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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOWAHB Gene

protein-coding   GIFtS: 32
GCID: GC04M077832

Sosondowah Ankyrin Repeat Domain Family Member B

(Previous name: ankyrin repeat domain 56)
(Previous symbol: ANKRD56)
  Search for SOWAHB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sosondowah Ankyrin Repeat Domain Family Member B1 2
ANKRD561 2 3
Ankyrin Repeat Domain 561 2
Ankyrin Repeat Domain-Containing Protein 562 3
Protein Sosondowah Homolog B2 3
Ankyrin Repeat Domain-Containing Protein SOWAHB2

External Ids:    HGNC: 329581   Entrez Gene: 3450792   Ensembl: ENSG000001862127   UniProtKB: A6NEL23   

Export aliases for SOWAHB gene to outside databases

Previous GC identifers: GC04M077817 GC04M077819 GC04M077824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SOWAHB Gene: 
SOWAHB (sosondowah ankyrin repeat domain family member B) is a protein-coding gene. An important paralog of this gene is SOWAHC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SOWAHB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SOWAHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOWAHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SOWAHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOWAHB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M077832:  view genomic region     (about GC identifiers)

Start:
77,816,082 bp from pter      End:
77,819,002 bp from pter
Size:
2,921 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein SOWAHB  
Size: 793 amino acids; 85742 Da
Secondary accessions: B2RP29

Explore the universe of human proteins at neXtProt for SOWAHB: NX_A6NEL2

Explore proteomics data for SOWAHB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NEL2

  • SOWAHB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOWAHB Protein Expression
    REFSEQ proteins: NP_001025041.1  
    ENSEMBL proteins: 
     ENSP00000334879  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry A6NEL2

    ProtoNet protein and cluster: A6NEL2

    UniProtKB/Swiss-Prot: SWAHB_HUMAN, A6NEL2
    Similarity: Belongs to the SOWAH family
    Similarity: Contains 2 ANK repeats


    SOWAHB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SOWAHB for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sowahb):
     embryogenesis  nervous system 

    SOWAHB for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOWAHB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOWAHB (SWAHB)

    Search CenterWatch for drugs/clinical trials and news about SOWAHB / SWAHB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOWAHB gene: 
    NM_001029870.1  

    Unigene Cluster for SOWAHB:

    Sosondowah ankyrin repeat domain family member B
    Hs.257292  [show with all ESTs]
    Unigene Representative Sequence: NM_001029870
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334306(uc003hki.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOWAHB

    Additional mRNA sequence: 

    BC137241.1 BC137255.1 

    1 DOTS entry:

    DT.95111577 

    11 AceView cDNA sequences:

    BE867934 AW450418 AI766830 AI590202 AI927656 BF757140 BX951334 BX478210 
    H41222 R44394 R24589 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOWAHB expression in normal human tissues (normalized intensities)      SOWAHB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SOWAHB Expression
    About this image


    SOWAHB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See SOWAHB Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.257292
        SABiosciences Custom PCR Arrays for SOWAHB
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOWAHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SOWAHB gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sowahb1 , 5 sosondowah ankyrin repeat domain family member B1, 5 76.8(n)1
    69.33(a)1
      5 (47.29 cM)5
    780881  NM_175270.41  NP_780479.11 
     930411235 
    chicken
    (Gallus gallus)
    Aves SOWAHB6
    sosondowah ankyrin repeat domain family member B
    44(a)
    1 ↔ 1
    4(49129165-49130967)
    lizard
    (Anolis carolinensis)
    Reptilia SOWAHB6
    Uncharacterized protein
    34(a)
    1 ↔ 1
    5(146413400-146415664)
    zebrafish
    (Danio rerio)
    Actinopterygii wufa55b052 Transcribed sequence with weak similarity to protein more 74.6(n)    BI889574.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sowah6
    sosondowah
    9(a)
    1 → many
    3L(12530613-12565642)


    ENSEMBL Gene Tree for SOWAHB (if available)
    TreeFam Gene Tree for SOWAHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOWAHB gene
    SOWAHC2  SOWAHA2  SOWAHD2  

    SOWAHB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/145 SNPs in SOWAHB are shown (see all 145)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506585091,2
    C,Funtested177817457(+) CTCATC/TGAGGT 2 N D mis11Minor allele frequency- T:0.00NA 4456
    rs1402406981,2
    --77815668(+) TAGTCC/TTGGTA 1 -- ds50010--------
    rs1444607751,2
    C--77815703(+) TGTTTA/CCCCAG 1 -- ds50010--------
    rs26456721,2
    C,F--77815717(+) GAAATC/AATTTC 1 -- ds50015Minor allele frequency- A:0.08NA WA EA 362
    rs1862228091,2
    --77815744(+) CAAACA/GTTGGC 1 -- ds50010--------
    rs1454200881,2
    --77815789(+) TGTTTA/GTTACA 1 -- ds50010--------
    rs750574551,2
    C,F--77815809(+) TCCATG/AAAAGA 1 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1909448671,2
    --77815893(+) AGCAGA/GGCCTG 1 -- ds50010--------
    rs1491829011,2
    C--77815908(+) ACAGTC/TATTCC 1 -- ds50010--------
    rs1834609101,2
    --77815988(+) AAGGAG/TGCATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SOWAHB (77816082 - 77819002 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SOWAHB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SOWAHB
    DNA2.0 Custom Variant and Variant Library Synthesis for SOWAHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOWAHB gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SOWAHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PubMed id 22234889)1, 3 Maeso I....Garcia-FernA ndez J. (2012)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 345079 HGNC: 32958 AceView: LOC345079 Ensembl:ENSG00000186212 euGenes: HUgn345079
    ECgene: SOWAHB H-InvDB: SOWAHB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOWAHB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOWAHB gene:
    Search GeneIP for patents involving SOWAHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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