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Aliases for SOS2 Gene

Aliases for SOS2 Gene

  • Son Of Sevenless Homolog 2 (Drosophila) 2 3
  • SOS-2 3 4
  • Son Of Sevenless (Drosophilia) Homolog 2 2
  • Guanine Nucleotide Releasing Factor 3
  • Guanine Nucleotide Exchange Factor 3
  • Son Of Sevenless Homolog 2 3

External Ids for SOS2 Gene

Previous GeneCards Identifiers for SOS2 Gene

  • GC14M047905
  • GC14M044379
  • GC14M048573
  • GC14M048575
  • GC14M049654
  • GC14M050583
  • GC14M030709

Summaries for SOS2 Gene

GeneCards Summary for SOS2 Gene

SOS2 (Son Of Sevenless Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for SOS2 Gene

  • Promotes the exchange of Ras-bound GDP by GTP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOS2 Gene

Genomics for SOS2 Gene

Regulatory Elements for SOS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOS2 Gene

50,117,120 bp from pter
50,231,558 bp from pter
114,439 bases
Minus strand

Genomic View for SOS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOS2 Gene

Proteins for SOS2 Gene

  • Protein details for SOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Son of sevenless homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7ZKT6
    • D3DSB4
    • Q15503
    • Q17RN1

    Protein attributes for SOS2 Gene

    1332 amino acids
    Molecular mass:
    152979 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOS2 Gene


neXtProt entry for SOS2 Gene

Proteomics data for SOS2 Gene at MOPED

Post-translational modifications for SOS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOS2 Gene

Domains for SOS2 Gene

Suggested Antigen Peptide Sequences for SOS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with SOS2: view

Function for SOS2 Gene

Molecular function for SOS2 Gene

GENATLAS Biochemistry:
Drosophila son of sevenless homolog 2, regulator of Ras
UniProtKB/Swiss-Prot Function:
Promotes the exchange of Ras-bound GDP by GTP.

Gene Ontology (GO) - Molecular Function for SOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 14679214
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SOS2: view

Phenotypes for SOS2 Gene

MGI mutant phenotypes for SOS2:
inferred from 1 alleles
GenomeRNAi human phenotypes for SOS2:
genes like me logo Genes that share phenotypes with SOS2: view

Animal Models for SOS2 Gene

MGI Knock Outs for SOS2:

Animal Model Products

miRNA for SOS2 Gene

miRTarBase miRNAs that target SOS2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SOS2 Gene

Localization for SOS2 Gene

Subcellular locations from

Jensen Localization Image for SOS2 Gene COMPARTMENTS Subcellular localization image for SOS2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SOS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOS2 Gene

Pathways for SOS2 Gene

SuperPathways for SOS2 Gene

Superpath Contained pathways
1 IL-9 Signaling Pathways
2 Translation Insulin regulation of translation
3 GPCR Pathway
4 Development Angiotensin activation of ERK
5 IL-2 Pathway
genes like me logo Genes that share pathways with SOS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SOS2: view

Drugs for SOS2 Gene

(1) HMDB Compounds for SOS2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(6) Novoseek inferred chemical compound relationships for SOS2 Gene

Compound -log(P) Hits PubMed IDs
gdp 69.8 2
gtp 51.6 3
guanine 51.5 5
tyrosine 44.7 3
threonine 20.8 1
genes like me logo Genes that share compounds with SOS2: view

Transcripts for SOS2 Gene

Unigene Clusters for SOS2 Gene

Son of sevenless homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOS2 Gene

No ASD Table

Relevant External Links for SOS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOS2 Gene

mRNA expression in normal human tissues for SOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SOS2 Gene

This gene is overexpressed in Fetal Brain (13.6), Heart (11.4), Testis (9.6), and Spleen (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOS2 Gene

SOURCE GeneReport for Unigene cluster for SOS2 Gene Hs.291533

genes like me logo Genes that share expressions with SOS2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SOS2 Gene

Orthologs for SOS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOS2 35
  • 93.21 (n)
  • 95.85 (a)
SOS2 36
  • 89 (a)
(Canis familiaris)
Mammalia SOS2 35
  • 93.71 (n)
  • 97.01 (a)
SOS2 36
  • 97 (a)
(Mus musculus)
Mammalia Sos2 35
  • 88.58 (n)
  • 95.04 (a)
Sos2 16
Sos2 36
  • 95 (a)
(Pan troglodytes)
Mammalia SOS2 35
  • 99.26 (n)
  • 99.08 (a)
SOS2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sos2 35
  • 87.94 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia SOS2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SOS2 36
  • 90 (a)
(Gallus gallus)
Aves SOS2 35
  • 79.17 (n)
  • 86.74 (a)
SOS2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SOS2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sos2 35
  • 75.93 (n)
  • 84.16 (a)
(Danio rerio)
Actinopterygii sos2 35
  • 67.68 (n)
  • 74.5 (a)
sos2 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009180 35
  • 53.36 (n)
  • 53.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sos 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea sos-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for SOS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOS2 Gene

Gene Tree for SOS2 (if available)
Gene Tree for SOS2 (if available)

Paralogs for SOS2 Gene

(2) SIMAP similar genes for SOS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SOS2: view

Variants for SOS2 Gene

Sequence variations from dbSNP and Humsavar for SOS2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs726797 -- 50,145,696(+) AAAGA(C/T)AGATG intron-variant
rs726798 -- 50,145,739(+) ATAGA(C/T)CCAAA intron-variant
rs735210 -- 50,203,343(+) AGCCC(A/G)GGCGA intron-variant
rs764350 -- 50,195,214(+) gtaac(A/G)tggtg intron-variant
rs990864 -- 50,232,831(+) CAGTA(C/T)TACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOS2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545

Relevant External Links for SOS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOS2 Gene

Disorders for SOS2 Gene

Relevant External Links for SOS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SOS2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SOS2 Gene

Publications for SOS2 Gene

  1. Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. (PMID: 8276400) Webb G.C. … Bowtell D.D. (Genomics 1993) 2 3 23
  2. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. (PMID: 17440948) Hamilton G. … Lovestone S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  3. Differential interactions of human Sos1 and Sos2 with Grb2. (PMID: 7629138) Yang S.S. … Bar-Sagi D. (J. Biol. Chem. 1995) 3 23
  4. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (PMID: 8493579) Chardin P. … Bar-Sagi D. (Science 1993) 3 4
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48

Products for SOS2 Gene

  • Addgene plasmids for SOS2

Sources for SOS2 Gene

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