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Aliases for SOS1 Gene

Aliases for SOS1 Gene

  • SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 2 3 5
  • Gingival Fibromatosis, Hereditary, 1 2 3
  • SOS-1 3 4
  • Son Of Sevenless Homolog 1 (Drosophila) 2
  • Guanine Nucleotide Exchange Factor 3
  • Son Of Sevenless Homolog 1 3
  • GINGF 3
  • GGF1 3
  • GF1 3
  • HGF 3
  • NS4 3

External Ids for SOS1 Gene

Previous HGNC Symbols for SOS1 Gene

  • GINGF

Previous GeneCards Identifiers for SOS1 Gene

  • GC02M039177
  • GC02M039359
  • GC02M039187
  • GC02M039124
  • GC02M039066
  • GC02M038947
  • GC02M039208

Summaries for SOS1 Gene

Entrez Gene Summary for SOS1 Gene

  • This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOS1 Gene

SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with SOS1 include Noonan Syndrome 4 and Fibromatosis, Gingival, 1. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include protein heterodimerization activity and SH3 domain binding. An important paralog of this gene is SOS2.

UniProtKB/Swiss-Prot for SOS1 Gene

  • Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).

Gene Wiki entry for SOS1 Gene

Additional gene information for SOS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOS1 Gene

Genomics for SOS1 Gene

Regulatory Elements for SOS1 Gene

Enhancers for SOS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H039215 1.5 FANTOM5 Ensembl ENCODE 35.2 -92.5 -92526 2 HDAC1 FOXA2 ARNT RARA GATA2 SIRT6 RUNX3 CREM ZC3H11A ZNF518A SOS1 ARHGEF33 ENSG00000202309 ENSG00000252473 MORN2 DHX57 CDKL4 GC02M039185
GH02H038749 1.4 ENCODE dbSUPER 35.6 +373.8 373785 3 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 SRSF7 SOS1 HNRNPLL DHX57 TTC39DP ENSG00000225284 LINC01883 ARHGEF33 GALM ASS1P2
GH02H039467 1.6 Ensembl ENCODE dbSUPER 30.4 -344.4 -344429 3 PKNOX1 ATF1 FOXA2 MLX ZNF133 ARID4B DMAP1 ZNF766 FOS CAVIN1 THUMPD2 SOS1 SRSF7 MAP4K3 DHX57 ENSG00000252473 LOC728730 TMEM178A PIR40288
GH02H039150 1.1 dbSUPER 41.4 -31.8 -31766 12 FOXA2 MLX ARNT ARID4B YY1 SLC30A9 ZNF766 SP5 ZHX2 ZNF592 SOS1 SRSF7 THUMPD2 ENSG00000202309 MAP4K3 ENSG00000252473 GC02M039185 GC02M039129
GH02H038540 1.6 FANTOM5 Ensembl ENCODE 17.5 +582.3 582304 3 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 CBX5 PAF1 SRSF7 SOS1 DHX57 ENSG00000235586 HNRNPLL ENSG00000232518 GALM MAP4K3 ENSG00000252473 CYP1B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOS1 on UCSC Golden Path with GeneCards custom track

Promoters for SOS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000290548 244 1401 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for SOS1 Gene

Chromosome:
2
Start:
38,981,396 bp from pter
End:
39,124,744 bp from pter
Size:
143,349 bases
Orientation:
Minus strand

Genomic View for SOS1 Gene

Genes around SOS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOS1 Gene

Proteins for SOS1 Gene

  • Protein details for SOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07889-SOS1_HUMAN
    Recommended name:
    Son of sevenless homolog 1
    Protein Accession:
    Q07889
    Secondary Accessions:
    • A8K2G3
    • B4DXG2

    Protein attributes for SOS1 Gene

    Size:
    1333 amino acids
    Molecular mass:
    152464 Da
    Quaternary structure:
    • Interacts (via C-terminus) with GRB2 (via SH3 domain) (PubMed:8493579, PubMed:7664271). Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains) (PubMed:7664271). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with NCK1 and NCK2 (PubMed:10026169). Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity). Interacts (Ser-1134 and Ser-1161 phosphorylated form) with YWHAB and YWHAE (PubMed:22827337).

    Three dimensional structures from OCA and Proteopedia for SOS1 Gene

    Alternative splice isoforms for SOS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOS1 Gene

Post-translational modifications for SOS1 Gene

  • Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SOS1 Gene

Domains & Families for SOS1 Gene

Gene Families for SOS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOS1: view

No data available for UniProtKB/Swiss-Prot for SOS1 Gene

Function for SOS1 Gene

Molecular function for SOS1 Gene

GENATLAS Biochemistry:
Drosophila son of sevenless homolog 1, regulator of Ras
UniProtKB/Swiss-Prot Function:
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).

Phenotypes From GWAS Catalog for SOS1 Gene

Gene Ontology (GO) - Molecular Function for SOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005096 GTPase activator activity TAS 9790532
genes like me logo Genes that share ontologies with SOS1: view
genes like me logo Genes that share phenotypes with SOS1: view

Human Phenotype Ontology for SOS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SOS1 Gene

MGI Knock Outs for SOS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOS1
  • Applied Biological Materials Clones for SOS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SOS1 Gene

Localization for SOS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOS1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 17515907
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with SOS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOS1 Gene

Pathways & Interactions for SOS1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Regulation of lipid metabolism Insulin signaling-generic cascades
4 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
5 Endometrial cancer
.52
genes like me logo Genes that share pathways with SOS1: view

Pathways by source for SOS1 Gene

SIGNOR curated interactions for SOS1 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001782 B cell homeostasis IEA --
GO:0001942 hair follicle development IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0003007 heart morphogenesis IEA --
genes like me logo Genes that share ontologies with SOS1: view

Drugs & Compounds for SOS1 Gene

(4) Drugs for SOS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for SOS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOS1: view

Transcripts for SOS1 Gene

Unigene Clusters for SOS1 Gene

Son of sevenless homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOS1
  • Applied Biological Materials Clones for SOS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SOS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23a · 23b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SOS1 Gene

GeneLoc Exon Structure for
SOS1
ECgene alternative splicing isoforms for
SOS1

Expression for SOS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SOS1 Gene

This gene is overexpressed in Plasma (26.4) and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOS1 Gene



Protein tissue co-expression partners for SOS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOS1 Gene:

SOS1

SOURCE GeneReport for Unigene cluster for SOS1 Gene:

Hs.709893

mRNA Expression by UniProt/SwissProt for SOS1 Gene:

Q07889-SOS1_HUMAN
Tissue specificity: Expressed in gingival tissues.

Evidence on tissue expression from TISSUES for SOS1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Blood(2.3)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SOS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tooth
Thorax:
  • aorta
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • liver
  • spleen
Pelvis:
  • pelvis
  • placenta
  • testicle
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • lymph node
  • lymph vessel
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with SOS1: view

Primer Products

No data available for mRNA differential expression in normal tissues for SOS1 Gene

Orthologs for SOS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOS1 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia SOS1 33 34
  • 96.07 (n)
oppossum
(Monodelphis domestica)
Mammalia SOS1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOS1 33 34
  • 95.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SOS1 34
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sos1 33
  • 91.5 (n)
mouse
(Mus musculus)
Mammalia Sos1 33 16 34
  • 91.1 (n)
chicken
(Gallus gallus)
Aves SOS1 34 33
  • 83.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOS1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sos1 33
  • 78.97 (n)
zebrafish
(Danio rerio)
Actinopterygii SOS1 (2 of 2) 34
  • 87 (a)
OneToMany
sos1 34
  • 83 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5679 33
fruit fly
(Drosophila melanogaster)
Insecta Sos 35 33 34
  • 52.73 (n)
worm
(Caenorhabditis elegans)
Secernentea sos-1 35 33 34
  • 48.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
Species where no ortholog for SOS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOS1 Gene

ENSEMBL:
Gene Tree for SOS1 (if available)
TreeFam:
Gene Tree for SOS1 (if available)

Paralogs for SOS1 Gene

(2) SIMAP similar genes for SOS1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SOS1: view

Variants for SOS1 Gene

Sequence variations from dbSNP and Humsavar for SOS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs137852812 Pathogenic, Noonan syndrome 4 (NS4) [MIM:610733] 39,051,211(-) AGATA(A/C)AGTAG reference, missense
rs137852813 Pathogenic, Noonan syndrome 4 (NS4) [MIM:610733], Noonan syndrome 4 (NS4) [MIM:610733] 39,051,202(-) AGAAA(C/G/T)GACAG reference, missense
rs137852814 Pathogenic, Noonan syndrome 4 (NS4) [MIM:610733] 39,022,774(-) TGGAA(A/G/T)GGATG reference, missense
rs142094234 Noonan syndrome 4 (NS4) [MIM:610733] 39,051,253(+) CATGT(A/G)TATCT reference, missense
rs267607079 Pathogenic, Noonan syndrome 4 (NS4) [MIM:610733] 39,022,772(-) GAAAG(C/G/T)ATGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SOS1 Gene

Variant ID Type Subtype PubMed ID
dgv6792n54 CNV gain 21841781
esv1269226 CNV insertion 17803354
esv1618069 CNV insertion 17803354
esv2552919 CNV insertion 19546169
esv3394965 CNV insertion 20981092
esv3555311 CNV deletion 23714750
esv3590425 CNV loss 21293372
nsv1071989 CNV deletion 25765185
nsv581495 CNV gain 21841781

Variation tolerance for SOS1 Gene

Residual Variation Intolerance Score: 2.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOS1 Gene

Human Gene Mutation Database (HGMD)
SOS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOS1 Gene

Disorders for SOS1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for SOS1 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
noonan syndrome 4
  • ns4
fibromatosis, gingival, 1
  • hereditary gingival fibromatosis
gingival fibromatosis
  • hereditary gingival fibromatosis
noonan syndrome 1
  • ns1
sos1-related noonan syndrome
  • noonan syndrome 4
- elite association - COSMIC cancer census association via MalaCards
Search SOS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SOS1_HUMAN
  • Gingival fibromatosis 1 (GGF1) [MIM:135300]: Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. {ECO:0000269 PubMed:11868160}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Noonan syndrome 4 (NS4) [MIM:610733]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS4 have polyarticular villonodular synovitis. {ECO:0000269 PubMed:17143282, ECO:0000269 PubMed:17143285, ECO:0000269 PubMed:19020799, ECO:0000269 PubMed:19438935, ECO:0000269 PubMed:19953625, ECO:0000269 PubMed:20673819, ECO:0000269 PubMed:20683980, ECO:0000269 PubMed:21387466}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SOS1

Genetic Association Database (GAD)
SOS1
Human Genome Epidemiology (HuGE) Navigator
SOS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOS1
genes like me logo Genes that share disorders with SOS1: view

No data available for Genatlas for SOS1 Gene

Publications for SOS1 Gene

  1. Effects of germline mutations in the Ras/MAPK signaling pathway on adaptive behavior: cardiofaciocutaneous syndrome and Noonan syndrome. (PMID: 20186801) Pierpont EI … Seidenberg MS (American journal of medical genetics. Part A 2010) 3 22 45 60
  2. Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. (PMID: 19953625) Denayer E … Legius E (Genes, chromosomes & cancer 2010) 3 4 22 60
  3. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. (PMID: 19206169) Sarkozy A … Tartaglia M (Human mutation 2009) 3 22 45 60
  4. Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade. (PMID: 19133693) Cesarini L … Zampino G (American journal of medical genetics. Part A 2009) 3 22 45 60
  5. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PMID: 19020799) Ko JM … Yoo HW (Journal of human genetics 2008) 3 4 45 60

Products for SOS1 Gene

  • Addgene plasmids for SOS1

Sources for SOS1 Gene

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