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Aliases for SOS2 Gene

Aliases for SOS2 Gene

  • SOS Ras/Rho Guanine Nucleotide Exchange Factor 2 2 3 5
  • SOS-2 3 4
  • Son Of Sevenless (Drosophilia) Homolog 2 2
  • Son Of Sevenless Homolog 2 (Drosophila) 2
  • Guanine Nucleotide Releasing Factor 3
  • Guanine Nucleotide Exchange Factor 3
  • NS9 3

External Ids for SOS2 Gene

Previous GeneCards Identifiers for SOS2 Gene

  • GC14M047905
  • GC14M044379
  • GC14M048573
  • GC14M048575
  • GC14M049654
  • GC14M050583
  • GC14M030709

Summaries for SOS2 Gene

GeneCards Summary for SOS2 Gene

SOS2 (SOS Ras/Rho Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with SOS2 include Noonan Syndrome 9 and Noonan Syndrome 1. Among its related pathways are Immune response IL-23 signaling pathway and p70S6K Signaling. GO annotations related to this gene include protein heterodimerization activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for SOS2 Gene

  • Promotes the exchange of Ras-bound GDP by GTP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOS2 Gene

Genomics for SOS2 Gene

Regulatory Elements for SOS2 Gene

Enhancers for SOS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOS2 on UCSC Golden Path with GeneCards custom track

Promoters for SOS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOS2 Gene

50,117,120 bp from pter
50,231,878 bp from pter
114,759 bases
Minus strand

Genomic View for SOS2 Gene

Genes around SOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOS2 Gene

Proteins for SOS2 Gene

  • Protein details for SOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Son of sevenless homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7ZKT6
    • D3DSB4
    • Q15503
    • Q17RN1

    Protein attributes for SOS2 Gene

    1332 amino acids
    Molecular mass:
    152979 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOS2 Gene


neXtProt entry for SOS2 Gene

Proteomics data for SOS2 Gene at MOPED

Post-translational modifications for SOS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOS2 Gene

No data available for DME Specific Peptides for SOS2 Gene

Domains & Families for SOS2 Gene

Suggested Antigen Peptide Sequences for SOS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with SOS2: view

Function for SOS2 Gene

Molecular function for SOS2 Gene

GENATLAS Biochemistry:
Drosophila son of sevenless homolog 2, regulator of Ras
UniProtKB/Swiss-Prot Function:
Promotes the exchange of Ras-bound GDP by GTP.
genes like me logo Genes that share phenotypes with SOS2: view

Human Phenotype Ontology for SOS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SOS2 Gene

MGI Knock Outs for SOS2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SOS2 Gene

Localization for SOS2 Gene

Subcellular locations from

Jensen Localization Image for SOS2 Gene COMPARTMENTS Subcellular localization image for SOS2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SOS2 Gene

Pathways & Interactions for SOS2 Gene

SuperPathways for SOS2 Gene

Superpath Contained pathways
1 IL-7 Signaling Pathways
2 Translation Insulin regulation of translation
3 GPCR Pathway
4 IL-2 Pathway
5 Development Angiotensin activation of ERK
genes like me logo Genes that share pathways with SOS2: view

SIGNOR curated interactions for SOS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0051057 positive regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with SOS2: view

Drugs & Compounds for SOS2 Gene

(5) Drugs for SOS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for SOS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOS2: view

Transcripts for SOS2 Gene

Unigene Clusters for SOS2 Gene

Son of sevenless homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOS2 Gene

No ASD Table

Relevant External Links for SOS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOS2 Gene

mRNA expression in normal human tissues for SOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SOS2 Gene

This gene is overexpressed in Fetal Brain (13.6), Heart (11.4), Testis (9.6), and Spleen (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOS2 Gene

SOURCE GeneReport for Unigene cluster for SOS2 Gene Hs.291533

genes like me logo Genes that share expression patterns with SOS2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SOS2 Gene

Orthologs for SOS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOS2 35
  • 93.21 (n)
  • 95.85 (a)
SOS2 36
  • 89 (a)
(Canis familiaris)
Mammalia SOS2 35
  • 93.71 (n)
  • 97.01 (a)
SOS2 36
  • 97 (a)
(Mus musculus)
Mammalia Sos2 35
  • 88.58 (n)
  • 95.04 (a)
Sos2 16
Sos2 36
  • 95 (a)
(Pan troglodytes)
Mammalia SOS2 35
  • 99.26 (n)
  • 99.08 (a)
SOS2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sos2 35
  • 87.94 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia SOS2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SOS2 36
  • 90 (a)
(Gallus gallus)
Aves SOS2 35
  • 79.17 (n)
  • 86.74 (a)
SOS2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SOS2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sos2 35
  • 75.93 (n)
  • 84.16 (a)
(Danio rerio)
Actinopterygii sos2 35
  • 67.68 (n)
  • 74.5 (a)
sos2 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009180 35
  • 53.36 (n)
  • 53.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sos 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea sos-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for SOS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOS2 Gene

Gene Tree for SOS2 (if available)
Gene Tree for SOS2 (if available)

Paralogs for SOS2 Gene

(2) SIMAP similar genes for SOS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SOS2: view

Variants for SOS2 Gene

Sequence variations from dbSNP and Humsavar for SOS2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34139502 - 50,157,042(-) CAGAC(A/C)TTAAA reference, missense
rs17122201 - 50,159,835(+) CTGCA(C/T)TACTG reference, missense
rs8010237 - 50,159,761(+) CTTGT(A/G)CTCAC reference, missense
VAR_075686 Noonan syndrome 9 (NS9)
VAR_075687 -

Structural Variations from Database of Genomic Variants (DGV) for SOS2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545

Variation tolerance for SOS2 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOS2 Gene

Disorders for SOS2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SOS2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
noonan syndrome 9
  • ns9
noonan syndrome 1
  • noonan syndrome
malignant spindle cell melanoma
  • desmoplastic melanoma
- elite association - COSMIC cancer census association via MalaCards
Search SOS2 in MalaCards View complete list of genes associated with diseases


  • Noonan syndrome 9 (NS9) [MIM:616559]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:25795793}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SOS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SOS2: view

No data available for Genatlas for SOS2 Gene

Publications for SOS2 Gene

  1. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. (PMID: 17440948) Hamilton G. … Lovestone S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48 67
  2. Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. (PMID: 8276400) Webb G.C. … Bowtell D.D. (Genomics 1993) 2 3 23
  3. Differential interactions of human Sos1 and Sos2 with Grb2. (PMID: 7629138) Yang S.S. … Bar-Sagi D. (J. Biol. Chem. 1995) 3 23
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome. (PMID: 25795793) Yamamoto G.L. … Bertola D.R. (J. Med. Genet. 2015) 3

Products for SOS2 Gene

  • Addgene plasmids for SOS2

Sources for SOS2 Gene