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Aliases for SORCS1 Gene

Aliases for SORCS1 Gene

  • Sortilin-Related VPS10 Domain Containing Receptor 1 2 3
  • HSorCS 3 4
  • VPS10 Domain-Containing Receptor SorCS1 3
  • VPS10 Domain Receptor Protein SORCS 1 3
  • SORCS 4

External Ids for SORCS1 Gene

Previous GeneCards Identifiers for SORCS1 Gene

  • GC10M107226
  • GC10M107567
  • GC10M108464
  • GC10M107998
  • GC10M108323
  • GC10M101965

Summaries for SORCS1 Gene

Entrez Gene Summary for SORCS1 Gene

  • This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SORCS1 Gene

SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1) is a Protein Coding gene. GO annotations related to this gene include neuropeptide receptor activity. An important paralog of this gene is SORCS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORCS1 Gene

Genomics for SORCS1 Gene

Regulatory Elements for SORCS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SORCS1 Gene

106,573,663 bp from pter
107,164,708 bp from pter
591,046 bases
Minus strand

Genomic View for SORCS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SORCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORCS1 Gene

Proteins for SORCS1 Gene

  • Protein details for SORCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    VPS10 domain-containing receptor SorCS1
    Protein Accession:
    Secondary Accessions:
    • A2RRF4
    • Q59GG7
    • Q5JVT7
    • Q5JVT8
    • Q5VY14
    • Q86WQ1
    • Q86WQ2
    • Q9H1Y1
    • Q9H1Y2

    Protein attributes for SORCS1 Gene

    1168 amino acids
    Molecular mass:
    129635 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92379.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40754.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40755.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SORCS1 Gene


neXtProt entry for SORCS1 Gene

Proteomics data for SORCS1 Gene at MOPED

Post-translational modifications for SORCS1 Gene

  • O-glycosylated.
  • Glycosylation at Thr68, Asn184, Asn352, Asn433, Asn765, Asn776, Asn816, Asn847, Asn908, and Asn929
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SORCS1 Gene

Domains for SORCS1 Gene

Protein Domains for SORCS1 Gene


Suggested Antigen Peptide Sequences for SORCS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8WY21
  • Contains 1 PKD domain.
  • Belongs to the VPS10-related sortilin family. SORCS subfamily.
  • Contains 5 BNR repeats.
genes like me logo Genes that share domains with SORCS1: view

No data available for Gene Families for SORCS1 Gene

Function for SORCS1 Gene

Gene Ontology (GO) - Molecular Function for SORCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12482870
GO:0008188 neuropeptide receptor activity NAS 11499680
genes like me logo Genes that share ontologies with SORCS1: view

Phenotypes for SORCS1 Gene

genes like me logo Genes that share phenotypes with SORCS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SORCS1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SORCS1 Gene

Localization for SORCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORCS1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SORCS1 Gene COMPARTMENTS Subcellular localization image for SORCS1 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SORCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 12482870
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SORCS1: view

Pathways for SORCS1 Gene

SuperPathways for SORCS1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for SORCS1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000345964 Q8WY21-SORC1_HUMAN for SORCS1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SORCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 11499680
genes like me logo Genes that share ontologies with SORCS1: view

No data available for Pathways by source for SORCS1 Gene

Transcripts for SORCS1 Gene

Unigene Clusters for SORCS1 Gene

Sortilin-related VPS10 domain containing receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SORCS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SORCS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^

ExUns: 25 ^ 26 ^ 27 ^ 28
SP1: - -
SP2: -

Relevant External Links for SORCS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SORCS1 Gene

mRNA expression in normal human tissues for SORCS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SORCS1 Gene

This gene is overexpressed in Nerve - Tibial (9.0) and Brain - Nucleus accumbens (basal ganglia) (4.1).

Protein differential expression in normal tissues for SORCS1 Gene

This gene is overexpressed in Colon (15.7), Fetal gut (14.4), and Rectum (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SORCS1 Gene

SOURCE GeneReport for Unigene cluster for SORCS1 Gene Hs.591915

mRNA Expression by UniProt/SwissProt for SORCS1 Gene

Tissue specificity: Detected in fetal and infant brain and in fetal retina
genes like me logo Genes that share expressions with SORCS1: view

In Situ Assay Products

No data available for Expression partners for SORCS1 Gene

Orthologs for SORCS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SORCS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SORCS1 35
  • 91.18 (n)
  • 95.16 (a)
  • 94 (a)
(Canis familiaris)
Mammalia SORCS1 35
  • 93.18 (n)
  • 97.73 (a)
  • 95 (a)
(Mus musculus)
Mammalia Sorcs1 35
  • 87.86 (n)
  • 93.69 (a)
Sorcs1 16
Sorcs1 36
  • 90 (a)
(Pan troglodytes)
Mammalia SORCS1 35
  • 99.38 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sorcs1 35
  • 87.57 (n)
  • 93.61 (a)
(Monodelphis domestica)
Mammalia SORCS1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SORCS1 36
  • 93 (a)
(Gallus gallus)
Aves SORCS1 35
  • 79.49 (n)
  • 86.49 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
-- 36
  • 92 (a)
(Danio rerio)
Actinopterygii sorcs1 35
  • 69.22 (n)
  • 71.29 (a)
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 23 (a)
-- 36
  • 17 (a)
-- 36
  • 18 (a)
-- 36
  • 11 (a)
-- 36
  • 14 (a)
PEP1 36
  • 12 (a)
VTH1 36
  • 11 (a)
VTH2 36
  • 11 (a)
-- 38
-- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for SORCS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORCS1 Gene

Gene Tree for SORCS1 (if available)
Gene Tree for SORCS1 (if available)

Paralogs for SORCS1 Gene

Paralogs for SORCS1 Gene

Selected SIMAP similar genes for SORCS1 Gene using alignment to 5 proteins: Pseudogenes for SORCS1 Gene

genes like me logo Genes that share paralogs with SORCS1: view

Variants for SORCS1 Gene

Sequence variations from dbSNP and Humsavar for SORCS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs581648 -- 107,116,723(+) atcaa(A/G)tctat intron-variant
rs584852 -- 107,148,405(-) TCTTA(C/T)TGGAA intron-variant
rs585782 -- 107,147,951(-) TCTGA(A/C)GATTT intron-variant
rs596577 -- 107,126,535(-) AGAAT(A/C)TCACA intron-variant
rs597122 -- 107,126,693(-) AATGA(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SORCS1 Gene

Variant ID Type Subtype PubMed ID
nsv831977 CNV Gain 17160897
nsv7539 CNV Insertion 18451855
esv269214 CNV Insertion 20981092
nsv25362 CNV Loss 16902084
nsv7540 CNV Insertion 18451855
esv2740640 CNV Deletion 23290073
nsv519092 CNV Loss 19592680
nsv831978 CNV Loss 17160897
esv272334 CNV Insertion 20981092
nsv7211 OTHER Inversion 18451855
esv2431185 CNV Deletion 19546169
nsv525854 CNV Loss 19592680
nsv7541 CNV Insertion 18451855
nsv895988 CNV Loss 21882294
esv2740651 CNV Deletion 23290073

Relevant External Links for SORCS1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORCS1 Gene

Disorders for SORCS1 Gene

Relevant External Links for SORCS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SORCS1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SORCS1 Gene

Publications for SORCS1 Gene

  1. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. (PMID: 12482870) Hermey G. … Gliemann J. (J. Biol. Chem. 2003) 3 4 23
  2. The genes for the human VPS10 domain-containing receptors are large and contain many small exons. (PMID: 11499680) Hampe W. … Schaller H.C. (Hum. Genet. 2001) 2 3 4
  3. Different motifs regulate trafficking of SorCS1 isoforms. (PMID: 18315530) Nielsen M.S. … Hermey G. (Traffic 2008) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for SORCS1 Gene

Sources for SORCS1 Gene

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