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Aliases for SORBS2 Gene

Aliases for SORBS2 Gene

  • Sorbin And SH3 Domain Containing 2 2 3
  • Arg/Abl-Interacting Protein 2 3 4
  • ARGBP2 3 4
  • Sorbin And SH3 Domain-Containing Protein 2 3
  • Arg/Abl Interacting Protein 2
  • Arg Binding Protein 2 3
  • KIAA0777 4
  • PRO0618 3
  • Sorbin 4

External Ids for SORBS2 Gene

Previous GeneCards Identifiers for SORBS2 Gene

  • GC04M186884
  • GC04M186743
  • GC04M186506
  • GC04M182259

Summaries for SORBS2 Gene

Entrez Gene Summary for SORBS2 Gene

  • Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SORBS2 Gene

SORBS2 (Sorbin And SH3 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and structural constituent of muscle. An important paralog of this gene is SORBS3.

UniProtKB/Swiss-Prot for SORBS2 Gene

  • Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Gene Wiki entry for SORBS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORBS2 Gene

Genomics for SORBS2 Gene

Regulatory Elements for SORBS2 Gene

Genomic Location for SORBS2 Gene

Start:
185,585,444 bp from pter
End:
185,956,716 bp from pter
Size:
371,273 bases
Orientation:
Minus strand

Genomic View for SORBS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SORBS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORBS2 Gene

Proteins for SORBS2 Gene

  • Protein details for SORBS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94875-SRBS2_HUMAN
    Recommended name:
    Sorbin and SH3 domain-containing protein 2
    Protein Accession:
    O94875
    Secondary Accessions:
    • A6NEK9
    • B3KPQ7
    • B7Z1G5
    • B7Z3X6
    • C9JKV9
    • D3DP62
    • D3DP63
    • E9PAS5
    • E9PAW4
    • G3XAI0
    • H7BXR4
    • J3KNZ5
    • O60592
    • O60593
    • Q96EX0

    Protein attributes for SORBS2 Gene

    Size:
    1100 amino acids
    Molecular mass:
    124108 Da
    Quaternary structure:
    • Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin, and WASF (By similarity). Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD and PAK1.
    SequenceCaution:
    • Sequence=BAA34497.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SORBS2 Gene

    Alternative splice isoforms for SORBS2 Gene

neXtProt entry for SORBS2 Gene

Proteomics data for SORBS2 Gene at MOPED

Post-translational modifications for SORBS2 Gene

No data available for DME Specific Peptides for SORBS2 Gene

Domains for SORBS2 Gene

Protein Domains for SORBS2 Gene

Graphical View of Domain Structure for InterPro Entry

O94875

UniProtKB/Swiss-Prot:

SRBS2_HUMAN :
  • O94875
Domain:
  • Contains 3 SH3 domains.
  • Contains 1 SoHo domain.
genes like me logo Genes that share domains with SORBS2: view

No data available for Gene Families for SORBS2 Gene

Function for SORBS2 Gene

Molecular function for SORBS2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Gene Ontology (GO) - Molecular Function for SORBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 9211900
GO:0005515 protein binding IPI 15161933
GO:0008093 cytoskeletal adaptor activity TAS 9211900
GO:0008307 structural constituent of muscle TAS 9211900
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with SORBS2: view

Phenotypes for SORBS2 Gene

GenomeRNAi human phenotypes for SORBS2:
genes like me logo Genes that share phenotypes with SORBS2: view

miRNA for SORBS2 Gene

miRTarBase miRNAs that target SORBS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SORBS2 Gene

Localization for SORBS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORBS2 Gene

Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SORBS2 Gene COMPARTMENTS Subcellular localization image for SORBS2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for SORBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9211900
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton TAS 9211900
GO:0030018 Z disc NAS 9211900
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SORBS2: view

Pathways for SORBS2 Gene

SuperPathways for SORBS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SORBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0007155 cell adhesion IEA --
GO:0008150 biological_process ND --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with SORBS2: view

No data available for Pathways by source for SORBS2 Gene

Compounds for SORBS2 Gene

(1) HMDB Compounds for SORBS2 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Novoseek inferred chemical compound relationships for SORBS2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 31.1 1
genes like me logo Genes that share compounds with SORBS2: view

Transcripts for SORBS2 Gene

Unigene Clusters for SORBS2 Gene

Sorbin and SH3 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SORBS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - -
SP11: - - - - - - - - - - - -
SP12:
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - -
SP15:
SP16: -
SP17: - - - - - - -
SP18: - - - - - - - - - -
SP19:
SP20: - - - - - - - - - - - -
SP21:
SP22: - - - - - - - - - - -
SP23:
SP24:
SP25:
SP26:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4:
SP5: - -
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - -
SP24:
SP25:
SP26:

ExUns: 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for SORBS2 Gene

GeneLoc Exon Structure for
SORBS2
ECgene alternative splicing isoforms for
SORBS2

Expression for SORBS2 Gene

mRNA expression in normal human tissues for SORBS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SORBS2 Gene

This gene is overexpressed in Heart - Left Ventricle (8.3) and Artery - Tibial (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SORBS2 Gene

SOURCE GeneReport for Unigene cluster for SORBS2 Gene Hs.619806

mRNA Expression by UniProt/SwissProt for SORBS2 Gene

O94875-SRBS2_HUMAN
Tissue specificity: Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells.
genes like me logo Genes that share expressions with SORBS2: view

Orthologs for SORBS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SORBS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SORBS2 35
  • 98.39 (n)
  • 97.58 (a)
SORBS2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101907303 35
  • 87.69 (n)
  • 91.48 (a)
SORBS2 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SORBS2 35
  • 84.71 (n)
  • 86.6 (a)
SORBS2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sorbs2 35
  • 86.62 (n)
  • 90.11 (a)
Sorbs2 16
Sorbs2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sorbs2 35
  • 85.67 (n)
  • 89.02 (a)
chicken
(Gallus gallus)
Aves SORBS2 35
  • 77.68 (n)
  • 80.13 (a)
SORBS2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SORBS2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sorbs2 35
  • 68.55 (n)
  • 69.36 (a)
zebrafish
(Danio rerio)
Actinopterygii sorbs2a 36
  • 51 (a)
OneToMany
sorbs2b 35
  • 61.5 (n)
  • 57.8 (a)
sorbs2b 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CAP 36
  • 12 (a)
OneToMany
Species with no ortholog for SORBS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORBS2 Gene

ENSEMBL:
Gene Tree for SORBS2 (if available)
TreeFam:
Gene Tree for SORBS2 (if available)

Paralogs for SORBS2 Gene

Paralogs for SORBS2 Gene

genes like me logo Genes that share paralogs with SORBS2: view

Variants for SORBS2 Gene

Sequence variations from dbSNP and Humsavar for SORBS2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3186 -- 185,587,569(+) TTCAG(A/G/T)CGCGT utr-variant-3-prime
rs3651 -- 185,756,777(+) TTTTT(C/G)TGAAC intron-variant
rs3653 -- 185,756,864(+) AGATA(C/T)CGAGT intron-variant
rs724072 -- 185,890,417(-) CACAG(G/T)CTTCT intron-variant
rs725184 -- 185,589,479(+) AAAAT(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SORBS2 Gene

Variant ID Type Subtype PubMed ID
nsv881506 CNV Gain 21882294
nsv527026 CNV Gain 19592680
nsv517035 CNV Gain+Loss 19592680
nsv830169 CNV Gain+Loss 17160897
esv2728915 CNV Deletion 23290073
nsv819075 CNV Loss 19587683
nsv521198 CNV Loss 19592680
nsv830171 CNV Gain+Loss 17160897
esv2672215 CNV Deletion 23128226
esv2728916 CNV Deletion 23290073
esv4636 CNV Deletion 18987735
nsv4640 CNV Insertion 18451855
nsv4641 CNV Insertion 18451855
esv2728919 CNV Deletion 23290073
esv2728920 CNV Deletion 23290073
dgv907e201 CNV Deletion 23290073
nsv507224 CNV Insertion 20534489
esv267939 CNV Insertion 20981092
nsv512841 CNV Insertion 21212237
esv2728921 CNV Deletion 23290073
esv2728922 CNV Deletion 23290073
esv2728923 CNV Deletion 23290073
esv2728924 CNV Deletion 23290073
esv2728925 CNV Deletion 23290073
nsv291687 CNV Insertion 16902084
nsv509952 CNV Loss 20534489

Relevant External Links for SORBS2 Gene

HapMap Linkage Disequilibrium report
SORBS2
Human Gene Mutation Database (HGMD)
SORBS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORBS2 Gene

Disorders for SORBS2 Gene

Relevant External Links for SORBS2

Genetic Association Database (GAD)
SORBS2
Human Genome Epidemiology (HuGE) Navigator
SORBS2
genes like me logo Genes that share disorders with SORBS2: view

No data available for UniProtKB/Swiss-Prot for SORBS2 Gene

Publications for SORBS2 Gene

  1. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl- interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. (PMID: 9211900) Wang B. … Kruh G.D. (J. Biol. Chem. 1997) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. (PMID: 11481476) Kimura A. … Saltiel A.R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  4. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c- Abl. (PMID: 12475393) Soubeyran P. … Dikic I. (Biochem. J. 2003) 3 4
  5. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. (PMID: 15128873) Haglund K. … Dikic I. (J. Cell. Sci. 2004) 3 23

Products for SORBS2 Gene

Sources for SORBS2 Gene

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