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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOSTDC1 Gene

protein-coding   GIFtS: 58
GCID: GC07M016467

Sclerostin Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sclerostin Domain Containing 11 2     Sclerostin Domain-Containing Protein 12
USAG12 3 5     Uterine Sensitization-Associated Protein-12
Ectodermal BMP Inhibitor2 3     Ectodin3
ECTODIN2 5     USAG-13
ectodin1     Uterine Sensitization-Associated Gene 1 Protein3
Cystine-Knot Containing Secreted Protein2     

External Ids:    HGNC: 217481   Entrez Gene: 259282   Ensembl: ENSG000001712437   OMIM: 6096755   UniProtKB: Q6X4U43   

Export aliases for SOSTDC1 gene to outside databases

Previous GC identifers: GC07M016211 GC07M016245 GC07M016274


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOSTDC1 Gene:
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal
cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically,
it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling
during cellular proliferation, differentiation, and programmed cell death. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOSTDC1 Gene: 
SOSTDC1 (sclerostin domain containing 1) is a protein-coding gene. Diseases associated with SOSTDC1 include hypohidrotic ectodermal dysplasia, and ectodermal dysplasia, and among its related super-pathways are Signaling by BMP. An important paralog of this gene is SOST.

UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
Function: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual
cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes
activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner

Gene Wiki entry for SOSTDC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOSTDC1 gene promoter:
         FOXO3   Nkx2-5   HNF-3beta   E47   FOXO3b   POU2F1   Nkx6-1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOSTDC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOSTDC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOSTDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.2

SOSTDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOSTDC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016467:  view genomic region     (about GC identifiers)

Start:
16,501,106 bp from pter      End:
16,570,205 bp from pter
Size:
69,100 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 16,554,239-16,558,607     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4 (See protein sequence)
Recommended Name: Sclerostin domain-containing protein 1 precursor  
Size: 206 amino acids; 23307 Da
Subunit: Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity
Subcellular location: Secreted
Secondary accessions: Q96HJ7 Q9Y3U3

Explore the universe of human proteins at neXtProt for SOSTDC1: NX_Q6X4U4

Explore proteomics data for SOSTDC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6X4U4

  • SOSTDC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOSTDC1 Protein Expression
    REFSEQ proteins: NP_056279.1  
    ENSEMBL proteins: 
     ENSP00000304930   ENSP00000379889  

    Human Recombinant Protein Products for SOSTDC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SOSTDC1 (USAG1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SOSTDC1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SOSTDC1
    GenScript Custom Purified and Recombinant Proteins Services for SOSTDC1
    Novus Biologicals SOSTDC1 Proteins
    Novus Biologicals SOSTDC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SOSTDC1
    Cloud-Clone Corp. Proteins for SOSTDC1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    SOSTDC1 for ontologies           About GeneDecksing



    SOSTDC1 Antibody Products: 
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    Novus Biologicals SOSTDC1 Antibody
    Abcam antibodies for SOSTDC1
    Cloud-Clone Corp. Antibodies for SOSTDC1 
    Search ThermoFisher Antibodies for SOSTDC1
    LSBio Antibodies in human, mouse, rat for SOSTDC1 

    Assay Products for SOSTDC1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOSTDC1 
    Cloud-Clone Corp. CLIAs for SOSTDC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006207 Cys_knot_C
     IPR008835 Sclerostin/SOSTDC1

    Graphical View of Domain Structure for InterPro Entry Q6X4U4

    ProtoNet protein and cluster: Q6X4U4

    2 Blocks protein domains:
    IPB006207 Cystine knot
    IPB008835 Sclerostin


    UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
    Similarity: Belongs to the sclerostin family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


    SOSTDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOSD1_HUMAN, Q6X4U4
    Function: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual
    cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes
    activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SOSTDC1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sostdc1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  renal/urinary system  skeleton 

    SOSTDC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SOSTDC1: Sostdc1tm1Noit Sostdc1tm1Nit

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOSTDC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOSTDC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOSTDC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOSTDC1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOSTDC1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SOSTDC1 (see all 13):
    hsa-miR-3607-3p hsa-miR-92a hsa-miR-520d-5p hsa-miR-3616-5p hsa-miR-367 hsa-miR-25 hsa-miR-3647-5p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSOSTDC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOSTDC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOSTDC1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SOSTDC1
    Sirion Biotech Customized adenovirus for overexpression of SOSTDC1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SOSTDC1 (see all 8)
    OriGene ORF clones in mouse, rat for SOSTDC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOSTDC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOSTDC1
    Sirion Biotech Customized lentivirus for stable overexpression of SOSTDC1 
                         Customized lentivirus expression plasmids for stable overexpression of SOSTDC1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SOSTDC1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOSTDC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOSTDC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31


    1 BioSystems Pathway for SOSTDC1
        BMP receptor signaling



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOSTDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for SOSTDC1 (Q6X4U43 ENSP000003049304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP4P126443, ENSP000002454514I2D: score=4 STRING: ENSP00000245451
    BMP2P126433, ENSP000003681044I2D: score=4 STRING: ENSP00000368104
    BMP7P180753, ENSP000003792044I2D: score=4 STRING: ENSP00000379204
    BMP6P220043, ENSP000002831474I2D: score=3 STRING: ENSP00000283147
    CDC20Q128343, ENSP000003084504I2D: score=1 STRING: ENSP00000308450
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process IEA--
    GO:0010454negative regulation of cell fate commitment IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030514negative regulation of BMP signaling pathway IEA--
    GO:0031069hair follicle morphogenesis IEA--

    SOSTDC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SOSTDC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOSTDC1 (SOSD1)

    1 Novoseek inferred chemical compound relationship for SOSTDC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystine 75.5 5 11328851 (1), 11179006 (1), 11148053 (1), 11134053 (1)

    Search CenterWatch for drugs/clinical trials and news about SOSTDC1 / SOSD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOSTDC1 gene: 
    NM_015464.2  

    Unigene Cluster for SOSTDC1:

    Sclerostin domain containing 1
    Hs.648106  [show with all ESTs]
    Unigene Representative Sequence: AK093408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307068(uc003stg.3) ENST00000396652(uc003sth.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOSTDC1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SOSTDC1 (see all 13):
    hsa-miR-3607-3p hsa-miR-92a hsa-miR-520d-5p hsa-miR-3616-5p hsa-miR-367 hsa-miR-25 hsa-miR-3647-5p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSOSTDC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOSTDC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOSTDC1
    Clone
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    OriGene clones in human, mouse for SOSTDC1 (see all 8)
    OriGene ORF clones in mouse, rat for SOSTDC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOSTDC1 (NM_015464)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOSTDC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOSTDC1
    Sirion Biotech Customized lentivirus for stable overexpression of SOSTDC1 
                         Customized lentivirus expression plasmids for stable overexpression of SOSTDC1 
    Primer
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    OriGene qPCR primer pairs and template standards for SOSTDC1
    OriGene qSTAR qPCR primer pairs in human, mouse for SOSTDC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOSTDC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOSTDC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOSTDC1

    Additional mRNA sequence: 

    AB059270.1 AF361494.1 AK093408.1 AK315682.1 AL050024.1 BC008484.1 

    4 DOTS entries:

    DT.214286  DT.100778853  DT.100020179  DT.101957200 

    24/97 AceView cDNA sequences (see all 97):

    NM_015464 AX748107 BX441985 AI373522 AA297283 AI540640 BM709058 AI244219 
    AA253126 Z40597 AI245868 AB059270 CR606874 AK093408 AA885131 CR614752 
    AI184036 Z44803 AF361494 BI763021 BM754590 BI770704 BU732520 T31716 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SOSTDC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:                                                      
    SP2:                                                      
    SP3:                                      -               


    ECgene alternative splicing isoforms for SOSTDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOSTDC1 expression in normal human tissues (normalized intensities)      SOSTDC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAACTTTA
    SOSTDC1 Expression
    About this image


    SOSTDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Metanephros
             visceral organ/metanephros/calyx   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
             Human Trabecular Meshwork Cells (HTMC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus
             brain/hindbrain/4th ventricle   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/calyx   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   

    See SOSTDC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOSTDC1

    SOURCE GeneReport for Unigene cluster: Hs.648106

    UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
    Tissue specificity: Highly expressed in kidney and weakly in lung

        SABiosciences Expression via Pathway-Focused PCR Array including SOSTDC1: 
              Lung Cancer in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOSTDC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOSTDC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SOSTDC1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sostdc11 , 5 sclerostin domain containing 11, 5 90.45(n)1
    94.66(a)1
      12 (16.82 cM)5
    660421  NM_025312.31  NP_079588.11 
     363141695 
    chicken
    (Gallus gallus)
    Aves SOSTDC11 sclerostin domain containing 1 80.74(n)
    87.86(a)
      378800  NM_204373.1  NP_989704.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOSTDC16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    6(27391000-27396431)
    African clawed frog
    (Xenopus laevis)
    Amphibia wise-A2 wise 77.53(n)    AY255636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sostdc1a1 sclerostin domain containing 1a 66.85(n)
    71.51(a)
      550261  NM_001017598.1  NP_001017598.1 


    ENSEMBL Gene Tree for SOSTDC1 (if available)
    TreeFam Gene Tree for SOSTDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOSTDC1 gene
    SOST2  
    1 SIMAP similar gene for SOSTDC1 using alignment to 3 protein entries:     SOSD1_HUMAN (see all proteins):
    SOST

    SOSTDC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 SNPs in SOSTDC1 are shown (see all 159)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858405331,2
    --16500718(+) ATACAA/GTAGTA 1 -- ds50010--------
    rs126997981,2
    C,F,H--16500884(+) ATTGGG/ATCTCA 1 -- ds500129Minor allele frequency- A:0.46NA NS EA WA CSA 2912
    rs758676451,2
    C,F--16501005(+) AACCTC/TCCATT 1 -- ds50012Minor allele frequency- T:0.17CSA WA 120
    rs125343331,2
    C,F,H--16501034(+) CCTGTC/GTCCCT 1 -- ds50015Minor allele frequency- G:0.00NS EA NA 530
    rs171694931,2
    C,F,H--16501077(+) AAGCTT/GGAATG 1 -- ds500121Minor allele frequency- G:0.04NA NS EA WA 2434
    rs1901620151,2
    --16501192(+) TTTTTG/TTTAAA 1 -- ut310--------
    rs1831188171,2
    --16501242(+) GCACAA/GATTAA 1 -- ut310--------
    rs775537981,2
    C--16501397(+) TTTCTA/TATCAA 1 -- ut310--------
    rs793222761,2
    C--16501400(+) CTAATA/CAACCA 1 -- ut310--------
    rs776387671,2
    C--16501402(+) AATCAA/GCCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SOSTDC1 (16501106 - 16570205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOSTDC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2064e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): SOSTDC1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609675    OMIM disorders: --

    6 diseases for SOSTDC1:    About MalaCards
    hypohidrotic ectodermal dysplasia    ectodermal dysplasia    wilms tumor    kidney disease
    lung cancer    breast cancer


    SOSTDC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SOSTDC1
    Human Genome Epidemiology (HuGE) Navigator: SOSTDC1 (1 document)

    Export disorders for SOSTDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOSTDC1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SOSTDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. (PubMed id 14623234)1, 2, 9 Laurikkala J.... Itoh N. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)1, 2 Yanagita M.... Sakurai T. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. (PubMed id 18032587)1, 9 Blish K.R....Torti S.V. (2008)
    6. BMP antagonists: their roles in development and involvement in pathophysiology. (PubMed id 15951218)1, 9 Yanagita M. (2005)
    7. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. (PubMed id 21113658)1 Clausen K.A....Torti S.V. (2011)
    8. Contribution of the sclerostin domain-containing prote in 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men. (PubMed id 21221677)1 He J.W....Zhang Z.L. (2011)
    9. Loss of heterozygosity and SOSTDC1 in adult and pedia tric renal tumors. (PubMed id 21080955)1 Blish K.R....Torti S.V. (2010)
    10. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25928 HGNC: 21748 AceView: SOSTDC1 Ensembl:ENSG00000171243 euGenes: HUgn25928
    ECgene: SOSTDC1 H-InvDB: SOSTDC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOSTDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOSTDC1 gene:
    Search GeneIP for patents involving SOSTDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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