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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOHLH2 Gene

protein-coding   GIFtS: 45
GCID: GC13M036742

spermatogenesis and oogenesis specific basic helix-loop-helix...

  Search for SOHLH2
in our new
 Human Malady Compendium 
Biological research products
for SOHLH2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 21 2     FLJ204491
TEB11 2 3     Spermatogenesis Associated 282
SPATA281 2     Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing
Protein 22
BHLHe811     

External Ids:    HGNC: 260261   Entrez Gene: 549372   Ensembl: ENSG000001206697   UniProtKB: Q9NX453   

Export aliases for SOHLH2 gene to outside databases

Previous GC identifers: GC13M035642 GC13M017554


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45
Function: Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOHLH2 gene promoter:
         TBP   S8   POU2F1   ATF-2   TFIID   POU2F1a   Sox9   Nkx2-5   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOHLH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOHLH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOHLH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

SOHLH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOHLH2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M036742:  view genomic region     (about GC identifiers)

Start:
36,742,345 bp from pter      End:
36,871,979 bp from pter
Size:
129,635 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45 (See protein sequence)
Recommended Name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2  
Size: 425 amino acids; 46941 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B4DX90 Q5EGC3 Q8TC74 Q96QX4
Alternative splicing: 3 isoforms:  Q9NX45-1   Q9NX45-2   Q9NX45-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SOHLH2: NX_Q9NX45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX45

  • SOHLH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060296.2  
    ENSEMBL proteins: 
     ENSP00000369210   ENSP00000326838   ENSP00000451542  

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    Uscn Proteins for SOHLH2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SOHLH2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SOHLH2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9NX45

    ProtoNet protein and cluster: Q9NX45

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SOLH2_HUMAN, Q9NX45
    Function: Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046983protein dimerization activity IEA--


    SOHLH2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SOHLH2: Sohlh2tm1Miya Sohlh2tm1Rajk
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sohlh2):
     cellular  endocrine/exocrine gland  reproductive system 

    SOHLH2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOHLH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SOHLH2 (Q9NX452, 3 ENSP000003692104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB3BQ8IYF12, 3, ENSP000003313024MINT-67917 I2D: score=5 STRING: ENSP00000331302
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--


    SOHLH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOHLH2
    Search CenterWatch for drugs/clinical trials and news about SOHLH2 / SOLH2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOHLH2 gene: 
    NM_017826.2  

    Unigene Cluster for SOHLH2:

    Spermatogenesis and oogenesis specific basic helix-loop-helix 2
    Hs.124519  [show with all ESTs]
    Unigene Representative Sequence: NM_001198910
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379881(uc001uvj.3 uc010tei.2) ENST00000317764 ENST00000554962


    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SOHLH2:
    hsa-miR-374a* hsa-miR-576-5p hsa-miR-361-5p hsa-miR-4276 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSOHLH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOHLH2
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    Additional cDNA sequence: 

    AK000456.1 AY884305.1 BC025383.2 

    3 DOTS entries:

    DT.442435  DT.97790744  DT.100778418 

    24/66 AceView cDNA sequences (see all 66):

    BU753277 BP356498 BC037403 BC063886 BQ950916 AI420335 AA861485 BI830751 
    AA398348 AA293855 BQ025079 BQ023303 NM_017826 AL703737 AI368806 AW573274 
    BM667860 AU136744 AK000456 BX115891 BI465027 BC025383 CB143633 BG723709 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOHLH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGACACGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SOHLH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatogonium Type BGerm Cells, Male Gametocytes
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesSpermatogonial Stem CellsGerm Cells, Male Gametocytes
    TestisSeminiferous TubulesSpermatogonium Type AGerm Cells, Male Gametocytes
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SOHLH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOHLH2

    SOURCE GeneReport for Unigene cluster: Hs.124519
        SABiosciences Custom PCR Arrays for SOHLH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for SOHLH2 (if available)
    TreeFam Gene Tree for SOHLH2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOHLH2 gene
    CCDC169-SOHLH22  

    SOHLH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/679 NCBI SNPs in SOHLH2 are shown (see all 679    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912275631,2
    --36741985(+) CCCCAA/GCAACA 2 -- ds5001 int10--------
    rs13286441,2
    C,F,A,H,--36742005(-) TGTTCC/GCAGCT 2 -- ds5001 int111Minor allele frequency- G:0.09NS EA CSA NA 1080
    rs1440276861,2
    --36742013(+) ACATAA/GGCAGT 2 -- ds5001 int10--------
    rs1833066901,2
    --36742317(+) AAACAC/TATATT 2 -- ds5001 int10--------
    rs13286431,2
    C,F,H,--36742341(-) AATCCA/GTTTTT 2 -- int1 ds500110Minor allele frequency- G:0.10NA NS EA WA 912
    rs583222841,2
    C,--36742353(+) CAATGC/TTCAGG 2 -- ut312Minor allele frequency- T:0.04WA 120
    rs740452241,2
    C,--36742605(+) TTAGTT/AGTCAA 2 -- ut312Minor allele frequency- A:0.04WA 120
    rs610300801,2
    C,--36742817(+) CTAATC/AATTTT 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs558725201,2
    C,--36742818(+) TAATCG/ATTTTA 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs785021631,2
    C,F,--36742884(+) TTTTTG/AAGAAA 2 -- ut311Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for SOHLH2 (36742345 - 36871979 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SOHLH2: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SOHLH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SOHLH2 for disorders           About MalaCards

    SOHLH2 for disorders           About GeneDecksing

    1 disease from the University of Copenhagen DISEASES database for SOHLH2:
    Infertility
    Human Genome Epidemiology (HuGE) Navigator: SOHLH2 (1 document)

    Export disorders for SOHLH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOHLH2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SOHLH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    4. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54937 HGNC: 26026 AceView: FLJ20449 Ensembl:ENSG00000120669 euGenes: HUgn54937
    ECgene: SOHLH2 H-InvDB: SOHLH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOHLH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOHLH2 gene:
    Search GeneIP for patents involving SOHLH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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