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SOX1 Gene

protein-coding   GIFtS: 55
GCID: GC13P112721

SRY (Sex Determining Region Y)-Box 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRY (Sex Determining Region Y)-Box 11 2
SRY-Related HMG-Box Gene 11 2
Transcription Factor SOX-12

External Ids:    HGNC: 111891   Entrez Gene: 66562   Ensembl: ENSG000001829687   OMIM: 6021485   UniProtKB: O005703   

Export aliases for SOX1 gene to outside databases

Previous GC identifers: GC13P111331 GC13P107359 GC13P111808 GC13P110669 GC13P111769 GC13P093184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOX1 Gene:
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in
the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as
a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein
regulates the gamma-crystallin genes and is essential for lens development. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOX1 Gene:
SOX1 (SRY (sex determining region Y)-box 1) is a protein-coding gene. GO annotations related to this gene include core promoter sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX13.

UniProtKB/Swiss-Prot: SOX1_HUMAN, O00570
Function: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells
undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_027140.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOX1 gene promoter:
         AhR   HNF-4alpha2   C/EBPalpha   Arnt   HNF-4alpha1   CREB   CHOP-10   FOXO4   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOX1 promoter sequence
   Search Chromatin IP Primers for SOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

SOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOX1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P112721:  view genomic region     (about GC identifiers)

Start:
112,721,913 bp from pter      End:
112,726,020 bp from pter
Size:
4,108 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SOX1_HUMAN, O00570 (See protein sequence)
Recommended Name: Transcription factor SOX-1  
Size: 391 amino acids; 39023 Da
Secondary accessions: Q5W0Q1

Explore the universe of human proteins at neXtProt for SOX1: NX_O00570

Explore proteomics data for SOX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005977.2  
    ENSEMBL proteins: 
     ENSP00000330218  

    SOX1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SOX1

     
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    antibodies-online proteins for SOX1 (4 products) 

     
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    antibodies-online antibodies for SOX1 (46 products) 

    SOX1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SOX1
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    antibodies-online kits for SOX1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOX: SRY (sex determining region Y)-boxes

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR022097 TF_SOX

    Graphical View of Domain Structure for InterPro Entry O00570

    ProtoNet protein and cluster: O00570

    UniProtKB/Swiss-Prot: SOX1_HUMAN, O00570
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with SOX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOX1_HUMAN, O00570
    Function: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells
    undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By
    similarity)

         Genatlas biochemistry entry for SOX1:
    SRY related HMG box gene 1,38.8kDa,moderately expressed in embryonic brain,involved in neural and lens
    development,modulator of LINE retroposons promoter activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA--
    GO:0003677DNA binding NAS9337405
    GO:0003700sequence-specific DNA binding transcription factor activity NAS9337405
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding ----
         
    Find genes that share ontologies with SOX1           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sox1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  vision/eye 

    Find genes that share phenotypes with SOX1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOX1

    miRNA
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    miRTarBase miRNAs that target SOX1:
    hsa-mir-335-5p (MIRT017005)

    Block miRNA regulation of human, mouse, rat SOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX1 (see all 36):
    hsa-miR-429 hsa-miR-139-5p hsa-miR-10b* hsa-miR-155 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-200b hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidSOX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOX1
    Predesigned siRNA for gene silencing in human, mouse, rat SOX1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SOX1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SOX1 (NM_002826)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SOX1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SOX1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOX1_HUMAN, O00570: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9337405

    Find genes that share ontologies with SOX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOX1 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51
    2Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    3Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOX1
        Molecular Mechanisms of Cancer

    2 BioSystems Pathways for SOX1
        Cardiac Progenitor Differentiation
    Wnt Signaling Pathway NetPath


        Pathway & Disease-focused RT2 Profiler PCR Array including SOX1: 
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOX1 (O005701, 3 ENSP000003302184) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, 3, ENSP000002646574EBI-2935583,EBI-518675 I2D: score=1 STRING: ENSP00000264657
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    POU2F1ENSP000002714114STRING: ENSP00000271411
    RPTORENSP000003072724STRING: ENSP00000307272
    PPIP5K1ENSP000003801294STRING: ENSP00000380129
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0002089lens morphogenesis in camera-type eye IEA--
    GO:0006325chromatin organization NAS9337405
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS9337405

    Find genes that share ontologies with SOX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOX1 gene: 
    NM_005986.2  

    Unigene Cluster for SOX1:

    SRY (sex determining region Y)-box 1
    Hs.202526  [show with all ESTs]
    Unigene Representative Sequence: NM_005986
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330949(uc001vsb.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOX1 (see all 36):
    hsa-miR-429 hsa-miR-139-5p hsa-miR-10b* hsa-miR-155 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-200b hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidSOX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SOX1
    Predesigned siRNA for gene silencing in human, mouse, rat SOX1
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    GenScript: all cDNA clones in your preferred vector (see all 2): SOX1 (NM_002826)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOX1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SOX1
    Primer
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    OriGene qPCR primer pairs and template standards for SOX1
    OriGene qSTAR qPCR primer pairs in human, mouse for SOX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOX1
      QuantiTect SYBR Green Assays in human, mouse, rat SOX1
      QuantiFast Probe-based Assays in human, mouse, rat SOX1

    1 DOTS entry:

    DT.428143 

    10 AceView cDNA sequences:

    NM_005986 BE222206 T07302 AI703171 AA961095 BE669725 BE504430 R46080 
    D81624 R20579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGCTGAG
    SOX1 Expression
    About this image


    SOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Neural Ectoderm (Nervous System)    fully expand to see all 24 entries
             Cranial Neural Plate Cells Neural Plate
             Matured neural rosettes
     
     Neural Tube (Nervous System)    fully expand to see all 19 entries
             Medial Hinge Point Cells Primitive Spinal Cord
             Telencephalon
             Neural rosettes
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Late MN Progenitor Cells Motor Neural Progenitor Domain
             Thalamus
             Neural progenitor cells
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Lens Vesicle Cells Lens Vesicle
             Lens
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Intraembryonic Ectoderm Cells Ectoderm
             Activin-induced cells
    SOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202526

    UniProtKB/Swiss-Prot: SOX1_HUMAN, O00570
    Tissue specificity: Mainly expressed in the developing central nervous system

        Pathway & Disease-focused RT2 Profiler PCR Array including SOX1: 
              Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SOX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sox11 , 5 SRY-box containing gene 15
    SRY (sex determining region Y)-box 11
    94.29(n)1
    99.49(a)1
      8 (5.73 cM)5
    206641  NM_009233.31  NP_033259.21 
     123952955 
    lizard
    (Anolis carolinensis)
    Reptilia SOX16
    SRY (sex determining region Y)-box 1
    79(a)
    1 ↔ 1
    3(105298539-105299823)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sox11 SRY (sex determining region Y)-box 1 70.48(n)
    76.06(a)
      779569  NM_001080996.1  NP_001074465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sox1a1 SRY-box containing gene 1a 73.62(n)
    79.46(a)
      436756  NM_001002483.1  NP_001002483.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sox21a3 transcription factor 88(a)
    (best of 4)
      70D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea sox-26
    Protein SOX-2, isoform a
    37(a)
    1 → many
    X(7458293-7463736) WBGene00004949
    rice
    (Oryza sativa)
    Liliopsida Os.78552 Oryza sativa (japonica cultivar-group) cDNA cloneJ033027E22, full insert sequence less 72.89(n)    AK073361.1 


    ENSEMBL Gene Tree for SOX1 (if available)
    TreeFam Gene Tree for SOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOX1 gene
    SOX132  SOX22  SOX42  SOX142  SOX32  SOX92  SOX122  SOX152  
    SOX182  SOX52  SOX212  ENSG000002587242  SOX172  SOX62  SOX112  SOX82  
    SRY2  SOX102  SOX72  
    5 SIMAP similar genes for SOX1 using alignment to 1 protein entry:     SOX1_HUMAN:
    SOX3    SOX10    SOX2    SOX14    SOX21

    Find genes that share paralogs with SOX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOX1 (see all 117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871554271,2
    --112720026(+) AGTGTA/GAGCGC 1 -- us2k10--------
    rs619556941,2
    F--112720181(+) GAGACC/TCGTCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1117343881,2
    C,F--112720332(+) CAACTG/ATTGTT 1 -- us2k12Minor allele frequency- A:0.03NA EA 240
    rs124299201,2
    C,F,H--112720354(+) TTCCAG/AATAGA 1 -- us2k19Minor allele frequency- A:0.26NA WA EA 370
    rs96041871,2
    C,F--112720365(+) TCTTGT/ATGTGT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs73322661,2
    C,F,A,H--112720386(+) TAGAAA/GTTCCT 1 -- us2k15Minor allele frequency- G:0.01NS EA WA 530
    rs1488896391,2
    --112720409(+) GAAGAC/TCCGGG 1 -- us2k10--------
    rs1819895801,2
    --112720677(+) CCCTCA/GGAGGG 1 -- us2k10--------
    rs1849943411,2
    --112721444(+) GGCTTA/CCCCCG 1 -- us2k10--------
    rs1895803281,2
    --112721817(+) TTTTGC/TTGTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOX1 (112721913 - 112726020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SOX1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826815CNV Loss20364138
    nsv456128CNV Loss19166990
    nsv832722CNV Loss17160897
    nsv901030CNV Loss21882294
    dgv1796n71CNV Loss21882294
    nsv819531CNV Gain19587683
    dgv351n67CNV Gain20364138
    nsv826816CNV Gain20364138
    dgv352n67CNV Gain20364138
    nsv826807CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602148    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SOX1:
    Lambert-Eaton myasthenic syndrome

    Find genes that share disorders with SOX1           About GenesLikeMe

    1 Novoseek inferred disease relationship for SOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 46.3 1 10760287 (1)

    Genetic Association Database (GAD): SOX1
    Human Genome Epidemiology (HuGE) Navigator: SOX1 (1 document)

    Export disorders for SOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOX1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain. (PubMed id 9337405)1, 2, 3 Malas S.... Episkopou V. (Mamm. Genome 1997)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival. (PubMed id 19667272)1, 9 Titulaer M.J....Verschuuren J.J. (J. Clin. Oncol. 2009)
    4. Cisplatin-induced downregulation of SOX1 increases drug resistance by activating autophagy in non-small cell lung cancer cell. (PubMed id 23994634)1 Li N....Zhou Q. (Biochem. Biophys. Res. Commun. 2013)
    5. SOX1 suppresses cell growth and invasion in cervical cancer. (PubMed id 23927962)1 Lin Y.W....Yan M.D. (Gynecol. Oncol. 2013)
    6. Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma. (PubMed id 23215838)1 Shih Y.L....Lin Y.W. (J. Gastroenterol. Hepatol. 2013)
    7. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. (PubMed id 22860217)1 Neely M.D....Bowman A.B. (ACS Chem Neurosci 2012)
    8. SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinoma. (PubMed id 23278580)1 Lipka A.F....Titulaer M.J. (Ann. N. Y. Acad. Sci. 2012)
    9. SOX1 functions as a tumor suppressor by antagonizing the WNT/I^-catenin signaling pathway in hepatocellular carcinoma. (PubMed id 22767186)1 Tsao C.M....Lin Y.W. (Hepatology 2012)
    10. Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord. (PubMed id 20844123)1 Panayi H....Malas S. (J. Neurosci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6656 HGNC: 11189 AceView: SOX1 Ensembl:ENSG00000182968 euGenes: HUgn6656
    ECgene: SOX1 H-InvDB: SOX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOX1 gene:
    Search GeneIP for patents involving SOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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