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Aliases for SOWAHA Gene

Aliases for SOWAHA Gene

  • Sosondowah Ankyrin Repeat Domain Family Member A 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 43 3 4
  • Protein Sosondowah Homolog A 3 4
  • ANKRD43 3 4
  • Ankyrin Repeat Domain-Containing Protein SOWAHA 3
  • Ankyrin Repeat Domain 43 2

External Ids for SOWAHA Gene

Previous HGNC Symbols for SOWAHA Gene

  • ANKRD43

Previous GeneCards Identifiers for SOWAHA Gene

  • GC05P132150

Summaries for SOWAHA Gene

GeneCards Summary for SOWAHA Gene

SOWAHA (Sosondowah Ankyrin Repeat Domain Family Member A) is a Protein Coding gene. An important paralog of this gene is SOWAHB.

Additional gene information for SOWAHA Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOWAHA Gene

Genomics for SOWAHA Gene

Regulatory Elements for SOWAHA Gene

Enhancers for SOWAHA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H132770 1.5 Ensembl ENCODE dbSUPER 11.8 -38.8 -38822 7.9 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 TCF12 ZNF766 GLIS2 GATA2 SEPT8 CCNI2 KIF3A SOWAHA SHROOM1 TH2LCRR IL13 IL4 RNU7-15P RNA5SP192
GH05H132384 1.5 Ensembl ENCODE dbSUPER 10.8 -425.6 -425640 6.6 HDGF ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 ZNF207 ATF7 FOS MIR3936HG SLC22A5 RAD50 ENSG00000248648 C5orf56 IRF1 ENSG00000202533 LOC105379175 LOC102723741 SOWAHA
GH05H132781 1 Ensembl dbSUPER 11.1 -31.0 -31027 0.6 L3MBTL2 JUN E2F5 MAX RELA ZNF592 FOSL1 CTBP1 JUND MTA3 KIF3A CCNI2 SOWAHA RNU7-15P RNA5SP192 IL13 TH2LCRR GC05M132777 GC05M132776 SEPT8
GH05H132767 1 Ensembl ENCODE dbSUPER 11.1 -45.5 -45456 1.4 ZSCAN4 PRDM10 FOXP2 SEPT8 CCNI2 KIF3A SHROOM1 SOWAHA TH2LCRR IL4 RNU7-15P RNA5SP192 ENSG00000230612
GH05H132529 1 FANTOM5 ENCODE 10.9 -283.9 -283862 0.2 HDAC1 ATF1 TAL1 TCF12 CTBP1 ZNF316 MAFK SMARCE1 DPF2 ZEB2 IL5 RAD50 SOWAHA IL4 ENSG00000230612 IL13 CSF2 IL3 SLC22A5 GC05P132531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOWAHA on UCSC Golden Path with GeneCards custom track

Promoters for SOWAHA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186901 276 401 ZNF202 KLF1 ZNF777 L3MBTL2 NR2F1 ZNF10 ZIC2 ZFHX2 ZNF692 GLIS1

Genomic Locations for SOWAHA Gene

Genomic Locations for SOWAHA Gene
chr5:132,813,324-132,816,797
(GRCh38/hg38)
Size:
3,474 bases
Orientation:
Plus strand
chr5:132,149,033-132,152,489
(GRCh37/hg19)

Genomic View for SOWAHA Gene

Genes around SOWAHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOWAHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOWAHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOWAHA Gene

Proteins for SOWAHA Gene

  • Protein details for SOWAHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3V2-SWAHA_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein SOWAHA
    Protein Accession:
    Q2M3V2
    Secondary Accessions:
    • Q8NAE7

    Protein attributes for SOWAHA Gene

    Size:
    549 amino acids
    Molecular mass:
    57443 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04772.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04776.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03975.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SOWAHA Gene

Post-translational modifications for SOWAHA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOWAHA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOWAHA Gene

Domains & Families for SOWAHA Gene

Gene Families for SOWAHA Gene

Protein Domains for SOWAHA Gene

Suggested Antigen Peptide Sequences for SOWAHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M3V2

UniProtKB/Swiss-Prot:

SWAHA_HUMAN :
  • Belongs to the SOWAH family.
Family:
  • Belongs to the SOWAH family.
genes like me logo Genes that share domains with SOWAHA: view

Function for SOWAHA Gene

Phenotypes From GWAS Catalog for SOWAHA Gene

genes like me logo Genes that share phenotypes with SOWAHA: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOWAHA Gene

Localization for SOWAHA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOWAHA gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SOWAHA Gene

Pathways & Interactions for SOWAHA Gene

SuperPathways for SOWAHA Gene

No Data Available

Interacting Proteins for SOWAHA Gene

Gene Ontology (GO) - Biological Process for SOWAHA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SOWAHA Gene

Drugs & Compounds for SOWAHA Gene

No Compound Related Data Available

Transcripts for SOWAHA Gene

mRNA/cDNA for SOWAHA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOWAHA Gene

Sosondowah ankyrin repeat domain family member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOWAHA Gene

No ASD Table

Relevant External Links for SOWAHA Gene

GeneLoc Exon Structure for
SOWAHA
ECgene alternative splicing isoforms for
SOWAHA

Expression for SOWAHA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOWAHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOWAHA Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.2), Brain - Putamen (basal ganglia) (x8.9), Brain - Caudate (basal ganglia) (x7.2), Brain - Amygdala (x6.0), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for SOWAHA Gene

This gene is overexpressed in Gallbladder (39.9), Pancreas (7.4), Prostate (7.4), and Urinary Bladder (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOWAHA Gene



Protein tissue co-expression partners for SOWAHA Gene

NURSA nuclear receptor signaling pathways regulating expression of SOWAHA Gene:

SOWAHA

SOURCE GeneReport for Unigene cluster for SOWAHA Gene:

Hs.13308
genes like me logo Genes that share expression patterns with SOWAHA: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOWAHA Gene

Orthologs for SOWAHA Gene

This gene was present in the common ancestor of animals.

Orthologs for SOWAHA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOWAHA 33 34
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia SOWAHA 33 34
  • 81.82 (n)
dog
(Canis familiaris)
Mammalia ANKRD43 33
  • 79.95 (n)
SOWAHA 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sowaha 33 16 34
  • 77.67 (n)
rat
(Rattus norvegicus)
Mammalia Sowaha 33
  • 77.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SOWAHA 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOWAHA 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOWAHA 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SOWAHA (2 of 2) 34
  • 34 (a)
OneToMany
sowahaa 34
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sowah 34
  • 11 (a)
OneToMany
Species where no ortholog for SOWAHA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOWAHA Gene

ENSEMBL:
Gene Tree for SOWAHA (if available)
TreeFam:
Gene Tree for SOWAHA (if available)

Paralogs for SOWAHA Gene

Paralogs for SOWAHA Gene

genes like me logo Genes that share paralogs with SOWAHA: view

Variants for SOWAHA Gene

Sequence variations from dbSNP and Humsavar for SOWAHA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000198572 -- 132,814,118(+) GCTTC(C/T)AGCCC reference, missense
rs1000535965 -- 132,815,842(+) CTATT(G/T)AAAAA utr-variant-3-prime
rs1000588315 -- 132,815,485(+) AGAGC(G/T)TCCTA utr-variant-3-prime
rs1001190677 -- 132,812,306(+) CATCG(C/T)GCCCG upstream-variant-2KB
rs1001241595 -- 132,812,653(+) AAAAA(A/T)AGTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOWAHA Gene

Variant ID Type Subtype PubMed ID
nsv830489 CNV loss 17160897
esv3890740 CNV loss 25118596

Variation tolerance for SOWAHA Gene

Gene Damage Index Score: 7.60; 82.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOWAHA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOWAHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOWAHA Gene

Disorders for SOWAHA Gene

Relevant External Links for SOWAHA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOWAHA

No disorders were found for SOWAHA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOWAHA Gene

Publications for SOWAHA Gene

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PMID: 22234889) Maeso I … Garcia-Fernàndez J (Genome research 2012) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for SOWAHA Gene

Sources for SOWAHA Gene

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