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Aliases for SOGA1 Gene

Aliases for SOGA1 Gene

  • Suppressor Of Glucose, Autophagy Associated 1 2 3 5
  • Suppressor Of Glucose By Autophagy 2 3 4
  • KIAA0889 2 3 4
  • Suppressor Of Glucose, Autophagy-Associated Protein 1 3 4
  • Suppressor Of Glucose From Autophagy 2 3
  • SOGA Family Member 1 3 4
  • C20orf117 3 4
  • SOGA 3 4
  • Chromosome 20 Open Reading Frame 117 2
  • Protein SOGA1 3

External Ids for SOGA1 Gene

Previous HGNC Symbols for SOGA1 Gene

  • C20orf117
  • KIAA0889

Previous GeneCards Identifiers for SOGA1 Gene

  • GC20M035407

Summaries for SOGA1 Gene

GeneCards Summary for SOGA1 Gene

SOGA1 (Suppressor Of Glucose, Autophagy Associated 1) is a Protein Coding gene. An important paralog of this gene is MTCL1.

UniProtKB/Swiss-Prot for SOGA1 Gene

  • Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.

Gene Wiki entry for SOGA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOGA1 Gene

Genomics for SOGA1 Gene

Regulatory Elements for SOGA1 Gene

Enhancers for SOGA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G036808 1.5 Ensembl ENCODE dbSUPER 12.4 +54.5 54472 2.1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 GLIS2 ZNF143 DEK REST SOGA1 GC20P036795
GH20G036854 2 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +4.8 4804 11.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 SOGA1 NDRG3 DLGAP4-AS1 MANBAL GC20P036795
GH20G036822 1.2 Ensembl ENCODE dbSUPER 12.2 +41.0 40994 2.3 ZNF362 BHLHE40 TEAD4 HLF ZNF592 ZSCAN5C TRIM24 PRDM10 MYC MGA DSN1 SOGA1 NDRG3 GC20P036795
GH20G036825 0.9 ENCODE dbSUPER 12.3 +38.1 38054 0.2 BCOR CTCF MXI1 RFX1 NR3C1 EP300 ZNF664 ZNF335 ZKSCAN8 ZBTB33 DSN1 SOGA1 NDRG3 GC20P036795
GH20G036812 0.8 ENCODE dbSUPER 12.4 +50.4 50395 1.5 CEBPA SCRT2 CEBPG ZNF384 NR3C1 ZNF24 NR2F2 SOGA1 NDRG3 GC20P036795
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOGA1 on UCSC Golden Path with GeneCards custom track

Promoters for SOGA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136752 386 2601 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143

Genomic Location for SOGA1 Gene

Chromosome:
20
Start:
36,777,442 bp from pter
End:
36,863,686 bp from pter
Size:
86,245 bases
Orientation:
Minus strand

Genomic View for SOGA1 Gene

Genes around SOGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA1 Gene

Proteins for SOGA1 Gene

  • Protein details for SOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94964-SOGA1_HUMAN
    Recommended name:
    Protein SOGA1
    Protein Accession:
    O94964
    Secondary Accessions:
    • A6NK10
    • Q14DB2
    • Q5JW51
    • Q6ZTG8

    Protein attributes for SOGA1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159760 Da
    Quaternary structure:
    • The C-terminal 25 kDa form occurs as a monomer.
    SequenceCaution:
    • Sequence=BAA74912.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOGA1 Gene

Post-translational modifications for SOGA1 Gene

  • Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.
  • Ubiquitination at isoforms=2, 4809, Lys867, isoforms=2, 4878, and Lys886
  • Modification sites at PhosphoSitePlus

Other Protein References for SOGA1 Gene

No data available for DME Specific Peptides for SOGA1 Gene

Domains & Families for SOGA1 Gene

Protein Domains for SOGA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94964

UniProtKB/Swiss-Prot:

SOGA1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with SOGA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SOGA1 Gene

Function for SOGA1 Gene

Molecular function for SOGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the plasma by adiponectin in healthy fasting female.

Gene Ontology (GO) - Molecular Function for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SOGA1: view
genes like me logo Genes that share phenotypes with SOGA1: view

Animal Model Products

miRNA for SOGA1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOGA1 Gene

Localization for SOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA1 Gene

C-terminal 80 kDa form: Secreted. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOGA1 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 20813965
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SOGA1: view

Pathways & Interactions for SOGA1 Gene

SuperPathways for SOGA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway ISS 20813965
GO:0010506 regulation of autophagy ISS,IEA --
GO:0045721 negative regulation of gluconeogenesis ISS 20813965
genes like me logo Genes that share ontologies with SOGA1: view

No data available for Pathways by source and SIGNOR curated interactions for SOGA1 Gene

Transcripts for SOGA1 Gene

mRNA/cDNA for SOGA1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOGA1 Gene

Suppressor of glucose, autophagy associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA1 Gene

No ASD Table

Relevant External Links for SOGA1 Gene

GeneLoc Exon Structure for
SOGA1
ECgene alternative splicing isoforms for
SOGA1

Expression for SOGA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for SOGA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for SOGA1 Gene

This gene is overexpressed in Lung (33.1) and Adrenal (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOGA1 Gene



Protein tissue co-expression partners for SOGA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SOGA1 Gene:

SOGA1

SOURCE GeneReport for Unigene cluster for SOGA1 Gene:

Hs.460807

Evidence on tissue expression from TISSUES for SOGA1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with SOGA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOGA1 Gene

Orthologs for SOGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOGA1 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia SOGA1 34 35
  • 90.11 (n)
cow
(Bos Taurus)
Mammalia SOGA1 34 35
  • 88.9 (n)
rat
(Rattus norvegicus)
Mammalia Soga1 34
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Soga1 34 16 35
  • 87.28 (n)
oppossum
(Monodelphis domestica)
Mammalia SOGA1 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SOGA1 34 35
  • 76.03 (n)
lizard
(Anolis carolinensis)
Reptilia SOGA1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia soga1 34
  • 65.31 (n)
zebrafish
(Danio rerio)
Actinopterygii soga1 34 35
  • 57.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18304 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 35
  • 12 (a)
OneToMany
Species where no ortholog for SOGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOGA1 Gene

ENSEMBL:
Gene Tree for SOGA1 (if available)
TreeFam:
Gene Tree for SOGA1 (if available)

Paralogs for SOGA1 Gene

Paralogs for SOGA1 Gene

(3) SIMAP similar genes for SOGA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOGA1: view

Variants for SOGA1 Gene

Sequence variations from dbSNP and Humsavar for SOGA1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000012996 -- 36,781,112(+) CTATG(A/C)TTAAG intron-variant, utr-variant-3-prime
rs1000018826 -- 36,838,501(+) GAGGT(A/G)GGGGT intron-variant
rs1000079053 -- 36,786,076(+) GGTCA(A/G)CAGGA intron-variant, utr-variant-3-prime
rs1000126185 -- 36,799,469(+) TCTGG(A/G)CAACA intron-variant
rs1000130704 -- 36,854,638(+) GGGGA(C/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOGA1 Gene

Variant ID Type Subtype PubMed ID
dgv2247n106 CNV deletion 24896259
esv2722381 CNV deletion 23290073
esv2722382 CNV deletion 23290073
esv29717 CNV loss 19812545
esv3567957 CNV loss 25503493
esv3645741 CNV gain 21293372
esv3645742 CNV gain 21293372
esv3645744 CNV loss 21293372
esv3645745 CNV gain 21293372
nsv1057192 CNV loss 25217958
nsv1057845 CNV gain 25217958
nsv475979 CNV novel sequence insertion 20440878
nsv7341 OTHER inversion 18451855

Variation tolerance for SOGA1 Gene

Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOGA1 Gene

Disorders for SOGA1 Gene

Relevant External Links for SOGA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOGA1

No disorders were found for SOGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOGA1 Gene

Publications for SOGA1 Gene

  1. Adiponectin lowers glucose production by increasing SOGA. (PMID: 20813965) Cowerd R.B. … Combs T.P. (Am. J. Pathol. 2010) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64

Products for SOGA1 Gene

Sources for SOGA1 Gene

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