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Aliases for SOHLH2 Gene

Aliases for SOHLH2 Gene

  • Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2 2 3 5
  • Spermatogenesis Associated 28 2 3
  • TEB1 3 4
  • Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing Protein 2 3
  • Testicular Secretory Protein Li 50 3
  • Testicular Secretory Protein Li 51 3
  • SPATA28 3
  • BHLHe81 3
  • SOSF2 3

External Ids for SOHLH2 Gene

Previous GeneCards Identifiers for SOHLH2 Gene

  • GC13M035642
  • GC13M036742
  • GC13M017554

Summaries for SOHLH2 Gene

Entrez Gene Summary for SOHLH2 Gene

  • This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for SOHLH2 Gene

SOHLH2 (Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2) is a Protein Coding gene. Diseases associated with SOHLH2 include Giardiasis. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is CCDC169-SOHLH2.

UniProtKB/Swiss-Prot for SOHLH2 Gene

  • Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOHLH2 Gene

Genomics for SOHLH2 Gene

Regulatory Elements for SOHLH2 Gene

Enhancers for SOHLH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F036275 0.2 ENCODE 44.1 -61.3 -61326 1.6 CTCF ZNF654 JUN SMC3 RAD21 NR2F2 SOHLH2 RFXAP RNU6-71P CCDC169 CCDC169-SOHLH2
GH13F036296 0.6 ENCODE 42.4 -84.4 -84425 4.3 PKNOX1 ATF1 FEZF1 GLI4 BRCA1 ZNF2 GLIS2 FOS KLF13 SP3 SOHLH2 CCDC169 CCDC169-SOHLH2 SPG20-AS1
GH13F036322 0.7 ENCODE 37.2 -110.0 -109967 3.4 FOS ZNF644 SOHLH2 CCDC169 SPG20-AS1 CCDC169-SOHLH2
GH13F036332 0.9 Ensembl ENCODE 35.7 -118.5 -118525 1.1 ZNF121 JUND ATF3 GLIS1 JUN FOS IRF1 SOHLH2 SPG20-AS1 CCDC169 CCDC169-SOHLH2
GH13F036343 0.5 ENCODE 33.6 -131.0 -130950 4.1 HDGF PKNOX1 CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF143 SOHLH2 SPG20 SPG20-AS1 CCDC169 EXOSC8 RFXAP CCDC169-SOHLH2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SOHLH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOHLH2 Gene

Chromosome:
13
Start:
36,168,208 bp from pter
End:
36,214,615 bp from pter
Size:
46,408 bases
Orientation:
Minus strand

Genomic View for SOHLH2 Gene

Genes around SOHLH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOHLH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOHLH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOHLH2 Gene

Proteins for SOHLH2 Gene

  • Protein details for SOHLH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX45-SOLH2_HUMAN
    Recommended name:
    Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
    Protein Accession:
    Q9NX45
    Secondary Accessions:
    • B4DX90
    • Q5EGC3
    • Q8TC74
    • Q96QX4

    Protein attributes for SOHLH2 Gene

    Size:
    425 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOHLH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOHLH2 Gene

Post-translational modifications for SOHLH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOHLH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOHLH2 Gene

Domains & Families for SOHLH2 Gene

Gene Families for SOHLH2 Gene

Protein Domains for SOHLH2 Gene

Suggested Antigen Peptide Sequences for SOHLH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX45

UniProtKB/Swiss-Prot:

SOLH2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with SOHLH2: view

Function for SOHLH2 Gene

Molecular function for SOHLH2 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

Gene Ontology (GO) - Molecular Function for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with SOHLH2: view
genes like me logo Genes that share phenotypes with SOHLH2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SOHLH2 Gene

Localization for SOHLH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOHLH2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOHLH2 Gene COMPARTMENTS Subcellular localization image for SOHLH2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with SOHLH2: view

Pathways & Interactions for SOHLH2 Gene

SuperPathways for SOHLH2 Gene

No Data Available

Interacting Proteins for SOHLH2 Gene

Selected Interacting proteins: Q9NX45-SOLH2_HUMAN for SOHLH2 Gene via IID

Symbol External ID(s) Details
ELOA2

Gene Ontology (GO) - Biological Process for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with SOHLH2: view

No data available for Pathways by source and SIGNOR curated interactions for SOHLH2 Gene

Transcripts for SOHLH2 Gene

mRNA/cDNA for SOHLH2 Gene

Unigene Clusters for SOHLH2 Gene

Spermatogenesis and oogenesis specific basic helix-loop-helix 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOHLH2 Gene

No ASD Table

Relevant External Links for SOHLH2 Gene

GeneLoc Exon Structure for
SOHLH2
ECgene alternative splicing isoforms for
SOHLH2

Expression for SOHLH2 Gene

mRNA expression in normal human tissues for SOHLH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOHLH2 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for SOHLH2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOHLH2 Gene



Protein tissue co-expression partners for SOHLH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOHLH2 Gene:

SOHLH2

SOURCE GeneReport for Unigene cluster for SOHLH2 Gene:

Hs.124519
genes like me logo Genes that share expression patterns with SOHLH2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SOHLH2 Gene

Orthologs for SOHLH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SOHLH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sohlh2 35
  • 46 (a)
OneToMany
Species where no ortholog for SOHLH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SOHLH2 Gene

ENSEMBL:
Gene Tree for SOHLH2 (if available)
TreeFam:
Gene Tree for SOHLH2 (if available)

Paralogs for SOHLH2 Gene

Paralogs for SOHLH2 Gene

genes like me logo Genes that share paralogs with SOHLH2: view

Variants for SOHLH2 Gene

Sequence variations from dbSNP and Humsavar for SOHLH2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10162231 -- 36,186,844(+) GTTTC(C/T)TTAAC intron-variant
rs10467456 -- 36,208,883(+) TCCTT(C/G)TGGAA intron-variant
rs10558599 -- 36,173,301(+) GGCTG(-/AGA)AGATC intron-variant
rs10660002 -- 36,201,049(+) CCTCA(-/A/AA)AAAAA intron-variant
rs111233891 -- 36,209,642(+) TAACG(C/T)CATCA intron-variant

Variation tolerance for SOHLH2 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOHLH2 Gene

Human Gene Mutation Database (HGMD)
SOHLH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOHLH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOHLH2 Gene

Disorders for SOHLH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOHLH2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
giardiasis
  • beaver feaver
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SOHLH2

Genetic Association Database (GAD)
SOHLH2
Human Genome Epidemiology (HuGE) Navigator
SOHLH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOHLH2
genes like me logo Genes that share disorders with SOHLH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOHLH2 Gene

Publications for SOHLH2 Gene

  1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. (PMID: 26869299) Park M. … Choi Y. (Sci Rep 2016) 3 64
  5. Association of genetic variants in SOHLH1 and SOHLH2 with non-obstructive azoospermia risk in the Chinese population. (PMID: 25463635) Song B. … Cao Y.X. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2015) 3 64

Products for SOHLH2 Gene

Sources for SOHLH2 Gene

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