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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SORL1 Gene

protein-coding GIFtS: 59
GCID: GC11P121356

sortilin-related receptor, L(DLR class) A repeats containing

(Previous names: chromosome 11 open reading frame 32, sortilin-related receptor,...)
(Previous symbol: C11orf32)

Explore 17 diseases affiliated with
SORL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sortilin-Related Receptor, L(DLR Class) A Repeats Containing¹ ²		Low-Density Lipoprotein Receptor Relative With 11 Ligand-Binding Repeats² ³
LR11¹ ² ³ ⁵		Sorting Protein-Related Receptor Containing LDLR Class A Repeats² ³
C11orf32¹ ² ³		LDLR Relative With 11 Ligand-Binding Repeats² ³
SorLA-1¹ ² ³		SORLA² ⁵
LRP9¹ ²		Chromosome 11 Open Reading Frame 32¹
Gp250¹		Mosaic Protein LR11²
Sortilin-Related Receptor, L(DLR Class) A Repeats-Containing¹ ²		Sortilin-Related Receptor²
SorLA¹ ³

External Ids:	HGNC: 11185¹	Entrez Gene: 6653²	Ensembl: ENSG00000137642⁷	OMIM: 602005⁵	UniProtKB: Q92673³

Export aliases for SORL1 gene to outside databases

Previous GC identifers: GC11P123323 GC11P122835 GC11P120860 GC11P120828 GC11P117266

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SORL1:

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10)

domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also

contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a

preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of

this locus and Alzheimer's Disease.(provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SORL_HUMAN, Q92673

Function: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and

of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by

endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SORL1 gene promoter:
COUP-TF1 GATA-3 COUP CUTL1 HNF-4alpha2 HNF-4alpha1 COUP-TF POU2F1 POU2F1a HSF2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SORL1 promoter sequence

Search SABiosciences Chromatin IP Primers for SORL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SORL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2-q24.2 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q23.2-q24.4

SORL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SORL1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P121356: view genomic region (about GC identifiers)

Start:	121,322,912 bp from pter	End:	121,504,471 bp from pter
Size:	181,560 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SORL_HUMAN, Q92673 (See protein sequence)

Recommended Name: Sortilin-related receptor precursor

Size: 2214 amino acids; 248426 Da

Subunit: Interacts with GGA1 and ROCK2

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Miscellaneous: Genetic variations in SORL1 may be associated with increased risk for late onset Alzheimer disease in

some populations

3 PDB 3D structures from and Proteopedia for SORL1:

2DM4 (3D)

3G2S (3D)

3G2T (3D)

Secondary accessions: B2RNX7 Q92856

Explore the universe of human proteins at neXtProt for SORL1: NX_Q92673

Post-translational modifications:

The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92673

SORL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003096.1

ENSEMBL proteins:

ENSP00000260197 ENSP00000434634 ENSP00000432131 ENSP00000436447 ENSP00000435405

Human Recombinant Protein Products for SORL1:

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	Uscn Proteins for SORL1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9157966
GO:0034362	low-density lipoprotein particle	IEA	--

SORL1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SORL1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002172 LDrepeatLR_classA_rpt

IPR000033 LDLR_classB_rpt

IPR023415 LDLR_class-A_CS

IPR000742 EG-like_dom

IPR003961 Fibronectin_type3

Graphical View of Domain Structure for InterPro Entry Q92673

ProtoNet protein and cluster: Q92673

5 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB002172 Low density lipoprotein-receptor

IPB003962 Fibronectin type III repeat signature

IPB006210 Type I EGF

IPB006581 VPS10

UniProtKB/Swiss-Prot: SORL_HUMAN, Q92673

Similarity: Belongs to the VPS10-related sortilin family. SORL1 subfamily

Similarity: Contains 5 BNR repeats

Similarity: Contains 1 EGF-like domain

Similarity: Contains 6 fibronectin type-III domains

Similarity: Contains 11 LDL-receptor class A domains

Similarity: Contains 5 LDL-receptor class B repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SORL_HUMAN, Q92673

Function: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and

of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by

endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	9157966
GO:0005515	protein binding	--	--
GO:0030169	low-density lipoprotein particle binding	IPI	17326667

SORL1 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sorl1):

cardiovascular system

homeostasis/metabolism

muscle

nervous system

other

SORL1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SORL1: Sorl1^tm1Bujo Sorl1^tm1Tew

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SORL1

miRNA Products:		OriGene 3'-UTR Clone: SORL1 Browse MicroRNA Expression Plasmids
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		hsa-miR-3130-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-519a hsa-miR-550a*

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SORL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/11 Interacting proteins for SORL1 (Q92673^{2, 3} ENSP00000260197⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GGA1	Q9UJY5²^,³, ENSP00000341344⁴	MINT-19063 MINT-19062 I2D: score=3 STRING: ENSP00000341344
GGA2	Q9UJY4²^,³, ENSP00000311962⁴	MINT-18468 MINT-18467 I2D: score=5 STRING: ENSP00000311962
FURIN	P09958³, ENSP00000268171⁴	I2D: score=2 STRING: ENSP00000268171
LRPAP1	P30533³	I2D: score=3
AMBRA1	Q9C0C7³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	IEA	--
GO:0006898	receptor-mediated endocytosis	TAS	9157966
GO:0008203	cholesterol metabolic process	IEA	--

SORL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SORL1
Search CenterWatch for drugs/clinical trials and news about SORL1 / SORL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SORL1 gene:

NM_003105.5

Unigene Cluster for SORL1:

Sortilin-related receptor, L(DLR class) A repeats containing

Hs.368592 [show with all ESTs]

Unigene Representative Sequence: NM_003105

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260197(uc001pxx.3 uc010rzp.1 uc010rzq.1) ENST00000532451

ENST00000529445 ENST00000524873 ENST00000525532 ENST00000532694 ENST00000534286

ENST00000527934 ENST00000528339 ENST00000534754 ENST00000524633 ENST00000527649

ENST00000530365

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		8/110 QIAGEN miScript miRNA Assays for microRNAs that regulate SORL1 (see all 110):
		hsa-miR-3130-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-519a hsa-miR-550a*

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		GenScript: all cDNA clones in your preferred vector: SORL1 (NM_003105)
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Additional cDNA sequence:

AK025583.1 AK096577.1 AK294404.1 AK295090.1 AK295878.1 AK302589.1 AK309523.1 AK316340.1

BC032903.1 BC040643.1 BC137171.1 U90916.1 Y08110.1

19 DOTS entries:

DT.95281400 DT.448402 DT.120698385 DT.95292130 DT.100653151 DT.203374 DT.116365 DT.99929646

DT.116364 DT.86850337 DT.91803724 DT.95261263 DT.95348862 DT.96086283 DT.102826206 DT.433650

DT.75133869 DT.92456699 DT.95370897

24/370 AceView cDNA sequences (see all 370):

BE858100 AI274126 BM929865 CD367677 AI377801 BF477344 AI919227 BQ001749

AI474852 BX497864 BG291539 BM970531 BX115748 AI359183 BQ893663 CB164043

H88651 AI146573 BQ613904 AV652701 N46668 T25741 BM978097 AW337784

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SORL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCTGGAG

About this image

SORL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

See SORL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SORL1

SOURCE GeneReport for Unigene cluster: Hs.368592

UniProtKB/Swiss-Prot: SORL_HUMAN, Q92673

Tissue specificity: Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the

occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord,

testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146,

expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone

marrow and adrenals

SABiosciences Expression via Pathway-Focused PCR Array including SORL1:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SORL1 gene from 3/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SORL1¹	sortilin-related receptor, L(DLR class) A repeats containing	75.79(n) 79.84(a)		395998 XM_001232945.2 XP_001232946.2
zebrafish (Danio rerio)	Actinopterygii	im:7135957¹	im:7135957	65.33(n) 65.56(a)		497306 XM_003200038.1 XP_003200086.1
fruit fly (Drosophila melanogaster)	Insecta	LpR1⁶ LpR2⁶	Lipophorin receptor 2	18(a) 18(a)	1 ↔ many 1 ↔ many	3R(21567070-21588827) 3R(21524488-21566187)

ENSEMBL Gene Tree for SORL1 (if available)
TreeFam Gene Tree for SORL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SORL1 gene

LRP5² LRP6² LRP2² LRP1B² EGF² LDLR² LRP5L² LRP4²

VLDLR² NID2² NID1² LRP8² LRP1²

4 SIMAP similar genes for SORL1 using alignment to 6 protein entries: SORL_HUMAN (see all proteins):

SORCS3 LRP5L VLDLR LRP1B

SORL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74687267^1,2	C	--	117265239(+)	`ATGGCG/AGAAGT`	1	--	us2k¹		1		WA	2
rs35972846^1,2	C,F,H	--	117266451(+)	`CTGCGG/TCTGTG`	2	R	syn¹		5		NS NA	520
rs60750170^1,2	C	--	117268589(+)	`TTGCTG/CTGAGG`	1	--	int¹		1		WA	2
rs75412516^1,2	F	--	117268998(+)	`ATGGTG/AATGTT`	1	--	int¹		1		NA	120
rs78726537^1,2		--	117269144(+)	`GTACCA/GGGATG`	1	--	int¹		1		EA	120
rs59806718^1,2	C	--	117269226(+)	`GCAGCG/ACATGG`	1	--	int¹		2		WA	120
rs112947652^1,2		--	117269858(+)	`TTGAAC/TCCCGG`	1	--	int¹		1		CSA	2
rs12270557^1,2	C,F	--	117271012(+)	`NNNNAA/GTAAGG`	1	--	int¹		4		WA CSA NA	242
rs74317692^1,2		--	117271147(+)	`GCTTTA/GCGAGG`	1	--	int¹		0	--	--	--	--
rs75410275^1,2		--	117271417(+)	`TTGGAA/GACTTG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for SORL1 (121322912 - 121504471 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for SORL1
     6 CNVs: 101359 30568 2958 9673 8699 71388
     1 Indel: 71389
     1 Inversion: 37115
Human Gene Mutation Database (HGMD): SORL1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SORL1 for disorders           About GeneDecksing

OMIM gene information: 602005
OMIM disorders: 104300
17 diseases for SORL1:    About MalaCards

alzheimer's disease alzheimer disease, pathogenesis, association with frontotemporal dementia mantle cell lymphoma

neurodegenerative disease alzheimer disease familial down syndrome dementia

amyloidosis parkinson's disease atherosclerosis hypertension

cerebritis cholesterol thyroiditis prostatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for SORL1:

Alzheimer's disease

5 Novoseek disease relationships for SORL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	66.9	25	19889229 (2), 19584446 (2), 19822782 (2), 18685254 (2) (see all 17)
senile plaques	48.2	2	19364929 (1), 16174740 (1)
neurodegenerative diseases	45.2	1	16407538 (1)
atherosclerosis	23.5	4	11425040 (2), 11557679 (1), 19661140 (1)
atherosclerotic plaque	20.6	1	11557679 (1)

Human Genome Epidemiology (HuGE) Navigator: SORL1 (38 documents)

Export disorders for SORL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SORL1 gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with SORL1)

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world of online information

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. (PubMed id 8940146)^{1, 2, 3, 9} Jacobsen L.... Petersen C.M. (1996)
A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens. (PubMed id 9157966)^{1, 2, 3, 9} Morwald S.... Saito Y. (1997)
Rho kinase II phosphorylation of the lipoprotein rece ptor LR11/SORLA alters amyloid-beta production. (PubMed id 21147781)^{1, 2} Herskowitz J.H....Lah J.J. (2011)
GGA autoinhibition revisited. (PubMed id 20015111)^{1, 2} Cramer J.F....Thirup S.S. (2010)
No association of SORL1 SNPs with Alzheimer's disease. (PubMed id 18562096)^{1, 2} Minster R.L.... Kamboh M.I. (2008)
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. (PubMed id 18407551)^{1, 2} Bettens K....Sleegers K. (2008)
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. (PubMed id 16407538)^{1, 9} Spoelgen R....Hyman B.T. (2006)
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. (PubMed id 19889229)^{1, 9} Grear K.E....Estus S. (2009)
Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain. (PubMed id 10375696)^{1, 9} Motoi Y....Ikeda K. (1999)
Implication of sex and SORL1 variants in italian pati ents with Alzheimer disease. (PubMed id 19822782)^{1, 9} Cellini E....Nacmias B. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6653	HGNC: 11185	AceView: SORL1	Ensembl:ENSG00000137642	euGenes: HUgn6653
ECgene: SORL1	H-InvDB: SORL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SORL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SORL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SORL1 gene:
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