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SOSTDC1 Gene

protein-coding   GIFtS: 58
GCID: GC07M016467

Sclerostin Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sclerostin Domain Containing 11 2     Sclerostin Domain-Containing Protein 12
USAG12 3 5     Uterine Sensitization-Associated Protein-12
Ectodermal BMP Inhibitor2 3     Ectodin3
ECTODIN2 5     USAG-13
ectodin1     Uterine Sensitization-Associated Gene 1 Protein3
Cystine-Knot Containing Secreted Protein2     

External Ids:    HGNC: 217481   Entrez Gene: 259282   Ensembl: ENSG000001712437   OMIM: 6096755   UniProtKB: Q6X4U43   

Export aliases for SOSTDC1 gene to outside databases

Previous GC identifers: GC07M016211 GC07M016245 GC07M016274


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOSTDC1 Gene:
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal
cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically,
it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling
during cellular proliferation, differentiation, and programmed cell death. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOSTDC1 Gene:
SOSTDC1 (sclerostin domain containing 1) is a protein-coding gene. An important paralog of this gene is SOST.

UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
Function: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual
cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes
activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner

Gene Wiki entry for SOSTDC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOSTDC1 gene promoter:
         FOXO3   Nkx2-5   HNF-3beta   E47   FOXO3b   POU2F1   Nkx6-1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOSTDC1 promoter sequence
   Search Chromatin IP Primers for SOSTDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOSTDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.2

SOSTDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOSTDC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016467:  view genomic region     (about GC identifiers)

Start:
16,501,106 bp from pter      End:
16,570,205 bp from pter
Size:
69,100 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 16,554,239-16,558,607     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4 (See protein sequence)
Recommended Name: Sclerostin domain-containing protein 1 precursor  
Size: 206 amino acids; 23307 Da
Subunit: Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity
Secondary accessions: Q96HJ7 Q9Y3U3

Explore the universe of human proteins at neXtProt for SOSTDC1: NX_Q6X4U4

Explore proteomics data for SOSTDC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47, Asn173

  • See SOSTDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056279.1  
    ENSEMBL proteins: 
     ENSP00000304930   ENSP00000379889  

    SOSTDC1 Human Recombinant Protein Products:

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    Novus Biologicals SOSTDC1 Proteins
    Novus Biologicals SOSTDC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SOSTDC1
    Cloud-Clone Corp. Proteins for SOSTDC1

     
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    antibodies-online proteins for SOSTDC1 (7 products) 

     
    antibodies-online peptides for SOSTDC1

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    antibodies-online antibodies for SOSTDC1 (20 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006207 Cys_knot_C
     IPR008835 Sclerostin/SOSTDC1

    Graphical View of Domain Structure for InterPro Entry Q6X4U4

    ProtoNet protein and cluster: Q6X4U4

    2 Blocks protein domains:
    IPB006207 Cystine knot
    IPB008835 Sclerostin


    UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
    Similarity: Belongs to the sclerostin family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


    Find genes that share domains with SOSTDC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOSD1_HUMAN, Q6X4U4
    Function: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual
    cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes
    activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SOSTDC1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sostdc1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  renal/urinary system  skeleton 

    Find genes that share phenotypes with SOSTDC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SOSTDC1: Sostdc1tm1Noit Sostdc1tm1Nit

       genOway: Develop your customized and physiologically relevant rodent model for SOSTDC1

    miRNA
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    miRTarBase miRNAs that target SOSTDC1:
    hsa-mir-335-5p (MIRT018039)

    Block miRNA regulation of human, mouse, rat SOSTDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOSTDC1 (see all 13):
    hsa-miR-3607-3p hsa-miR-92a hsa-miR-520d-5p hsa-miR-3616-5p hsa-miR-367 hsa-miR-25 hsa-miR-3647-5p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSOSTDC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOSTDC1
    Predesigned siRNA for gene silencing in human, mouse, rat SOSTDC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SOSTDC1 (NM_015464)
    Sino Biological Human cDNA Clone for SOSTDC1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOSTDC1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOSD1_HUMAN, Q6X4U4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with SOSTDC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOSTDC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31


    1 BioSystems Pathway for SOSTDC1
        BMP receptor signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including SOSTDC1: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOSTDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SOSTDC1 (Q6X4U43 ENSP000003049304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP4P126443, ENSP000002454514I2D: score=4 STRING: ENSP00000245451
    BMP2P126433, ENSP000003681044I2D: score=4 STRING: ENSP00000368104
    BMP7P180753, ENSP000003792044I2D: score=4 STRING: ENSP00000379204
    BMP6P220043, ENSP000002831474I2D: score=3 STRING: ENSP00000283147
    CDC20Q128343, ENSP000003084504I2D: score=1 STRING: ENSP00000308450
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process IEA--
    GO:0010454negative regulation of cell fate commitment IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030514negative regulation of BMP signaling pathway IEA--
    GO:0031069hair follicle morphogenesis IEA--

    Find genes that share ontologies with SOSTDC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOSTDC1 (SOSD1)

    1 Novoseek inferred chemical compound relationship for SOSTDC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystine 75.5 5 11328851 (1), 11179006 (1), 11148053 (1), 11134053 (1)



    Find genes that share compounds with SOSTDC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOSTDC1 gene: 
    NM_015464.2  

    Unigene Cluster for SOSTDC1:

    Sclerostin domain containing 1
    Hs.648106  [show with all ESTs]
    Unigene Representative Sequence: AK093408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307068(uc003stg.3) ENST00000396652(uc003sth.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat SOSTDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOSTDC1 (see all 13):
    hsa-miR-3607-3p hsa-miR-92a hsa-miR-520d-5p hsa-miR-3616-5p hsa-miR-367 hsa-miR-25 hsa-miR-3647-5p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSOSTDC1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for SOSTDC1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOSTDC1
      QuantiTect SYBR Green Assays in human, mouse, rat SOSTDC1
      QuantiFast Probe-based Assays in human, mouse, rat SOSTDC1

    Additional mRNA sequence: 

    AB059270.1 AF361494.1 AK093408.1 AK315682.1 AL050024.1 BC008484.1 

    4 DOTS entries:

    DT.214286  DT.100778853  DT.100020179  DT.101957200 

    Selected AceView cDNA sequences (see all 97):

    AX748107 NM_015464 AI245868 Z40597 CR606874 AA885131 AK093408 BM709058 
    AA297283 AI184036 AF361494 AI244219 BX441985 AA253126 CR614752 AI373522 
    AB059270 AI540640 Z44803 BM709516 BI763021 CD677937 BU733520 AI889217 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SOSTDC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:                                                      
    SP2:                                                      
    SP3:                                      -               


    ECgene alternative splicing isoforms for SOSTDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOSTDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAACTTTA
    SOSTDC1 Expression
    About this image


    SOSTDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Dental Placode Cells Dental Placode
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    SOSTDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOSTDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.648106

    UniProtKB/Swiss-Prot: SOSD1_HUMAN, Q6X4U4
    Tissue specificity: Highly expressed in kidney and weakly in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including SOSTDC1: 
              Lung Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOSTDC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SOSTDC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sostdc11 , 5 sclerostin domain containing 11, 5 90.45(n)1
    94.66(a)1
      12 (16.82 cM)5
    660421  NM_025312.31  NP_079588.11 
     363141695 
    chicken
    (Gallus gallus)
    Aves SOSTDC11 sclerostin domain containing 1 80.74(n)
    87.86(a)
      378800  NM_204373.1  NP_989704.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOSTDC16
    sclerostin domain containing 1
    82(a)
    1 ↔ 1
    6(27391000-27396431)
    African clawed frog
    (Xenopus laevis)
    Amphibia wise-A2 wise 77.53(n)    AY255636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sostdc1a1 sclerostin domain containing 1a 65.42(n)
    69.52(a)
      550261  NM_001017598.1  NP_001017598.1 


    ENSEMBL Gene Tree for SOSTDC1 (if available)
    TreeFam Gene Tree for SOSTDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOSTDC1 gene
    SOST2  
    1 SIMAP similar gene for SOSTDC1 using alignment to 3 protein entries:     SOSD1_HUMAN (see all proteins):
    SOST

    Find genes that share paralogs with SOSTDC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOSTDC1 (see all 159)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858405331,2
    --16500718(+) ATACAA/GTAGTA 1 -- ds50010--------
    rs126997981,2
    C,F,H--16500884(+) ATTGGG/ATCTCA 1 -- ds500129Minor allele frequency- A:0.46NA NS EA WA CSA 2912
    rs758676451,2
    C,F--16501005(+) AACCTC/TCCATT 1 -- ds50012Minor allele frequency- T:0.17CSA WA 120
    rs125343331,2
    C,F,H--16501034(+) CCTGTC/GTCCCT 1 -- ds50015Minor allele frequency- G:0.00NS EA NA 530
    rs171694931,2
    C,F,H--16501077(+) AAGCTT/GGAATG 1 -- ds500121Minor allele frequency- G:0.04NA NS EA WA 2434
    rs1901620151,2
    --16501192(+) TTTTTG/TTTAAA 1 -- ut310--------
    rs1831188171,2
    --16501242(+) GCACAA/GATTAA 1 -- ut310--------
    rs775537981,2
    C--16501397(+) TTTCTA/TATCAA 1 -- ut310--------
    rs793222761,2
    C--16501400(+) CTAATA/CAACCA 1 -- ut310--------
    rs776387671,2
    C--16501402(+) AATCAA/GCCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SOSTDC1 (16501106 - 16570205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOSTDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2064e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SOSTDC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOSTDC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SOSTDC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609675    OMIM disorders: --


    Find genes that share disorders with SOSTDC1           About GenesLikeMe

    Genetic Association Database (GAD): SOSTDC1
    Human Genome Epidemiology (HuGE) Navigator: SOSTDC1 (1 document)

    Export disorders for SOSTDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOSTDC1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SOSTDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. (PubMed id 14623234)1, 2, 9 Laurikkala J.... Itoh N. (Dev. Biol. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)1, 2 Yanagita M.... Sakurai T. (Biochem. Biophys. Res. Commun. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. (PubMed id 18032587)1, 9 Blish K.R....Torti S.V. (Mol. Biol. Cell 2008)
    6. BMP antagonists: their roles in development and involvement in pathophysiology. (PubMed id 15951218)1, 9 Yanagita M. (amp 2005)
    7. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes. (PubMed id 24190897)1 Hsieh J.C....Haussler M.R. (J. Endocrinol. 2014)
    8. SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer. (PubMed id 23830730)1 Gopal G....Rajkumar T. (Cancer Genet 2013)
    9. Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men. (PubMed id 21221677)1 He J.W....Zhang Z.L. (J. Bone Miner. Metab. 2011)
    10. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. (PubMed id 21113658)1 Clausen K.A....Torti S.V. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25928 HGNC: 21748 AceView: SOSTDC1 Ensembl:ENSG00000171243 euGenes: HUgn25928
    ECgene: SOSTDC1 H-InvDB: SOSTDC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOSTDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOSTDC1 gene:
    Search GeneIP for patents involving SOSTDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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