Aliases for SOST Gene
External Ids for SOST Gene
- HGNC: 13771
- Entrez Gene: 50964
- Ensembl: ENSG00000167941
- OMIM: 605740
- UniProtKB: Q9BQB4
Previous GeneCards Identifiers for SOST Gene
- GC17M041573
- GC17M044008
- GC17M041841
- GC17M042306
- GC17M039186
- GC17M037597
Summaries for SOST Gene
-
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOST Gene
SOST (Sclerostin) is a Protein Coding gene. Diseases associated with SOST include Van Buchem Disease and Sclerosteosis 1. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include transcription factor binding and heparin binding. An important paralog of this gene is SOSTDC1.
UniProtKB/Swiss-Prot for SOST Gene
-
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOST Gene
Genomics for SOST Gene
Regulatory Elements for SOST Gene
Enhancers for SOST Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SOST on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SOST gene promoter:
Regulatory Element Products
Genomic Location for SOST Gene
- Chromosome:
- 17
- Start:
- 43,753,731 bp from pter
- End:
- 43,758,788 bp from pter
- Size:
- 5,058 bases
- Orientation:
- Minus strand
Genomic View for SOST Gene
Genes around SOST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
SOST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOST Gene
Proteins for SOST Gene
-
Protein details for SOST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQB4-SOST_HUMAN
- Recommended name:
- Sclerostin
- Protein Accession:
- Q9BQB4
- Q495N9
Protein attributes for SOST Gene
- Size:
- 213 amino acids
- Molecular mass:
- 24031 Da
- Quaternary structure:
-
- Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
Post-translational modifications for SOST Gene
- Glycosylation at Asn 53 and Asn 175
Other Protein References for SOST Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SOST
- R&D Systems Antibodies for SOST (SOST/Sclerostin)
-
Custom Antibody ServicesOriGene Antibodies for SOST
- Novus Biologicals Antibodies for SOST
-
Abcam antibodies for SOST
-
Cloud-Clone Corp. Antibodies for SOST
- Invitrogen Antibodies for SOST
- antibodies-online Antibodies for SOST: See all 88
- GeneTex SOST antibody for SOST
-
St John's Laboratory Antibodies for SOST
Protein Products
- R&D Systems Proteins and Enzymes for SOST (SOST/Sclerostin)
-
OriGene Purified Proteins for SOST
- Search Origene for MassSpec and Protein Over-expression Lysates for SOST
- Origene Custom Protein Services for SOST
- Novus Biologicals lysates for SOST
- Sino Biological Recombinant Proteins for SOST
- Sino Biological Cell Lysates for SOST
- ProSpec Recombinant Proteins for SOST
-
Cloud-Clone Corp. Proteins for SOST
- antibodies-online Proteins for SOST: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SOST
-
Abcam proteins for SOST
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for SOST
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for SOST (SOST/Sclerostin)
- Enzo Life Sciences assays for SOST
-
Cloud-Clone Corp Assay Kits for SOST
- antibodies-online Kits for SOST: See all 46
No data available for DME Specific Peptides for SOST Gene
Domains & Families for SOST Gene
Gene Families for SOST Gene
- HGNC:
Protein Domains for SOST Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SOST Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BQB4UniProtKB/Swiss-Prot:
SOST_HUMAN :- Contains 1 CTCK (C-terminal cystine knot-like) domain.
- Belongs to the sclerostin family.
- Domain:
-
- Contains 1 CTCK (C-terminal cystine knot-like) domain.
- Family:
-
- Belongs to the sclerostin family.
Function for SOST Gene
Molecular function for SOST Gene
- UniProtKB/Swiss-Prot Function:
- Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15908424 |
| GO:0008134 | transcription factor binding | IDA | 17696759 |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for SOST Gene
- MGI mutant phenotypes for SOST:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SOST:
Animal Models for SOST Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SOST
- Cyagen custom Knockout/knockin (KOKI) mouse models for SOST
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SOST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SOST gene
- Search ViGene Biosciences for SOST
CRISPR Products
-
OriGene CRISPR knockouts for SOST
- GenScript: Design CRISPR guide RNA sequences for SOST
miRNA for SOST Gene
- miRTarBase miRNAs that target SOST
miRNA Products
- Search ViGene Biosciences for SOST
Clone Products
- Sino Biological Human cDNA Clone for SOST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SOST
- VectorBuilder custom plasmid, inducible vectors for SOST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOST
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SOST
-
ViGene Biosciences adenoviral particle packaged cDNA for SOST gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SOST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SOST gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SOST Gene
Localization for SOST Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOST Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0031012 | colocalizes_with extracellular matrix | IDA | 20551380 |
Pathways & Interactions for SOST Gene
Pathways by source for SOST Gene
4 Reactome pathways for SOST Gene
1 KEGG pathway for SOST Gene
1 R&D Systems pathway for SOST Gene
Interacting Proteins for SOST Gene
Selected Interacting proteins:
Q9BQB4-SOST_HUMAN
ENSP00000301691
for SOST Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001503 | ossification | IEA | -- |
| GO:0009612 | response to mechanical stimulus | IEP | 21723865 |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0030279 | negative regulation of ossification | NAS | 11181578 |
| GO:0030514 | negative regulation of BMP signaling pathway | IDA | 14633986 |
Transcripts for SOST Gene
mRNA/cDNA for SOST Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for SOST
- GenScript: Design CRISPR guide RNA sequences for SOST
miRNA Products
- Search ViGene Biosciences for SOST
Clone Products
- Sino Biological Human cDNA Clone for SOST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SOST
- VectorBuilder custom plasmid, inducible vectors for SOST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOST
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for SOST Gene
mRNA differential expression in normal tissues according to GTEx for SOST Gene
This gene is overexpressed in Artery - Aorta (x27.8), Artery - Tibial (x14.3), and Kidney - Cortex (x5.6).
NURSA nuclear receptor signaling pathways regulating expression of SOST Gene:
SOSTSOURCE GeneReport for Unigene cluster for SOST Gene:
Hs.349204mRNA Expression by UniProt/SwissProt for SOST Gene:
Q9BQB4-SOST_HUMAN
Tissue specificity:
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).
Primer Products
-
OriGene qPCR primer pairs for SOST
-
OriGene qPCR primer pairs and template standards for SOST
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SOST Gene
Orthologs for SOST Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SOST 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SOST 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SOST 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sost 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Sost 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SOST 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SOST 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SOST 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | sost 34 35 |
|
- Species where no ortholog for SOST was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SOST Gene
(1) SIMAP similar genes for SOST Gene using alignment to 1 proteins:
Variants for SOST Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs387907169 | Craniodiaphyseal dysplasia autosomal dominant (CDD) [MIM:122860], Pathogenic | 43,758,681(-) | GTGTA(A/G)TGGAG | reference, missense | |
| VAR_063982 | Sclerosteosis 1 (SOST1) [MIM:269500] | ||||
| VAR_065766 | Craniodiaphyseal dysplasia autosomal dominant (CDD) [MIM:122860] | ||||
| rs104894644 | Pathogenic | 43,755,612(-) | AAGTG(A/G)TGGCG | reference, stop-gained | |
| rs104894645 | Pathogenic | 43,755,608(-) | GGTGG(C/T)GACCT | reference, stop-gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv2060 | CNV | insertion | 18451855 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv1060861 | CNV | gain | 25217958 |
| esv3640635 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.39;
8.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SOST Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOST Gene
Disorders for SOST Gene
(14) MalaCards diseases for SOST Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| van buchem disease |
|
|
| sclerosteosis 1 |
|
|
| craniodiaphyseal dysplasia, autosomal dominant |
|
|
| sclerosteosis |
|
|
| craniodiaphyseal dysplasia |
|
|
Search SOST in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SOST_HUMAN- Craniodiaphyseal dysplasia autosomal dominant (CDD) [MIM:122860]: A severe bone dysplasia characterized by massive generalized hyperostosis and sclerosis, especially involving the skull and facial bones. The sclerosis is so severe that the resulting facial distortion is referred to as leontiasis ossea (leonine faces) and the bone deposition results in progressive stenosis of craniofacial foramina. Respiratory obstruction due to choanal stenosis compromises the clinical outcomes of affected patients. {ECO:0000269 PubMed:21221996}. Note=The disease is caused by mutations affecting the gene represented in this entry. Heterozygous mutations located in the secretion signal of the SOST gene prevent sclerostin secretion and can be responsible for craniodiaphyseal dysplasia.
- Sclerosteosis 1 (SOST1) [MIM:269500]: An autosomal recessive sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients. {ECO:0000269 PubMed:11179006, ECO:0000269 PubMed:11181578, ECO:0000269 PubMed:20583295}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Van Buchem disease (VBCH) [MIM:239100]: VBCH is an autosomal recessive sclerosing bone dysplasia characterized by endosteal hyperostosis of the mandible, skull, ribs, clavicles, and diaphyses of the long bones. Affected patients present a symmetrically increased thickness of bones, most frequently found as an enlarged jawbone, but also an enlargement of the skull, ribs, diaphysis of long bones, as well as tubular bones of hands and feet. The clinical consequence of increased thickness of the skull include facial nerve palsy causing hearing loss, visual problems, neurological pain, and, very rarely, blindness as a consequence of optic atrophy. Serum alkaline phosphatase levels are elevated. {ECO:0000269 PubMed:11836356}. Note=The disease is caused by mutations affecting the gene represented in this entry. A 52 kb deletion downstream of SOST results in SOST transcription suppression causing van Buchem disease.
Relevant External Links for SOST
No data available for Genatlas for SOST Gene
Publications for SOST Gene
- Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. (PMID: 11179006) Brunkow M.E. … Mulligan J.T. (Am. J. Hum. Genet. 2001) 2 3 4 22 64
- Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). (PMID: 11181578) Balemans W. … Van Hul W. (Hum. Mol. Genet. 2001) 2 3 4 22 64
- Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation. (PMID: 19208630) Veverka V. … Carr M.D. (J. Biol. Chem. 2009) 3 4 22 64
- The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. (PMID: 19371798) Huang Q.Y. … Kung A.W. (Bone 2009) 3 22 46 64
- Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population. (PMID: 19898734) Mencej-Bedrac S. … Marc J. (Calcif. Tissue Int. 2009) 3 22 46 64
Products for SOST Gene
- R&D Systems Antibodies for SOST (SOST/Sclerostin)
- R&D Systems Proteins and Enzymes for SOST (SOST/Sclerostin)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for SOST (SOST/Sclerostin)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SOST
- Custom Assay ServicesOriGene ELISA Kits for SOST
- OriGene Purified Proteins for SOST
- Search Origene for MassSpec and Protein Over-expression Lysates for SOST
- Origene Custom Protein Services for SOST
- Origene siRNA, mouse_rna, shRNA, rat_shrna, and RNAi products in human, mouse, rat for SOST
- Browse OriGene Inhibitory RNA Products For SOST
- OriGene qPCR primer pairs and template standards for SOST
- OriGene qPCR primer pairs for SOST
- OriGene CRISPR knockouts for SOST
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SOST
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SOST
- GenScript Custom Assay Services for SOST
- GenScript Custom overexpressing Cell Line Services for SOST
- GenScript: Design CRISPR guide RNA sequences for SOST
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SOST
- Sino Biological Human cDNA Clone for SOST
- Sino Biological Cell Lysates for SOST
- Sino Biological Recombinant Proteins for SOST
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SOST
- Novus Biologicals lysates for SOST
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for SOST
- Abcam proteins for SOST
- Search for Assays for SOST at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for SOST
- Cloud-Clone Corp. Antibodies for SOST
- Cloud-Clone Corp. Proteins for SOST
- Cloud-Clone Corp Assay Kits for SOST
- Taconic Biosciences Mouse Models for SOST
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for SOST
- antibodies-online Antibodies for SOST: See all 88
- antibodies-online Kits for SOST: See all 46
- antibodies-online Proteins for SOST: See all 14
- Search antibodies-online for peptides
- GeneTex SOST antibody for SOST
- Search GeneTex for Proteins for SOST
- ViGene Biosciences adenoviral particle packaged cDNA for SOST gene
- ViGene Biosciences lentiviral particle packaged cDNA for SOST gene
- ViGene Biosciences ready-to-package AAV shRNAs for SOST gene
- Search ViGene Biosciences for SOST
- Horizon Cell Lines for SOST
- Cyagen custom Knockout/knockin (KOKI) mouse models for SOST
- VectorBuilder custom plasmid, inducible vectors for SOST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOST
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SOST Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab