Aliases for SOSTDC1 Gene
External Ids for SOSTDC1 Gene
Previous GeneCards Identifiers for SOSTDC1 Gene
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOSTDC1 Gene
SOSTDC1 (Sclerostin Domain Containing 1) is a Protein Coding gene. Diseases associated with SOSTDC1 include renal fibrosis. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Signaling by BMP. An important paralog of this gene is SOST.
UniProtKB/Swiss-Prot for SOSTDC1 Gene
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.