SOHLH2 Gene
protein-coding GIFtS : 45
GCID: GC13 M036742
spermatogenesis and oogenesis specific basic helix-loop-helix...
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Aliasesfor SOHLH2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2 1 2 FLJ204491 TEB11 2 3 Spermatogenesis Associated 282 SPATA281 2 Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-ContainingProtein 22 BHLHe811
Export aliases for SOHLH2 gene to outside databases Previous GC identifers: GC13M035642 GC13M017554
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Summariesfor SOHLH2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45 Function : Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity)
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Genomic Viewsfor SOHLH2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_024524.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SOHLH2 gene promoter: TBP S8 POU2F1 ATF-2 TFIID POU2F1a Sox9 Nkx2-5 LCR-F1 Other transcription factors Search SABiosciences Chromatin IP Primers for SOHLH2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SOHLH2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.3 SOHLH2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13M036742: view genomic region
(about GC identifiers )
Start:
36,742,345 bp from pter
End:
36,871,979 bp from pter
Size:
129,635 bases
Orientation:
minus strand
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Proteinsfor SOHLH2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45 (See
protein sequence )Recommended Name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 Size : 425 amino acids; 46941 Da
Subcellular location : Nucleus (By similarity)
Secondary accessions : B4DX90 Q5EGC3 Q8TC74 Q96QX4Alternative splicing : 3 isoforms : Q9NX45-1 Q9NX45-2 Q9NX45-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SOHLH2: NX_Q9NX45 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NX45 SOHLH2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060296.2 ENSEMBL proteins: ENSP00000369210 ENSP00000326838 ENSP00000451542 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
SOHLH2 for ontologies About GeneDecksing SOHLH2 Antibody Products: Assay Products for SOHLH2:
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Protein
Domains / Familiesfor SOHLH2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SOHLH2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9NX45 ProtoNet protein and cluster: Q9NX45
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45 Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor SOHLH2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45 Function : Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SOHLH2 (NM_017826 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOHLH2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0046983 protein dimerization activity
IEA --
SOHLH2 for ontologies About GeneDecksing Animal Models: Mouse knock-outs for SOHLH2: Sohlh2 tm1Miya Sohlh2 tm1Rajk 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sohlh2) :
SOHLH2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SOHLH2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOHLH2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SOHLH2 (Q9NX45 2 , 3 ENSP00000369210 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
IEA -- GO:0007283 spermatogenesis
IEA -- GO:0030154 cell differentiation
IEA --
SOHLH2 for ontologies About GeneDecksing
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Drugs & Compoundsfor SOHLH2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SOHLH2 Search CenterWatch for drugs/clinical trials and news about SOHLH2 / SOLH2
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Transcriptsfor SOHLH2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SOHLH2 gene: NM_017826.2 Unigene Cluster for SOHLH2:
Spermatogenesis and oogenesis specific basic helix-loop-helix 2 Hs.124519 [show with all ESTs ] Unigene Representative Sequence: NM_001198910 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000379881 (uc001uvj.3 uc010tei.2 ) ENST00000317764 ENST00000554962 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SOHLH2 (NM_017826 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOHLH2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH2
Additional cDNA sequence: AK000456.1 AY884305.1 BC025383.2
3 DOTS entries : DT.442435 DT.97790744
DT.100778418 24/66 AceView cDNA sequences (see all 66 ):
BU753277 BP356498 BC037403 BC063886 BQ950916 AI420335 AA861485 BI830751 AA398348 AA293855 BQ025079 BQ023303 NM_017826 AL703737 AI368806 AW573274 BM667860 AU136744 AK000456 BX115891 BI465027 BC025383 CB143633 BG723709 GeneLoc Exon Structure
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Expression for SOHLH2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SOHLH2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAGACACGAT
About this image SOHLH2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SOHLH2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SOHLH2 SOURCE GeneReport for Unigene cluster: Hs.124519 SABiosciences Custom PCR Arrays for SOHLH2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SOHLH2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SOHLH2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SOHLH2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SOHLH2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH2
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Orthologsfor SOHLH2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for SOHLH2 (if available)TreeFam Gene Tree for SOHLH2 (if available)
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Paralogsfor SOHLH2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SOHLH2 gene CCDC169-SOHLH2 2
SOHLH2 for paralogs About GeneDecksing
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Genomic Variantsfor SOHLH2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SOHLH2 (36742345 - 36871979 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SOHLH2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SOHLH2
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Disorders
/ Diseasesfor SOHLH2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section SOHLH2 for disorders About MalaCards
SOHLH2 for disorders About GeneDecksing 1 disease from the University of Copenhagen DISEASES database for SOHLH2 :Infertility Human Genome Epidemiology (HuGE) Navigator: SOHLH2 (1 document)Export disorders for SOHLH2 gene to outside databases
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Publicationsfor SOHLH2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SOHLH2 gene integrated from 9 sources : (articles sorted by number of sources associating them with SOHLH2) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) The genetic architecture of economic and political pre ferences. (PubMed id 22566634) 1 Benjamin D.J....Visscher P.M. (2012) Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535) 1 Wheeler H.E....Kim S.K. (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 2 Dunham A.... Ross M.T. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for SOHLH2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SOHLH2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SOHLH2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SOHLH2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SOHLH2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SOHLH2 gene: Search GeneIP for patents involving SOHLH2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SOHLH2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SOHLH2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SOHLH2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SOHLH2 OriGene 3'-UTR Clone for SOHLH2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SOHLH2 OriGene Custom Protein Services for SOHLH2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOHLH2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SOHLH2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SOHLH2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SOHLH2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SOHLH2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SOHLH2
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SOHLH2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH2
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