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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SON Gene

protein-coding   GIFtS: 54
GCID: GC21P034914

SON DNA binding protein


(Previous symbol: C21orf50)
 Explore 7 diseases affiliated with
SON via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SON    

Aliases
for SON gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
SON DNA Binding Protein1 2     Protein DBP-52 3
BASS11 2 3     SON32 3
C21orf501 2 3     NRE-Binding Protein2 3
NREBP1 2 3     FLJ210991
DBP-51 2     FLJ339141
KIAA10191 3     SON DNA-Binding Protein, KIAA101911
Bax Antagonist Selected In Saccharomyces 12 3     Protein SON2
Negative Regulatory Element-Binding Protein2 3     DBP53

External Ids:    HGNC: 111831   Entrez Gene: 66512   Ensembl: ENSG000001591407   OMIM: 1824655   UniProtKB: P185833   

Export aliases for SON gene to outside databases

Previous GC identifers: GC21P031492 GC21P031575 GC21P033835 GC21P033837 GC21P020393


Summaries
for SON gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SON:
The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the
core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core
promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities
with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It
may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding
different isoforms have been described for this gene, but the full-length nature of only two of them has been
determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SON_HUMAN, P18583
Function: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that
possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess
weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating
the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA;
binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core
promoter activity and transcription of HBV genes and production of HBV virions

Gene Wiki entry for SON


Genomic Views
for SON gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SON gene promoter:
         E2F-3a   E2F-5   E2F-1   E2F   Sp1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): SON promoter sequence

   Search SABiosciences Chromatin IP Primers for SON

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SON


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1-q22.2
Nature(405: 311-319) cytogenetic band:   21q22.11
SON Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SON gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034914:   GeneLoc Nature:405,311-319
Start:
 34,914,924 bp from pter       20,499,844 bp from centromere
End:
 34,949,812 bp from pter 20,526,435 bp from centromere
Size:
 34,889 bases 26,592 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X63753
genomic clones: pT604 pT377


Proteins
for SON gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SON_HUMAN, P18583 (See protein sequence)
Recommended Name: Protein SON  
Size: 2426 amino acids; 263830 Da
Subunit: Interacts with SRSF2. Associates with the spliceosome. Interacts with the AML1-MTG8 (AML1-ETO) fusion protein,
possibly leading to trigger signals inhibiting leukemogenesis
Subcellular location: Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2
Sequence caution: Sequence=AAH02422.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAA82971.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA44793.1; Type=Frameshift; Positions=2315, 2412, 2417; Sequence=CAC69885.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Secondary accessions: D3DSF5 D3DSF6 E7ETE8 E7EU67 E7EVW3 E9PFQ2 O14487 O95981 Q14120 Q6PKE0 Q9H7B1
Q9P070 Q9P072 Q9UKP9 Q9UPY0
Alternative splicing: 10 isoforms:  P18583-1   P18583-2   P18583-3   P18583-4   P18583-5   P18583-6   P18583-7   P18583-8   
P18583-9   P18583-10   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SON: NX_P18583

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18583

    • SON Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_115571.1  NP_620305.1  

    ENSEMBL proteins: 
     ENSP00000348984   ENSP00000371111   ENSP00000300278   ENSP00000399783   ENSP00000371095  
     ENSP00000400985   ENSP00000405807   ENSP00000401942   ENSP00000404135   ENSP00000290239  

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    OriGene Custom Protein Services for SON 
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    Novus Biologicals SON Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SON

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IDA--


    SON for ontologies           About GeneDecksing



    SON Antibody Products: 
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    Novus Biologicals SON Antibodies
    Search for Antibodies for SON at Abcam  
    Uscn Antibodies for SON
    Search ThermoFisher Antibodies for SON

    Assay Products for SON: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SON
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SON

    Protein Domains /
    Families
    for SON gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SON for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001159 Ds-RNA-bd
     IPR000467 G_patch_dom
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry P18583

    ProtoNet protein and cluster: P18583

    2 Blocks protein families:
    IPB000467 D111/G-patch domain
    IPB001159 Double-stranded RNA binding (DsRBD) domain


    UniProtKB/Swiss-Prot: SON_HUMAN, P18583
    Domain: Contains 8 types of repeats which are distributed in 3 regions
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain
    Similarity: Contains 1 G-patch domain


    Function
    for SON gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SON_HUMAN, P18583
    Function: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that
    possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess
    weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating
    the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA;
    binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core
    promoter activity and transcription of HBV genes and production of HBV virions

         Genatlas biochemistry entry for SON:
    DNA binding protein with some homology to c-mos,ubiquitously expressed,involved in chromatin remodeling

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SON
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SON (see all 52):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-15a hsa-miR-200a hsa-miR-624 hsa-miR-30d hsa-miR-141 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: SON 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SON (see all 4)
    OriGene shRNA RFP: SON
    OriGene siRNA: SON
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SON

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SON

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SON (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SON (NM_032195)
    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SON 

    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS1944255
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IDA--
    GO:0003725double-stranded RNA binding IEA--
    GO:0005515protein binding IPI--


    SON for ontologies           About GeneDecksing


    15/16 GenomeRNAi human phenotypes for SON (see all 16):
     Abundance of large cells with   Cell cycle / mitosis defect  Cell division defect  Decreased NANOG protein expres 
     Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased cell number, increas  Decreased homologous recombina 
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Increased number of cells in m 


    Pathways & Interactions
    for SON gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SON

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for SON (P185832, 3 ENSP000003489844) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50859 I2D: score=4 STRING: ENSP00000306330
    YWHABP319462, 3, ENSP000003001614MINT-50971 I2D: score=3 STRING: ENSP00000300161
    PRPF40AO754002, 3MINT-61857 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62155 I2D: score=3 
    TRIP6Q156543, ENSP000002004574I2D: score=1 STRING: ENSP00000200457
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000073spindle pole body separation ----
    GO:0000226microtubule cytoskeleton organization IMP--
    GO:0000910cytokinesis IMP--
    GO:0006397mRNA processing IDA--
    GO:0007049cell cycle IEA--


    SON for ontologies           About GeneDecksing



    Drugs & Compounds
    for SON gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SON
    Search CenterWatch for drugs/clinical trials and news about SON 

    Transcripts
    for SON gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SON gene (6 alternative transcripts): 
    NM_032195.1  NM_138927.1  NM_003103.5  NM_058183.2  NM_138925.1  NM_138926.1  

    Unigene Cluster for SON:

    SON DNA binding protein
    Hs.517262  [show with all ESTs]
    Unigene Representative Sequence: NM_138927
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000356577 ENST00000475072 ENST00000381692 ENST00000300278(uc002ysc.3)
    ENST00000455528 ENST00000381679(uc002ysb.1) ENST00000492229 ENST00000436227(uc002ysg.3)
    ENST00000421541 ENST00000429093 ENST00000474355 ENST00000457208 ENST00000467616
    ENST00000484294 ENST00000473102 ENST00000470533 ENST00000478183(uc002ysh.3)
    ENST00000465834

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SON
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SON (see all 52):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-15a hsa-miR-200a hsa-miR-624 hsa-miR-30d hsa-miR-141 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: SON 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SON (see all 4)
    OriGene shRNA RFP: SON
    OriGene siRNA: SON
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SON
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SON (NM_032195)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SON 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SON
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SON
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SON

    Additional cDNA sequence: 

    AB028942.2 AF139897.1 AF161428.1 AF161430.1 AF380180.1 AF380182.1 AF380184.1 AF435977.1 
    AK024752.1 AK074269.1 AK091233.1 AK127947.1 AK128071.1 AK307612.1 BC002422.2 BC005337.1 
    BC017278.2 BC029455.1 BC046101.1 BC054029.1 BC066303.1 BC104656.1 BC113911.1 DQ102771.1 
    EF212261.1 X63071.1 X63751.1 X63753.1 

    24/40 DOTS entries (see all 40):

    DT.91915247  DT.100059515  DT.95255347  DT.75102580  DT.95255367  DT.91767070  DT.99983617  DT.91767056 
    DT.75134514  DT.86849430  DT.121141317  DT.91696305  DT.419506  DT.100879195  DT.121141046  DT.100016039 
    DT.121140988  DT.100865109  DT.121141465  DT.100879194  DT.91931698  DT.121365317  DT.95369227  DT.100879201 

    24/682 AceView cDNA sequences (see all 682):

    AF380180 AI650942 NM_032195 CD724075 T05675 BM927467 BI871364 BM477925 
    CD724305 CF887020 AF380179 T29865 AI820671 BQ216503 BU186243 AF380181 
    CA487193 AA279464 BQ073424 NM_138927 BM451848 BM477987 BU579696 AA627162 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SON (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
    SP1:                                                                                                                                      -     -     -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -     -           -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                        -   

    ExUns: 18b · 18c ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g
    SP1:  -                       -                                       
    SP2:  -                                                               
    SP3:  -                                                               
    SP4:  -                       -                                       
    SP5:  -                                                               


    ECgene alternative splicing isoforms for SON

    Expression
    for SON gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SON expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATTACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SON expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SON Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SON

    SOURCE GeneReport for Unigene cluster: Hs.517262

    UniProtKB/Swiss-Prot: SON_HUMAN, P18583
    Tissue specificity: Widely expressed, with the higher expression seen in leukocyte and heart

        SABiosciences Expression via Pathway-Focused PCR Array including SON: 
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    Orthologs
    for SON gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SON gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Son1 , 5 Son DNA binding protein1, 5 88.29(n)1
    87.44(a)1    		   16 (53.22 cM)5
    206581  NM_178880.41  NP_849211.31 
     916475065 
    chicken
    (Gallus gallus)    		 Aves SON1 SON DNA binding protein 45.61(n)
    36.2(a)    		   770637  XM_003640519.1  XP_003640567.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SON6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 3(142960692-143004345)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.212682 Xenopus laevis transcribed sequence with weak similarity more 76.01(n)    BJ618719.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01113192.16
    		 --
    		 47(a)
    		 1 ↔ 1
    		 1(683992-706241)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG82733 double-stranded RNA binding 38(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea D1037.13   -- 44(a)   I(3684779-3685944)   --


    ENSEMBL Gene Tree for SON (if available)
    TreeFam Gene Tree for SON (if available) 

    Paralogs
    for SON gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SON gene
    CLASRP2  RSRC12  C1orf632  

    SON for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SON
    PGOHUM00000245020


    Genomic Variants
    for SON gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/671 NCBI SNPs in SON are shown (see all 671)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1149503191,2
    		F,--34917446(+) CTTCAC/ACTCTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1835900311,2
    		--34917483(+) TTCTTA/CATTTA 2 -- int10--------
    rs1873982001,2
    		--34917623(+) GCCAGA/CTGTTC 2 -- int10--------
    rs1384043251,2
    		--34917695(+) AGGTAA/GTGGAG 2 -- int10--------
    rs1429119691,2
    		--34917709(+) AATTGA/TTGTGT 2 -- int10--------
    rs1174478711,2
    		--34917749(+) CAAACT/AGTTGC 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1459712631,2
    		--34917825(+) TGATAC/TGTTCT 2 -- int10--------
    rs1385710901,2
    		--34918115(+) GCACAC/GCTGTG 2 -- int10--------
    rs1411598431,2
    		--34918142(+) GGTTTC/TTACCA 2 -- int10--------
    rs1907031631,2
    		--34918341(+) AAATGA/GAATGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for SON (34914924 - 34949812 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SON: --

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    Disorders / Diseases
    for SON gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SON for disorders           About GeneDecksing

    OMIM gene information: 182465    OMIM disorders: --

    7 diseases for SON:    About MalaCards
    hepatitis b    blue color blindness    color blindness    hepatitis
    blepharospasm    blindness    influenza


    Export disorders for SON gene to outside databases

    Publications
    for SON gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SON gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with SON)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON. (PubMed id 11306577)1, 2, 9 Sun C.-T....Ting L.-P. (2001)
    2. The origins, evolution and functional potential of al ternative splicing in vertebrates. (PubMed id 21551269)1, 3 Mudge J.M....Harrow J. (2011)
    3. SON controls cell-cycle progression by coordinated regulation of RNA splicing. (PubMed id 21504830)1, 2 Ahn E.Y.... Zhang D.E. (2011)
    4. SON is a spliceosome-associated factor required for mitotic progression. (PubMed id 20581448)1, 2 Huen M.S.... Chen J. (2010)
    5. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. (PubMed id 18952841)1, 2 Ahn E.Y....Zhang D.E. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    9. mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs. (PubMed id 14637006)1, 2 Casadei R....Zannotti M. (2003)
    10. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (2001)

    External Searches for SON gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing SON gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6651 HGNC: 11183 AceView: SON Ensembl:ENSG00000159140 euGenes: HUgn6651
    ECgene: SON H-InvDB: SON

    Other Databases showing SON gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1019

    Specialized Databases showing SON gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SON Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SON Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SON gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SON gene:
    Search GeneIP for patents involving SON

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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