Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SOS2 Gene

protein-coding GIFtS: 60
GCID: GC14M050583

son of sevenless homolog 2 (Drosophila)

(Previous name: son of sevenless (Drosophilia) homolog 2 )

Explore 22 diseases affiliated with
SOS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Son Of Sevenless Homolog 2 (Drosophila)¹ ²
SOS-2² ³
Son Of Sevenless (Drosophilia) Homolog 2¹
Guanine Nucleotide Exchange Factor²
Guanine Nucleotide Releasing Factor²
Son Of Sevenless Homolog 2²

External Ids:	HGNC: 11188¹	Entrez Gene: 6655²	Ensembl: ENSG00000100485⁷	OMIM: 601247⁵	UniProtKB: Q07890³

Export aliases for SOS2 gene to outside databases

Previous GC identifers: GC14M047905 GC14M044379 GC14M048573 GC14M048575 GC14M049654 GC14M030709

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890

Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SOS2 gene promoter:
TBP GCNF AREB6 MEF-2A Nkx6-1 HSF2 GCNF-1 IRF-7A aMEF-2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOS2 promoter sequence

Search SABiosciences Chromatin IP Primers for SOS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q21

SOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOS2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M050583: view genomic region (about GC identifiers)

Start:	50,583,846 bp from pter	End:	50,698,276 bp from pter
Size:	114,431 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890 (See protein sequence)

Recommended Name: Son of sevenless homolog 2

Size: 1332 amino acids; 152979 Da

Secondary accessions: D3DSB4 Q15503 Q17RN1

Explore the universe of human proteins at neXtProt for SOS2: NX_Q07890

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07890

SOS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_008870.2

ENSEMBL proteins:

ENSP00000216373 ENSP00000445328 ENSP00000452553

Reactome Protein details: Q07890
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SOS2
	GenScript Custom Purified and Recombinant Proteins Services for SOS2
	Novus Biologicals SOS2 Protein Novus Biologicals SOS2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOS2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--

SOS2 for ontologies About GeneDecksing

SOS2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SOS2
	Browse OriGene Antibodies OriGene Custom Antibody Services for SOS2
	GenScript Custom Superior Antibodies Services for SOS2
	Novus Biologicals SOS2 Antibodies
	Search for Antibodies for SOS2 at Abcam
	Uscn Antibodies for SOS2
	Search ThermoFisher Antibodies for SOS2

Assay Products for SOS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SOS2 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR008937 Ras_GEF

IPR000219 DH-domain

IPR007125 Histone_core_D

IPR015759 Sos

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry Q07890

ProtoNet protein and cluster: Q07890

3 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 N-terminal Ras-GEF domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-GEF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890

Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)

Genatlas biochemistry entry for SOS2:

Drosophila son of sevenless homolog 2, regulator of Ras

miRNA Products:		OriGene 3'-UTR Clone: SOS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOS2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SOS2 (see all 44):
		hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b

		SwitchGear 3'UTR luciferase reporter plasmid: SOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOS2 (see all 6) OriGene shRNA RFP: SOS2 OriGene siRNA: SOS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SOS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOS2
		Search LifeMap BioReagents cell lines for SOS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005085	guanyl-nucleotide exchange factor activity	NAS	--
GO:0005088	Ras guanyl-nucleotide exchange factor activity	--	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	--

SOS2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SOS2:

Increased G1 DNA content

Animal Models:
Mouse knock-out Sos2^tm1Esn for SOS2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sos2):

normal

SOS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/95 super-pathways (see all 95) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

8/21 pathways (see all 21)
Development_CNTF receptor signaling	1.00	Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34
Development CNTF receptor signaling	1.00	Translation _Regulation of EIF4F activity	0.32
Transcription Receptor-mediated HIF regulation	0.43	Translation Regulation activity of EIF4F	0.32
Transcription_Receptor-mediated HIF regulation	0.43	Immune response_IL-6 signaling pathway	0.30

Development HGF signaling pathway

8/13 pathways (see all 13)
Development HGF signaling pathway	1.00	Development_PDGF signaling via MAPK cascades	0.41
Development_HGF signaling pathway	0.78	Apoptosis and survival_NGF signaling pathway	0.25
Development_Neurotrophin family signaling	0.45	Apoptosis and survival NGF signaling pathway	0.25
Development Neurotrophin family signaling	0.45	Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24

IL-9 Signaling Pathways

8/12 pathways (see all 12)
IL-9 Signaling Pathways	1.00	IL-4 Signaling Pathways	0.80
IL-21 Signaling Pathways	0.90	Immune response_IL-9 signaling pathway	0.42
IL-7 Signaling Pathways	0.90	Immune response IL-9 signaling pathway	0.42
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Development_Thrombopoietin-regulated cell processes	0.36

Development Angiotensin activation of ERK

Development Angiotensin activation of ERK	1.00	Development_G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_ACM2 and ACM4 activation of ERK	0.74	Development_EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54

Development EGFR signaling pathway

Development EGFR signaling pathway	1.00	EGF Pathway	0.39
Development_EGFR signaling pathway	0.87	GDNF-Family Ligands and Receptor Interactions	0.21
Development_GDNF family signaling	0.45	BDNF Pathway	0.14
Development GDNF family signaling	0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

5/73 EMD Millipore Pathways for SOS2 (see all 73)

	Chemotaxis CXCR4 signaling pathway
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling FAK signaling
	G-protein signaling G-Protein beta/gamma signaling cascades
	Immune response Role of integrins in NK cells cytotoxicity

5/9 R&D Systems Pathways for SOS2 (see all 9)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	Adipocytokines & Insulin Signaling
	IL-7 Signaling Pathways

5/73 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOS2 (see all 73)

	Molecular Mechanisms of Cancer
	eIF2 Pathway
	JNK Pathway
	ITK and TCR Signaling
	ErbB Family Pathway

5/76 GeneGo (Thomson Reuters) Pathways for SOS2 (see all 76)

	G-protein signaling H-RAS regulation pathway
	Development CNTF receptor signaling
	Development EGFR signaling pathway
	Immune response IL-9 signaling pathway
	Transcription PPAR Pathway

5/6 BioSystems Pathways for SOS2 (see all 6)

	EGFR1 Signaling Pathway
	DNA damage response (only ATM dependent)
	MAPK signaling pathway
	Regulation of Actin Cytoskeleton
	B Cell Receptor Signaling Pathway

5/14 Reactome Pathways for SOS2 (see all 14)

	GPCR downstream signaling
	Signaling by Rho GTPases
	Developmental Biology
	G alpha (12/13) signalling events
	Cell death signalling via NRAGE, NRIF and NADE

5/24 Kegg Pathways (Kegg details for SOS2) (see all 24):

	MAPK signaling pathway
	ErbB signaling pathway
	Chemokine signaling pathway
	Dorso-ventral axis formation
	Focal adhesion

SOS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SOS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/109 Interacting proteins for SOS2 (Q07890^{1, 2, 3} ENSP00000216373⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 109)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹^,²^,³, ENSP00000361423⁴	EBI-298181,EBI-1550796 MINT-8110779 I2D: score=5 STRING: ENSP00000361423
PLCG1	P19174¹^,²^,³, ENSP00000244007⁴	EBI-298181,EBI-79387 MINT-8112807 I2D: score=5 STRING: ENSP00000244007
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8112279 I2D: score=3 STRING: ENSP00000274335
CRK	P46108¹^,³, ENSP00000300574⁴	EBI-298181,EBI-886 I2D: score=2 STRING: ENSP00000300574
PACSIN3	Q9UKS6¹^,³, ENSP00000298838⁴	EBI-298181,EBI-77926 I2D: score=2 STRING: ENSP00000298838

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007411	axon guidance	TAS	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--
GO:0048011	nerve growth factor receptor signaling pathway	TAS	--

SOS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SOS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOS2

1 HMDB Compound for SOS2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

6 Novoseek chemical compound relationships for SOS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	69.8	3	1331063 (1), 8226729 (1)
gtp	51.6	4	1379346 (1), 1331063 (1), 8484124 (1)
guanine	51.5	5	7684828 (2), 7988425 (1), 7513704 (1), 9228027 (1)
tyrosine	44.7	4	8275713 (1), 8208538 (1), 8049487 (1)
threonine	20.8	2	8049487 (1)
serine	5.28	1	8049487 (1)

Search CenterWatch for drugs/clinical trials and news about SOS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOS2 gene:

NM_006939.2

Unigene Cluster for SOS2:

Son of sevenless homolog 2 (Drosophila)

Hs.291533 [show with all ESTs]

Unigene Representative Sequence: NM_006939

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216373(uc010ans.3 uc001wxs.4 uc010tql.2) ENST00000543680(uc010tqm.1)

ENST00000555794(uc001wxt.2) ENST00000556469 ENST00000555666 ENST00000556452

miRNA Products:		OriGene 3'-UTR Clone: SOS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOS2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SOS2 (see all 44):
		hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b

		SwitchGear 3'UTR luciferase reporter plasmid: SOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOS2 (see all 6) OriGene shRNA RFP: SOS2 OriGene siRNA: SOS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOS2

Additional cDNA sequence:

AB209277.1 AK295868.1 AK302825.1 AK308978.1 AK309123.1 BC117261.1 BC143366.1 BC143367.1

L13858.1 L20686.1

11 DOTS entries:

DT.315010 DT.454409 DT.70104429 DT.91655622 DT.95371713 DT.415759 DT.40121137 DT.99983087

DT.415762 DT.97778280 DT.99947804

24/289 AceView cDNA sequences (see all 289):

AA713679 AA633530 AI783684 AA374200 CR601939 BQ023799 N41721 CA776438

BI753530 AA809852 CA418398 R78735 BQ025283 BI758040 AI419975 AA256588

AI253151 BX247997 CK818831 BQ023936 AW518885 AA412572 AI272033 BM263987

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTACAGT

About this image
See SOS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOS2

SOURCE GeneReport for Unigene cluster: Hs.291533

SABiosciences Expression via Pathway-Focused PCR Arrays including SOS2:

Focal Adhesions in human mouse rat

Gap Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOS2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SOS2¹	son of sevenless homolog 2 (Drosophila)	79.17(n) 86.74(a)		423572 XM_421461.3 XP_421461.3
lizard (Anolis carolinensis)	Reptilia	SOS2⁶	--	87(a)	1 ↔ 1	GL343627.1(238612-275364)
African clawed frog (Xenopus laevis)	Amphibia	CD328036.1²	--	74.3(n)		CD328036.1
zebrafish (Danio rerio)	Actinopterygii	sos2¹	son of sevenless homolog 2 (Drosophila)	67.89(n) 74.96(a)		561670 XM_685079.4 XP_690171.2
fruit fly (Drosophila melanogaster)	Insecta	Sos⁶	Son of sevenless	36(a)	1 → many	2L(13813816-13819826)
worm (Caenorhabditis elegans)	Secernentea	sos-1⁶	Drosophila SOS homolog family member (sos-1)	23(a)	1 → many	V(4517668-4549277)

ENSEMBL Gene Tree for SOS2 (if available)
TreeFam Gene Tree for SOS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SOS2 gene

RALGPS2² RAPGEF1² RASGRF1² RGL2² RASGRF2² SOS1² RGL3² RALGPS1²

RALGDS² RGL1² RGL4²

2 SIMAP similar genes for SOS2 using alignment to 4 protein entries: SOS2_HUMAN (see all proteins):

SOS1 DKFZp781H1715

SOS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56044583^1,2		--	50583425(+)	`GCCGAA/GCGTGG`	5	--	us2k¹ ds500¹		0	--	--	--	--
rs186814891^1,2		--	50583512(+)	`TAAATC/TACTTT`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs189562548^1,2		--	50583664(+)	`TTACAA/GTCTTC`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs17115311^1,2	C,F,	--	50583765(-)	`ACACA-/CAATTTT`	5	--	ds500¹ us2k¹		2		MN EA	356
rs183335780^1,2		--	50583765(+)	`AAAAAG/TTGTGT`	5	--	us2k¹ ds500¹		0	--	--	--	--
rs3841294^1,2	C	--	50583786(+)	`TGTGT-/GTCTATA`	5	--	us2k¹ ds500¹		0	--	--	--	--
rs76978190^1,2	F,	--	50583822(+)	`CCTTAT/CAATGA`	5	--	us2k¹ ds500¹		1		NA	120
rs148504789^1,2	C,	--	50583987(+)	`GCAAA-/AC ACTCTATCAC`	5	--	us2k¹ ut3¹		0	--	--	--	--
rs151328040^1,2		--	50584115(+)	`ATATTA/TAAAAA`	5	--	us2k¹ ut3¹		0	--	--	--	--
rs187872579^1,2		--	50584116(+)	`TATTTA/TAAAAA`	5	--	ut3¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SOS2 (50583846 - 50698276 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SOS2
1 CNV: 66642

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOS2

DNA2.0 Custom Variant and Variant Library Synthesis for SOS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SOS2 for disorders           About GeneDecksing

OMIM gene information: 601247    OMIM disorders: --

20/22 diseases for SOS2 (see all 22):    About MalaCards

myeloid leukemia noonan syndrome chronic myeloid leukemia acute myeloid leukemia

renal cell carcinoma diabetes mellitus hepatitis c endometrial cancer

spasticity leukemia alzheimer's disease lung cancer

prostate cancer breast cancer hepatitis prostatitis

carcinoma neuronitis colorectal cancer glioblastoma

Human Genome Epidemiology (HuGE) Navigator: SOS2 (2 documents)

Export disorders for SOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOS2 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with SOS2)

Utopia: connect your pdf to the dynamic
world of online information

Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. (PubMed id 8276400)^{1, 3, 9} Webb G.C....Bowtell D.D. (1993)
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (PubMed id 8493579)^{1, 2} Chardin P....Bar-Sagi D. (1993)
Differential interactions of human Sos1 and Sos2 with Grb2. (PubMed id 7629138)^{1, 9} Yang S.S....Bar-Sagi D. (1995)
Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. (PubMed id 17440948)^{1, 9} Hamilton G....Lovestone S. (2007)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
The proximal signaling network of the BCR-ABL1 oncoge ne shows a modular organization. (PubMed id 20697350)¹ Titz B....Graeber T.G. (2010)
Triggering Ras signalling by intracellular Francisell a tularensis through recruitment of PKCI+ and I^I to the SOS2/GrB2 complex is ess ential for bacterial proliferation in the cytosol. (PubMed id 20618341)¹ Al-Khodor S. and Abu Kwaik Y. (2010)
Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)¹ Takefuji M....Kaibuchi K. (2010)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6655	HGNC: 11188	AceView: SOS2andC14orf138	Ensembl:ENSG00000100485	euGenes: HUgn6655
ECgene: SOS2	Kegg: 6655	H-InvDB: SOS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SOS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SOS2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Son_of_Sevenless

Intellectual Property for SOS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SOS2 gene:
Search GeneIP for patents involving SOS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for SOS2 (SOS2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SOS2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOS2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOS2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SOS2		OriGene 3'-UTR Clone for SOS2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOS2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SOS2		OriGene Custom Protein Services for SOS2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOS2

	GenScript Custom Purified and Recombinant Proteins Services for SOS2		GenScript cDNA clones with any tag delivered in your preferred vector for SOS2
	GenScript Custom Assay Services for SOS2		GenScript Custom Superior Antibodies Services for SOS2
	GenScript Custom overexpressing Cell Line Services for SOS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SOS2 promoter
	Search Chromatin IP Primers for SOS2
	RT² qPCR Primer Assay in human, mouse, rat SOS2
	GNC Network for SOS2
	SABiosciences PCR Arrays including human, mouse, rat SOS2

Search Tocris compounds for SOS2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SOS2 antibodies
	SOS2 proteins
	SOS2 lysates

	Search for Antibodies for SOS2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SOS2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SOS2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SOS2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2

	SwitchGear 3'UTR luciferase reporter plasmids for SOS2
	SwitchGear Promoter luciferase reporter plasmids for SOS2

Search ThermoFisher Antibodies for SOS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SOS2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SOS2 Gene

son of sevenless homolog 2 (Drosophila)

Aliases
for SOS2 gene

Summaries
for SOS2 gene

Genomic Views
for SOS2 gene

Proteins
for SOS2 gene

Protein Domains /
Families
for SOS2 gene

Function
for SOS2 gene

Pathways & Interactions
for SOS2 gene

Drugs & Compounds
for SOS2 gene

Transcripts
for SOS2 gene

Expression
for SOS2 gene

Orthologs
for SOS2 gene

Paralogs
for SOS2 gene

Genomic Variants
for SOS2 gene

Disorders / Diseases
for SOS2 gene

Publications
for SOS2 gene

External Searches for SOS2 gene

Genome Databases showing SOS2 gene

Other Databases showing SOS2 gene

Specialized Databases showing SOS2 gene

Intellectual Property
for SOS2 gene

Products
for SOS2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SOS2 Gene

son of sevenless homolog 2 (Drosophila)

Aliasesfor SOS2 gene

Summariesfor SOS2 gene

Genomic Viewsfor SOS2 gene

Proteinsfor SOS2 gene

Protein Domains /Familiesfor SOS2 gene

Functionfor SOS2 gene

Pathways & Interactionsfor SOS2 gene

Drugs & Compoundsfor SOS2 gene

Transcriptsfor SOS2 gene

Expression for SOS2 gene

Orthologsfor SOS2 gene

Paralogsfor SOS2 gene

Genomic Variantsfor SOS2 gene

Disorders / Diseasesfor SOS2 gene

Publicationsfor SOS2 gene

External Searches for SOS2 gene

Genome Databases showing SOS2 gene

Other Databases showing SOS2 gene

Specialized Databases showing SOS2 gene

Intellectual Propertyfor SOS2 gene

Productsfor SOS2 gene

View Random Gene

Aliases
for SOS2 gene

Summaries
for SOS2 gene

Genomic Views
for SOS2 gene

Proteins
for SOS2 gene

Protein Domains /
Families
for SOS2 gene

Function
for SOS2 gene

Pathways & Interactions
for SOS2 gene

Drugs & Compounds
for SOS2 gene

Transcripts
for SOS2 gene

Expression
for SOS2 gene

Orthologs
for SOS2 gene

Paralogs
for SOS2 gene

Genomic Variants
for SOS2 gene

Disorders / Diseases
for SOS2 gene

Publications
for SOS2 gene

Intellectual Property
for SOS2 gene

Products
for SOS2 gene