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Aliases for SOX1 Gene

Aliases for SOX1 Gene

  • SRY-Box 1 2 3 5
  • SRY (Sex Determining Region Y)-Box 1 2
  • SRY-Related HMG-Box Gene 1 2
  • SRY Box 1 2

External Ids for SOX1 Gene

Previous GeneCards Identifiers for SOX1 Gene

  • GC13P111331
  • GC13P107359
  • GC13P111808
  • GC13P110669
  • GC13P111769
  • GC13P112721
  • GC13P093184

Summaries for SOX1 Gene

Entrez Gene Summary for SOX1 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX1 Gene

SOX1 (SRY-Box 1) is a Protein Coding gene. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX1 Gene

  • Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX1 Gene

Genomics for SOX1 Gene

Regulatory Elements for SOX1 Gene

Genomic Location for SOX1 Gene

Chromosome:
13
Start:
112,067,599 bp from pter
End:
112,071,706 bp from pter
Size:
4,108 bases
Orientation:
Plus strand

Genomic View for SOX1 Gene

Genes around SOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX1 Gene

Proteins for SOX1 Gene

  • Protein details for SOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00570-SOX1_HUMAN
    Recommended name:
    Transcription factor SOX-1
    Protein Accession:
    O00570
    Secondary Accessions:
    • Q5W0Q1

    Protein attributes for SOX1 Gene

    Size:
    391 amino acids
    Molecular mass:
    39023 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX1 Gene

Proteomics data for SOX1 Gene at MOPED

Post-translational modifications for SOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOX1 (SOX1)

No data available for DME Specific Peptides for SOX1 Gene

Domains & Families for SOX1 Gene

Gene Families for SOX1 Gene

Protein Domains for SOX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00570

UniProtKB/Swiss-Prot:

SOX1_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX1: view

Function for SOX1 Gene

Molecular function for SOX1 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 1,38.8kDa,moderately expressed in embryonic brain,involved in neural and lens development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for SOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,NAS 9337405
GO:0005515 protein binding IPI 20929579
genes like me logo Genes that share ontologies with SOX1: view
genes like me logo Genes that share phenotypes with SOX1: view

Animal Models for SOX1 Gene

MGI Knock Outs for SOX1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SOX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX1 Gene

Localization for SOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX1 Gene COMPARTMENTS Subcellular localization image for SOX1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SOX1 Gene

Pathways & Interactions for SOX1 Gene

genes like me logo Genes that share pathways with SOX1: view

Interacting Proteins for SOX1 Gene

Gene Ontology (GO) - Biological Process for SOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0021521 ventral spinal cord interneuron specification IEA --
GO:0030900 forebrain development IEA --
genes like me logo Genes that share ontologies with SOX1: view

No data available for SIGNOR curated interactions for SOX1 Gene

Drugs & Compounds for SOX1 Gene

No Compound Related Data Available

Transcripts for SOX1 Gene

mRNA/cDNA for SOX1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX1 Gene

SRY (sex determining region Y)-box 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX1 Gene

No ASD Table

Relevant External Links for SOX1 Gene

GeneLoc Exon Structure for
SOX1
ECgene alternative splicing isoforms for
SOX1

Expression for SOX1 Gene

mRNA expression in normal human tissues for SOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX1 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.6), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Caudate (basal ganglia) (x5.4), Brain - Amygdala (x5.4), Brain - Putamen (basal ganglia) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for SOX1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX1 Gene



SOURCE GeneReport for Unigene cluster for SOX1 Gene Hs.202526

mRNA Expression by UniProt/SwissProt for SOX1 Gene

O00570-SOX1_HUMAN
Tissue specificity: Mainly expressed in the developing central nervous system.
genes like me logo Genes that share expression patterns with SOX1: view

Protein tissue co-expression partners for SOX1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SOX1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sox1 35
  • 94.29 (n)
  • 99.49 (a)
Sox1 16
Sox1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912302 35
  • 95.76 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia SOX1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOX1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOX1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOX1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sox1 35
  • 70.48 (n)
  • 76.06 (a)
zebrafish
(Danio rerio)
Actinopterygii sox1a 35
  • 73.62 (n)
  • 79.46 (a)
sox1a 36
  • 82 (a)
OneToMany
sox1b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta D 37
  • 80 (a)
Sox21a 37
  • 88 (a)
Sox21b 37
  • 81 (a)
SoxN 37
  • 79 (a)
SoxN 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sox-2 36
  • 37 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.7855 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX1 Gene

ENSEMBL:
Gene Tree for SOX1 (if available)
TreeFam:
Gene Tree for SOX1 (if available)

Paralogs for SOX1 Gene

(5) SIMAP similar genes for SOX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX1: view

Variants for SOX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOX1 Gene

Variant ID Type Subtype PubMed ID
nsv901030 CNV Loss 21882294
nsv456128 CNV Loss 19166990
dgv351n67 CNV Gain 20364138
nsv826807 CNV Gain 20364138
nsv826813 CNV Gain 20364138
nsv826815 CNV Loss 20364138
nsv826816 CNV Gain 20364138
dgv1796n71 CNV Loss 21882294
nsv832722 CNV Loss 17160897
dgv352n67 CNV Gain 20364138
nsv819531 CNV Gain 19587683

Variation tolerance for SOX1 Gene

Gene Damage Index Score: 8.35; 85.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX1 Gene

HapMap Linkage Disequilibrium report
SOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SOX1 Gene

Disorders for SOX1 Gene

Relevant External Links for SOX1

Genetic Association Database (GAD)
SOX1
Human Genome Epidemiology (HuGE) Navigator
SOX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX1

No disorders were found for SOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX1 Gene

Publications for SOX1 Gene

  1. Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain. (PMID: 9337405) Malas S. … Episkopou V. (Mamm. Genome 1997) 2 3 4 67
  2. CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4. (PMID: 20049565) Iqbal M.S. … Kawano M.M. (Int. J. Hematol. 2010) 3 23
  3. SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival. (PMID: 19667272) Titulaer M.J. … Verschuuren J.J. (J. Clin. Oncol. 2009) 3 23
  4. Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. (PMID: 25234806) Dijkstra A.E. … Postma D.S. (Eur. Respir. J. 2015) 3
  5. Generation of highly purified neural stem cells from human adipose-derived mesenchymal stem cells by Sox1 activation. (PMID: 24138016) Feng N. … Zhao R.C. (Stem Cells Dev. 2014) 3

Products for SOX1 Gene

Sources for SOX1 Gene

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