SOGA1 Gene
protein-coding GIFtS: 41
GCID: GC20M035407
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suppressor of glucose, autophagy associated 1(Previous names: chromosome 20 open reading frame 117, KIAA0889 )
(Previous symbols: C20orf117, KIAA0889)
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Aliases
for SOGA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Suppressor Of Glucose, Autophagy Associated 11 2 | | SOGA Family Member 12 3 | | C20orf1171 2 3 | | FLJ446701 | | KIAA08891 2 3 | | Chromosome 20 Open Reading Frame 1171 | | SOGA1 2 3 | | DJ132F21.11 | | Suppressor Of Glucose By Autophagy2 3 | | Protein SOGA12 | | Suppressor Of Glucose, Autophagy-Associated Protein 12 3 | | Suppressor Of Glucose From Autophagy2 |
Export aliases for SOGA1 gene to outside databases |
Summaries
for SOGA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SOGA1_HUMAN, O94964Function: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- andinsulin-dependent manner (By similarity)
Gene Wiki entry for SOGA1 (C20orf117)
|
Genomic Views
for SOGA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SOGA1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SOGA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOGA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23SOGA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M035407: view genomic region
(about GC identifiers)
Start:
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35,405,845 bp from pter |
End:
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35,492,089 bp from pter |
Size:
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86,245 bases |
Orientation:
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minus strand |
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Proteins
for SOGA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SOGA1_HUMAN, O94964 (See
protein sequence)Recommended Name: Protein SOGA1 Size: 1423 amino acids; 159760 Da
Subunit: The C-terminal 25 kDa form occurs as a monomer (By similarity)
Subcellular location: C-terminal 80 kDa form: Secreted (By similarity). Note=Secreted in primary hepatocyte-conditionedmedia (By similarity)
Sequence caution: Sequence=BAA74912.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NK10 Q14DB2 Q5JW51 Q6ZTG8Alternative splicing: 4 isoforms: O94964-1 O94964-2 O94964-3 O94964-4 (No experimental confirmation available. Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for SOGA1: NX_O94964
Post-translational modifications:
Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleavedinto a C-terminal SOGA 25 kDa form that is detected in plasma1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94964
SOGA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_542194.2 NP_954650.2
ENSEMBL proteins: ENSP00000237536 ENSP00000433939 ENSP00000279034 ENSP00000350424 ENSP00000413886
Human Recombinant Protein Products for SOGA1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IDA | -- |
SOGA1 for ontologies About GeneDecksing
SOGA1 Antibody Products:
Assay Products for SOGA1: |
Protein
Domains /
Families
for SOGA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SOGA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O94964ProtoNet protein and cluster: O94964 UniProtKB/Swiss-Prot: SOGA1_HUMAN, O94964Similarity: Belongs to the SOGA family |
Function
for SOGA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SOGA1_HUMAN, O94964Function: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- andinsulin-dependent manner (By similarity)Induction: Up-regulated in the plasma by adiponectin in healthy fasting femalePhenotypes:
3 GenomeRNAi human phenotypes for SOGA1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SOGA1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOGA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOGA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOGA1 |
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Pathways & Interactions
for SOGA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOGA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for SOGA1 (O949643 ENSP000002790344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010506 | regulation of autophagy |
ISS | -- |
SOGA1 for ontologies About GeneDecksing
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Drugs & Compounds
for SOGA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SOGA1
Search CenterWatch for drugs/clinical trials and news about SOGA1
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Transcripts
for SOGA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SOGA1 gene (3 alternative transcripts): NM_152257.1 NM_080627.2 NM_199181.2 Unigene Cluster for SOGA1: Suppressor of glucose, autophagy associated 1 Hs.460807 [show with all ESTs]Unigene Representative Sequence: NM_0806277 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000237536(uc021wcx.1) ENST00000489902 ENST00000465671 ENST00000463491
ENST00000279034(uc002xgd.1) ENST00000357779 ENST00000456801
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SOGA1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SOGA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOGA1 |
Additional cDNA sequence: AK094762.1 AK126630.1 AL833153.1 BC113405.1 BC113433.1 11 DOTS entries: DT.447504 DT.100018265 DT.91703933 DT.100740201 DT.65288417 DT.40109885 DT.86842817 DT.97795757 DT.97803215 DT.91944842 DT.97815663
GeneLoc Exon Structure
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Expression
for SOGA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SOGA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATAACTG
About this image
See SOGA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOGA1
SOURCE GeneReport for Unigene cluster: Hs.460807
SABiosciences Custom PCR Arrays for SOGA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOGA1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SOGA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOGA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOGA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOGA1 |
Orthologs
for SOGA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SOGA1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for SOGA1 (if available)
TreeFam Gene Tree for SOGA1 (if available) |
Paralogs
for SOGA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SOGA1 gene
- SOGA22 SOGA32
3 SIMAP similar genes for SOGA1 using alignment to 3 protein entries: SOGA1_HUMAN (see all proteins):C6orf174 SOGA3 SOGA2
SOGA1 for paralogs About GeneDecksing
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Genomic Variants
for SOGA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SOGA1 (35405845 - 35492089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SOGA1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOGA1 |
|
Disorders
/ Diseases
for SOGA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SOGA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SOGA1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SOGA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Adiponectin lowers glucose production by increasing SOGA. (PubMed id 20813965)1, 2, 3 Cowerd R.B.... Combs T.P. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
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External Searches for SOGA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SOGA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SOGA1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SOGA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SOGA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SOGA1 gene:
Search GeneIP for patents involving SOGA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SOGA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SOGA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOGA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOGA1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SOGA1 | | OriGene 3'-UTR Clone for SOGA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOGA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SOGA1 | | OriGene Custom Protein Services for SOGA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOGA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOGA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOGA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOGA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOGA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOGA1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SOGA1 |
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 | | | SOGA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOGA1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SOGA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOGA1 |
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