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SOS2 Gene

protein-coding   GIFtS: 64
GCID: GC14M050583

Son Of Sevenless Homolog 2 (Drosophila)

(Previous name: son of sevenless (Drosophilia) homolog 2)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Son Of Sevenless Homolog 2 (Drosophila)1 2
SOS-22 3
Son Of Sevenless (Drosophilia) Homolog 21
Guanine Nucleotide Exchange Factor2
Guanine Nucleotide Releasing Factor2
Son Of Sevenless Homolog 22

External Ids:    HGNC: 111881   Entrez Gene: 66552   Ensembl: ENSG000001004857   OMIM: 6012475   UniProtKB: Q078903   

Export aliases for SOS2 gene to outside databases

Previous GC identifers: GC14M047905 GC14M044379 GC14M048573 GC14M048575 GC14M049654 GC14M030709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SOS2 Gene:
SOS2 (son of sevenless homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with SOS2 include noonan syndrome, and chronic myeloid leukemia. GO annotations related to this gene include protein heterodimerization activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOS2 gene promoter:
         TBP   GCNF   AREB6   MEF-2A   Nkx6-1   HSF2   GCNF-1   IRF-7A   aMEF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOS2 promoter sequence
   Search Chromatin IP Primers for SOS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21

SOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050583:  view genomic region     (about GC identifiers)

Start:
50,583,846 bp from pter      End:
50,698,276 bp from pter
Size:
114,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890 (See protein sequence)
Recommended Name: Son of sevenless homolog 2  
Size: 1332 amino acids; 152979 Da
Secondary accessions: D3DSB4 Q15503 Q17RN1

Explore the universe of human proteins at neXtProt for SOS2: NX_Q07890

Explore proteomics data for SOS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008870.2  
    ENSEMBL proteins: 
     ENSP00000216373   ENSP00000445328   ENSP00000452553  
    Reactome Protein details: Q07890

    SOS2 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for SOS2
    GenScript Custom Purified and Recombinant Proteins Services for SOS2
    Novus Biologicals SOS2 Protein
    Novus Biologicals SOS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOS2

    SOS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals SOS2 Antibodies
    Abcam antibodies for SOS2
    Cloud-Clone Corp. Antibodies for SOS2
    ThermoFisher Antibodies for SOS2
    LSBio Antibodies in human, mouse, rat for SOS2

    SOS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOS2
    Cloud-Clone Corp. CLIAs for SOS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 10):
     IPR008937 Ras_GEF
     IPR000219 DH-domain
     IPR007125 Histone_core_D
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q07890

    ProtoNet protein and cluster: Q07890

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: SOS2_HUMAN, Q07890
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GEF domain


    SOS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOS2_HUMAN, Q07890
    Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity)

         Genatlas biochemistry entry for SOS2:
    Drosophila son of sevenless homolog 2, regulator of Ras

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI14679214
    GO:0046982protein heterodimerization activity IEA--
         
    SOS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOS2:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sos2):
     normal 

    SOS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sos2tm1Esn for SOS2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOS2:
    hsa-mir-124-3p (MIRT023126), hsa-mir-335-5p (MIRT019010), hsa-mir-1 (MIRT046544)

    Block miRNA regulation of human, mouse, rat SOS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOS2 (see all 44):
    hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSOS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOS2
    Predesigned siRNA for gene silencing in human, mouse, rat SOS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOS2

    Clone
    Products:
         
    OriGene clones in human, mouse for SOS2 (see all 7)
    OriGene ORF clones in mouse, rat for SOS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    SOS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOS2 About   (see all 92)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Immune response IL 4 signaling pathway0.39
    Development IGF 1 receptor signaling0.48
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor mediated HIF regulation0.51
    Transcription PPAR Pathway0.34
    Translation Regulation activity of EIF20.47
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    5Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for SOS2 (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOS2 (see all 73)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    JNK Pathway
    ITK and TCR Signaling
    ErbB Family Pathway

    Selected GeneGo (Thomson Reuters) Pathways for SOS2 (see all 76)
        G-protein signaling H-RAS regulation pathway
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway
    Transcription PPAR Pathway

    Selected BioSystems Pathways for SOS2 (see all 6)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    Insulin Signaling
    DNA damage response (only ATM dependent)
    Regulation of Actin Cytoskeleton

    4 Reactome Pathways for SOS2
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle
    Activation of Rac


    Selected Kegg Pathways  (Kegg details for SOS2) (see all 32):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    FoxO signaling pathway


    SOS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOS2: 
              Focal Adhesions in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOS2 (Q078901, 2, 3 ENSP000002163734) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-298181,EBI-401755 MINT-1782552 MINT-1782468 I2D: score=12 STRING: ENSP00000339007
    ABL1P005191, 2, 3, ENSP000003614234EBI-298181,EBI-375543 MINT-8110779 I2D: score=5 STRING: ENSP00000361423
    PLCG1P191741, 2, 3, ENSP000002440074EBI-298181,EBI-79387 MINT-8112807 I2D: score=5 STRING: ENSP00000244007
    CRKP461081, 3, ENSP000003005744EBI-298181,EBI-886 I2D: score=2 STRING: ENSP00000300574
    NCK1P163331, 3, ENSP000002889864EBI-298181,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    SOS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOS2

    1 HMDB Compound for SOS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    6 Novoseek inferred chemical compound relationships for SOS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 69.8 3 1331063 (1), 8226729 (1)
    gtp 51.6 4 1379346 (1), 1331063 (1), 8484124 (1)
    guanine 51.5 5 7684828 (2), 7988425 (1), 7513704 (1), 9228027 (1)
    tyrosine 44.7 4 8275713 (1), 8208538 (1), 8049487 (1)
    threonine 20.8 2 8049487 (1)
    serine 5.28 1 8049487 (1)



    SOS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SOS2 gene: 
    NM_006939.2  

    Unigene Cluster for SOS2:

    Son of sevenless homolog 2 (Drosophila)
    Hs.291533  [show with all ESTs]
    Unigene Representative Sequence: NM_006939
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216373(uc010ans.3 uc001wxs.4 uc010tql.2) ENST00000543680(uc010tqm.1)
    ENST00000555794(uc001wxt.2) ENST00000556469 ENST00000555666 ENST00000556452


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOS2 (see all 44):
    hsa-miR-4291 hsa-miR-193a-3p hsa-miR-15a hsa-miR-3653 hsa-miR-301a hsa-miR-124 hsa-miR-424 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidSOS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOS2
    Clone
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    OriGene ORF clones in mouse, rat for SOS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOS2 (NM_006939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SOS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOS2
      QuantiTect SYBR Green Assays in human, mouse, rat SOS2
      QuantiFast Probe-based Assays in human, mouse, rat SOS2

    Additional mRNA sequence: 

    AB209277.1 AK295868.1 AK302825.1 AK308978.1 AK309123.1 BC117261.1 BC143366.1 BC143367.1 
    L13858.1 L20686.1 

    11 DOTS entries:

    DT.315010  DT.454409  DT.70104429  DT.91655622  DT.95371713  DT.415759  DT.40121137  DT.99983087 
    DT.415762  DT.97778280  DT.99947804 

    Selected AceView cDNA sequences (see all 289):

    N54196 AA291216 BE675872 BI758040 CA447489 BU618577 AL705140 AA374200 
    AI003776 AI783684 AL135612 AA713679 AA633530 AI918702 CR601939 N54093 
    N41721 AL135375 BG617243 BM263987 N56889 CR597030 AA256544 AI272033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTACAGT
    SOS2 Expression
    About this image


    SOS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Pancreas (Endocrine System)
    SOS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291533
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOS2: 
              Focal Adhesions in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SOS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOS2
    QuantiTect SYBR Green Assays in human, mouse, rat SOS2
    QuantiFast Probe-based Assays in human, mouse, rat SOS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SOS2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sos21 , 5 son of sevenless homolog 2 (Drosophila)1, 5 88.58(n)1
    95.04(a)1
      12 (28.93 cM)5
    206631  NM_001135559.11  NP_001129031.11 
     695837625 
    chicken
    (Gallus gallus)
    Aves SOS21 son of sevenless homolog 2 (Drosophila) 79.17(n)
    86.74(a)
      423572  XM_421461.4  XP_421461.4 
    lizard
    (Anolis carolinensis)
    Reptilia SOS26
    son of sevenless homolog 2 (Drosophila)
    86(a)
    1 ↔ 1
    GL343627.1(237623-275388)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328036.12   -- 74.3(n)    CD328036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sos21 son of sevenless homolog 2 (Drosophila) 67.68(n)
    74.5(a)
      561670  XM_685079.5  XP_690171.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sos6
    Son of sevenless
    38(a)
    1 → many
    2L(13813816-13819826)
    worm
    (Caenorhabditis elegans)
    Secernentea sos-16
    Protein SOS-1 (sos-1) mRNA, complete cds
    30(a)
    1 → many
    V(4517682-4549291) WBGene00004947
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC256
    Membrane bound guanine nucleotide exchange factor ...
    16(a)
    1 → many
    XII(752224-756993) YLR310C


    ENSEMBL Gene Tree for SOS2 (if available)
    TreeFam Gene Tree for SOS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOS2 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  RASGRF22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL12  RGL42  
    2 SIMAP similar genes for SOS2 using alignment to 4 protein entries:     SOS2_HUMAN (see all proteins):
    SOS1    DKFZp781H1715

    SOS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOS2 (see all 2505)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381330101,2
    C,F--50585317(+) CTGAGC/ACAGTC 2 /W /C mis11Minor allele frequency- A:0.00NA 4552
    rs2017561681,2
    --50585363(+) GAAGAG/TTAAAT 2 N T mis10--------
    rs1493219831,2
    C--50585389(+) TGTTCG/TGGAGG 2 P syn10--------
    rs1136601131,2
    C,F--50585447(+) GTGGCG/AGAGGT 2 /P /L mis12Minor allele frequency- A:0.00CSA NA 4554
    rs798584751,2
    C,F--50585589(+) AGTAAT/GTAAAT 1 -- int15Minor allele frequency- G:0.13NA CSA WA EU 975
    rs1144519331,2
    --50585627(+) AAAAAA/TTTTTT 1 -- int10--------
    rs1883129311,2
    --50585849(+) GTAGGC/TAAGTG 1 -- int10--------
    rs1807315911,2
    --50585864(+) TAATTG/TATTGC 1 -- int10--------
    rs71564141,2
    C,F,A--50585865(+) AATTTA/GTTGCT 1 -- int16Minor allele frequency- G:0.29NA WA CSA EA 364
    rs792506401,2
    F--50585972(+) AGTAGA/GTCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SOS2 (50583846 - 50698276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28926CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SOS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601247    OMIM disorders: --

    Selected diseases for SOS2 (see all 23):    
    About MalaCards
    noonan syndrome    chronic myeloid leukemia    glioblastoma multiforme    myeloid leukemia
    spasticity    acute myeloid leukemia    hepatitis c    renal cell carcinoma
    diabetes mellitus    leukemia    colorectal cancer    tonsillitis
    hepatitis    alzheimer's disease    prostatitis    adenocarcinoma
    lung cancer    prostate cancer    pancreatitis    breast cancer


    SOS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SOS2
    Human Genome Epidemiology (HuGE) Navigator: SOS2 (2 documents)

    Export disorders for SOS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOS2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with SOS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. (PubMed id 17440948)1, 4, 9 Hamilton G....Lovestone S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    2. Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. (PubMed id 8276400)1, 3, 9 Webb G.C....Bowtell D.D. (Genomics 1993)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    4. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (PubMed id 8493579)1, 2 Chardin P....Bar-Sagi D. (Science 1993)
    5. Differential interactions of human Sos1 and Sos2 with Grb2. (PubMed id 7629138)1, 9 Yang S.S....Bar-Sagi D. (J. Biol. Chem. 1995)
    6. A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome. (PubMed id 23761422)1 Clayton P....Olivier C. (Eur. J. Endocrinol. 2013)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6655 HGNC: 11188 AceView: SOS2andC14orf138 Ensembl:ENSG00000100485 euGenes: HUgn6655
    ECgene: SOS2 Kegg: 6655 H-InvDB: SOS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOS2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Son_of_Sevenless

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOS2 gene:
    Search GeneIP for patents involving SOS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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