SORCS3 Gene
protein-coding GIFtS: 55
GCID: GC10P106390
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|
sortilin-related VPS10 domain containing receptor 3
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Aliases
for SORCS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sortilin-Related VPS10 Domain Containing Receptor 31 2 | | KIAA10591 3 5 | | SORCS1 2 | | 6330404A12Rik2 | | VPS10 Domain Receptor Protein SORCS 3 (SORCS3)2 | | VPS10 Domain-Containing Receptor SorCS32 |
Export aliases for SORCS3 gene to outside databasesPrevious GC identifers: GC10P105294 GC10P105634 GC10P106532 GC10P106065 GC10P100032 |
Summaries
for SORCS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SORCS3:
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. TheVPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene familyare large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate theexons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes arestrongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-relatedreceptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein.(provided by RefSeq, Jul 2008)
|
Genomic Views
for SORCS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SORCS3 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2gamma AP-2beta AP-2alpha isoform 4 AP-2alpha Zic3 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for SORCS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SORCS3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23-q25 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q23-q25SORCS3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P106390: view genomic region
(about GC identifiers)
Start:
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106,400,859 bp from pter |
End:
|
107,024,993 bp from pter |
Size:
|
624,135 bases |
Orientation:
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plus strand |
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Proteins
for SORCS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3 (See
protein sequence)Recommended Name: VPS10 domain-containing receptor SorCS3 precursor Size: 1222 amino acids; 135755 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q5VXF9 Q9NQJ2Explore the universe of human proteins at neXtProt for SORCS3: NX_Q9UPU3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPU3
SORCS3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055793.1
ENSEMBL proteins: ENSP00000358715 ENSP00000376876 ENSP00000358713
Human Recombinant Protein Products for SORCS3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SORCS3 for ontologies About GeneDecksing
SORCS3 Antibody Products:
Assay Products for SORCS3: |
Protein
Domains /
Families
for SORCS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SORCS3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UPU3ProtoNet protein and cluster: Q9UPU3 2 Blocks protein families: IPB000601 PKD IPB006581 VPS10
UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3Similarity: Belongs to the VPS10-related sortilin family. SORCS subfamilySimilarity: Contains 6 BNR repeatsSimilarity: Contains 1 PKD domain |
Function
for SORCS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SORCS3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SORCS3:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SORCS3 (NM_014978) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SORCS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SORCS3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORCS3 |
|
Pathways & Interactions
for SORCS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | Signaling by FGFR | | | 4 | Ceramide signalling | |
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SORCS3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SORCS3 (Q9UPU32, 3 ENSP000003587154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
NAS | 11499680 |
SORCS3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SORCS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SORCS3
Search CenterWatch for drugs/clinical trials and news about SORCS3 / SORC3
|
Transcripts
for SORCS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SORCS3 gene: NM_014978.1 Unigene Cluster for SORCS3: Sortilin-related VPS10 domain containing receptor 3 Hs.671950 [show with all ESTs]Unigene Representative Sequence: AB0289823 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369701(uc001kyi.1) ENST00000393176 ENST00000369699(uc010qqz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SORCS3 (NM_014978) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SORCS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SORCS3 |
Additional cDNA sequence: AB028982.1 AK303009.1 BC045754.1 BC117417.1 2 DOTS entries: DT.86859751 DT.92051633 16 AceView cDNA sequences: AB028982 NM_014978 CD626462 CD626459 BX509712 BC045754 CD626470 CD626464 CD626458 CD626468 CD626465 BG714353 BF090119 BF967389 AW452734 CD246034
GeneLoc Exon Structure
|
Expression
for SORCS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SORCS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCATATCT
About this image
See SORCS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SORCS3
SOURCE GeneReport for Unigene cluster: Hs.671950
UniProtKB/Swiss-Prot: SORC3_HUMAN, Q9UPU3Tissue specificity: Highly expressed in brain
SABiosciences Expression via Pathway-Focused PCR Array including SORCS3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SORCS3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SORCS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SORCS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SORCS3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORCS3 |
Orthologs
for SORCS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SORCS3 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SORCS31 |
sortilin-related VPS10 domain containing receptor 3 |
74.96(n)
80.07(a) |
|
423884 XM_421749.3 XP_421749.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SORCS36 |
-- |
80(a) |
1 ↔ 1 |
3(42499178-42652712) |
zebrafish
(Danio rerio) |
Actinopterygii |
sorcs31 |
sortilin-related VPS10 domain containing receptor 3 |
66.7(n)
67.16(a) |
|
100534837 XM_003197716.1 XP_003197764.1 |
ENSEMBL Gene Tree for SORCS3 (if available)
TreeFam Gene Tree for SORCS3 (if available) |
Paralogs
for SORCS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SORCS3 gene
- SORCS12 SORCS22 SORT12
3 SIMAP similar genes for SORCS3 using alignment to 5 protein entries: SORC3_HUMAN (see all proteins):SORCS1 SORCS2 SORL1
SORCS3 for paralogs About GeneDecksing
|
Genomic Variants
for SORCS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SORCS3 (106400859 - 106650859 bp, first 250kb of SORCS3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SORCS3
1 CNV: 71106 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SORCS3 |
|
Disorders
/ Diseases
for SORCS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SORCS3 for disorders About GeneDecksing
OMIM gene information: 606285
OMIM disorders: --
2  diseases for SORCS3: About MalaCardsalzheimer's disease malaria
Human Genome Epidemiology (HuGE) Navigator: SORCS3 (2 documents)
Export disorders for SORCS3 gene to outside databases
|
Publications
for SORCS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SORCS3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SORCS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The genes for the human VPS10 domain-containing receptors are large and contain many small exons. (PubMed id 11499680)1, 2, 3 Hampe W.... Schaller H.C. (2001)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- SorCS3 does not require propeptide cleavage to bind nerve growth factor. (PubMed id 15710408)1 Westergaard U.B....Madsen P. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Vps10p-domain receptor family. (PubMed id 19434368)9 Hermey G. (2009)
|
External Searches for SORCS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SORCS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SORCS3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SORCS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SORCS3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SORCS3 gene:
Search GeneIP for patents involving SORCS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SORCS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SORCS3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SORCS3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SORCS3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SORCS3 | | OriGene 3'-UTR Clone for SORCS3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SORCS3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SORCS3 | | OriGene Custom Protein Services for SORCS3 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SORCS3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SORCS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SORCS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SORCS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SORCS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SORCS3 |
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| | | | Search Tocris compounds for SORCS3 |
| |  |  |  |  | | | | |
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 | | | SORCS3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SORCS3 |
|  |  |  |  | | | | ThermoFisher Antibodies for SORCS3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SORCS3 |
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