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Aliases for SOWAHA Gene

Aliases for SOWAHA Gene

  • Sosondowah Ankyrin Repeat Domain Family Member A 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 43 3 4
  • Protein Sosondowah Homolog A 3 4
  • ANKRD43 3 4
  • Ankyrin Repeat Domain-Containing Protein SOWAHA 3
  • Ankyrin Repeat Domain 43 2

External Ids for SOWAHA Gene

Previous HGNC Symbols for SOWAHA Gene

  • ANKRD43

Previous GeneCards Identifiers for SOWAHA Gene

  • GC05P132150

Summaries for SOWAHA Gene

GeneCards Summary for SOWAHA Gene

SOWAHA (Sosondowah Ankyrin Repeat Domain Family Member A) is a Protein Coding gene. An important paralog of this gene is SOWAHB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOWAHA Gene

Genomics for SOWAHA Gene

Regulatory Elements for SOWAHA Gene

Enhancers for SOWAHA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F132780 0.8 FANTOM5 13.2 -33.2 -33177 0.2 SEPT8 KIF3A SHROOM1 SOWAHA CCNI2 TH2LCRR IL13 RNU7-15P RNA5SP192 IL4
GH05F132788 0.6 ENCODE 12.2 -24.4 -24390 1.7 BCOR HDAC1 LEF1 ZNF146 PKNOX1 TBL1XR1 TAL1 NFRKB ZMYM3 ZIC2 SEPT8 SOWAHA SHROOM1 CCNI2 KIF3A RNU7-15P RNA5SP192 ENSG00000230612 LEAP2 GC05M132776
GH05F132770 1.2 Ensembl ENCODE 11.8 -38.8 -38822 7.9 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 GLIS2 CBX5 GATA2 ZNF143 SEPT8 CCNI2 KIF3A RAD50 ENSG00000224431 SOWAHA SHROOM1 TH2LCRR IL13 IL4
GH05F132781 0.6 Ensembl 11.1 -30.8 -30830 1.0 JUN BHLHE40 MAX RELA JUND ZNF157 IKZF1 FOS MGA CCNI2 KIF3A SOWAHA RNU7-15P RNA5SP192 TH2LCRR IL13 GC05M132776 GC05M132777 SEPT8
GH05F132767 0.9 Ensembl ENCODE 11.1 -45.3 -45335 1.6 ATF1 PKNOX1 ARNT CREB3L1 ZNF766 GATA2 FOS JUNB NCOA1 TBX21 SEPT8 CCNI2 KIF3A SHROOM1 SOWAHA TH2LCRR IL4 RNU7-15P RNA5SP192 ENSG00000230612
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SOWAHA on UCSC Golden Path with GeneCards custom track

Promoters for SOWAHA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001873784 477 1600 KLF1 ESRRA EBF1 ZIC2 ZFHX2 PATZ1 KLF8 ZBTB20 EZH2 EGR2

Genomic Location for SOWAHA Gene

Chromosome:
5
Start:
132,813,324 bp from pter
End:
132,816,797 bp from pter
Size:
3,474 bases
Orientation:
Plus strand

Genomic View for SOWAHA Gene

Genes around SOWAHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOWAHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOWAHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOWAHA Gene

Proteins for SOWAHA Gene

  • Protein details for SOWAHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3V2-SWAHA_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein SOWAHA
    Protein Accession:
    Q2M3V2
    Secondary Accessions:
    • Q8NAE7

    Protein attributes for SOWAHA Gene

    Size:
    549 amino acids
    Molecular mass:
    57443 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04772.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04776.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03975.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SOWAHA Gene

Post-translational modifications for SOWAHA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOWAHA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOWAHA Gene

Domains & Families for SOWAHA Gene

Gene Families for SOWAHA Gene

Protein Domains for SOWAHA Gene

Suggested Antigen Peptide Sequences for SOWAHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M3V2

UniProtKB/Swiss-Prot:

SWAHA_HUMAN :
  • Belongs to the SOWAH family.
  • Contains 2 ANK repeats.
Family:
  • Belongs to the SOWAH family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with SOWAHA: view

Function for SOWAHA Gene

genes like me logo Genes that share phenotypes with SOWAHA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOWAHA Gene

Localization for SOWAHA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOWAHA Gene COMPARTMENTS Subcellular localization image for SOWAHA gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SOWAHA Gene

Pathways & Interactions for SOWAHA Gene

SuperPathways for SOWAHA Gene

No Data Available

Interacting Proteins for SOWAHA Gene

Gene Ontology (GO) - Biological Process for SOWAHA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SOWAHA Gene

Transcripts for SOWAHA Gene

mRNA/cDNA for SOWAHA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOWAHA Gene

Sosondowah ankyrin repeat domain family member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOWAHA Gene

No ASD Table

Relevant External Links for SOWAHA Gene

GeneLoc Exon Structure for
SOWAHA
ECgene alternative splicing isoforms for
SOWAHA

Expression for SOWAHA Gene

mRNA expression in normal human tissues for SOWAHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOWAHA Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.2), Brain - Putamen (basal ganglia) (x8.9), Brain - Caudate (basal ganglia) (x7.2), Brain - Amygdala (x6.0), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for SOWAHA Gene

This gene is overexpressed in Gallbladder (39.9), Pancreas (7.4), Prostate (7.4), and Urinary Bladder (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOWAHA Gene



Protein tissue co-expression partners for SOWAHA Gene

NURSA nuclear receptor signaling pathways regulating expression of SOWAHA Gene:

SOWAHA

SOURCE GeneReport for Unigene cluster for SOWAHA Gene:

Hs.13308
genes like me logo Genes that share expression patterns with SOWAHA: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SOWAHA Gene

Orthologs for SOWAHA Gene

This gene was present in the common ancestor of animals.

Orthologs for SOWAHA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOWAHA 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia SOWAHA 34 35
  • 81.82 (n)
dog
(Canis familiaris)
Mammalia ANKRD43 34
  • 79.95 (n)
SOWAHA 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sowaha 34 16 35
  • 77.67 (n)
rat
(Rattus norvegicus)
Mammalia Sowaha 34
  • 77.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SOWAHA 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOWAHA 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOWAHA 35
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SOWAHA (2 of 2) 35
  • 34 (a)
OneToMany
sowahaa 35
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sowah 35
  • 11 (a)
OneToMany
Species where no ortholog for SOWAHA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOWAHA Gene

ENSEMBL:
Gene Tree for SOWAHA (if available)
TreeFam:
Gene Tree for SOWAHA (if available)

Paralogs for SOWAHA Gene

Paralogs for SOWAHA Gene

genes like me logo Genes that share paralogs with SOWAHA: view

Variants for SOWAHA Gene

Sequence variations from dbSNP and Humsavar for SOWAHA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10051188 -- 132,816,165(+) TTTTT(A/T)AAAAA utr-variant-3-prime
rs10075719 -- 132,816,386(+) CCATT(G/T)GAAAG utr-variant-3-prime
rs111532674 -- 132,815,102(+) GGCCC(A/G)AGGCT reference, missense
rs111577433 -- 132,815,024(+) GGTGG(A/C/T)CGCCA reference, missense
rs111670249 -- 132,816,163(+) ATTTT(A/T)TAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOWAHA Gene

Variant ID Type Subtype PubMed ID
esv3890740 CNV loss 25118596
nsv830489 CNV loss 17160897

Variation tolerance for SOWAHA Gene

Gene Damage Index Score: 7.60; 82.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOWAHA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOWAHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOWAHA Gene

Disorders for SOWAHA Gene

Relevant External Links for SOWAHA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOWAHA

No disorders were found for SOWAHA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOWAHA Gene

Publications for SOWAHA Gene

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PMID: 22234889) Maeso I. … Garcia-FernA ndez J. (Genome Res. 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3 64

Products for SOWAHA Gene

Sources for SOWAHA Gene

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