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Aliases for SORCS2 Gene

Aliases for SORCS2 Gene

  • Sortilin Related VPS10 Domain Containing Receptor 2 2 3
  • Sortilin-Related VPS10 Domain Containing Receptor 2 2 5
  • KIAA1329 4

External Ids for SORCS2 Gene

Previous GeneCards Identifiers for SORCS2 Gene

  • GC04P007099
  • GC04P007315
  • GC04P007258
  • GC04P007259
  • GC04P007312

Summaries for SORCS2 Gene

Entrez Gene Summary for SORCS2 Gene

  • This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for SORCS2 Gene

SORCS2 (Sortilin Related VPS10 Domain Containing Receptor 2) is a Protein Coding gene. GO annotations related to this gene include neuropeptide receptor activity. An important paralog of this gene is SORCS3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORCS2 Gene

Genomics for SORCS2 Gene

Regulatory Elements for SORCS2 Gene

Enhancers for SORCS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SORCS2 on UCSC Golden Path with GeneCards custom track

Promoters for SORCS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SORCS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SORCS2 Gene

7,192,538 bp from pter
7,742,837 bp from pter
550,300 bases
Plus strand

Genomic View for SORCS2 Gene

Genes around SORCS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SORCS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SORCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORCS2 Gene

Proteins for SORCS2 Gene

  • Protein details for SORCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    VPS10 domain-containing receptor SorCS2
    Protein Accession:
    Secondary Accessions:
    • Q9P2L7

    Protein attributes for SORCS2 Gene

    1159 amino acids
    Molecular mass:
    128152 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SORCS2 Gene

neXtProt entry for SORCS2 Gene

Proteomics data for SORCS2 Gene at MOPED

Post-translational modifications for SORCS2 Gene

  • Glycosylation at Thr 65, Asn 158, Asn 328, Asn 362, Asn 600, Asn 830, Asn 891, and Asn 902
  • Modification sites at PhosphoSitePlus

Other Protein References for SORCS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SORCS2 Gene

Domains & Families for SORCS2 Gene

Protein Domains for SORCS2 Gene

Suggested Antigen Peptide Sequences for SORCS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PKD domain.
  • Belongs to the VPS10-related sortilin family. SORCS subfamily.
  • Contains 6 BNR repeats.
  • Contains 1 PKD domain.
  • Belongs to the VPS10-related sortilin family. SORCS subfamily.
  • Contains 6 BNR repeats.
genes like me logo Genes that share domains with SORCS2: view

No data available for Gene Families for SORCS2 Gene

Function for SORCS2 Gene

genes like me logo Genes that share phenotypes with SORCS2: view

Animal Models for SORCS2 Gene

MGI Knock Outs for SORCS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SORCS2

miRNA for SORCS2 Gene

miRTarBase miRNAs that target SORCS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SORCS2 Gene

Localization for SORCS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORCS2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SORCS2 Gene COMPARTMENTS Subcellular localization image for SORCS2 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SORCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SORCS2: view

Pathways & Interactions for SORCS2 Gene

SuperPathways for SORCS2 Gene

No Data Available

Interacting Proteins for SORCS2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000422185 for SORCS2 Gene via STRING

Gene Ontology (GO) - Biological Process for SORCS2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SORCS2 Gene

Drugs & Compounds for SORCS2 Gene

No Compound Related Data Available

Transcripts for SORCS2 Gene

Unigene Clusters for SORCS2 Gene

Sortilin-related VPS10 domain containing receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SORCS2 Gene

No ASD Table

Relevant External Links for SORCS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SORCS2 Gene

mRNA expression in normal human tissues for SORCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SORCS2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (44.7) and Retina (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SORCS2 Gene

SOURCE GeneReport for Unigene cluster for SORCS2 Gene Hs.479099

mRNA Expression by UniProt/SwissProt for SORCS2 Gene

Tissue specificity: Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
genes like me logo Genes that share expression patterns with SORCS2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SORCS2 Gene

Orthologs for SORCS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SORCS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SORCS2 35
  • 87.64 (n)
  • 86.55 (a)
  • 86 (a)
(Canis familiaris)
Mammalia SORCS2 35
  • 88.69 (n)
  • 90.68 (a)
  • 89 (a)
(Mus musculus)
Mammalia Sorcs2 35
  • 84.13 (n)
  • 86.23 (a)
Sorcs2 16
Sorcs2 36
  • 86 (a)
(Pan troglodytes)
Mammalia SORCS2 35
  • 99.02 (n)
  • 99.39 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Sorcs2 35
  • 84.65 (n)
  • 87.24 (a)
(Monodelphis domestica)
Mammalia SORCS2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SORCS2 36
  • 85 (a)
(Gallus gallus)
Aves SORCS2 35
  • 73.84 (n)
  • 79.94 (a)
-- 36
  • 79 (a)
-- 36
  • 75 (a)
(Anolis carolinensis)
Reptilia SORCS2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sorcs2 35
  • 70.59 (n)
  • 73.37 (a)
(Danio rerio)
Actinopterygii sorcs2 35
  • 68.36 (n)
  • 70.14 (a)
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
-- 36
  • 17 (a)
-- 36
  • 19 (a)
-- 36
  • 10 (a)
-- 36
  • 14 (a)
PEP1 36
  • 11 (a)
VTH1 36
  • 10 (a)
VTH2 36
  • 10 (a)
PEP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for SORCS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORCS2 Gene

Gene Tree for SORCS2 (if available)
Gene Tree for SORCS2 (if available)

Paralogs for SORCS2 Gene

Paralogs for SORCS2 Gene

(2) SIMAP similar genes for SORCS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SORCS2: view

Variants for SORCS2 Gene

Sequence variations from dbSNP and Humsavar for SORCS2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34058821 - 7,664,433(-) AGACC(C/T)GTGGT reference, missense
rs16840892 - 7,714,334(+) GCTCA(C/T)GTCCC reference, missense
rs16840899 - 7,715,293(+) CCAGA(C/T)CTACA reference, missense
rs3825 -- 7,742,708(-) GGCCT(A/C/T)GTTCC utr-variant-3-prime
rs4086 -- 7,489,081(-) CCCCA(A/G)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SORCS2 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv34033 CNV Loss 18971310
dgv1568e1 CNV Complex 17122850
nsv428436 CNV Gain 18775914
nsv829850 CNV Loss 17160897
nsv461197 CNV Loss 19166990
nsv878540 CNV Loss 21882294
esv2727026 CNV Deletion 23290073
esv2727027 CNV Deletion 23290073
nsv508994 CNV Insertion 20534489
nsv878541 CNV Gain 21882294
esv23563 CNV Gain 19812545
nsv878542 CNV Loss 21882294
esv993203 CNV Gain 20482838
nsv4218 CNV Loss 18451855
esv2727030 CNV Deletion 23290073
esv2678075 CNV Deletion 23128226
esv1258015 CNV Deletion 17803354
nsv291426 CNV Loss 16902084
esv2727031 CNV Deletion 23290073
esv991612 CNV Deletion 20482838
esv1533109 CNV Deletion 17803354
esv2727032 CNV Deletion 23290073
nsv461199 CNV Loss 19166990
esv2727033 CNV Deletion 23290073
nsv291540 CNV Loss 16902084
esv2727034 CNV Deletion 23290073
esv1010050 CNV Deletion 20482838
esv1352937 CNV Deletion 17803354
esv1005726 CNV Insertion 20482838
dgv5445n71 CNV Gain 21882294
esv2727035 CNV Deletion 23290073
nsv878548 CNV Gain 21882294
esv24474 CNV Loss 19812545
nsv878552 CNV Loss 21882294
nsv878553 CNV Gain 21882294
dgv5446n71 CNV Loss 21882294
nsv878557 CNV Gain 21882294
nsv878558 CNV Gain 21882294
esv3748 CNV Deletion 18987735
esv2351379 CNV Deletion 18987734
esv2668075 CNV Deletion 23128226
esv1005920 CNV Deletion 20482838
esv2727036 CNV Deletion 23290073
nsv878559 CNV Gain 21882294
esv2727037 CNV Deletion 23290073
esv2727038 CNV Deletion 23290073
esv2727039 CNV Deletion 23290073
nsv469758 CNV Complex 16826518
esv2672283 CNV Deletion 23128226
dgv861e201 CNV Deletion 23290073
esv2727042 CNV Deletion 23290073
esv2656824 CNV Deletion 23128226
esv2727044 CNV Deletion 23290073
esv1046425 CNV Deletion 17803354
esv1514799 CNV Deletion 17803354
esv2727045 CNV Deletion 23290073
nsv878560 CNV Gain 21882294
dgv5447n71 CNV Loss 21882294
nsv878562 CNV Loss 21882294
nsv878565 CNV Loss 21882294
nsv470008 CNV Loss 18288195
nsv461203 CNV Loss 19166990
nsv461204 CNV Loss 19166990
nsv461205 CNV Loss 19166990
esv24504 CNV Gain+Loss 19812545
esv27263 CNV Loss 19812545
esv2727046 CNV Deletion 23290073
nsv292306 CNV Loss 16902084
dgv5448n71 CNV Loss 21882294
esv2727047 CNV Deletion 23290073
nsv520804 CNV Loss 19592680
nsv527419 CNV Loss 19592680
esv34002 CNV Loss 18971310
nsv291240 CNV Loss 16902084
esv26887 CNV Loss 19812545
nsv820610 CNV Deletion 20802225
esv2727048 CNV Deletion 23290073
esv999654 CNV Deletion 20482838
esv1007737 CNV Insertion 20482838
esv1009076 CNV Insertion 20482838
esv1161122 CNV Insertion 17803354
nsv290990 CNV Insertion 16902084
esv2673985 CNV Deletion 23128226
nsv878568 CNV Loss 21882294
dgv921e199 CNV Deletion 23128226
esv7927 CNV Loss 19470904
nsv878569 CNV Loss 21882294
esv2671770 CNV Deletion 23128226
esv25923 CNV Gain 19812545
esv2727049 CNV Deletion 23290073
nsv526748 CNV Loss 19592680
dgv641n27 CNV Loss 19166990
esv2727050 CNV Deletion 23290073
esv2024202 CNV Deletion 18987734
esv2920 CNV Deletion 18987735
esv2678974 CNV Deletion 23128226
esv8036 CNV Loss 19470904
esv2727052 CNV Deletion 23290073
esv34156 CNV Loss 18971310
esv2727053 CNV Deletion 23290073
esv2727054 CNV Deletion 23290073
esv1111596 CNV Deletion 17803354
esv25539 CNV Loss 19812545
dgv642n27 CNV Loss 19166990
nsv528667 CNV Loss 19592680
nsv878570 CNV Gain 21882294
nsv524838 CNV Loss 19592680
esv2727055 CNV Deletion 23290073
esv2727056 CNV Deletion 23290073
esv2727057 CNV Deletion 23290073
esv2727058 CNV Deletion 23290073
esv267658 CNV Insertion 20981092
nsv508272 CNV Loss 20534489
nsv508995 CNV Insertion 20534489
dgv859n67 CNV Gain 20364138
nsv820732 CNV Deletion 20802225
nsv517503 CNV Loss 19592680
nsv513120 CNV Loss 21212237
esv23725 CNV Gain 19812545
esv4108 CNV Deletion 18987735
esv2727059 CNV Deletion 23290073
esv2658823 CNV Deletion 23128226
esv1317344 CNV Deletion 17803354
nsv878571 CNV Loss 21882294
esv2727060 CNV Deletion 23290073
esv2727061 CNV Deletion 23290073
nsv4219 CNV Loss 18451855
esv2727063 CNV Deletion 23290073
esv3110 CNV Deletion 18987735
esv2727064 CNV Deletion 23290073
nsv290116 CNV Loss 16902084
esv1391135 CNV Deletion 17803354
esv988567 CNV Deletion 20482838
esv2727065 CNV Deletion 23290073
esv2727066 CNV Deletion 23290073
esv2727067 CNV Deletion 23290073
dgv5449n71 CNV Loss 21882294
esv26900 CNV Loss 19812545
nsv293826 CNV Loss 16902084
dgv5450n71 CNV Loss 21882294
nsv878575 CNV Loss 21882294
nsv291783 CNV Loss 16902084
esv4191 CNV Deletion 18987735
esv2727068 CNV Deletion 23290073
esv8000 CNV Loss 19470904
esv2727069 CNV Deletion 23290073
nsv819855 CNV Insertion 19587683

Variation tolerance for SORCS2 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SORCS2 Gene

Disorders for SORCS2 Gene

Relevant External Links for SORCS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SORCS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SORCS2 Gene

Publications for SORCS2 Gene

  1. The genes for the human VPS10 domain-containing receptors are large and contain many small exons. (PMID: 11499680) Hampe W. … Schaller H.C. (Hum. Genet. 2001) 2 3 4 67
  2. Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis. (PMID: 26420026) Mori F. … Wakabayashi K. (Neurosci. Lett. 2015) 3
  3. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan R.C. … Wallaschofski H. (Hum. Mol. Genet. 2011) 3

Products for SORCS2 Gene

Sources for SORCS2 Gene