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SORBS2 Gene

protein-coding GIFtS: 59

GC04M186743

sorbin and SH3 domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARGBP2 ^¹, ², ³
ArgBP2 ^³
FLJ93447 ^²
KIAA0777 ^¹, ², ³
PRO0618 ^²
Sorbin ^³

Descriptions
Arg binding protein 2 ^²
Arg/Abl interacting protein ^²
Arg/Abl-interacting protein 2 ^², ³
sorbin and SH3 domain containing 2 ^²

External Ids
HGNC: 24098¹
Entrez Gene: 8470²
UniProtKB: O94875³
Ensembl: ENSG00000154556⁷

Search outside databases for aliases for SORBS2 gene

Previous GC identifer: GC04M186884

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SORBS2:

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor

protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains

present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3

domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology

(SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this

protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to

assemble signaling complexes in stress fibers, and that it is a potential link between Abl family

kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants

encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875

Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link

between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting

ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated

activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and

gall-bladder

Gene Wiki entry for SORBS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SORBS2 gene

Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1

SORBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M186743: (about GC identifiers)

Start:	186,743,592 bp from pter
End:	187,114,516 bp from pter
Size:	370,925 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_022792.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875 (See protein sequence)

Recommended Name: Sorbin and SH3 domain-containing protein 2

Size: 1100 amino acids; 124108 Da

Subunit: Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1,

SYNJ1, SYNJ2, VCL/vinculin, and WASF (By similarity). Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg,

ACTN, AKT1, CBL, PALLD and PAK1

Subcellular location: Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress

fibers, dense bodies and focal adhesion

Secondary accessions: A6NEK9 O60592 O60593 Q96EX0

Alternative splicing: 6 isoforms: O94875-1 O94875-2 O94875-3 O94875-4 O94875-5 O94875-6

Post-translational modifications:

Ubiquitinated by CBL¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (8 alternative transcripts):

NP_001139142.1 NP_001139143.1 NP_001139144.1 NP_001139145.1 NP_001139146.1 NP_001139147.1 NP_003594.3 NP_066547.1

ENSEMBL proteins:

ENSP00000377158 ENSP00000284776 ENSP00000321983 ENSP00000377162 ENSP00000322182 ENSP00000347852

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SORBS2)
	Human Recombinant Proteins from Abnova (SORBS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	9211900
GO:0005737	cytoplasm	IEA	--
GO:0015629	actin cytoskeleton	TAS	9211900
GO:0030018	Z disc	NAS	9211900

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Antibodies for SORBS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SORBS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SORBS2)
	Novus Biologicals Antibodies for SORBS2

Assays for SORBS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O94875

ProtoNet protein and cluster: O94875

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB003127 Sorbin-like

UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875

Similarity: Contains 3 SH3 domains

Similarity: Contains 1 SoHo domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SORBS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SORBS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_001145670

Applied Biosystems Silencer® siRNAs for SORBS2

Sigma-Aldrich siRNA for SORBS2

Sigma-Aldrich shRNA Panels and shRNA for SORBS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): NM_001145670
Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): NM_001145670
untagged cDNA clones in CMV expression vector (see all 10): AF396457

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: AK056628

UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875

Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link

between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting

ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated

activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and

gall-bladder

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005200	structural constituent of cytoskeleton	TAS	9211900
GO:0005515	protein binding	NAS	9211900
GO:0008093	cytoskeletal adaptor activity	TAS	9211900
GO:0008307	structural constituent of muscle	TAS	9211900

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SORBS2

5/8 Interacting proteins for SORBS2 (ENSP00000347852³ O94875²) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	ENSP00000361423³	STRING (score=.944)
CBL	ENSP00000264033³	STRING (score=.927)
VCL	ENSP00000211998³	STRING (score=.897)
MLLT4	ENSP00000252692³	STRING (score=.853)
PTK2B	ENSP00000332816³	STRING (score=.798)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SORBS2
1 Novoseek chemical compound relationship for SORBS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	22.51	1	9211900 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SORBS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SORBS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_001145670

Sigma-Aldrich siRNA for SORBS2

Sigma-Aldrich shRNA Panels and shRNA for SORBS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003603 NM_021069

REFSEQ mRNAs for SORBS2 gene (8 alternative transcripts):

NM_001145670.1 NM_001145671.1 NM_001145672.1 NM_001145673.1 NM_001145674.1 NM_001145675.1 NM_003603.5 NM_021069.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003603 NM_021069

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): NM_001145670
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): NM_001145670
                                 untagged cDNA clones in CMV expression vector (see all 10): AF396457

Additional cDNA sequence:

AB018320.1 AF049884.1 AF049885.1 AK000782.1 AK056628.1 AK056758.1 AK225327.1 AK225812.1

AK293400.1 AK295742.1 AK296461.1 AK304653.1 BC011883.1 BC035329.1 CR625998.1 EF139852.1

24/54 DOTS entries (see all 54 ):

DT.95296114 DT.121264072 DT.91765661 DT.121263879 DT.95296147 DT.454495 DT.102837396 DT.97846879

DT.95296143 DT.95182172 DT.121263881 DT.97799403 DT.307436 DT.121263920 DT.121264079 DT.121264030

DT.121264032 DT.95255892 DT.121263934 DT.304196 DT.70103389 DT.95296176 DT.97778169 DT.121264081

24/394 AceView cDNA sequences (see all 394 ):

BX486136 AI659181 BC011883 R58128 AW003712 BI226140 CB162502 BQ447625

BF002981 CA391426 CB270104 AA939266 AI377927 CR625998 CK300430 CA389522

AL702536 CB069742 BE407758 CN481856 AA877735 BC030082 AA682476 AL707786

highest scoring ESTs for SORBS2:

AA114994 BC035329 BI755847 AB018320 AK056628 AA001823 AA002027 AA035033 AA035086 AA035370

Unigene Clusters for SORBS2:

Sorbin and SH3 domain containing 2

Hs.619806 [show with all ESTs], Hs.655143 [show with all ESTs]

Unigene Representative Sequences: BC069025, NM_021069

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for SORBS2 (see all 26 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9	^	10	^	11	^	12	^	13a	·
SP1:																															-								-		-		-		-
SP2:																													-		-								-		-		-				-				-
SP3:
SP4:																													-		-								-		-		-
SP5:																													-		-								-		-		-		-		-

ExUns:	13b	^	14	^	15	^	16a	·	16b	·	16c	·	16d	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	^	20	^	21	^	22a	·	22b	·	22c	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^
SP1:			-		-								-				-		-		-												-		-		-				-										-
SP2:			-		-								-				-		-		-												-		-		-		-												-
SP3:																											-						-		-		-				-										-
SP4:
SP5:			-		-

ExUns:	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38a	·	38b	^	39a	·	39b
SP1:	-												-				-
SP2:	-												-
SP3:	-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SORBS2

6 Ensembl transcripts including schematic representations:

ENST00000393523 ENST00000284776 ENST00000319454 ENST00000393528 ENST00000319471 ENST00000355634

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SORBS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SORBS2

¹ / ² / ³

15 probe-sets matching SORBS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39295_s_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.65	AF049884	0.80	0.80	0.80	1
84730_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.93	Z43198	0.60	0.75	0.68	1
50411_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.62	AI659533	0.60	0.75	0.68	1
74022_at²^{, 3}	U95-D	1	0.75	1.00	0.37	0.87	AI968161	0.60	1.00	0.82	1
225728_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI659533	0.60	0.75	0.68	1
204288_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021069	0.60	1.00	0.82	1
220858_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
237285_at²^{, 3}	U133-B	1	0.73	1.00	--	--	BF056896	0.40	1.00	0.76	1
233720_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AK000782	0.40	1.00	0.76	1
1558815_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225728_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204288_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220858_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
237285_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
233720_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SORBS2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGCTTTGCT

SOURCE GeneReport for Unigene clusters: Hs.619806 Hs.655143
UniProtKB/Swiss-Prot: SRBS2_HUMAN, O94875
Tissue specificity: Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks
of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus,
colon, spleen, prostate, testis, brain, ovary and epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SORBS2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	SORBS2¹	--	sorbin and SH3 domain containing 2	98.3(n) 97.55(a)	461640 XM_001165395.1 XP_001165395.1
cow (Bos taurus)	SORBS2¹	--	sorbin and SH3 domain containing 2	87.07(n) 90.07(a)	614391 XM_865206.2 XP_870299.2
mouse (Mus musculus)	Sorbs2⁵	8	sorbin and SH3 domain containing 2	--	CV883960
chicken (Gallus gallus)	SORBS2¹	--	sorbin and SH3 domain containing 2	77.86(n) 80.29(a)	422719 XM_420674.2 XP_420674.2
zebrafish (Danio rerio)	LOC563408¹	--	similar to KIAA0777 protein	61.55(n) 59.13(a)	563408 XM_686765.2 XP_691857.2

About this table Species with no ortholog for SORBS2

ENSEMBL Gene Tree for SORBS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SORBS2 gene

SORBS3² SORBS1² SH3D19²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2884 NCBI SNPs in SORBS2 are shown (see all 2884 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 924)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7674108^1,2	A,C,F,H	186744274(+)	`GCTACA/GTACAT`	2	--	ut3¹ ese³		7	EU EA WA NA	560
	rs6831183^1,2	A,C,F,H	186744433(+)	`TGAACT/CATATT`	2	--	ut3¹ ese³		11	EU EA WA NA	978
	rs6823937^1,2	A,C,F,H	186743119(+)	`TGTCCA/GTATTT`	2	--	ng5¹		4	EU EA WA	420
	rs6823490^1,2	A,C,F,H	186743159(+)	`GGGTCC/AAAACA`	2	--	ng5¹		8	EU EA WA	838
	rs6824017^1,2	A,C,F,H	186743341(+)	`TAGGGT/CAAAGA`	2	--	ng5¹		4	EU EA WA	420
	rs1046236^1,2	C,F,H,O	186744181(-)	`TTATCC/TTGCGA`	2	--	ut3¹ ese³		13	MN EA NA EU WA	1238
	rs6552924^1,2	A,C,F,H	186970897(+)	`AAGATC/ATTTAA`	2	--	ng3¹ int¹		6	MN EA EU WA	1670
	rs10031753^1,2	C,F,H	186744403(+)	`GTTTTC/TGGAGC`	2	--	ut3¹		8	EU EA WA	838
	rs13122948^1,2	C,F,H	186971997(+)	`TGTCAC/TGCCCT`	2	--	ng3¹ int¹		8	EU EA WA	832
	rs3172664^1,2	A,C,F	186744970(-)	`AAAATG/ATAATG`	2	--	ut3¹		1	MN	184

About this table

HapMap Linkage Disequilibrium images for SORBS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: SORBS2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for SORBS2 gene (see all 38 ):

ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl- interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. (PubMed id 9211900)^{1, 2, 3, 4} Wang B.... Kruh G.D. (1997)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{2, 3, 4} Nagase T....Ohara O. (1998)
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. (PubMed id 15784622)^{3, 4} Yuan Z.Q....Cheng J.Q. (2005)
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. (PubMed id 12475393)^{3, 4} Soubeyran P....Dikic I. (2003)
Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus. (PubMed id 15949647)^{1, 3} Hand D. and Eiden L.E. (2005)
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. (PubMed id 15128873)^{1, 3} Haglund K....Dikic I. (2004)
The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. (PubMed id 11481476)^{1, 3} Kimura A....Saltiel A.R. (2001)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity. (PubMed id 18559503)³ Taieb D....Soubeyran P. (2008)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8470	HGNC: 24098	AceView: ARGBP2	Ensembl:ENSG00000154556	euGenes: HUgn8470
ECgene: SORBS2	H-InvDB: SORBS2

(According to HUGE)
About This Section

HUGE: KIAA0777

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SORBS2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SORBS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SORBS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SORBS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SORBS2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SORBS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SORBS2)
	Antibodies (SORBS2)
	Chimera RNAi (SORBS2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (SORBS2)
	Antibodies (SORBS2)

Search OriGene for SORBS2

Search Tocris compounds for SORBS2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SORBS2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SORBS2 Gene at Home site.
Version 2.41.1
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SORBS2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for SORBS2

Summaries
for SORBS2

Genomic Location
for SORBS2

Proteins
for SORBS2

Protein Domains/
Families
for SORBS2

Gene Function
for SORBS2

Pathways & Interactions
for SORBS2

Drugs & Compounds
for SORBS2

Transcripts
for SORBS2

Expression
for SORBS2

Orthologs
for SORBS2

Paralogs
for SORBS2

SNPs/Variants
for SORBS2

Disorders & Mutations
for SORBS2

Medical News
for SORBS2

Publications
for SORBS2

Search for SORBS2

Genome Databases showing SORBS2

Other Databases showing SORBS2

Specialized Databases showing SORBS2

Licensable Technologies
for SORBS2

Services
for SORBS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SORBS2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor SORBS2

Summariesfor SORBS2

Genomic Locationfor SORBS2

Proteinsfor SORBS2

Protein Domains/Familiesfor SORBS2

Gene Functionfor SORBS2

Pathways & Interactionsfor SORBS2

Drugs & Compoundsfor SORBS2

Transcriptsfor SORBS2

Expression for SORBS2

Orthologsfor SORBS2

Paralogsfor SORBS2

SNPs/Variantsfor SORBS2

Disorders & Mutationsfor SORBS2

Medical Newsfor SORBS2

Publicationsfor SORBS2

Search for SORBS2

Genome Databases showing SORBS2

Other Databases showing SORBS2

Specialized Databases showing SORBS2

Licensable Technologiesfor SORBS2

Servicesfor SORBS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SORBS2

Summaries
for SORBS2

Genomic Location
for SORBS2

Proteins
for SORBS2

Protein Domains/
Families
for SORBS2

Gene Function
for SORBS2

Pathways & Interactions
for SORBS2

Drugs & Compounds
for SORBS2

Transcripts
for SORBS2

Expression
for SORBS2

Orthologs
for SORBS2

Paralogs
for SORBS2

SNPs/Variants
for SORBS2

Disorders & Mutations
for SORBS2

Medical News
for SORBS2

Publications
for SORBS2

Licensable Technologies
for SORBS2

Services
for SORBS2