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Aliases for SOGA3 Gene

Aliases for SOGA3 Gene

  • SOGA Family Member 3 2 3 5
  • C6orf174 3 4
  • Chromosome 6 Open Reading Frame 174 2
  • Protein SOGA3 3
  • DJ403A15.3 3

External Ids for SOGA3 Gene

Previous HGNC Symbols for SOGA3 Gene

  • C6orf174

Previous GeneCards Identifiers for SOGA3 Gene

  • GC06M127760

Summaries for SOGA3 Gene

GeneCards Summary for SOGA3 Gene

SOGA3 (SOGA Family Member 3) is a Protein Coding gene. An important paralog of this gene is ENSG00000255330.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOGA3 Gene

Genomics for SOGA3 Gene

Regulatory Elements for SOGA3 Gene

Enhancers for SOGA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SOGA3 on UCSC Golden Path with GeneCards custom track

Promoters for SOGA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SOGA3 Gene

127,438,406 bp from pter
127,519,355 bp from pter
80,950 bases
Minus strand

Genomic View for SOGA3 Gene

Genes around SOGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA3 Gene

Proteins for SOGA3 Gene

  • Protein details for SOGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SOGA3
    Protein Accession:

    Protein attributes for SOGA3 Gene

    947 amino acids
    Molecular mass:
    103199 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOGA3 Gene

Post-translational modifications for SOGA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOGA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOGA3 Gene

Domains & Families for SOGA3 Gene

Protein Domains for SOGA3 Gene


Suggested Antigen Peptide Sequences for SOGA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SOGA family.
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with SOGA3: view

No data available for Gene Families for SOGA3 Gene

Function for SOGA3 Gene

Phenotypes for SOGA3 Gene

genes like me logo Genes that share phenotypes with SOGA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOGA3 Gene

Localization for SOGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SOGA3 Gene COMPARTMENTS Subcellular localization image for SOGA3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SOGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SOGA3: view

Pathways & Interactions for SOGA3 Gene

SuperPathways for SOGA3 Gene

No Data Available

Interacting Proteins for SOGA3 Gene

Selected Interacting proteins: Q5TF21-SOGA3_HUMAN for SOGA3 Gene via IID

Gene Ontology (GO) - Biological Process for SOGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010506 regulation of autophagy IEA --
genes like me logo Genes that share ontologies with SOGA3: view

No data available for Pathways by source and SIGNOR curated interactions for SOGA3 Gene

Drugs & Compounds for SOGA3 Gene

No Compound Related Data Available

Transcripts for SOGA3 Gene

mRNA/cDNA for SOGA3 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOGA3 Gene

SOGA family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA3 Gene

No ASD Table

Relevant External Links for SOGA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOGA3 Gene

mRNA expression in normal human tissues for SOGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SOGA3 Gene

This gene is overexpressed in Breast (25.4), Fetal Brain (15.4), Frontal cortex (13.0), and Liver, secretome (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOGA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SOGA3 Gene:


SOURCE GeneReport for Unigene cluster for SOGA3 Gene:

genes like me logo Genes that share expression patterns with SOGA3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SOGA3 Gene

Orthologs for SOGA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOGA3 34
  • 92.06 (n)
  • 93.96 (a)
-- 35
  • 93 (a)
(Canis familiaris)
Mammalia SOGA3 34
  • 90.63 (n)
  • 92.01 (a)
-- 35
  • 89 (a)
(Mus musculus)
Mammalia Soga3 34
  • 87.76 (n)
  • 89.84 (a)
Soga3 16
Soga3 35
  • 91 (a)
(Pan troglodytes)
Mammalia SOGA3 34
  • 99.33 (n)
  • 99.47 (a)
-- 35
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100363248 34
  • 87.92 (n)
  • 89.83 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
(Gallus gallus)
Aves C3H6ORF174 34
  • 80.96 (n)
  • 95.25 (a)
-- 35
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
-- 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia soga3 34
  • 76.5 (n)
  • 90.85 (a)
(Danio rerio)
Actinopterygii LOC100332515 34
  • 74.04 (n)
  • 81.8 (a)
CABZ01118047.1 35
  • 11 (a)
si:ch211-197l9.2 35
  • 7 (a)
soga3a 35
  • 64 (a)
soga3b 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18304 35
  • 8 (a)
(Caenorhabditis elegans)
Secernentea tag-241 35
  • 7 (a)
Species where no ortholog for SOGA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOGA3 Gene

Gene Tree for SOGA3 (if available)
Gene Tree for SOGA3 (if available)

Paralogs for SOGA3 Gene

Paralogs for SOGA3 Gene

(3) SIMAP similar genes for SOGA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOGA3: view

Variants for SOGA3 Gene

Sequence variations from dbSNP and Humsavar for SOGA3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs802939 -- 127,507,857(-) ttttt(C/T)ttttt intron-variant
rs910536 -- 127,463,348(+) TTATG(C/G/T)TATGA intron-variant
rs1080708 -- 127,489,220(+) acgat(G/T)aactt intron-variant
rs4995777 -- 127,507,858(+) AAAAA(A/G)AAAAA intron-variant
rs5879853 -- 127,518,614(+) TGAAC(-/A)AATCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SOGA3 Gene

Variant ID Type Subtype PubMed ID
esv3610724 CNV loss 21293372

Variation tolerance for SOGA3 Gene

Residual Variation Intolerance Score: 6.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOGA3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOGA3 Gene

Disorders for SOGA3 Gene

Relevant External Links for SOGA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SOGA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOGA3 Gene

Publications for SOGA3 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 65
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PMID: 19505873) Ku W.C. … Chen Y.J. (Mol. Cell Proteomics 2009) 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65

Products for SOGA3 Gene

Sources for SOGA3 Gene

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