SOHLH1 Gene
protein-coding GIFtS : 47
GCID: GC09 M138585
spermatogenesis and oogenesis specific basic helix-loop-helix... (Previous name: chromosome 9 open reading frame 157 ) (Previous symbol: C9orf157 )
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Aliasesfor SOHLH1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 1 1 2 BHLHe801 C9orf1571 2 3 Chromosome 9 Open Reading Frame 1571 NOHLH1 2 3 Newborn Ovary Helix Loop Helix2 TEB21 2 3 Spermatogenesis Associated 272 SPATA271 2 Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-ContainingProtein 12 BA100C15.31
Export aliases for SOHLH1 gene to outside databases Previous GC identifers: GC09M137726 GC09M108046
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Summariesfor SOHLH1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2 Function : Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development (Bysimilarity)
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Genomic Viewsfor SOHLH1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_019501.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SOHLH1 gene promoter: NF-1 NF-1/L p53 FOXD3 MyoD LUN-1 NF-kappaB S8 ARP-1 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for SOHLH1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SOHLH1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3 SOHLH1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M138585: view genomic region
(about GC identifiers )
Start:
138,585,253 bp from pter
End:
138,591,374 bp from pter
Size:
6,122 bases
Orientation:
minus strand
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Proteinsfor SOHLH1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2 (See
protein sequence )Recommended Name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 Size : 328 amino acids; 34526 Da
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution : Sequence=AAW78548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : C9JG81 Q5EE14 Q5EGC2 Q8NEE3Alternative splicing : 2 isoforms : Q5JUK2-1 Q5JUK2-2 Explore the universe of human proteins at neXtProt for SOHLH1: NX_Q5JUK2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5JUK2 SOHLH1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001012415.2 NP_001095147.1 ENSEMBL proteins: ENSP00000298466 ENSP00000404438 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
SOHLH1 for ontologies About GeneDecksing SOHLH1 Antibody Products: Assay Products for SOHLH1:
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Protein
Domains / Familiesfor SOHLH1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SOHLH1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5JUK2 ProtoNet protein and cluster: Q5JUK2
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2 Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor SOHLH1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2 Function : Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development (Bysimilarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SOHLH1 (NM_001012415 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOHLH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0046983 protein dimerization activity
IEA --
SOHLH1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SOHLH1 :Animal Models: Mouse knock-out Sohlh1 tm1Rajk for SOHLH1 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sohlh1) :
SOHLH1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SOHLH1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOHLH1 Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001541 ovarian follicle development
IEA -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0007275 multicellular organismal development
-- -- GO:0007283 spermatogenesis
IEA --
SOHLH1 for ontologies About GeneDecksing
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Drugs & Compoundsfor SOHLH1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SOHLH1 Search CenterWatch for drugs/clinical trials and news about SOHLH1 / SOLH1
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Transcriptsfor SOHLH1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SOHLH1 gene (2 alternative transcripts): NM_001012415.2 NM_001101677.1 Unigene Cluster for SOHLH1:
Spermatogenesis and oogenesis specific basic helix-loop-helix 1 Hs.120464 [show with all ESTs ] Unigene Representative Sequence: BC031861 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000298466 (uc010nbe.3 uc004cgl.3 ) ENST00000425225 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SOHLH1 (NM_001012415 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOHLH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH1
Additional cDNA sequence: AY884306.1 AY902244.1 BC031861.1 BC096724.1 BC101937.1
2 DOTS entries : DT.99928874 DT.121208483
2 AceView cDNA sequences :
BG722738 BC031861 GeneLoc Exon Structure
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Expression for SOHLH1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SOHLH1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTGCCCTGC
About this image SOHLH1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SOHLH1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SOHLH1 SOURCE GeneReport for Unigene cluster: Hs.120464 SABiosciences Custom PCR Arrays for SOHLH1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SOHLH1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SOHLH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SOHLH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SOHLH1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH1
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Orthologsfor SOHLH1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for SOHLH1 gene from 1/5 species (see all 5 ) About this table
ENSEMBL Gene Tree for SOHLH1 (if available)TreeFam Gene Tree for SOHLH1 (if available)
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Paralogsfor SOHLH1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor SOHLH1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SOHLH1 (138585253 - 138591374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 9 variations for SOHLH1 9 CNVs : 53672 52745 9629 30345 52744 9628 4661 30343 52746 Human Gene Mutation Database (HGMD) : SOHLH1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SOHLH1
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Disorders
/ Diseasesfor SOHLH1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SOHLH1 for disorders About GeneDecksing
OMIM gene information: 610224
OMIM disorders : --UniProtKB/Swiss-Prot: SOLH1_HUMAN, Q5JUK2
Note=Genetic variations in SOHLH1 may be associated with non-obstructive azoospermia 1 disease for SOHLH1 : About MalaCards azoospermia 2 diseases from the University of Copenhagen DISEASES database for SOHLH1 :Premature ovarian failure Infertility Human Genome Epidemiology (HuGE) Navigator: SOHLH1 (1 document)Export disorders for SOHLH1 gene to outside databases
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Publicationsfor SOHLH1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SOHLH1 gene integrated from 9 sources : (articles sorted by number of sources associating them with SOHLH1) Utopia : connect your pdf to the dynamic world of online information
Mutations in SOHLH1 gene associate with nonobstructiv e azoospermia. (PubMed id 20506135) 1 , 2 Choi Y....Shim S.H. (2010) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. (PubMed id 16690745) 1 Pangas S.A....Rajkovic A. (2006) Sohlh1 is essential for spermatogonial differentiation. (PubMed id 16564520) 2 Ballow D.... Rajkovic A. (2006) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for SOHLH1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SOHLH1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SOHLH1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SOHLH1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SOHLH1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SOHLH1 gene: Search GeneIP for patents involving SOHLH1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SOHLH1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SOHLH1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SOHLH1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SOHLH1 OriGene Protein Over-expression Lysate for SOHLH1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SOHLH1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SOHLH1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SOHLH1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SOHLH1 OriGene Custom Protein Services for SOHLH1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOHLH1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SOHLH1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SOHLH1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SOHLH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SOHLH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SOHLH1
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SOHLH1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOHLH1
ThermoFisher Antibody for SOHLH1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SOHLH1
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