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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOS2 Gene

protein-coding   GIFtS: 64
GCID: GC14M050583

Son Of Sevenless Homolog 2 (Drosophila)

(Previous name: son of sevenless (Drosophilia) homolog 2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Son Of Sevenless Homolog 2 (Drosophila)1 2
SOS-22 3
Son Of Sevenless (Drosophilia) Homolog 21
Guanine Nucleotide Exchange Factor2
Guanine Nucleotide Releasing Factor2
Son Of Sevenless Homolog 22

External Ids:    HGNC: 111881   Entrez Gene: 66552   Ensembl: ENSG000001004857   OMIM: 6012475   UniProtKB: Q078903   

Export aliases for SOS2 gene to outside databases

Previous GC identifers: GC14M047905 GC14M044379 GC14M048573 GC14M048575 GC14M049654 GC14M030709


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SOS2 Gene: 
SOS2 (son of sevenless homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with SOS2 include noonan syndrome, and chronic myeloid leukemia, and among its related super-pathways are IL-9 Signaling Pathways and Translation Insulin regulation of translation. GO annotations related to this gene include protein heterodimerization activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOS2 gene promoter:
         TBP   GCNF   AREB6   MEF-2A   Nkx6-1   HSF2   GCNF-1   IRF-7A   aMEF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21

SOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050583:  view genomic region     (about GC identifiers)

Start:
50,583,846 bp from pter      End:
50,698,276 bp from pter
Size:
114,431 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890 (See protein sequence)
Recommended Name: Son of sevenless homolog 2  
Size: 1332 amino acids; 152979 Da
Secondary accessions: D3DSB4 Q15503 Q17RN1

Explore the universe of human proteins at neXtProt for SOS2: NX_Q07890

Explore proteomics data for SOS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07890

  • SOS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOS2 Protein Expression
    REFSEQ proteins: NP_008870.2  
    ENSEMBL proteins: 
     ENSP00000216373   ENSP00000445328   ENSP00000452553  
    Reactome Protein details: Q07890
    Human Recombinant Protein Products for SOS2: 
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for SOS2
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    Novus Biologicals SOS2 Protein
    Novus Biologicals SOS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOS2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    SOS2 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for SOS2 

    Assay Products for SOS2: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOS2 
    Cloud-Clone Corp. CLIAs for SOS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    5/11 InterPro protein domains (see all 11):
     IPR008937 Ras_GEF
     IPR000219 DH-domain
     IPR007125 Histone_core_D
     IPR015759 Sos
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q07890

    ProtoNet protein and cluster: Q07890

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GEF domain


    SOS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOS2_HUMAN, Q07890
    Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)

         Genatlas biochemistry entry for SOS2:
    Drosophila son of sevenless homolog 2, regulator of Ras

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005085guanyl-nucleotide exchange factor activity NAS--
    GO:0005088Ras guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI14679214
         
    SOS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOS2:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sos2):
     normal 

    SOS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sos2tm1Esn for SOS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOS2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOS2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SOS2 (see all 44):
    hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSOS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOS2
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SOS2

    Clone
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    GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2
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                         Customized lentivirus expression plasmids for stable overexpression of SOS2 

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    Search LifeMap BioReagents cell lines for SOS2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOS2 About   (see all 90)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin-regulated cell processes0.38
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor-mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.31
    3Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Renal cell carcinoma0.30
    4Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Immune response BCR pathway0.45
    Immune response Role of DAP12 receptors in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    Immune response IL-4 signaling pathway0.38
    5Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    GDNF-Family Ligands and Receptor Interactions0.41
    Development ERBB-family signaling0.57
    EGF Pathway0.41
    Development GDNF family signaling0.45
    BDNF Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/73 EMD Millipore Pathways for SOS2 (see all 73)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    G-protein signaling G-Protein beta/gamma signaling cascades
    Immune response Role of integrins in NK cells cytotoxicity

    5/10 R&D Systems Pathways for SOS2 (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/73 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOS2 (see all 73)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    JNK Pathway
    ITK and TCR Signaling
    ErbB Family Pathway

    5/76 GeneGo (Thomson Reuters) Pathways for SOS2 (see all 76)
        G-protein signaling H-RAS regulation pathway
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway
    Transcription PPAR Pathway

    5/6 BioSystems Pathways for SOS2 (see all 6)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    DNA damage response (only ATM dependent)
    Insulin Signaling
    Regulation of Actin Cytoskeleton

    5/14        Reactome Pathways for SOS2 (see all 14)
        GPCR downstream signaling
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE


    5/30         Kegg Pathways  (Kegg details for SOS2) (see all 30):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Dorso-ventral axis formation


    SOS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/114 Interacting proteins for SOS2 (Q078901, 2, 3 ENSP000002163734) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-298181,EBI-375543 MINT-8110779 I2D: score=5 STRING: ENSP00000361423
    PLCG1P191741, 2, 3, ENSP000002440074EBI-298181,EBI-79387 MINT-8112807 I2D: score=5 STRING: ENSP00000244007
    PIK3R1P279862, 3, ENSP000002743354MINT-8112279 I2D: score=3 STRING: ENSP00000274335
    CRKP461081, 3, ENSP000003005744EBI-298181,EBI-886 I2D: score=2 STRING: ENSP00000300574
    PACSIN3Q9UKS61, 3, ENSP000002988384EBI-298181,EBI-77926 I2D: score=2 STRING: ENSP00000298838
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    SOS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SOS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOS2

    1 HMDB Compound for SOS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    6 Novoseek inferred chemical compound relationships for SOS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 69.8 3 1331063 (1), 8226729 (1)
    gtp 51.6 4 1379346 (1), 1331063 (1), 8484124 (1)
    guanine 51.5 5 7684828 (2), 7988425 (1), 7513704 (1), 9228027 (1)
    tyrosine 44.7 4 8275713 (1), 8208538 (1), 8049487 (1)
    threonine 20.8 2 8049487 (1)
    serine 5.28 1 8049487 (1)

    Search CenterWatch for drugs/clinical trials and news about SOS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOS2 gene: 
    NM_006939.2  

    Unigene Cluster for SOS2:

    Son of sevenless homolog 2 (Drosophila)
    Hs.291533  [show with all ESTs]
    Unigene Representative Sequence: NM_006939
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216373(uc010ans.3 uc001wxs.4 uc010tql.2) ENST00000543680(uc010tqm.1)
    ENST00000555794(uc001wxt.2) ENST00000556469 ENST00000555666 ENST00000556452


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    hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSOS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2
    Sirion Biotech Customized lentivirus for stable overexpression of SOS2 
                         Customized lentivirus expression plasmids for stable overexpression of SOS2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SOS2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOS2

    Additional mRNA sequence: 

    AB209277.1 AK295868.1 AK302825.1 AK308978.1 AK309123.1 BC117261.1 BC143366.1 BC143367.1 
    L13858.1 L20686.1 

    11 DOTS entries:

    DT.315010  DT.454409  DT.70104429  DT.91655622  DT.95371713  DT.415759  DT.40121137  DT.99983087 
    DT.415762  DT.97778280  DT.99947804 

    24/289 AceView cDNA sequences (see all 289):

    AI695006 BI753530 AI783684 CR601939 AI272033 BI324870 AW518885 AA374200 
    AL135612 CA447489 N51071 AA262031 AI918702 N54196 CK818831 N41721 
    BG286823 AA256588 BM542870 BX247997 AA809852 BI439841 AA291216 BQ023936 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOS2 expression in normal human tissues (normalized intensities)      SOS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTACAGT
    SOS2 Expression
    About this image


    SOS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   

    See SOS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOS2

    SOURCE GeneReport for Unigene cluster: Hs.291533
        SABiosciences Expression via Pathway-Focused PCR Arrays including SOS2: 
              Focal Adhesions in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SOS2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sos21 , 5 son of sevenless homolog 2 (Drosophila)1, 5 88.58(n)1
    95.04(a)1
      12 (28.93 cM)5
    206631  NM_001135559.11  NP_001129031.11 
     695837625 
    chicken
    (Gallus gallus)
    Aves SOS21 son of sevenless homolog 2 (Drosophila) 79.17(n)
    86.74(a)
      423572  XM_421461.3  XP_421461.3 
    lizard
    (Anolis carolinensis)
    Reptilia SOS26
    RAPGEF16
    Uncharacterized protein
    86(a)
    8(a)
    1 ↔ 1
    possible ortholog
    GL343627.1(237623-275388)
    GL343812.1(1439-4616)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328036.12   -- 74.3(n)    CD328036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sos21 son of sevenless homolog 2 (Drosophila) 67.89(n)
    74.96(a)
      561670  XM_685079.4  XP_690171.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sos6
    Son of sevenless
    37(a)
    1 → many
    2L(13813816-13819826)
    worm
    (Caenorhabditis elegans)
    Secernentea sos-16
    Protein SOS-1
    29(a)
    1 → many
    V(4517682-4549291)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC256
    Membrane bound guanine nucleotide exchange factor ...
    12(a)
    1 → many
    XII(752224-756993)


    ENSEMBL Gene Tree for SOS2 (if available)
    TreeFam Gene Tree for SOS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOS2 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  RASGRF22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL42  RGL12  
    2 SIMAP similar genes for SOS2 using alignment to 4 protein entries:     SOS2_HUMAN (see all proteins):
    SOS1    DKFZp781H1715

    SOS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2505 SNPs in SOS2 are shown (see all 2505)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381330101,2
    C,F--50585317(+) CTGAGC/ACAGTC 2 /W /C mis11Minor allele frequency- A:0.00NA 4552
    rs2017561681,2
    --50585363(+) GAAGAG/TTAAAT 2 N T mis10--------
    rs1493219831,2
    C--50585389(+) TGTTCG/TGGAGG 2 P syn10--------
    rs1136601131,2
    C,F--50585447(+) GTGGCG/AGAGGT 2 /P /L mis12Minor allele frequency- A:0.00CSA NA 4554
    rs798584751,2
    C,F--50585589(+) AGTAAT/GTAAAT 1 -- int15Minor allele frequency- G:0.13NA CSA WA EU 975
    rs1144519331,2
    --50585627(+) AAAAAA/TTTTTT 1 -- int10--------
    rs1883129311,2
    --50585849(+) GTAGGC/TAAGTG 1 -- int10--------
    rs1807315911,2
    --50585864(+) TAATTG/TATTGC 1 -- int10--------
    rs71564141,2
    C,F,A--50585865(+) AATTTA/GTTGCT 1 -- int16Minor allele frequency- G:0.29NA WA CSA EA 364
    rs792506401,2
    F--50585972(+) AGTAGA/GTCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SOS2 (50583846 - 50698276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28926CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601247    OMIM disorders: --

    20 diseases for SOS2:    About MalaCards
    noonan syndrome    chronic myeloid leukemia    myeloid leukemia    spasticity
    acute myeloid leukemia    renal cell carcinoma    hepatitis c    glioblastoma
    diabetes mellitus    leukemia    alzheimer's disease    colorectal cancer
    lung cancer    hepatitis    adenocarcinoma    prostate cancer
    prostatitis    pancreatitis    breast cancer    neuronitis


    SOS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SOS2
    Human Genome Epidemiology (HuGE) Navigator: SOS2 (2 documents)

    Export disorders for SOS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOS2 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with SOS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. (PubMed id 17440948)1, 4, 9 Hamilton G....Lovestone S. (2007)
    2. Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. (PubMed id 8276400)1, 3, 9 Webb G.C....Bowtell D.D. (1993)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    4. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (PubMed id 8493579)1, 2 Chardin P....Bar-Sagi D. (1993)
    5. Differential interactions of human Sos1 and Sos2 with Grb2. (PubMed id 7629138)1, 9 Yang S.S....Bar-Sagi D. (1995)
    6. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)
    9. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    10. The proximal signaling network of the BCR-ABL1 oncoge ne shows a modular organization. (PubMed id 20697350)1 Titz B....Graeber T.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6655 HGNC: 11188 AceView: SOS2andC14orf138 Ensembl:ENSG00000100485 euGenes: HUgn6655
    ECgene: SOS2 Kegg: 6655 H-InvDB: SOS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOS2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Son_of_Sevenless

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOS2 gene:
    Search GeneIP for patents involving SOS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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