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SOWAHD Gene

protein-coding   GIFtS: 29
GCID: GC0XP118893

Sosondowah Ankyrin Repeat Domain Family Member D

(Previous name: ankyrin repeat domain 58)
(Previous symbol: ANKRD58)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sosondowah Ankyrin Repeat Domain Family Member D1 2
ANKRD581 2 3
Ankyrin Repeat Domain 581 2
Ankyrin Repeat Domain-Containing Protein 582 3
Protein Sosondowah Homolog D2 3
Ankyrin Repeat Domain-Containing Protein SOWAHD2

External Ids:    HGNC: 329601   Entrez Gene: 3474542   Ensembl: ENSG000001878087   UniProtKB: A6NJG23   

Export aliases for SOWAHD gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SOWAHD Gene:
SOWAHD (sosondowah ankyrin repeat domain family member D) is a protein-coding gene. An important paralog of this gene is SOWAHB.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SOWAHD
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SOWAHD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOWAHD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

SOWAHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOWAHD gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP118893:  view genomic region     (about GC identifiers)

Start:
118,892,576 bp from pter      End:
118,894,165 bp from pter
Size:
1,590 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SWAHD_HUMAN, A6NJG2 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein SOWAHD  
Size: 315 amino acids; 33803 Da

Explore the universe of human proteins at neXtProt for SOWAHD: NX_A6NJG2

Explore proteomics data for SOWAHD at MOPED


See SOWAHD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001099046.1  
ENSEMBL proteins: 
 ENSP00000340975  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR020683 Ankyrin_rpt-contain_dom
 IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry A6NJG2

ProtoNet protein and cluster: A6NJG2

UniProtKB/Swiss-Prot: SWAHD_HUMAN, A6NJG2
Similarity: Belongs to the SOWAH family
Similarity: Contains 3 ANK repeats


SOWAHD for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
SOWAHD for ontologies           About GeneDecksing


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOWAHD
Interactions:

    Search GeneGlobe Interaction Network for SOWAHD

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SOWAHD (SWAHD)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SOWAHD gene: 
NM_001105576.2  

Unigene Cluster for SOWAHD:

Sosondowah ankyrin repeat domain family member D
Hs.355223  [show with all ESTs]
Unigene Representative Sequence: NM_001105576
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000343905(uc010nql.3)
miRNA
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1 DOTS entry:

DT.91721314 

11 AceView cDNA sequences:

BI825771 BM919803 CD368490 CR593492 BX338026 BX338025 BG118506 CD369313 
BQ953121 BX417053 BM811427 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SOWAHD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATCACAGGT
SOWAHD Expression
About this image


SOWAHD expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
SOWAHD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SOWAHD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.355223
    Custom PCR Arrays for SOWAHD
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SOWAHD gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sowahd1 , 5 sosondowah ankyrin repeat domain family member D1, 5 70.85(n)1
63.34(a)1
  X (21.46 cM)5
2453811  NM_173779.31  NP_776140.11 
 370488455 
chicken
(Gallus gallus)
Aves SOWAHD6
sosondowah ankyrin repeat domain family member D
40(a)
1 ↔ 1
4(16016340-16016780)
lizard
(Anolis carolinensis)
Reptilia SOWAHD6
sosondowah ankyrin repeat domain family member D
27(a)
1 ↔ 1
AAWZ02039220(1619-2638)
zebrafish
(Danio rerio)
Actinopterygii SOWAHD6
sosondowah ankyrin repeat domain family member D
25(a)
1 ↔ 1
14(34305436-34306468) ENSDARG00000087152
fruit fly
(Drosophila melanogaster)
Insecta sowah6
sosondowah
8(a)
1 → many
3L(12530613-12565642)


ENSEMBL Gene Tree for SOWAHD (if available)
TreeFam Gene Tree for SOWAHD (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SOWAHD gene
SOWAHB2  SOWAHC2  SOWAHA2  

SOWAHD for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SOWAHD (see all 59)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs27822211,2
C,A--118890603(+) CCCCCA/GCCCCC 1 -- us2k11Minor allele frequency- G:0.00NA 1
rs66464741,2
C,F--118890827(+) GAGGGG/ATCACT 1 -- us2k1 trp32Minor allele frequency- A:0.00NA CSA 3
rs1399872921,2
C--118890866(+) CTAGAC/GGTGGA 1 -- us2k10--------
rs59106531,2
C,A--118890879(+) CTAAGC/TGCAAC 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1866116781,2
--118890910(+) CTACAC/TAGAAG 1 -- us2k10--------
rs1897724841,2
--118890914(+) ATAGAA/CGCTCT 1 -- us2k10--------
rs572629541,2
C,F--118890976(+) TTTTGA/GCTGGA 1 -- us2k12Minor allele frequency- G:0.25WA 4
rs1810769471,2
--118891468(+) TTAACA/TCAACC 1 -- us2k10--------
rs1998872811,2
C--118891475(+) AACCT-/CCATCA 1 -- us2k10--------
rs1864187021,2
--118891632(+) AAAAAA/GAAAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SOWAHD (118892576 - 118894165 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SOWAHD: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SOWAHD
DNA2.0 Custom Variant and Variant Library Synthesis for SOWAHD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SOWAHD gene integrated from 10 sources:
(articles sorted by number of sources associating them with SOWAHD)
    Utopia: connect your pdf to the dynamic
world of online information

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PubMed id 22234889)1, 3 Maeso I....Garcia-FernA ndez J. (Genome Res. 2012)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  3. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 347454 HGNC: 32960 AceView: LOC347454 Ensembl:ENSG00000187808 euGenes: HUgn347454
ECgene: SOWAHD H-InvDB: SOWAHD

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SOWAHD Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SOWAHD gene:
Search GeneIP for patents involving SOWAHD

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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