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SORCS3 Gene

protein-coding   GIFtS: 55
GCID: GC10P106390

Sortilin-Related VPS10 Domain Containing Receptor 3

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Sortilin-Related VPS10 Domain Containing Receptor 31 2
KIAA10593 5
6330404A12Rik2
SORCS2
VPS10 Domain Receptor Protein SORCS 3 (SORCS3)2
VPS10 Domain-Containing Receptor SorCS32

External Ids:    HGNC: 166991   Entrez Gene: 229862   Ensembl: ENSG000001563957   OMIM: 6062855   UniProtKB: Q9UPU33   

Export aliases for SORCS3 gene to outside databases

Previous GC identifiers: GC10P105294 GC10P105634 GC10P106532 GC10P106065 GC10P100032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for SORCS3 Gene:
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins.
The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this
gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns
typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized
introns. These genes are strongly expressed in the central nervous system. Two of the five family members
(sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded
protein is also a preproprotein. (provided by RefSeq, Jul 2008)

GeneCards Summary for SORCS3 Gene:
SORCS3 (sortilin-related VPS10 domain containing receptor 3) is a protein-coding gene. GO annotations related to this gene include neuropeptide receptor activity. An important paralog of this gene is SORCS1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:
   Regulatory transcription factor binding sites in the SORCS3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2gamma   AP-2beta   AP-2alpha isoform 4   AP-2alpha   Zic3   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SORCS3 promoter sequence
   Search Chromatin IP Primers for SORCS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SORCS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q25   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q23-q25

SORCS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SORCS3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106390:  view genomic region     (about GC identifiers)

Start:
106,400,859 bp from pter      End:
107,024,993 bp from pter
Size:
624,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3 (See protein sequence)
Recommended Name: VPS10 domain-containing receptor SorCS3 precursor  
Size: 1222 amino acids; 135755 Da
Secondary accessions: Q5VXF9 Q9NQJ2

Explore the universe of human proteins at neXtProt for SORCS3: NX_Q9UPU3

Explore proteomics data for SORCS3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn207, Asn456, Asn789, Asn800, Asn840, Asn932, Asn953, Asn1065
  • Modification sites at PhosphoSitePlus

  • See SORCS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055793.1  
    ENSEMBL proteins: 
     ENSP00000358715   ENSP00000376876   ENSP00000358713  

    SORCS3 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for SORCS3
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    Novus Biologicals SORCS3 Protein
    Novus Biologicals SORCS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SORCS3

     
    Search eBioscience for Proteins for SORCS3 

     
    Search GeneTex for Proteins for SORCS3 

     
    antibodies-online proteins for SORCS3 (2 products) 

     
    Search antibodies-online for peptides for SORCS3

    SORCS3 Antibody Products:

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    ThermoFisher Antibodies for SORCS3

     
    Search GeneTex for Antibodies for SORCS3 
    antibodies-online antibodies for SORCS3 (20 products) 

    SORCS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SORCS3
    Cloud-Clone Corp. CLIAs for SORCS3
    Search eBioscience for ELISAs for SORCS3 
    antibodies-online kits for SORCS3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    2 InterPro protein domains:
     IPR000601 PKD_dom
     IPR006581 VPS10

    Graphical View of Domain Structure for InterPro Entry Q9UPU3

    ProtoNet protein and cluster: Q9UPU3

    2 Blocks protein domains:
    IPB000601 PKD
    IPB006581 VPS10


    UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3
    Similarity: Belongs to the VPS10-related sortilin family. SORCS subfamily
    Similarity: Contains 6 BNR repeats
    Similarity: Contains 1 PKD domain


    Find genes that share domains with SORCS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008188neuropeptide receptor activity NAS11499680
         
    Find genes that share ontologies with SORCS3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SORCS3:
     Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SORCS3

        Search Taconic Biosciences for animal models for SORCS3 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for SORCS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SORCS3:
    hsa-mir-335-5p (MIRT017921), hsa-mir-26b-5p (MIRT029554)

    Block miRNA regulation of human, mouse, rat SORCS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SORCS3 (see all 51):
    hsa-miR-607 hsa-miR-4272 hsa-miR-25 hsa-miR-632 hsa-miR-346 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSORCS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SORCS3
    Predesigned siRNA for gene silencing in human, mouse, rat SORCS3

    Clone
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    GenScript: all cDNA clones in your preferred vector: SORCS3 (NM_014978)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SORCS3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SORCS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORCS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    SORC3_HUMAN, Q9UPU3: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endosome2
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane NAS11499680
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SORCS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section






    SuperPaths for SORCS3 About    
    See pathways by source

          Powered
    by
         
    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NFG and proNGF binds to p75NTR0.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58



        Pathway & Disease-focused RT2 Profiler PCR Array including SORCS3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SORCS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SORCS3 (Q9UPU32, 3 ENSP000003587154) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFP011382, 3, ENSP000003585254MINT-56552 MINT-56551 MINT-56550 I2D: score=2 STRING: ENSP00000358525
    NGFRENSP000001722294STRING: ENSP00000172229
    VPS35ENSP000002991384STRING: ENSP00000299138
    VPS26AENSP000002635594STRING: ENSP00000263559
    VPS26BENSP000002811874STRING: ENSP00000281187
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007218neuropeptide signaling pathway NAS11499680

    Find genes that share ontologies with SORCS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SORCS3 (SORC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for SORCS3 gene: 
    NM_014978.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369701(uc001kyi.1) ENST00000393176 ENST00000369699(uc010qqz.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SORCS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SORCS3 (see all 51):
    hsa-miR-607 hsa-miR-4272 hsa-miR-25 hsa-miR-632 hsa-miR-346 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSORCS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SORCS3
    Predesigned siRNA for gene silencing in human, mouse, rat SORCS3
    Clone
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    OriGene clones in human, mouse for SORCS3 (see all 6)
    OriGene ORF clones in mouse, rat for SORCS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SORCS3 (NM_014978)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SORCS3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SORCS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SORCS3
      QuantiTect SYBR Green Assays in human, mouse, rat SORCS3
      QuantiFast Probe-based Assays in human, mouse, rat SORCS3

    16 AceView cDNA sequences:

    CD626462 NM_014978 AB028982 CD626458 CD626464 CD626468 BC045754 CD626470 
    CD626459 BX509712 AW452734 CD626465 BF967389 BG714353 BF090119 CD246034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SORCS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCATATCT
    SORCS3 Expression
    About this image


    SORCS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Testis (Reproductive System)
    SORCS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SORCS3 Protein Expression

    UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3
    Tissue specificity: Highly expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including SORCS3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SORCS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SORCS3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORCS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SORCS3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sorcs31 , 5 sortilin-related VPS10 domain containing receptor 31, 5 88.35(n)1
    92.62(a)1
      19 (41.32 cM)5
    666731  NM_025696.31  NP_079972.11 
     482060255 
    chicken
    (Gallus gallus)
    Aves SORCS31 sortilin-related VPS10 domain containing receptor 3 75.12(n)
    80.03(a)
      423884  XM_004942271.1  XP_004942328.1 
    lizard
    (Anolis carolinensis)
    Reptilia SORCS36
    sortilin-related VPS10 domain containing receptor ...
    81(a)
    1 ↔ 1
    3(42499178-42656986)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004983331 VPS10 domain-containing receptor SorCS3-like 73.59(n)
    76.94(a)
      100498333  XM_002942142.2  XP_002942188.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sorcs31 sortilin-related VPS10 domain containing receptor 3 66.7(n)
    67.16(a)
      100534837  XM_003197716.2  XP_003197764.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    --
    (see all 8)
    Putative protein of unknown function
    (see all 8)
    18(a)
    18(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    III(300832-301299) YCR099C
    III(301271-302221) YCR100C


    ENSEMBL Gene Tree for SORCS3 (if available)
    TreeFam Gene Tree for SORCS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for SORCS3 gene
    SORCS12  SORL12  SORCS22  SORT12  
    3 SIMAP similar genes for SORCS3 using alignment to 5 protein entries:     SORC3_HUMAN (see all proteins):
    SORCS1    SORCS2    SORL1

    Find genes that share paralogs with SORCS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for SORCS3 (see all 11911)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70911691,2
    C,F,Auntested1106687551(+) GAATCA/G/TCTTGA 1 -- int15NA WA CSA 10
    rs675127271,2
    C--100043490(-) TTAAA-/ACACACA 1 -- int11Minor allele frequency- AC:0.00NA 2
    rs678041601,2
    C--100402207(-) TGGGG-/T/TT  
     T
    /TTTTT
    TTTTT
    1 -- int11NA 2
    rs16700111,2
    C,A--100469967(-) TCCCtC/Gtgtgt 1 -- int10--------
    rs3720942771,2
    C--100469968(+) acaca-/CACA  
      CACAGA
    GGGAT
    1 -- int11Minor allele frequency- CACACACAGA:0.00NA 2
    rs1391005001,2
    --106398892(+) TTGGAA/CACCCA 1 -- us2k10--------
    rs728116901,2
    C,F--106398930(+) GCCGGA/CCGTTG 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1881162641,2
    C--106399023(+) CGGGGA/GCTCTC 1 -- us2k10--------
    rs1167219481,2
    F--106399048(+) GTCTTC/TTTCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1440766671,2
    --106399098(+) CATCCC/GTCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SORCS3 (106400859 - 106650859 bp, first 250kb of SORCS3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SORCS3 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662027CNV Deletion23128226
    esv1433381CNV Deletion17803354
    esv2740395CNV Deletion23290073
    dgv168e199CNV Deletion23128226
    esv995155CNV Deletion20482838
    esv2740406CNV Deletion23290073
    esv272563CNV Insertion20981092
    esv270102CNV Insertion20981092
    esv271813CNV Insertion20981092
    nsv7537CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SORCS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 606285    OMIM disorders: --


    Find genes that share disorders with SORCS3           About GenesLikeMe

    Genetic Association Database (GAD): SORCS3
    Human Genome Epidemiology (HuGE) Navigator: SORCS3 (2 documents)

    Export disorders for SORCS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for SORCS3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SORCS3)

    1. The genes for the human VPS10 domain-containing receptors are large and contain many small exons. (PubMed id 11499680)1, 2, 3 Hampe W.... Schaller H.C. (Hum. Genet. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    9. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    10. SorCS3 does not require propeptide cleavage to bind nerve growth factor. (PubMed id 15710408)1 Westergaard U.B....Madsen P. (FEBS Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22986 HGNC: 16699 AceView: SORCS3 Ensembl:ENSG00000156395 euGenes: HUgn22986
    ECgene: SORCS3 H-InvDB: SORCS3

    (According to HUGE)
    About This Section
    HUGE: KIAA1059

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SORCS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SORCS3 gene:
    Search GeneIP for patents involving SORCS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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