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Aliases for SORBS3 Gene

Aliases for SORBS3 Gene

  • Sorbin And SH3 Domain Containing 3 2 3
  • SCAM1 3 4 6
  • Sorbin And SH3 Domain-Containing Protein 3 3 4
  • SCAM-1 3 4
  • SH3D4 3 6
  • Vinexin Beta (SH3-Containing Adaptor Molecule-1) 3
  • SH3-Containing Adapter Molecule 1 4
  • Vinexin 3

External Ids for SORBS3 Gene

Summaries for SORBS3 Gene

Entrez Gene Summary for SORBS3 Gene

  • This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SORBS3 Gene

SORBS3 (Sorbin And SH3 Domain Containing 3) is a Protein Coding gene. Among its related pathways are Striated Muscle Contraction and Striated Muscle Contraction. GO annotations related to this gene include transcription factor binding and vinculin binding. An important paralog of this gene is SORBS2.

UniProtKB/Swiss-Prot for SORBS3 Gene

  • Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain

Gene Wiki entry for SORBS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORBS3 Gene

Genomics for SORBS3 Gene

Genomic Location for SORBS3 Gene

Start:
22,544,783 bp from pter
End:
22,575,788 bp from pter
Size:
31,006 bases
Orientation:
Plus strand

Genomic View for SORBS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SORBS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORBS3 Gene

Regulatory Elements for SORBS3 Gene

Proteins for SORBS3 Gene

  • Protein details for SORBS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60504-VINEX_HUMAN
    Recommended name:
    Vinexin
    Protein Accession:
    O60504
    Secondary Accessions:
    • Q5BJE4
    • Q6NX54
    • Q96FY4
    • Q9UQE4

    Protein attributes for SORBS3 Gene

    Size:
    671 amino acids
    Molecular mass:
    75341 Da
    Quaternary structure:
    • Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SORBS3 Gene

    Alternative splice isoforms for SORBS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SORBS3 Gene

Proteomics data for SORBS3 Gene at MOPED

Post-translational modifications for SORBS3 Gene

  • Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SORBS3 Gene

Domains for SORBS3 Gene

Protein Domains for SORBS3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

VINEX_HUMAN
Domain:
  • Contains 3 SH3 domains.:
    • O60504
  • Contains 1 SoHo domain.:
    • O60504
genes like me logo Genes that share domains with SORBS3: view

No data available for Gene Families for SORBS3 Gene

Function for SORBS3 Gene

Molecular function for SORBS3 Gene

UniProtKB/Swiss-Prot Function: Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain

Gene Ontology (GO) - Molecular Function for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 9885244
GO:0005515 protein binding IPI 12660241
GO:0008134 transcription factor binding IEA --
GO:0017166 vinculin binding IPI 9885244
genes like me logo Genes that share ontologies with SORBS3: view
genes like me logo Genes that share phenotypes with SORBS3: view

Animal Models for SORBS3 Gene

MGI Knock Outs for SORBS3:

miRNA for SORBS3 Gene

miRTarBase miRNAs that target SORBS3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SORBS3 Gene

Localization for SORBS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORBS3 Gene

Isoform Alpha: Cell junction. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.
Isoform Beta: Cell junction. Nucleus. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SORBS3 Gene COMPARTMENTS Subcellular localization image for SORBS3 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 colocalizes_with focal adhesion IDA 9885244
genes like me logo Genes that share ontologies with SORBS3: view

Pathways for SORBS3 Gene

SuperPathways for SORBS3 Gene

genes like me logo Genes that share pathways with SORBS3: view

Pathways by source for SORBS3 Gene

2 Reactome pathways for SORBS3 Gene

Gene Ontology (GO) - Biological Process for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006936 muscle contraction TAS --
GO:0007015 actin filament organization IEA --
GO:0007155 cell adhesion TAS 9885244
GO:0031589 cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with SORBS3: view

Compounds for SORBS3 Gene

(3) HMDB Compounds for SORBS3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SORBS3: view

Transcripts for SORBS3 Gene

Unigene Clusters for SORBS3 Gene

Sorbin and SH3 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SORBS3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ·
SP1: - - - - - - - - - - -
SP2:
SP3: - - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19: - - - - - - -
SP20: - - -
SP21:
SP22: - -
SP23: - - -
SP24: - - - - -

ExUns: 15c · 15d · 15e · 15f ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d · 22e · 22f · 22g ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - -
SP14: - -
SP15:
SP16:
SP17: - - - - - - - - -
SP18: -
SP19:
SP20: - - - - - - - - - -
SP21:
SP22:
SP23: - - - - - - - -
SP24: - - - - - - - - - - - - - - - -

ExUns: 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26a · 26b
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for SORBS3 Gene

GeneLoc Exon Structure for
SORBS3
ECgene alternative splicing isoforms for
SORBS3

Expression for SORBS3 Gene

mRNA expression in normal human tissues for SORBS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SORBS3 Gene

SOURCE GeneReport for Unigene cluster for SORBS3 Gene Hs.528572

mRNA Expression by UniProt/SwissProt for SORBS3 Gene

O60504-VINEX_HUMAN
Tissue specificity: Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver
genes like me logo Genes that share expressions with SORBS3: view

Orthologs for SORBS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SORBS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SORBS3 36
  • 99.01 (n)
  • 98.66 (a)
SORBS3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SORBS3 36
  • 86.68 (n)
  • 84.38 (a)
SORBS3 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SORBS3 36
  • 81.19 (n)
  • 76.15 (a)
SORBS3 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sorbs3 36
  • 83.66 (n)
  • 82.81 (a)
Sorbs3 16
Sorbs3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SORBS3 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SORBS3 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sorbs3 36
  • 84.41 (n)
  • 83.41 (a)
lizard
(Anolis carolinensis)
Reptilia SORBS3 37
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sorbs3 36
  • 52.02 (n)
  • 48.79 (a)
sorbs3 37
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CAP 37
  • 7 (a)
OneToMany
Species with no ortholog for SORBS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORBS3 Gene

ENSEMBL:
Gene Tree for SORBS3 (if available)
TreeFam:
Gene Tree for SORBS3 (if available)

Paralogs for SORBS3 Gene

Paralogs for SORBS3 Gene

genes like me logo Genes that share paralogs with SORBS3: view

Variants for SORBS3 Gene

Sequence variations from dbSNP and Humsavar for SORBS3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs710098 -- 22,574,864(+) GCAGC(A/C)TTTCC utr-variant-3-prime
rs745786 -- 22,553,376(+) GGCAG(G/T)GGCAG intron-variant, upstream-variant-2KB
rs752091 -- 22,551,889(+) GACCC(A/G)GTCAC utr-variant-5-prime, intron-variant
rs754270 -- 22,552,369(-) AGACC(G/T)CCCCT intron-variant
rs754271 -- 22,552,315(-) GCGGG(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SORBS3 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
dgv451n21 CNV Loss 19592680
nsv890673 CNV Loss 21882294
dgv7762n71 CNV Loss 21882294
nsv890675 CNV Loss 21882294

Relevant External Links for SORBS3 Gene

HapMap Linkage Disequilibrium report
SORBS3

Disorders for SORBS3 Gene

Relevant External Links for SORBS3

Genetic Association Database (GAD)
SORBS3
genes like me logo Genes that share disorders with SORBS3: view

No data available for UniProtKB/Swiss-Prot for SORBS3 Gene

Publications for SORBS3 Gene

  1. Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. (PMID: 10585480) Akamatsu M. … Kioka N. (J. Biol. Chem. 1999) 3 4 23
  2. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PMID: 15242778) Martens N. … Hooghe-Peters E.L. (Exp. Cell Res. 2004) 3 4 23
  3. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PMID: 12660241) Townson S.M. … Oesterreich S. (J. Biol. Chem. 2003) 3 4 23
  4. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. (PMID: 9885244) Kioka N. … Aota S. (J. Cell Biol. 1999) 2 3 4
  5. Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. (PMID: 15184391) Mitsushima M. … Kioka N. (J. Biol. Chem. 2004) 3 23

Products for SORBS3 Gene

  • antibodies-online proteins for SORBS3
  • antibodies-online antibodies for SORBS3
  • antibodies-online kits for SORBS3

Sources for SORBS3 Gene

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