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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SORBS2 Gene

protein-coding   GIFtS: 55
GCID: GC04M186506

sorbin and SH3 domain containing 2
 Explore 6 diseases affiliated with
SORBS2 via
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 Human Malady Compendium 
Biological research products
for SORBS2    

Aliases
for SORBS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sorbin And SH3 Domain Containing 21 2     Arg Binding Protein 22
ARGBP21 2 3     Sorbin And SH3 Domain-Containing Protein 22
KIAA07771 3     ArgBP23
Arg/Abl-Interacting Protein 22 3     Sorbin3
PRO06182     

External Ids:    HGNC: 240981   Entrez Gene: 84702   Ensembl: ENSG000001545567   UniProtKB: O948753   

Export aliases for SORBS2 gene to outside databases

Previous GC identifers: GC04M186884 GC04M186743 GC04M182259


Summaries
for SORBS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SORBS2:
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They
interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of
proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an
N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this
protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling
complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875
Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases
and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or
with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption
in the intestine and gall-bladder

Gene Wiki entry for SORBS2


Genomic Views
for SORBS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SORBS2 gene promoter:
         SREBP-1a   Chx10   FOXD3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SORBS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SORBS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SORBS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

SORBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SORBS2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M186506:  view genomic region     (about GC identifiers)

Start:
 186,506,598 bp from pter      End:
 186,877,870 bp from pter
Size:
 371,273 bases      Orientation:
 minus strand

Proteins
for SORBS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875 (See protein sequence)
Recommended Name: Sorbin and SH3 domain-containing protein 2  
Size: 1100 amino acids; 124108 Da
Subunit: Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2,
VCL/vinculin, and WASF (By similarity). Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD and PAK1
Subcellular location: Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies
and focal adhesion
Sequence caution: Sequence=BAA34497.2; Type=Erroneous initiation;
Secondary accessions: A6NEK9 B7Z1G5 B7Z3X6 C9JKV9 D3DP62 D3DP63 E9PAS5 E9PAW4 G3XAI0 O60592 O60593
Q96EX0
Alternative splicing: 10 isoforms:  O94875-1   O94875-2   O94875-3   O94875-4   O94875-5   O94875-6   O94875-7   O94875-8   
O94875-9   O94875-10   (No experimental confirmation available. Ref.5 (AK225812) sequence is in conflict in position: 424:K->E)

Explore the universe of human proteins at neXtProt for SORBS2: NX_O94875

Post-translational modifications:

  • Ubiquitinated by CBL1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94875

    • SORBS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (9 alternative transcripts): 
    NP_001139142.1  NP_001139143.1  NP_001139144.1  NP_001139145.1  NP_001139146.1  NP_001139147.1  NP_001257700.1  NP_003594.3  
    NP_066547.1  

    ENSEMBL proteins: 
     ENSP00000284776   ENSP00000396008   ENSP00000322182   ENSP00000397262   ENSP00000347852  
     ENSP00000377162   ENSP00000321983   ENSP00000401818   ENSP00000389995   ENSP00000391940  
     ENSP00000399048   ENSP00000408909   ENSP00000410483   ENSP00000405349   ENSP00000415680  
     ENSP00000397664   ENSP00000398335   ENSP00000410967   ENSP00000415637   ENSP00000416464  
     ENSP00000405092   ENSP00000396183   ENSP00000403417   ENSP00000408504   ENSP00000377158  
     ENSP00000410233   ENSP00000405646   ENSP00000405314   ENSP00000405432   ENSP00000415166  
     ENSP00000415392   ENSP00000407006   ENSP00000404430   ENSP00000402328   ENSP00000393258  
     ENSP00000412447   ENSP00000390162   ENSP00000389829   ENSP00000409158   ENSP00000411764  
     ENSP00000397482  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SORBS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9211900
    GO:0015629actin cytoskeleton TAS9211900
    GO:0030018Z disc NAS9211900
    GO:0048471perinuclear region of cytoplasm IEA--


    SORBS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SORBS2

    Protein Domains /
    Families
    for SORBS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SORBS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011511 SH3_2
     IPR000108 p67phox
     IPR001452 SH3_domain
     IPR003127 Sorb
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O94875

    ProtoNet protein and cluster: O94875

    2 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB003127 Sorbin-like


    UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875
    Similarity: Contains 3 SH3 domains
    Similarity: Contains 1 SoHo domain


    Function
    for SORBS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875
    Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases
    and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or
    with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption
    in the intestine and gall-bladder

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SORBS2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS9211900
    GO:0008093cytoskeletal adaptor activity TAS9211900
    GO:0008270zinc ion binding IEA--
    GO:0008307structural constituent of muscle TAS9211900


    SORBS2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SORBS2:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for SORBS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SORBS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for SORBS2 (O948752, 3 ENSP000002847764) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-61471 MINT-61474 MINT-61475 MINT-61478 MINT-61470 MINT-61472 MINT-61477 MINT-61473 I2D: score=2 STRING: ENSP00000278568
    AKT1P317492, 3, ENSP000002702024MINT-61344 MINT-61469 MINT-61464 MINT-61466 MINT-61479 MINT-61468 MINT-61467 MINT-61463 MINT-61346 MINT-61345 MINT-61462 MINT-61465 I2D: score=2 STRING: ENSP00000270202
    RPL9P329692, 3, ENSP000003460224MINT-63671 I2D: score=4 STRING: ENSP00000346022
    RPL9P7P329692, 3MINT-63671 I2D: score=4 
    RPL9P8P329692, 3MINT-63671 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    SORBS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SORBS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SORBS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SORBS2

    1 HMDB Compound for SORBS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    1 Novoseek chemical compound relationship for SORBS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.1 1 9211900 (1)

    Search CenterWatch for drugs/clinical trials and news about SORBS2 / SRBS2 

    Transcripts
    for SORBS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SORBS2 gene (9 alternative transcripts): 
    NM_001145670.1  NM_001145671.2  NM_001145672.1  NM_001145673.1  NM_001145674.1  NM_001145675.1  NM_001270771.1  NM_003603.6  
    NM_021069.4  

    Unigene Clusters for SORBS2:

    Sorbin and SH3 domain containing 2
    Hs.619806  [show with all ESTs], Hs.655143  [show with all ESTs]
    Unigene Representative Sequences: BC069025, NM_001270771
    18/65 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 65):
    ENST00000284776(uc003iyh.3 uc011ckx.2 uc003iym.3 uc003iyl.3)
    ENST00000437304 ENST00000319471(uc003iyn.1) ENST00000449407 ENST00000355634(uc011cky.1)
    ENST00000393528 ENST00000478461 ENST00000319454 ENST00000498125(uc003iyo.1)
    ENST00000480146 ENST00000451974 ENST00000438278 ENST00000487184 ENST00000445625
    ENST00000487836 ENST00000495932 ENST00000490562 ENST00000492104

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SORBS2 (see all 21):
    hsa-miR-320a hsa-miR-26a-2* hsa-miR-200a hsa-miR-141 hsa-miR-4325 hsa-miR-891b hsa-miR-3155b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: SORBS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB018320.1 AF049884.1 AF049885.1 AK000782.1 AK056628.1 AK056758.1 AK225327.1 AK225812.1 
    AK293400.1 AK295742.1 AK296461.1 AK304653.1 BC011883.1 BC035329.1 BC122526.1 EF139852.1 

    24/54 DOTS entries (see all 54):

    DT.95296114  DT.121264072  DT.91765661  DT.95296147  DT.121263879  DT.454495  DT.102837396  DT.97846879 
    DT.95296143  DT.95182172  DT.121263881  DT.97799403  DT.121264079  DT.307436  DT.121264030  DT.121264032 
    DT.95255892  DT.121263920  DT.121263934  DT.121264103  DT.70103389  DT.95296176  DT.97778169  DT.121264081 

    24/394 AceView cDNA sequences (see all 394):

    CA389522 AA877735 AW009119 NM_003603 AA909633 CD676765 CB162502 BE857254 
    BX486136 CB069742 AL702536 BC030082 BM908682 CN481856 BM310164 AI139775 
    AI659181 T30939 AW955595 R58128 CD678345 CA389523 BE407758 AW270994 

    GeneLoc Exon Structure

    5/26 Alternative Splicing Database (ASD) splice patterns (SP) for SORBS2 (see all 26)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
    SP1:                                                                                            -                       -     -     -     -                     
    SP2:                                                                                      -     -                       -     -     -           -           -   
    SP3:                                                                                                                                                            
    SP4:                                                                                      -     -                       -     -     -                           
    SP5:                                                                                      -     -                       -     -     -     -     -               

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^
    SP1:        -     -                       -           -     -     -                                   -     -     -           -                             -   
    SP2:        -     -                       -           -     -     -                                   -     -     -     -                                   -   
    SP3:                                                                                -                 -     -     -           -                             -   
    SP4:                                                                                                                                                            
    SP5:        -     -                                                                                                                                             

    ExUns: 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b
    SP1:  -                                   -           -                     
    SP2:  -                                   -                                 
    SP3:  -                                                                     
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for SORBS2

    Expression
    for SORBS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SORBS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTAAACACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SORBS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    SomiteLumbar Vertebral BodySomite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage

    See SORBS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SORBS2

    SOURCE GeneReport for Unigene clusters: Hs.619806 Hs.655143

    UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875
    Tissue specificity: Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also
    found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain,
    ovary and epithelial cells

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    Orthologs
    for SORBS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SORBS2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SORBS21 sorbin and SH3 domain containing 2 77.86(n)
    80.29(a)    		   422719  XM_420674.3  XP_420674.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SORBS26
    		 --
    		 41(a)
    		 1 ↔ 1
    		 5(112611439-112727414)
    zebrafish
    (Danio rerio)    		 Actinopterygii sorbs2b1 sorbin and SH3 domain containing 2b 61.83(n)
    59.71(a)    		   563408  XM_686765.4  XP_691857.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CAP6
    		 CAP
    		 6(a)
    		 1 → many
    		 2R(6156528-6194529)
    worm
    (Caenorhabditis elegans)    		 Secernentea sorb-16
    		 Temporarily Assigned Gene name family member (tag-...
    		 12(a)
    		 1 → many
    		 IV(13750312-13770583)


    ENSEMBL Gene Tree for SORBS2 (if available)
    TreeFam Gene Tree for SORBS2 (if available) 

    Paralogs
    for SORBS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SORBS2 gene
    SH3RF32  SH3RF22  SORBS32  SH3RF12  SORBS12  SH3D192  
    6 SIMAP similar genes for SORBS2 using alignment to 32 protein entries:     SRBS2_HUMAN (see all proteins):
    SH3GL2    ARHGEF7    SH3GL1    SORBS3    DKFZp686N08224    SORBS1

    SORBS2 for paralogs           About GeneDecksing



    Genomic Variants
    for SORBS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SORBS2
         1 CNV: 59196
         1 Indel: 41313
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SORBS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SORBS2

    Disorders / Diseases
    for SORBS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SORBS2 for disorders           About GeneDecksing

    6 diseases for SORBS2:    About MalaCards
    facioscapulohumeral muscular dystrophy    muscular dystrophy    hepatocellular carcinoma    carcinoma
    pancreatitis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: SORBS2 (2 documents)

    Export disorders for SORBS2 gene to outside databases

    Publications
    for SORBS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SORBS2 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SORBS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl- interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. (PubMed id 9211900)1, 2, 3, 9 Wang B.... Kruh G.D. (1997)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. (PubMed id 16125169)1, 2 Roenty M.... Carpen O. (2005)
    4. ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. (PubMed id 15784622)1, 2 Yuan Z.Q....Cheng J.Q. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. (PubMed id 12475393)1, 2 Soubeyran P....Dikic I. (2003)
    7. Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus. (PubMed id 15949647)1, 9 Hand D. and Eiden L.E. (2005)
    8. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. (PubMed id 15128873)1, 9 Haglund K....Dikic I. (2004)
    9. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. (PubMed id 11481476)1, 9 Kimura A....Saltiel A.R. (2001)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)

    External Searches for SORBS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SORBS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8470 HGNC: 24098 AceView: ARGBP2 Ensembl:ENSG00000154556 euGenes: HUgn8470
    ECgene: SORBS2 H-InvDB: SORBS2

    Other Databases showing SORBS2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0777

    Specialized Databases showing SORBS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SORBS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SORBS2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SORBS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SORBS2 gene:
    Search GeneIP for patents involving SORBS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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