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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOX11 Gene

protein-coding   GIFtS: 56
GCID: GC02P005842

SRY (Sex Determining Region Y)-Box 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SRY (Sex Determining Region Y)-Box 111 2
SRY-Related HMG-Box Gene 111 2
SRY (Sex-Determining Region Y)-Box 112
Transcription Factor SOX-112

External Ids:    HGNC: 111911   Entrez Gene: 66642   Ensembl: ENSG000001768877   OMIM: 6008985   UniProtKB: P357163   

Export aliases for SOX11 gene to outside databases

Previous GC identifers: GC02P005617 GC02P005884 GC02P005854 GC02P005783 GC02P005834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOX11 Gene:
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in
the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as
a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the
developing nervous system and play a role in tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX11 Gene: 
SOX11 (SRY (sex determining region Y)-box 11) is a protein-coding gene. Diseases associated with SOX11 include mantle cell lymphoma, and malignant glioma, and among its related super-pathways are Rho Family GTPases. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
development

Gene Wiki entry for SOX11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOX11 gene promoter:
         Sp1   AP-2gamma   NF-AT   HEN1   NF-AT4   NF-AT2   AP-2beta   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOX11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25

SOX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P005842:  view genomic region     (about GC identifiers)

Start:
5,832,799 bp from pter      End:
5,841,517 bp from pter
Size:
8,719 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716 (See protein sequence)
Recommended Name: Transcription factor SOX-11  
Size: 441 amino acids; 46679 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4ZFV8

Explore the universe of human proteins at neXtProt for SOX11: NX_P35716

Explore proteomics data for SOX11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35716

  • SOX11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOX11 Protein Expression
    REFSEQ proteins: NP_003099.1  
    ENSEMBL proteins: 
     ENSP00000322568  

    Human Recombinant Protein Products for SOX11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SOX11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SOX11
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    Novus Biologicals SOX11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOX11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17934069
    GO:0005737cytoplasm IDA17934069

    SOX11 for ontologies           About GeneDecksing



    SOX11 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SOX11 

    Assay Products for SOX11: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SOX11 
    Cloud-Clone Corp. CLIAs for SOX11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR017386 SOX-12/11/4a

    Graphical View of Domain Structure for InterPro Entry P35716

    ProtoNet protein and cluster: P35716

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Similarity: Contains 1 HMG box DNA-binding domain


    SOX11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX11_HUMAN, P35716
    Function: Probably important in the developing nervous system. May also have a role in tissue modeling during
    development

         Genatlas biochemistry entry for SOX11:
    SRY related HMG box gene 11,expressed in the developing central and peripheral nervous system,somites,developing
    limbs,facial mesenchyme,kidney,lung,specific postmitotic neuronal subpopulation,modulator of LINE retroposons
    promoter activity

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA--
    GO:0001071nucleic acid binding transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0001105RNA polymerase II transcription coactivator activity ISS--
         
    SOX11 for ontologies           About GeneDecksing


    Phenotypes:
         15/18 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sox11) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  normal 

    SOX11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sox11tm2.2Weg for SOX11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOX11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOX11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX11 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX11
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOX11
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SOX11

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SOX11 (see all 6)
    OriGene ORF clones in mouse, rat for SOX11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11
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                         Customized lentivirus expression plasmids for stable overexpression of SOX11 

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    Search LifeMap BioReagents cell lines for SOX11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOX11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho Family GTPases
    Molecular Mechanisms of Cancer0.51
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SOX11
        Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOX11
        Molecular Mechanisms of Cancer



    SOX11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOX11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SOX11 (P357163 ENSP000003225684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU3F2P202653, ENSP000003291704I2D: score=1 STRING: ENSP00000329170
    POU3F3P202643, ENSP000003550014I2D: score=1 STRING: ENSP00000355001
    About this table

    Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19808959
    GO:0001501skeletal system development ISS--
    GO:0001822kidney development IEA--
    GO:0001841neural tube formation ISS--
    GO:0002089lens morphogenesis in camera-type eye ISS--

    SOX11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOX11

    Search CenterWatch for drugs/clinical trials and news about SOX11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOX11 gene: 
    NM_003108.3  

    Unigene Cluster for SOX11:

    SRY (sex determining region Y)-box 11
    Hs.432638  [show with all ESTs]
    Unigene Representative Sequence: AB028641
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322002(uc002qyj.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOX11
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate SOX11 (see all 145):
    hsa-miR-128 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-92b hsa-miR-455-5p hsa-miR-1231 hsa-miR-200c* hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOX11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOX11
    Clone
    Products:
         
    OriGene clones in human, mouse for SOX11 (see all 6)
    OriGene ORF clones in mouse, rat for SOX11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOX11 (NM_003108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOX11
    Sirion Biotech Customized lentivirus for stable overexpression of SOX11 
                         Customized lentivirus expression plasmids for stable overexpression of SOX11 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOX11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOX11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOX11

    Additional mRNA sequence: 

    AB028641.1 BC025789.1 BC127200.1 BC127201.1 U23752.1 

    4 DOTS entries:

    DT.434667  DT.92414003  DT.102828070  DT.121028601 

    24/96 AceView cDNA sequences (see all 96):

    AI699997 AA975478 AI378888 AI374754 BE350824 F11451 AW275020 BM682112 
    AW157202 AI939636 CA445903 AI470073 AI214294 AW236986 BI524334 BE328685 
    AA897354 AI362665 BC025789 AI423179 BM729190 BI524024 AI418677 AW090162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOX11 expression in normal human tissues (normalized intensities)      SOX11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGTGTAG
    SOX11 Expression
    About this image


    SOX11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 32 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Thalamus
             Human Cerebellar Astrocytes   
             Substantia Nigra   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Retina
             Human Keratocyte (HK)   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             limb/hindlimb   

    See SOX11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOX11

    SOURCE GeneReport for Unigene cluster: Hs.432638

    UniProtKB/Swiss-Prot: SOX11_HUMAN, P35716
    Tissue specificity: Expressed mainly in the nervous system

        SABiosciences Custom PCR Arrays for SOX11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SOX11 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox111 , 5 SRY-box containing gene 111, 5 88.32(n)1
    88.32(a)1
      12 (9.95 cM)5
    206661  NM_009234.61  NP_033260.41 
     273342645 
    chicken
    (Gallus gallus)
    Aves SOX111 SRY (sex determining region Y)-box 11 81.09(n)
    80.41(a)
      396104  NM_205187.1  NP_990518.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOX116
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343240.1(2101117-2102346)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8912 Xenopus laevis mRNA for XLS13A protein, complete cds 82.74(n)    D87209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ237812.12   -- 80.78(n)   30602  AJ237812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox146
    Sox box protein 14
    14(a)
    1 → many
    2R(19866744-19872700)
    worm
    (Caenorhabditis elegans)
    Secernentea sem-26
    Protein SEM-2
    26(a)
    1 → many
    I(5205103-5215218)


    ENSEMBL Gene Tree for SOX11 (if available)
    TreeFam Gene Tree for SOX11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOX11 gene
    SOX132  SOX22  SOX42  SOX12  SOX142  SOX32  SOX92  SOX122  
    SOX152  SOX182  SOX52  ENSG000002587242  SOX212  SOX172  SOX62  SOX82  
    SRY2  SOX102  SOX72  
    15 SIMAP similar genes for SOX11 using alignment to 3 protein entries:     SOX11_HUMAN (see all proteins):
    SOX14    SOX17    SOX28    SOX26    SOX25    SOX27
    soxB    SOX5    SRY    SOX10    SOX15    SOX30
    SOX4    SOX21    SOX12

    SOX11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 SNPs in SOX11 are shown (see all 188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931690061,2
    --5830835(+) TTATCC/GCAATG 1 -- us2k10--------
    rs2021429731,2
    C--5830845(-) AAATTA/CCCGCC 1 -- us2k10--------
    rs173627721,2
    C,F,H--5830918(+) ATCCAA/GTACTT 1 -- us2k113Minor allele frequency- G:0.04NA NS EA 1104
    rs1850532701,2
    --5830921(+) CAATAC/GTTAAG 1 -- us2k10--------
    rs1486223561,2
    C--5830972(+) AGATTC/TGGATA 1 -- us2k10--------
    rs1894276331,2
    C--5831024(+) TCCGGG/TCAGTG 1 -- us2k10--------
    rs1818233771,2
    C--5831151(+) CCGTAA/GAGGTA 1 -- us2k10--------
    rs1852189451,2
    --5831216(+) TCCGCC/GGCTGC 1 -- us2k10--------
    rs1456570001,2
    --5831251(+) GTCGCA/GGCTCC 1 -- us2k10--------
    rs1881519411,2
    --5831318(+) GTGCAC/TCTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOX11 (5832799 - 5841517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SOX11:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv676e199CNV Deletion23128226
    dgv609n67CNV Gain20364138
    nsv828241CNV Gain20364138
    dgv608n67CNV Gain20364138
    nsv833292CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600898    OMIM disorders: --

    10 diseases for SOX11:    About MalaCards
    mantle cell lymphoma    malignant glioma    burkitt's lymphoma    male infertility
    infertility    medulloblastoma    kidney disease    ovarian cancer
    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SOX11:
    Mantle cell lymphoma

    SOX11 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SOX11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 65 1 19880779 (1)
    malignant glioma 53.5 2 15583815 (1), 16504379 (1)
    lymphoma 20.8 2 17934069 (1), 19880778 (1), 19880779 (1)

    Genetic Association Database (GAD): SOX11

    Export disorders for SOX11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOX11 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with SOX11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. (PubMed id 8666406)1, 2, 3, 9 Jay P.... Berta P. (1995)
    2. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
    3. Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. (PubMed id 12637543)1, 3 Wiebe M.S....Rizzino A. (2003)
    4. Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. (PubMed id 10574465)1, 2 Azuma T....Muramatsu M. (1999)
    5. Partial cloning of SOX-11 and SOX-12, two new human SOX genes. (PubMed id 8332506)1, 2 Goze C.... Berta P. (1993)
    6. Strong lymphoid nuclear expression of SOX11 transcrip tion factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (PubMed id 19880779)1, 9 Dictor M....Borrebaeck C. (2009)
    7. SOX11 expression is highly specific for mantle cell l ymphoma and identifies the cyclin D1-negative subtype. (PubMed id 19880778)1, 9 Mozos A....Campo E. (2009)
    8. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. (PubMed id 17934069)1, 9 Ek S....Borrebaeck C.A. (2008)
    9. Members of the SRY family regulate the human LINE retrotransposons. (PubMed id 10606637)1, 9 Tchenio T....Heidmann T. (2000)
    10. Sox11 expression in astrocytic gliomas: correlation wi th nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival. (PubMed id 23619925)1 Korkolopoulou P....Piperi C. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6664 HGNC: 11191 AceView: SOX11 Ensembl:ENSG00000176887 euGenes: HUgn6664
    ECgene: SOX11 H-InvDB: SOX11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOX11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOX11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOX11 gene:
    Search GeneIP for patents involving SOX11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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