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Aliases for SOWAHB Gene

Aliases for SOWAHB Gene

  • Sosondowah Ankyrin Repeat Domain Family Member B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 56 3 4
  • Protein Sosondowah Homolog B 3 4
  • Ankyrin Repeat Domain 56 2 3
  • ANKRD56 3 4
  • Ankyrin Repeat Domain-Containing Protein SOWAHB 3

External Ids for SOWAHB Gene

Previous HGNC Symbols for SOWAHB Gene

  • ANKRD56

Previous GeneCards Identifiers for SOWAHB Gene

  • GC04M077817
  • GC04M077819
  • GC04M077824
  • GC04M077832
  • GC04M077838

Summaries for SOWAHB Gene

GeneCards Summary for SOWAHB Gene

SOWAHB (Sosondowah Ankyrin Repeat Domain Family Member B) is a Protein Coding gene. An important paralog of this gene is SOWAHA.

Additional gene information for SOWAHB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOWAHB Gene

Genomics for SOWAHB Gene

GeneHancer (GH) Regulatory Elements for SOWAHB Gene

Promoters and enhancers for SOWAHB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I076896 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 595.4 +0.3 314 1.8 RAD21 YY1 ZNF335 GLIS2 SP3 RXRA ZBTB11 REST PPARG GLIS1 SOWAHB GC04P076892
GH04I076899 Enhancer 0.7 ENCODE 550.8 -1.0 -1013 0.1 SOX13 TFAP4 FOXA2 TEAD1 SP5 FOXA3 ARID4B TEAD3 FOXK2 TCF7 SOWAHB GC04M076939
GH04I076947 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -52.1 -52104 5.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 KLF13 SEPT11 GC04M076939 LOC105377294 NUP54 SDAD1 SOWAHB RPL7P17 CNOT6L MRPL1 GC04P076953
GH04I076855 Enhancer 1.1 Ensembl ENCODE 19.3 +41.3 41316 2.6 FOXA2 FEZF1 YY1 TCF12 RXRA REST PPARG NFIL3 RFX3 STAT3 SOWAHB CNOT6L NUP54 RPL7P17 PIR31989 LOC105377289
GH04I076830 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15 +66.3 66344 3.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF766 ELK1 RXRA ZHX2 SOWAHB ENSG00000224218 LOC105377289 PIR31989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOWAHB on UCSC Golden Path with GeneCards custom track

Genomic Locations for SOWAHB Gene

Genomic Locations for SOWAHB Gene
3,220 bases
Minus strand

Genomic View for SOWAHB Gene

Genes around SOWAHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOWAHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOWAHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOWAHB Gene

Proteins for SOWAHB Gene

  • Protein details for SOWAHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein SOWAHB
    Protein Accession:
    Secondary Accessions:
    • B2RP29

    Protein attributes for SOWAHB Gene

    793 amino acids
    Molecular mass:
    85742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOWAHB Gene

Post-translational modifications for SOWAHB Gene

No Post-translational modifications

Other Protein References for SOWAHB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOWAHB Gene

Domains & Families for SOWAHB Gene

Gene Families for SOWAHB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SOWAHB Gene

Suggested Antigen Peptide Sequences for SOWAHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SOWAH family.
  • Belongs to the SOWAH family.
genes like me logo Genes that share domains with SOWAHB: view

Function for SOWAHB Gene

Phenotypes From GWAS Catalog for SOWAHB Gene

Phenotypes for SOWAHB Gene

genes like me logo Genes that share phenotypes with SOWAHB: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOWAHB Gene

Localization for SOWAHB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOWAHB gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SOWAHB Gene

Pathways & Interactions for SOWAHB Gene

SuperPathways for SOWAHB Gene

No Data Available

Interacting Proteins for SOWAHB Gene

Selected Interacting proteins: A6NEL2-SWAHB_HUMAN for SOWAHB Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SOWAHB Gene


No data available for Pathways by source and SIGNOR curated interactions for SOWAHB Gene

Drugs & Compounds for SOWAHB Gene

No Compound Related Data Available

Transcripts for SOWAHB Gene


(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOWAHB Gene

Sosondowah ankyrin repeat domain family member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOWAHB Gene

No ASD Table

Relevant External Links for SOWAHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOWAHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOWAHB Gene

mRNA differential expression in normal tissues according to GTEx for SOWAHB Gene

This gene is overexpressed in Liver (x6.3), Esophagus - Mucosa (x5.4), Brain - Frontal Cortex (BA9) (x5.0), Brain - Cortex (x5.0), and Colon - Transverse (x4.1).

Protein differential expression in normal tissues from HIPED for SOWAHB Gene

This gene is overexpressed in Pancreas (39.6), Heart (14.9), and Adipocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOWAHB Gene

Protein tissue co-expression partners for SOWAHB Gene

NURSA nuclear receptor signaling pathways regulating expression of SOWAHB Gene:


SOURCE GeneReport for Unigene cluster for SOWAHB Gene:

genes like me logo Genes that share expression patterns with SOWAHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOWAHB Gene

Orthologs for SOWAHB Gene

This gene was present in the common ancestor of animals.

Orthologs for SOWAHB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOWAHB 33
  • 98.23 (n)
(Canis familiaris)
Mammalia SOWAHB 33 34
  • 80.15 (n)
(Bos Taurus)
Mammalia SOWAHB 33 34
  • 79.49 (n)
(Rattus norvegicus)
Mammalia Sowahb 33
  • 77.67 (n)
(Mus musculus)
Mammalia Sowahb 33 16 34
  • 77.29 (n)
(Monodelphis domestica)
Mammalia SOWAHB 34
  • 55 (a)
(Gallus gallus)
Aves SOWAHB 33 34
  • 61.25 (n)
(Anolis carolinensis)
Reptilia SOWAHB 34
  • 33 (a)
(Danio rerio)
Actinopterygii CR381544.1 34
  • 22 (a)
wufa55b05 33
fruit fly
(Drosophila melanogaster)
Insecta sowah 34
  • 11 (a)
Species where no ortholog for SOWAHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOWAHB Gene

Gene Tree for SOWAHB (if available)
Gene Tree for SOWAHB (if available)

Paralogs for SOWAHB Gene

Paralogs for SOWAHB Gene

genes like me logo Genes that share paralogs with SOWAHB: view

Variants for SOWAHB Gene

Sequence variations from dbSNP and Humsavar for SOWAHB Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001196946 -- 76,898,398(-) C/T upstream_transcript_variant
rs1002990785 -- 76,897,186(-) C/T coding_sequence_variant, missense_variant
rs1003294124 -- 76,896,127(-) A/T coding_sequence_variant, missense_variant
rs1003350593 -- 76,897,389(-) C/T coding_sequence_variant, missense_variant
rs1003675809 -- 76,896,046(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SOWAHB Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855
nsv829973 CNV loss 17160897

Variation tolerance for SOWAHB Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOWAHB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOWAHB Gene

Disorders for SOWAHB Gene

Additional Disease Information for SOWAHB

No disorders were found for SOWAHB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOWAHB Gene

Publications for SOWAHB Gene

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PMID: 22234889) Maeso I … Garcia-Fernàndez J (Genome research 2012) 2 3 58
  2. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. (PMID: 27669027) Boueiz A … COPDGene and ECLIPSE Investigators (American journal of respiratory and critical care medicine 2017) 3 58
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  4. Ankyrin repeat: a unique motif mediating protein-protein interactions. (PMID: 17176038) Li J … Tsai MD (Biochemistry 2006) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for SOWAHB Gene

Sources for SOWAHB Gene

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