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Aliases for SOWAHC Gene

Aliases for SOWAHC Gene

  • Sosondowah Ankyrin Repeat Domain Family Member C 2 3
  • Ankyrin Repeat Domain-Containing Protein 57 3 4
  • Protein Sosondowah Homolog C 3 4
  • Ankyrin Repeat Domain 57 2 3
  • ANKRD57 3 4
  • C2orf26 3 4

External Ids for SOWAHC Gene

Previous HGNC Symbols for SOWAHC Gene

  • C2orf26
  • ANKRD57

Previous GeneCards Identifiers for SOWAHC Gene

  • GC02P110372

Summaries for SOWAHC Gene

GeneCards Summary for SOWAHC Gene

SOWAHC (Sosondowah Ankyrin Repeat Domain Family Member C) is a Protein Coding gene. An important paralog of this gene is SOWAHD.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOWAHC Gene

Genomics for SOWAHC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOWAHC Gene

Chromosome:
2
Start:
109,614,334 bp from pter
End:
109,618,990 bp from pter
Size:
4,657 bases
Orientation:
Plus strand

Genomic View for SOWAHC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOWAHC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOWAHC Gene

No data available for Regulatory Elements for SOWAHC Gene

Proteins for SOWAHC Gene

  • Protein details for SOWAHC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53LP3-SWAHC_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein SOWAHC
    Protein Accession:
    Q53LP3
    Secondary Accessions:
    • Q8NE15
    • Q9H6U1

    Protein attributes for SOWAHC Gene

    Size:
    525 amino acids
    Molecular mass:
    55672 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15161.1; Type=Frameshift; Positions=311; Evidence={ECO:0000305};

neXtProt entry for SOWAHC Gene

Proteomics data for SOWAHC Gene at MOPED

Post-translational modifications for SOWAHC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOWAHC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOWAHC Gene

Domains & Families for SOWAHC Gene

Gene Families for SOWAHC Gene

Protein Domains for SOWAHC Gene

Suggested Antigen Peptide Sequences for SOWAHC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53LP3

UniProtKB/Swiss-Prot:

SWAHC_HUMAN :
  • Belongs to the SOWAH family.
  • Contains 2 ANK repeats.
Family:
  • Belongs to the SOWAH family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with SOWAHC: view

Function for SOWAHC Gene

Gene Ontology (GO) - Molecular Function for SOWAHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SOWAHC: view
genes like me logo Genes that share phenotypes with SOWAHC: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOWAHC

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SOWAHC Gene

Localization for SOWAHC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SOWAHC Gene

Pathways & Interactions for SOWAHC Gene

SuperPathways for SOWAHC Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOWAHC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SOWAHC Gene

Drugs & Compounds for SOWAHC Gene

No Compound Related Data Available

Transcripts for SOWAHC Gene

mRNA/cDNA for SOWAHC Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOWAHC Gene

Sosondowah ankyrin repeat domain family member C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOWAHC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOWAHC Gene

No ASD Table

Relevant External Links for SOWAHC Gene

GeneLoc Exon Structure for
SOWAHC
ECgene alternative splicing isoforms for
SOWAHC

Expression for SOWAHC Gene

mRNA expression in normal human tissues for SOWAHC Gene

mRNA differential expression in normal tissues according to GTEx for SOWAHC Gene

This gene is overexpressed in Esophagus - Mucosa (x5.4) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for SOWAHC Gene

This gene is overexpressed in Blymphocyte (19.4), Fetal Brain (12.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOWAHC Gene



SOURCE GeneReport for Unigene cluster for SOWAHC Gene Hs.355455

genes like me logo Genes that share expression patterns with SOWAHC: view

Protein tissue co-expression partners for SOWAHC Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SOWAHC Gene

Orthologs for SOWAHC Gene

This gene was present in the common ancestor of animals.

Orthologs for SOWAHC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SOWAHC 35
  • 81.29 (n)
  • 80.63 (a)
SOWAHC 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sowahc 35
  • 77.07 (n)
  • 74.16 (a)
Sowahc 16
Sowahc 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOWAHC 35
  • 98.21 (n)
  • 97.8 (a)
SOWAHC 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sowahc 35
  • 76.8 (n)
  • 75.8 (a)
chicken
(Gallus gallus)
Aves SOWAHC 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sowahc 35
  • 65.83 (n)
  • 63.45 (a)
zebrafish
(Danio rerio)
Actinopterygii sowahcb 35
  • 52.89 (n)
  • 47.27 (a)
SOWAHC (2 of 3) 36
  • 37 (a)
OneToMany
sowahca 36
  • 34 (a)
OneToMany
sowahcb 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sowah 36
  • 12 (a)
OneToMany
Species with no ortholog for SOWAHC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOWAHC Gene

ENSEMBL:
Gene Tree for SOWAHC (if available)
TreeFam:
Gene Tree for SOWAHC (if available)

Paralogs for SOWAHC Gene

Paralogs for SOWAHC Gene

Pseudogenes.org Pseudogenes for SOWAHC Gene

genes like me logo Genes that share paralogs with SOWAHC: view

Variants for SOWAHC Gene

Sequence variations from dbSNP and Humsavar for SOWAHC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1046645 -- 109,618,442(+) ATGTC(A/G)TTTAC utr-variant-3-prime
rs1046646 -- 109,618,479(+) CTTTT(C/T)TGata utr-variant-3-prime
rs4953847 -- 109,616,228(+) CTGGG(A/G)AAAGT utr-variant-3-prime
rs4953848 -- 109,616,272(+) CCTGT(A/G)CCTCT utr-variant-3-prime
rs4953849 -- 109,616,342(+) ATTGG(A/G)GGAAC utr-variant-3-prime

Variation tolerance for SOWAHC Gene

Gene Damage Index Score: 3.83; 58.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOWAHC Gene

HapMap Linkage Disequilibrium report
SOWAHC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOWAHC Gene

Disorders for SOWAHC Gene

Relevant External Links for SOWAHC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOWAHC
genes like me logo Genes that share disorders with SOWAHC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOWAHC Gene

Publications for SOWAHC Gene

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PMID: 22234889) Maeso I. … Garcia-FernA ndez J. (Genome Res. 2012) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for SOWAHC Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SOWAHC
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SOWAHC
    • Block miRNA regulation of SOWAHC using miScript Target Protectors

    Sources for SOWAHC Gene

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