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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOWAHB Gene

protein-coding   GIFtS: 33
GCID: GC04M077824

sosondowah ankyrin repeat domain family member B

(Previous name: ankyrin repeat domain 56 )
(Previous symbol: ANKRD56)
  Search for SOWAHB
in
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 Human Malady Compendium 
Biological research products
for SOWAHB    

Aliases
for SOWAHB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sosondowah Ankyrin Repeat Domain Family Member B1 2
ANKRD561 2 3
Ankyrin Repeat Domain 561 2
Ankyrin Repeat Domain-Containing Protein 562 3
Protein Sosondowah Homolog B2 3
Ankyrin Repeat Domain-Containing Protein SOWAHB2

External Ids:    HGNC: 329581   Entrez Gene: 3450792   Ensembl: ENSG000001862127   UniProtKB: A6NEL23   

Export aliases for SOWAHB gene to outside databases

Previous GC identifers: GC04M077817 GC04M077819


Summaries
for SOWAHB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for SOWAHB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SOWAHB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SOWAHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOWAHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SOWAHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOWAHB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M077824:  view genomic region     (about GC identifiers)

Start:
 77,816,082 bp from pter      End:
 77,819,002 bp from pter
Size:
 2,921 bases      Orientation:
 minus strand

Proteins
for SOWAHB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein SOWAHB  
Size: 793 amino acids; 85742 Da
Secondary accessions: B2RP29

Explore the universe of human proteins at neXtProt for SOWAHB: NX_A6NEL2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NEL2

    • SOWAHB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001025041.1  
    ENSEMBL proteins: 
     ENSP00000334879  

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    Protein Domains /
    Families
    for SOWAHB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SOWAHB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry A6NEL2

    ProtoNet protein and cluster: A6NEL2

    UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2
    Similarity: Belongs to the SOWAH family
    Similarity: Contains 2 ANK repeats


    Function
    for SOWAHB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sowahb):
     embryogenesis  nervous system 

    SOWAHB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SOWAHB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOWAHB

    Drugs & Compounds
    for SOWAHB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SOWAHB
    Search CenterWatch for drugs/clinical trials and news about SOWAHB / SWAHB 

    Transcripts
    for SOWAHB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for SOWAHB gene: 
    NM_001029870.1  

    Unigene Cluster for SOWAHB:

    Sosondowah ankyrin repeat domain family member B
    Hs.257292  [show with all ESTs]
    Unigene Representative Sequence: NM_001029870
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334306(uc003hki.3)

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    BC137241.1 BC137255.1 

    1 DOTS entry:

    DT.95111577 

    11 AceView cDNA sequences:

    AI590202 BX478210 BX951334 BE867934 AI927656 AI766830 BF757140 AW450418 
    H41222 R44394 R24589 

    GeneLoc Exon Structure


    Expression
    for SOWAHB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOWAHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SOWAHB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SOWAHB Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.257292
        SABiosciences Custom PCR Arrays for SOWAHB
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SOWAHB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SOWAHB gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANKRD566
    		 Uncharacterized protein
    		 42(a)
    		 1 ↔ 1
    		 4(51201365-51203851)
    lizard
    (Anolis carolinensis)    		 Reptilia ANKRD566
    		 --
    		 36(a)
    		 1 ↔ 1
    		 5(146413400-146415664)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa55b052 Transcribed sequence with weak similarity to protein more 74.6(n)    BI889574.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sowah6
    		 sosondowah
    		 12(a)
    		 1 → many
    		 3L(12530613-12565642)


    ENSEMBL Gene Tree for SOWAHB (if available)
    TreeFam Gene Tree for SOWAHB (if available) 

    Paralogs
    for SOWAHB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOWAHB gene
    SOWAHC2  SOWAHD2  SOWAHA2  

    SOWAHB for paralogs           About GeneDecksing



    Genomic Variants
    for SOWAHB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOWAHB
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    Disorders / Diseases
    for SOWAHB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for SOWAHB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOWAHB gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SOWAHB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PubMed id 22234889)1, 3 Maeso I....Garcia-FernA ndez J. (2012)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SOWAHB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SOWAHB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 345079 HGNC: 32958 AceView: LOC345079 Ensembl:ENSG00000186212 euGenes: HUgn345079
    ECgene: SOWAHB H-InvDB: SOWAHB

    Other Databases showing SOWAHB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SOWAHB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOWAHB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SOWAHB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SOWAHB gene:
    Search GeneIP for patents involving SOWAHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SOWAHB gene

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    About This Section

     
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