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SOHLH1 Gene

protein-coding   GIFtS: 45
GCID: GC09M138585

Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix...

(Previous name: chromosome 9 open reading frame 157)
(Previous symbol: C9orf157)
  See SOHLH1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 11 2     SPATA272
C9orf1571 2 3     bA100C15.32
Spermatogenesis Associated 271 2     bHLHe802
NOHLH2 3     Newborn Ovary Helix Loop Helix2
TEB22 3     Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing
Protein 12
Chromosome 9 Open Reading Frame 1571     

External Ids:    HGNC: 278451   Entrez Gene: 4023812   Ensembl: ENSG000001656437   OMIM: 6102245   UniProtKB: Q5JUK23   

Export aliases for SOHLH1 gene to outside databases

Previous GC identifers: GC09M137726 GC09M108046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOHLH1 Gene:
This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis
and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with
nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for SOHLH1 Gene:
SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1) is a protein-coding gene. Diseases associated with SOHLH1 include azoospermia. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2
Function: Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOHLH1 gene promoter:
         NF-1   NF-1/L   p53   FOXD3   MyoD   LUN-1   NF-kappaB   S8   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOHLH1 promoter sequence
   Search Chromatin IP Primers for SOHLH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOHLH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

SOHLH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOHLH1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M138585:  view genomic region     (about GC identifiers)

Start:
138,585,253 bp from pter      End:
138,591,374 bp from pter
Size:
6,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2 (See protein sequence)
Recommended Name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1  
Size: 328 amino acids; 34526 Da
Sequence caution: Sequence=AAW78548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JG81 Q5EE14 Q5EGC2 Q8NEE3
Alternative splicing: 2 isoforms:  Q5JUK2-1   Q5JUK2-2   

Explore the universe of human proteins at neXtProt for SOHLH1: NX_Q5JUK2

Explore proteomics data for SOHLH1 at MOPED


See SOHLH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001012415.2  NP_001095147.1  

ENSEMBL proteins: 
 ENSP00000298466   ENSP00000404438  

SOHLH1 Human Recombinant Protein Products:

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Search eBioscience for ELISAs for SOHLH1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

1 InterPro protein domain:
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q5JUK2

ProtoNet protein and cluster: Q5JUK2

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


Find genes that share domains with SOHLH1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SOLH1_HUMAN, Q5JUK2
Function: Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development
(By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0046983protein dimerization activity IEA--
     
Find genes that share ontologies with SOHLH1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SOHLH1:
 Increased G1 DNA content 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sohlh1):
 endocrine/exocrine gland  no phenotypic analysis  reproductive system 

Find genes that share phenotypes with SOHLH1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Sohlh1tm1Rajk for SOHLH1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOHLH1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOHLH1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOHLH1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOHLH1

miRNA
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3 qRT-PCR Assays for microRNAs that regulate SOHLH1:
hsa-miR-642a hsa-miR-516a-3p hsa-miR-516b*
SwitchGear 3'UTR luciferase reporter plasmidSOHLH1 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SOLH1_HUMAN, Q5JUK2: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with SOHLH1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOHLH1
Interactions:

    Search GeneGlobe Interaction Network for SOHLH1

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001541ovarian follicle development IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0007283spermatogenesis IEA--
GO:0030154cell differentiation IEA--
GO:0045893positive regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with SOHLH1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SOHLH1 (SOLH1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SOHLH1 gene (2 alternative transcripts): 
NM_001012415.2  NM_001101677.1  

Unigene Cluster for SOHLH1:

Spermatogenesis and oogenesis specific basic helix-loop-helix 1
Hs.120464  [show with all ESTs]
Unigene Representative Sequence: BC031861
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000298466(uc010nbe.3 uc004cgl.3) ENST00000425225
miRNA
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Block miRNA regulation of human, mouse, rat SOHLH1 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate SOHLH1:
hsa-miR-642a hsa-miR-516a-3p hsa-miR-516b*
SwitchGear 3'UTR luciferase reporter plasmidSOHLH1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SOHLH1
Predesigned siRNA for gene silencing in human, mouse, rat SOHLH1
Clone
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GenScript: all cDNA clones in your preferred vector (see all 2): SOHLH1 (NM_001012415)
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOHLH1
  QuantiTect SYBR Green Assays in human, mouse, rat SOHLH1
  QuantiFast Probe-based Assays in human, mouse, rat SOHLH1

Additional mRNA sequence: 

AY884306.1 AY902244.1 BC031861.1 BC096724.1 BC101937.1 

2 DOTS entries:

DT.99928874  DT.121208483 

2 AceView cDNA sequences:

BG722738 BC031861 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SOHLH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGCCCTGC
SOHLH1 Expression
About this image


SOHLH1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Gonad
         Spermatogonium Type A Seminiferous Tubules
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Spermatogonium Type A Seminiferous Tubules
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Primary Oocyte Primary Follicle
SOHLH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SOHLH1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.120464
    Custom PCR Arrays for SOHLH1
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOHLH1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for SOHLH1 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sohlh11 , 5 spermatogenesis and oogenesis specific basic helix-loop-helix more1, 5 62.86(n)1
51.65(a)1
  2 (18.21 cM)5
2276311  NM_001001714.11  NP_001001714.11 
 258429955 


ENSEMBL Gene Tree for SOHLH1 (if available)
TreeFam Gene Tree for SOHLH1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SOHLH1 (see all 327)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1846002841,2
--138584763(+) TTCCTC/TTAAGT 2 -- int10--------
rs1383660351,2
--138584783(+) ACCCCA/GACCCC 2 -- int10--------
rs5384021,2
C,F,A,H--138584786(+) CCGACT/CCCGAA 2 -- int110Minor allele frequency- C:0.43NA WA CSA EA 374
rs1903816771,2
--138584796(+) AGTAAA/CCCAGC 2 -- int10--------
rs5400181,2
C,F,A,H--138584921(+) GTGGAA/GGTGGA 2 -- int122Minor allele frequency- G:0.48NS EA NA WA CSA 2352
rs1439017831,2
C--138585017(+) GCAACA/C/GAGCAG 2 -- int10--------
rs1472819591,2
--138585086(+) AGGGAG/TCAGGT 2 -- int10--------
rs1407051151,2
--138585134(+) TATTCC/TGGGAT 2 -- int10--------
rs1825723231,2
--138585214(+) GATCCA/GCCTGA 2 -- int10--------
rs126858971,2
H--138585272(+) GGAAAA/GCTGCT 2 -- ut31 ese30--------

HapMap Linkage Disequilibrium report for SOHLH1 (138585253 - 138591374 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SOHLH1 (see all 16):    About this table    
Variant IDTypeSubtypePubMed ID
nsv415350CNV Insertion16902084
esv1601054CNV Insertion17803354
nsv415465CNV Insertion16902084
dgv8371n71CNV Loss21882294
nsv894256CNV Loss21882294
nsv517335CNV Loss19592680
dgv954n27CNV Loss19166990
nsv831756CNV Loss17160897
dgv8369n71CNV Loss21882294
dgv8368n71CNV Loss21882294

Human Gene Mutation Database (HGMD): SOHLH1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SOHLH1
DNA2.0 Custom Variant and Variant Library Synthesis for SOHLH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610224    OMIM disorders: --

UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2
  • Note=Genetic variations in SOHLH1 may be associated with non-obstructive azoospermia

  • 1 disease for SOHLH1:    
    About MalaCards
    azoospermia

    2 diseases from the University of Copenhagen DISEASES database for SOHLH1:
    Premature ovarian failure     Infertility

    Find genes that share disorders with SOHLH1           About GenesLikeMe

    Genetic Association Database (GAD): SOHLH1
    Human Genome Epidemiology (HuGE) Navigator: SOHLH1 (1 document)

    Export disorders for SOHLH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOHLH1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SOHLH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in SOHLH1 gene associate with nonobstructive azoospermia. (PubMed id 20506135)1, 2, 4 Choi Y.... Shim S.H. (Hum. Mutat. 2010)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Transcriptional control of KIT gene expression during germ cell development. (PubMed id 23784828)1 Rossi P. (Int. J. Dev. Biol. 2013)
    4. SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development. (PubMed id 22328502)1 Barrios F....Dolci S. (J. Cell. Sci. 2012)
    5. Transcription factors in the maintenance and survival of primordial follicles. (PubMed id 23346521)1 Lim E.J. and Choi Y. (Clin Exp Reprod Med 2012)
    6. Candidate genes for premature ovarian failure. (PubMed id 17305537)1 Suzumori N....Rajkovic A. (Curr. Med. Chem. 2007)
    7. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. (PubMed id 16690745)1 Pangas S.A....Rajkovic A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Sohlh1 is essential for spermatogonial differentiation. (PubMed id 16564520)2 Ballow D.... Rajkovic A. (Dev. Biol. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 402381 HGNC: 27845 AceView: C9orf157 Ensembl:ENSG00000165643 euGenes: HUgn402381
    ECgene: SOHLH1 H-InvDB: SOHLH1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOHLH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOHLH1 gene:
    Search GeneIP for patents involving SOHLH1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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