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SOWAHB Gene

protein-coding   GIFtS: 32
GCID: GC04M077838

Sosondowah Ankyrin Repeat Domain Family Member B

(Previous name: ankyrin repeat domain 56)
(Previous symbol: ANKRD56)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sosondowah Ankyrin Repeat Domain Family Member B1 2
ANKRD561 2 3
Ankyrin Repeat Domain 561 2
Ankyrin Repeat Domain-Containing Protein 562 3
Protein Sosondowah Homolog B2 3
Ankyrin Repeat Domain-Containing Protein SOWAHB2

External Ids:    HGNC: 329581   Entrez Gene: 3450792   Ensembl: ENSG000001862127   UniProtKB: A6NEL23   

Export aliases for SOWAHB gene to outside databases

Previous GC identifers: GC04M077817 GC04M077819 GC04M077824 GC04M077832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SOWAHB Gene:
SOWAHB (sosondowah ankyrin repeat domain family member B) is a protein-coding gene. An important paralog of this gene is SOWAHC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SOWAHB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SOWAHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOWAHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SOWAHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOWAHB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M077838:  view genomic region     (about GC identifiers)

Start:
77,816,082 bp from pter      End:
77,819,002 bp from pter
Size:
2,921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein SOWAHB  
Size: 793 amino acids; 85742 Da
Secondary accessions: B2RP29

Explore the universe of human proteins at neXtProt for SOWAHB: NX_A6NEL2

Explore proteomics data for SOWAHB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOWAHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001025041.1  
    ENSEMBL proteins: 
     ENSP00000334879  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry A6NEL2

    ProtoNet protein and cluster: A6NEL2

    UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2
    Similarity: Belongs to the SOWAH family
    Similarity: Contains 2 ANK repeats


    Find genes that share domains with SOWAHB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SOWAHB           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sowahb):
     embryogenesis  nervous system 

    Find genes that share phenotypes with SOWAHB           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOWAHB
    Interactions:

        Search GeneGlobe Interaction Network for SOWAHB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOWAHB (SWAHB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOWAHB gene: 
    NM_001029870.1  

    Unigene Cluster for SOWAHB:

    Sosondowah ankyrin repeat domain family member B
    Hs.257292  [show with all ESTs]
    Unigene Representative Sequence: NM_001029870
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334306(uc003hki.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SOWAHB

    Additional mRNA sequence: 

    BC137241.1 BC137255.1 

    1 DOTS entry:

    DT.95111577 

    11 AceView cDNA sequences:

    BX951334 BF757140 AI766830 AW450418 AI927656 BX478210 AI590202 BE867934 
    H41222 R44394 R24589 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOWAHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SOWAHB Expression
    About this image

    SOWAHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOWAHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.257292
        Custom PCR Arrays for SOWAHB
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOWAHB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sowahb1 , 5 sosondowah ankyrin repeat domain family member B1, 5 77.29(n)1
    69.31(a)1
      5 (47.29 cM)5
    780881  NM_175270.41  NP_780479.11 
     930411235 
    chicken
    (Gallus gallus)
    Aves SOWAHB1 sosondowah ankyrin repeat domain family member B 61.25(n)
    55.72(a)
      101748297  XM_004941247.1  XP_004941304.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOWAHB6
    sosondowah ankyrin repeat domain family member B
    33(a)
    1 ↔ 1
    5(146413400-146415664)
    zebrafish
    (Danio rerio)
    Actinopterygii wufa55b052 Transcribed sequence with weak similarity to protein more 74.6(n)    BI889574.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sowah6
    sosondowah
    11(a)
    1 → many
    3L(12530613-12565642)


    ENSEMBL Gene Tree for SOWAHB (if available)
    TreeFam Gene Tree for SOWAHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOWAHB gene
    SOWAHC2  SOWAHA2  SOWAHD2  

    Find genes that share paralogs with SOWAHB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOWAHB (see all 145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506585091,2
    C,Funtested177817457(+) CTCATC/TGAGGT 2 N D mis11Minor allele frequency- T:0.00NA 4456
    rs1402406981,2
    --77815668(+) TAGTCC/TTGGTA 1 -- ds50010--------
    rs1444607751,2
    C--77815703(+) TGTTTA/CCCCAG 1 -- ds50010--------
    rs26456721,2
    C,F--77815717(+) GAAATC/AATTTC 1 -- ds50015Minor allele frequency- A:0.08NA WA EA 362
    rs1862228091,2
    --77815744(+) CAAACA/GTTGGC 1 -- ds50010--------
    rs1454200881,2
    --77815789(+) TGTTTA/GTTACA 1 -- ds50010--------
    rs750574551,2
    C,F--77815809(+) TCCATG/AAAAGA 1 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1909448671,2
    --77815893(+) AGCAGA/GGCCTG 1 -- ds50010--------
    rs1491829011,2
    C--77815908(+) ACAGTC/TATTCC 1 -- ds50010--------
    rs1834609101,2
    --77815988(+) AAGGAG/TGCATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SOWAHB (77816082 - 77819002 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SOWAHB: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOWAHB
    DNA2.0 Custom Variant and Variant Library Synthesis for SOWAHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOWAHB gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SOWAHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PubMed id 22234889)1, 3 Maeso I....Garcia-FernA ndez J. (Genome Res. 2012)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345079 HGNC: 32958 AceView: LOC345079 Ensembl:ENSG00000186212 euGenes: HUgn345079
    ECgene: SOWAHB H-InvDB: SOWAHB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOWAHB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOWAHB gene:
    Search GeneIP for patents involving SOWAHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SOWAHB
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOWAHB
     SwitchGear 3'UTR luciferase reporter plasmids for SOWAHB
     Browse SwitchGear Promoter luciferase reporter plasmids for SOWAHB
     Search ThermoFisher Antibodies for SOWAHB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOWAHB
     Browse compounds at ApexBio
     Search Addgene for plasmids for SOWAHB
      Search eBioscience for proteins for SOWAHB
      Search eBioscience for elisas for SOWAHB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SOWAHB
     antibodies-online antibodies for SOWAHB (10 products)
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     antibodies-online proteins for SOWAHB
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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