rs1894276331,2
    C--5831024(+) TCCGGG/TCAGTG 1 -- us2k10--------
    rs1818233771,2
    C--5831151(+) CCGTAA/GAGGTA 1 -- us2k10--------
    rs1852189451,2
    --5831216(+) TCCGCC/GGCTGC 1 -- us2k10--------
    rs1456570001,2
    --5831251(+) GTCGCA/GGCTCC 1 -- us2k10--------
    rs1881519411,2
    --5831318(+) GTGCAC/TCTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOX11 (5832799 - 5841517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SOX11:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv676e199CNV Deletion23128226
    dgv609n67CNV Gain20364138
    nsv828241CNV Gain20364138
    dgv608n67CNV Gain20364138
    nsv833292CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOX11
    DNA2.0 Custom Variant and Variant Library Synthesis for SOX11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600898    OMIM disorders: --

    17 diseases for SOX11:    About MalaCards
    mantle cell lymphoma    malignant glioma    burkitt's lymphoma    male infertility
    infertility    medulloblastoma    kidney disease    retinitis
    ovarian cancer    crohn's disease    hiv-1    obesity
    neuronitis    cerebritis    pancreatitis    endotheliitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SOX11:
    Mantle cell lymphoma

    SOX11 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SOX11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 65 1 19880779 (1)
    malignant glioma 53.5 2 15583815 (1), 16504379 (1)
    lymphoma 20.8 2 17934069 (1), 19880778 (1), 19880779 (1)

    Genetic Association Database (GAD): SOX11

    Export disorders for SOX11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOX11 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with SOX11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. (PubMed id 8666406)1, 2, 3, 9 Jay P.... Berta P. (Genomics 1995)
    2. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    3. Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. (PubMed id 12637543)1, 3 Wiebe M.S....Rizzino A. (J. Biol. Chem. 2003)
    4. Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. (PubMed id 10574465)1, 2 Azuma T....Muramatsu M. (DNA Res. 1999)
    5. Partial cloning of SOX-11 and SOX-12, two new human SOX genes. (PubMed id 8332506)1, 2 Goze C.... Berta P. (Nucleic Acids Res. 1993)
    6. Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (PubMed id 19880779)1, 9 Dictor M....Borrebaeck C. (Haematologica 2009)
    7. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. (PubMed id 19880778)1, 9 Mozos A....Campo E. (Haematologica 2009)
    8. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. (PubMed id 17934069)1, 9 Ek S....Borrebaeck C.A. (Blood 2008)
    9. Members of the SRY family regulate the human LINE retrotransposons. (PubMed id 10606637)1, 9 TchAcnio T....Heidmann T. (Nucleic Acids Res. 2000)
    10. Assessment of SOX11 Expression in Routine Lymphoma Tissue Sections: Characterization of New Monoclonal Antibodies for Diagnosis of Mantle Cell Lymphoma. (PubMed id 24145648)1 Soldini D....Campo E. (Am. J. Surg. Pathol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6664 HGNC: 11191 AceView: SOX11 Ensembl:ENSG00000176887 euGenes: HUgn6664
    ECgene: SOX11 H-InvDB: SOX11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOX11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOX11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOX11 gene:
    Search GeneIP for patents involving SOX11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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