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Aliases for SORBS3 Gene

Aliases for SORBS3 Gene

  • Sorbin And SH3 Domain Containing 3 2 3 5
  • Sorbin And SH3 Domain-Containing Protein 3 3 4
  • SCAM-1 3 4
  • SCAM1 3 4
  • Vinexin Beta (SH3-Containing Adaptor Molecule-1) 3
  • SH3-Containing Adapter Molecule 1 4
  • Vinexin 3
  • SH3D4 3

External Ids for SORBS3 Gene

Previous GeneCards Identifiers for SORBS3 Gene

  • GC08P022466
  • GC08P022409
  • GC08P020951

Summaries for SORBS3 Gene

Entrez Gene Summary for SORBS3 Gene

  • This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SORBS3 Gene

SORBS3 (Sorbin And SH3 Domain Containing 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. GO annotations related to this gene include transcription factor binding and vinculin binding. An important paralog of this gene is SORBS1.

UniProtKB/Swiss-Prot for SORBS3 Gene

  • Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Gene Wiki entry for SORBS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORBS3 Gene

Genomics for SORBS3 Gene

Regulatory Elements for SORBS3 Gene

Enhancers for SORBS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G022450 0.9 dbSUPER 50.8 -94.6 -94551 0.8 ZNF493 ZFP64 ZEB1 ZNF354C ZNF202 ZNF654 ZNF680 ZNF426 OVOL3 REST SORBS3 ENSG00000253200 POLR3D LOC100507156 LOC107986927 LOC100507071 PPP3CC ENSG00000251034 C8orf58 BTF3P3
GH08G022451 0.9 dbSUPER 50.8 -94.4 -94441 0.8 ZNF493 ZFP64 ZEB1 ZNF354C ZNF202 ZNF654 ZNF680 ZNF426 OVOL3 REST SORBS3 ENSG00000253200 POLR3D LOC100507156 LOC107986927 LOC100507071 PPP3CC ENSG00000251034 C8orf58 BTF3P3
GH08G022439 2 FANTOM5 Ensembl ENCODE dbSUPER 21.4 -100.3 -100321 10.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 ENSG00000253200 PPP3CC C8orf58 SORBS3 POLR3D LOC100507071 BIN3 ENSG00000251034 PDLIM2 ENSG00000248235
GH08G022355 1.5 Ensembl ENCODE dbSUPER 21.3 -186.7 -186700 6.4 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 FOS ZNF263 PIWIL2 SORBS3 ENSG00000251034 RNU6-336P PPP3CC SLC39A14
GH08G022950 1.1 Ensembl ENCODE 19.4 +405.8 405759 1.2 HDAC1 TBP HDGF ATF1 CREB3L1 ZNF473 NFRKB YBX1 ZNF366 CREM SORBS3 PHYHIP FGF17 RHOBTB2 PEBP4 ENSG00000253200 LOC101929237 LOC100507071 LOC100507156 PIR56864
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SORBS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SORBS3 Gene

Chromosome:
8
Start:
22,544,986 bp from pter
End:
22,575,788 bp from pter
Size:
30,803 bases
Orientation:
Plus strand

Genomic View for SORBS3 Gene

Genes around SORBS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SORBS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SORBS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORBS3 Gene

Proteins for SORBS3 Gene

  • Protein details for SORBS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60504-VINEX_HUMAN
    Recommended name:
    Vinexin
    Protein Accession:
    O60504
    Secondary Accessions:
    • Q5BJE4
    • Q6NX54
    • Q96FY4
    • Q9UQE4

    Protein attributes for SORBS3 Gene

    Size:
    671 amino acids
    Molecular mass:
    75341 Da
    Quaternary structure:
    • Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SORBS3 Gene

    Alternative splice isoforms for SORBS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SORBS3 Gene

Post-translational modifications for SORBS3 Gene

  • Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SORBS3 Gene

Domains & Families for SORBS3 Gene

Protein Domains for SORBS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SORBS3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SORBS3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SORBS3 Gene

Function for SORBS3 Gene

Molecular function for SORBS3 Gene

UniProtKB/Swiss-Prot Function:
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Gene Ontology (GO) - Molecular Function for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 9885244
GO:0005515 protein binding IPI 12660241
GO:0008134 transcription factor binding IEA --
GO:0017166 vinculin binding IPI 9885244
genes like me logo Genes that share ontologies with SORBS3: view
genes like me logo Genes that share phenotypes with SORBS3: view

Animal Models for SORBS3 Gene

MGI Knock Outs for SORBS3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SORBS3 Gene

Localization for SORBS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORBS3 Gene

Isoform Alpha: Cell junction. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.
Isoform Beta: Cell junction. Nucleus. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SORBS3 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 colocalizes_with focal adhesion IDA 9885244
genes like me logo Genes that share ontologies with SORBS3: view

Pathways & Interactions for SORBS3 Gene

genes like me logo Genes that share pathways with SORBS3: view

Pathways by source for SORBS3 Gene

2 Reactome pathways for SORBS3 Gene

SIGNOR curated interactions for SORBS3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for SORBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006936 muscle contraction TAS --
GO:0007015 actin filament organization IEA --
GO:0007155 cell adhesion TAS,IEA 9885244
GO:0031589 cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with SORBS3: view

Drugs & Compounds for SORBS3 Gene

(3) Drugs for SORBS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SORBS3: view

Transcripts for SORBS3 Gene

Unigene Clusters for SORBS3 Gene

Sorbin and SH3 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SORBS3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ·
SP1: - - - - - - - - - - -
SP2:
SP3: - - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19: - - - - - - -
SP20: - - -
SP21:
SP22: - -
SP23: - - -
SP24: - - - - -

ExUns: 15c · 15d · 15e · 15f ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d · 22e · 22f · 22g ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - -
SP14: - -
SP15:
SP16:
SP17: - - - - - - - - -
SP18: -
SP19:
SP20: - - - - - - - - - -
SP21:
SP22:
SP23: - - - - - - - -
SP24: - - - - - - - - - - - - - - - -

ExUns: 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26a · 26b
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for SORBS3 Gene

GeneLoc Exon Structure for
SORBS3
ECgene alternative splicing isoforms for
SORBS3

Expression for SORBS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SORBS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SORBS3 Gene

This gene is overexpressed in Gallbladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SORBS3 Gene



Protein tissue co-expression partners for SORBS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SORBS3 Gene:

SORBS3

SOURCE GeneReport for Unigene cluster for SORBS3 Gene:

Hs.528572

mRNA Expression by UniProt/SwissProt for SORBS3 Gene:

O60504-VINEX_HUMAN
Tissue specificity: Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Evidence on tissue expression from TISSUES for SORBS3 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Muscle(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SORBS3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SORBS3 Gene

Orthologs for SORBS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SORBS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SORBS3 34 35
  • 99.01 (n)
cow
(Bos Taurus)
Mammalia SORBS3 34 35
  • 86.68 (n)
rat
(Rattus norvegicus)
Mammalia Sorbs3 34
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Sorbs3 34 16 35
  • 83.66 (n)
dog
(Canis familiaris)
Mammalia SORBS3 34 35
  • 81.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SORBS3 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SORBS3 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SORBS3 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sorbs3 34 35
  • 52.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta CAP 35
  • 7 (a)
OneToMany
Species where no ortholog for SORBS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORBS3 Gene

ENSEMBL:
Gene Tree for SORBS3 (if available)
TreeFam:
Gene Tree for SORBS3 (if available)

Paralogs for SORBS3 Gene

Variants for SORBS3 Gene

Sequence variations from dbSNP and Humsavar for SORBS3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000008683 -- 22,566,224(+) GACCC(G/T)GGAGA intron-variant, utr-variant-5-prime
rs1000039262 -- 22,552,251(+) GCACC(A/C)AAGGT intron-variant
rs1000067775 -- 22,565,984(+) GGGAG(A/G)AAGGA intron-variant, upstream-variant-2KB
rs1000224455 -- 22,567,436(+) TCACC(A/C/T)TTCAG intron-variant
rs1000246479 -- 22,560,652(+) AGTGG(A/T)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SORBS3 Gene

Variant ID Type Subtype PubMed ID
dgv451n21 CNV loss 19592680
esv2759604 CNV loss 17122850
nsv1075125 CNV deletion 25765185
nsv1075546 CNV deletion 25765185

Variation tolerance for SORBS3 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SORBS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SORBS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORBS3 Gene

Disorders for SORBS3 Gene

Relevant External Links for SORBS3

Genetic Association Database (GAD)
SORBS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SORBS3

No disorders were found for SORBS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SORBS3 Gene

Publications for SORBS3 Gene

  1. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PMID: 15242778) Martens N. … Hooghe-Peters E.L. (Exp. Cell Res. 2004) 3 4 22 64
  2. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PMID: 12660241) Townson S.M. … Oesterreich S. (J. Biol. Chem. 2003) 3 4 22 64
  3. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. (PMID: 9885244) Kioka N. … Aota S. (J. Cell Biol. 1999) 2 3 4 64
  4. Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. (PMID: 10585480) Akamatsu M. … Kioka N. (J. Biol. Chem. 1999) 3 4 22 64
  5. Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. (PMID: 20361963) Kioka N. … Ueda K. (Exp. Cell Res. 2010) 3 22 64

Products for SORBS3 Gene

Sources for SORBS3 Gene

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