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Aliases for SOSTDC1 Gene

Aliases for SOSTDC1 Gene

  • Sclerostin Domain Containing 1 2 3 5
  • Ectodin 2 3 4
  • Ectodermal BMP Inhibitor 3 4
  • USAG1 3 4
  • Wise 2 3
  • Uterine Sensitization-Associated Gene 1 Protein 4
  • Uterine Sensitization-Associated Protein-1 3
  • Cystine-Knot Containing Secreted Protein 3
  • Sclerostin Domain-Containing Protein 1 3
  • CDA019 3
  • USAG-1 4
  • DAND7 3

External Ids for SOSTDC1 Gene

Previous GeneCards Identifiers for SOSTDC1 Gene

  • GC07M016211
  • GC07M016245
  • GC07M016274

Summaries for SOSTDC1 Gene

Entrez Gene Summary for SOSTDC1 Gene

  • This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOSTDC1 Gene

SOSTDC1 (Sclerostin Domain Containing 1) is a Protein Coding gene. Diseases associated with SOSTDC1 include Alveolar Periostitis. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Signaling by BMP. An important paralog of this gene is SOST.

UniProtKB/Swiss-Prot for SOSTDC1 Gene

  • May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.

Gene Wiki entry for SOSTDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOSTDC1 Gene

Genomics for SOSTDC1 Gene

Regulatory Elements for SOSTDC1 Gene

Enhancers for SOSTDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F016490 1.2 Ensembl ENCODE 9.2 +38.3 38295 2.7 HDAC1 ATF1 ARNT TBL1XR1 CREB3L1 NFRKB RARA CREM PPARG POLR2H SOSTDC1 GC07M016477 LRRC72
GH07F016484 0.8 ENCODE 5.3 +45.5 45520 1.6 SOX13 JUN FEZF1 FOS KLF8 TCF7L2 SOX5 GATAD2A FOXA3 HMG20A SOSTDC1 GC07M016477 LRRC72
GH07F016464 0.8 ENCODE 4.5 +65.0 64984 2.2 TBP HDAC1 PKNOX1 ZNF175 POLR2A ZSCAN29 NFE2 FOS FOSL2 EZH2 SOSTDC1 LOC105375168 GC07M016477
GH07F016216 0.6 Ensembl 4.3 +313.9 313874 0.6 BCOR ZNF146 HDAC2 ZBTB33 TRIM24 KDM1A CHAMP1 RPL36AP29 SOSTDC1 ISPD-AS1 GC07P016267
GH07F016563 0.8 Ensembl ENCODE 0.3 -33.1 -33064 0.9 IRF2 RFX1 NR2F6 IRF1 PRDM1 BZW2 ANKMY2 GC07P016564 SOSTDC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOSTDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOSTDC1 Gene

Chromosome:
7
Start:
16,461,481 bp from pter
End:
16,530,580 bp from pter
Size:
69,100 bases
Orientation:
Minus strand

Genomic View for SOSTDC1 Gene

Genes around SOSTDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOSTDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOSTDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOSTDC1 Gene

Proteins for SOSTDC1 Gene

  • Protein details for SOSTDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X4U4-SOSD1_HUMAN
    Recommended name:
    Sclerostin domain-containing protein 1
    Protein Accession:
    Q6X4U4
    Secondary Accessions:
    • A8MUA6
    • Q96HJ7
    • Q9Y3U3

    Protein attributes for SOSTDC1 Gene

    Size:
    206 amino acids
    Molecular mass:
    23307 Da
    Quaternary structure:
    • Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.

    Alternative splice isoforms for SOSTDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOSTDC1 Gene

Post-translational modifications for SOSTDC1 Gene

  • Glycosylation at Asn 47 and Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SOSTDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOSTDC1 Gene

Domains & Families for SOSTDC1 Gene

Gene Families for SOSTDC1 Gene

Protein Domains for SOSTDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6X4U4

UniProtKB/Swiss-Prot:

SOSD1_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the sclerostin family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Family:
  • Belongs to the sclerostin family.
genes like me logo Genes that share domains with SOSTDC1: view

Function for SOSTDC1 Gene

Molecular function for SOSTDC1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
genes like me logo Genes that share phenotypes with SOSTDC1: view

Animal Models for SOSTDC1 Gene

MGI Knock Outs for SOSTDC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SOSTDC1

miRNA for SOSTDC1 Gene

miRTarBase miRNAs that target SOSTDC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOSTDC1 Gene

Localization for SOSTDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOSTDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOSTDC1 gene
Compartment Confidence
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SOSTDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with SOSTDC1: view

Pathways & Interactions for SOSTDC1 Gene

genes like me logo Genes that share pathways with SOSTDC1: view

Pathways by source for SOSTDC1 Gene

1 BioSystems pathway for SOSTDC1 Gene
1 R&D Systems pathway for SOSTDC1 Gene

Gene Ontology (GO) - Biological Process for SOSTDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007389 pattern specification process IEA --
GO:0010454 negative regulation of cell fate commitment IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0031069 hair follicle morphogenesis IEA --
genes like me logo Genes that share ontologies with SOSTDC1: view

No data available for SIGNOR curated interactions for SOSTDC1 Gene

Drugs & Compounds for SOSTDC1 Gene

(1) Additional Compounds for SOSTDC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOSTDC1: view

Transcripts for SOSTDC1 Gene

mRNA/cDNA for SOSTDC1 Gene

Unigene Clusters for SOSTDC1 Gene

Sclerostin domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOSTDC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1:
SP2:
SP3: -

Relevant External Links for SOSTDC1 Gene

GeneLoc Exon Structure for
SOSTDC1
ECgene alternative splicing isoforms for
SOSTDC1

Expression for SOSTDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOSTDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOSTDC1 Gene

This gene is overexpressed in Lung (x6.3), Stomach (x5.5), Skin - Not Sun Exposed (Suprapubic) (x5.0), and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for SOSTDC1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOSTDC1 Gene



Protein tissue co-expression partners for SOSTDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOSTDC1 Gene:

SOSTDC1

SOURCE GeneReport for Unigene cluster for SOSTDC1 Gene:

Hs.648106

mRNA Expression by UniProt/SwissProt for SOSTDC1 Gene:

Q6X4U4-SOSD1_HUMAN
Tissue specificity: Highly expressed in kidney and weakly in lung.
genes like me logo Genes that share expression patterns with SOSTDC1: view

Primer Products

Orthologs for SOSTDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOSTDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOSTDC1 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia SOSTDC1 34 35
  • 96.6 (n)
cow
(Bos Taurus)
Mammalia SOSTDC1 34 35
  • 93.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SOSTDC1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sostdc1 34
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Sostdc1 34 16 35
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia SOSTDC1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOSTDC1 34 35
  • 80.74 (n)
lizard
(Anolis carolinensis)
Reptilia SOSTDC1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sostdc1 34
  • 70.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia wise-A 34
zebrafish
(Danio rerio)
Actinopterygii sostdc1a 34 35
  • 65.42 (n)
Species where no ortholog for SOSTDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOSTDC1 Gene

ENSEMBL:
Gene Tree for SOSTDC1 (if available)
TreeFam:
Gene Tree for SOSTDC1 (if available)

Paralogs for SOSTDC1 Gene

Paralogs for SOSTDC1 Gene

(1) SIMAP similar genes for SOSTDC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOSTDC1: view

Variants for SOSTDC1 Gene

Sequence variations from dbSNP and Humsavar for SOSTDC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085370 -- 16,490,867(+) AATTA(C/T)TTTGT intron-variant
rs10085371 -- 16,490,727(+) CAACC(A/G)CAATA intron-variant
rs10085372 -- 16,490,741(+) AACAT(A/G)TAATA intron-variant
rs10085373 -- 16,490,765(+) GGCTT(C/G)AGTGC intron-variant
rs10085374 -- 16,490,767(+) CTTGA(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOSTDC1 Gene

Variant ID Type Subtype PubMed ID
esv2759514 CNV loss 17122850
dgv6289n100 CNV gain 25217958

Variation tolerance for SOSTDC1 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOSTDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOSTDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOSTDC1 Gene

Disorders for SOSTDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOSTDC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alveolar periostitis
  • alveolitis of jaw
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SOSTDC1

Genetic Association Database (GAD)
SOSTDC1
Human Genome Epidemiology (HuGE) Navigator
SOSTDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOSTDC1
genes like me logo Genes that share disorders with SOSTDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOSTDC1 Gene

Publications for SOSTDC1 Gene

  1. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. (PMID: 14623234) Laurikkala J. … Itoh N. (Dev. Biol. 2003) 3 4 22 64
  2. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. (PMID: 18032587) Blish K.R. … Torti S.V. (Mol. Biol. Cell 2008) 3 22 64
  3. BMP antagonists: their roles in development and involvement in pathophysiology. (PMID: 15951218) Yanagita M. (Cytokine Growth Factor Rev. 2005) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PMID: 15020244) Yanagita M. … Sakurai T. (Biochem. Biophys. Res. Commun. 2004) 3 4 64

Products for SOSTDC1 Gene

  • Cloud-Clone Corp. Antibodies for SOSTDC1
  • Cloud-Clone Corp. Proteins for SOSTDC1
  • Cloud-Clone Corp Assay Kits for SOSTDC1

Sources for SOSTDC1 Gene

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