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Aliases for SOHLH2 Gene

Aliases for SOHLH2 Gene

  • Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2 2 3
  • Spermatogenesis Associated 28 2 3
  • TEB1 3 4
  • Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing Protein 2 3
  • SPATA28 3
  • BHLHe81 3

External Ids for SOHLH2 Gene

Summaries for SOHLH2 Gene

Entrez Gene Summary for SOHLH2 Gene

  • This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for SOHLH2 Gene

SOHLH2 (Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is CCDC169-SOHLH2.

UniProtKB/Swiss-Prot for SOHLH2 Gene

  • Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOHLH2 Gene

Genomics for SOHLH2 Gene

Genomic Location for SOHLH2 Gene

36,168,208 bp from pter
36,214,615 bp from pter
46,408 bases
Minus strand

Genomic View for SOHLH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOHLH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOHLH2 Gene

Regulatory Elements for SOHLH2 Gene

Proteins for SOHLH2 Gene

  • Protein details for SOHLH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DX90
    • Q5EGC3
    • Q8TC74
    • Q96QX4

    Protein attributes for SOHLH2 Gene

    425 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOHLH2 Gene


neXtProt entry for SOHLH2 Gene

Proteomics data for SOHLH2 Gene at MOPED

Post-translational modifications for SOHLH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOHLH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOHLH2 Gene

Domains for SOHLH2 Gene

Gene Families for SOHLH2 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for SOHLH2 Gene


  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q9NX45
genes like me logo Genes that share domains with SOHLH2: view

Function for SOHLH2 Gene

Molecular function for SOHLH2 Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor, which may be involved in spermatogenesis and oogenesis.

Gene Ontology (GO) - Molecular Function for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with SOHLH2: view
genes like me logo Genes that share phenotypes with SOHLH2: view

Animal Models for SOHLH2 Gene

MGI Knock Outs for SOHLH2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SOHLH2 Gene

Localization for SOHLH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOHLH2 Gene

Subcellular locations from

Jensen Localization Image for SOHLH2 Gene COMPARTMENTS Subcellular localization image for SOHLH2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SOHLH2: view

Pathways for SOHLH2 Gene

SuperPathways for SOHLH2 Gene

No Data Available

Interacting Proteins for SOHLH2 Gene

Selected Interacting proteins: Q9NX45-SOLH2_HUMAN for SOHLH2 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SOHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0048477 oogenesis IEA --
genes like me logo Genes that share ontologies with SOHLH2: view

No data available for Pathways by source for SOHLH2 Gene

Transcripts for SOHLH2 Gene

mRNA/cDNA for SOHLH2 Gene

Unigene Clusters for SOHLH2 Gene

Spermatogenesis and oogenesis specific basic helix-loop-helix 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOHLH2 Gene

No ASD Table

Relevant External Links for SOHLH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOHLH2 Gene

mRNA expression in normal human tissues for SOHLH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOHLH2 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SOHLH2 Gene

SOURCE GeneReport for Unigene cluster for SOHLH2 Gene Hs.124519

genes like me logo Genes that share expressions with SOHLH2: view

Orthologs for SOHLH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SOHLH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
(Bos Taurus)
Mammalia -- 37
  • 72 (a)
(Canis familiaris)
Mammalia -- 37
  • 72 (a)
(Mus musculus)
Mammalia Sohlh2 16
Sohlh2 37
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
Species with no ortholog for SOHLH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SOHLH2 Gene

Gene Tree for SOHLH2 (if available)
Gene Tree for SOHLH2 (if available)

Paralogs for SOHLH2 Gene

Paralogs for SOHLH2 Gene

genes like me logo Genes that share paralogs with SOHLH2: view

Variants for SOHLH2 Gene

Sequence variations from dbSNP and Humsavar for SOHLH2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_038283 -
VAR_038284 -

Structural Variations from Database of Genomic Variants (DGV) for SOHLH2 Gene

Variant ID Type Subtype PubMed ID
nsv899992 CNV Loss 21882294
nsv899993 CNV Gain 21882294

Relevant External Links for SOHLH2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SOHLH2 Gene

Relevant External Links for SOHLH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SOHLH2: view

No data available for UniProtKB/Swiss-Prot for SOHLH2 Gene

Publications for SOHLH2 Gene

  1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 49
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SOHLH2 Gene

Sources for SOHLH2 Gene

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