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Aliases for SOHLH2 Gene

Aliases for SOHLH2 Gene

  • Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2 2 3 5
  • Spermatogenesis Associated 28 2 3
  • TEB1 3 4
  • Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing Protein 2 3
  • Testicular Secretory Protein Li 50 3
  • Testicular Secretory Protein Li 51 3
  • SPATA28 3
  • BHLHe81 3
  • SOSF2 3

External Ids for SOHLH2 Gene

Previous GeneCards Identifiers for SOHLH2 Gene

  • GC13M035642
  • GC13M036742
  • GC13M017554

Summaries for SOHLH2 Gene

Entrez Gene Summary for SOHLH2 Gene

  • This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for SOHLH2 Gene

SOHLH2 (Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2) is a Protein Coding gene. Diseases associated with SOHLH2 include Giardiasis. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is CCDC169-SOHLH2.

UniProtKB/Swiss-Prot for SOHLH2 Gene

  • Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

Additional gene information for SOHLH2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOHLH2 Gene

Genomics for SOHLH2 Gene

GeneHancer (GH) Regulatory Elements for SOHLH2 Gene

Promoters and enhancers for SOHLH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I036214 Promoter 0.9 EPDnew 550.8 +0.1 51 0.1 L3MBTL2 BHLHE40 NRF1 MNT POLR2A ZBTB33 MYC ZFX SETDB1 MGA SOHLH2 RNU6-71P CCDC169-SOHLH2 DCLK1
GH13I036296 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 42.4 -84.4 -84425 4.2 ATF1 SIN3A FEZF1 GLI4 ZNF2 BRCA1 POLR2B GLIS2 ZNF213 ATF7 CCDC169 CCDC169-SOHLH2 SOHLH2 SPART-AS1
GH13I036343 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 33.6 -130.9 -130949 4.1 HDGF PKNOX1 SMAD1 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SPART SPART-AS1 SOHLH2 CCDC169 RFXAP CCDC169-SOHLH2
GH13I036130 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 14.1 +83.0 82964 2.7 ZSCAN4 SIN3A ZNF335 ZNF121 GLIS2 ZNF366 EGR2 SP3 ZNF398 GLIS1 DCLK1 SOHLH2 EXOSC8 CCDC169 RFXAP SUPT20H NMTRQ-TTG10-1
GH13I036332 Enhancer 0.7 Ensembl ENCODE 35.7 -118.6 -118587 1.2 FOSL1 ZNF121 JUND GLIS1 JUN FOS SOHLH2 SPART-AS1 SPART CCDC169 CCDC169-SOHLH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOHLH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOHLH2 gene promoter:

Genomic Locations for SOHLH2 Gene

Genomic Locations for SOHLH2 Gene
46,408 bases
Minus strand

Genomic View for SOHLH2 Gene

Genes around SOHLH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOHLH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOHLH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOHLH2 Gene

Proteins for SOHLH2 Gene

  • Protein details for SOHLH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DX90
    • Q5EGC3
    • Q8TC74
    • Q96QX4

    Protein attributes for SOHLH2 Gene

    425 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOHLH2 Gene


neXtProt entry for SOHLH2 Gene

Post-translational modifications for SOHLH2 Gene

No Post-translational modifications

Other Protein References for SOHLH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOHLH2 Gene

Domains & Families for SOHLH2 Gene

Gene Families for SOHLH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOHLH2 Gene

Suggested Antigen Peptide Sequences for SOHLH2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOHLH2: view

No data available for UniProtKB/Swiss-Prot for SOHLH2 Gene

Function for SOHLH2 Gene

Molecular function for SOHLH2 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

Phenotypes From GWAS Catalog for SOHLH2 Gene

Gene Ontology (GO) - Molecular Function for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with SOHLH2: view
genes like me logo Genes that share phenotypes with SOHLH2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SOHLH2 Gene

Localization for SOHLH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOHLH2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOHLH2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SOHLH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOHLH2 Gene

Pathways & Interactions for SOHLH2 Gene

SuperPathways for SOHLH2 Gene

No Data Available

Interacting Proteins for SOHLH2 Gene

Selected Interacting proteins: Q9NX45-SOLH2_HUMAN for SOHLH2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with SOHLH2: view

No data available for Pathways by source and SIGNOR curated interactions for SOHLH2 Gene

Drugs & Compounds for SOHLH2 Gene

No Compound Related Data Available

Transcripts for SOHLH2 Gene

mRNA/cDNA for SOHLH2 Gene

Unigene Clusters for SOHLH2 Gene

Spermatogenesis and oogenesis specific basic helix-loop-helix 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOHLH2 Gene

No ASD Table

Relevant External Links for SOHLH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOHLH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOHLH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOHLH2 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for SOHLH2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOHLH2 Gene

Protein tissue co-expression partners for SOHLH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOHLH2 Gene:


SOURCE GeneReport for Unigene cluster for SOHLH2 Gene:

genes like me logo Genes that share expression patterns with SOHLH2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOHLH2 Gene

Orthologs for SOHLH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SOHLH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
(Bos Taurus)
Mammalia -- 34
  • 72 (a)
(Canis familiaris)
Mammalia -- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Mus musculus)
Mammalia Sohlh2 34
  • 46 (a)
Species where no ortholog for SOHLH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SOHLH2 Gene

Gene Tree for SOHLH2 (if available)
Gene Tree for SOHLH2 (if available)

Paralogs for SOHLH2 Gene

Paralogs for SOHLH2 Gene

genes like me logo Genes that share paralogs with SOHLH2: view

Variants for SOHLH2 Gene

Sequence variations from dbSNP and Humsavar for SOHLH2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000031280 -- 36,211,420(-) G/A intron_variant
rs1000074576 -- 36,216,412(-) G/T upstream_transcript_variant
rs1000112672 -- 36,178,601(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000205408 -- 36,183,662(-) T/C intron_variant
rs1000224269 -- 36,191,209(-) GAGAGAGAGAGAGA/GAGAGAGAGAGAGAGA intron_variant

Variation tolerance for SOHLH2 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOHLH2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOHLH2 Gene

Disorders for SOHLH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOHLH2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • beaver feaver
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SOHLH2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SOHLH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOHLH2 Gene

Publications for SOHLH2 Gene

  1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9. (PMID: 26153894) Zhang H … Hao J (Molecular carcinogenesis 2016) 3 58
  5. SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. (PMID: 26869299) Park M … Choi Y (Scientific reports 2016) 3 58

Products for SOHLH2 Gene

Sources for SOHLH2 Gene

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