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Aliases for SOGA1 Gene

Aliases for SOGA1 Gene

  • Suppressor Of Glucose, Autophagy Associated 1 2 3
  • Suppressor Of Glucose By Autophagy 2 3 4
  • KIAA0889 2 3 4
  • Suppressor Of Glucose, Autophagy-Associated Protein 1 3 4
  • Suppressor Of Glucose From Autophagy 2 3
  • SOGA Family Member 1 3 4
  • C20orf117 3 4
  • SOGA 3 4
  • Chromosome 20 Open Reading Frame 117 2

External Ids for SOGA1 Gene

Previous HGNC Symbols for SOGA1 Gene

  • C20orf117
  • KIAA0889

Previous GeneCards Identifiers for SOGA1 Gene

  • GC20M035407

Summaries for SOGA1 Gene

GeneCards Summary for SOGA1 Gene

SOGA1 (Suppressor Of Glucose, Autophagy Associated 1) is a Protein Coding gene. An important paralog of this gene is SOGA3.

UniProtKB/Swiss-Prot for SOGA1 Gene

  • Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.

Gene Wiki entry for SOGA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOGA1 Gene

Genomics for SOGA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOGA1 Gene

Chromosome:
20
Start:
36,777,442 bp from pter
End:
36,863,686 bp from pter
Size:
86,245 bases
Orientation:
Minus strand

Genomic View for SOGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA1 Gene

No data available for Regulatory Elements for SOGA1 Gene

Proteins for SOGA1 Gene

  • Protein details for SOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94964-SOGA1_HUMAN
    Recommended name:
    Protein SOGA1
    Protein Accession:
    O94964
    Secondary Accessions:
    • A6NK10
    • Q14DB2
    • Q5JW51
    • Q6ZTG8

    Protein attributes for SOGA1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159760 Da
    Quaternary structure:
    • The C-terminal 25 kDa form occurs as a monomer.
    SequenceCaution:
    • Sequence=BAA74912.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOGA1 Gene

Proteomics data for SOGA1 Gene at MOPED

Post-translational modifications for SOGA1 Gene

  • Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.
  • Ubiquitination at Lys 809, Lys 867, Lys 878, and Lys 886
  • Modification sites at PhosphoSitePlus

Other Protein References for SOGA1 Gene

Antibody Products

No data available for DME Specific Peptides for SOGA1 Gene

Domains & Families for SOGA1 Gene

Protein Domains for SOGA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94964

UniProtKB/Swiss-Prot:

SOGA1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with SOGA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SOGA1 Gene

Function for SOGA1 Gene

Molecular function for SOGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the plasma by adiponectin in healthy fasting female.

Gene Ontology (GO) - Molecular Function for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SOGA1: view
genes like me logo Genes that share phenotypes with SOGA1: view

Animal Model Products

miRNA for SOGA1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOGA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SOGA1 Gene

Localization for SOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA1 Gene

C-terminal 80 kDa form: Secreted. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOGA1 Gene COMPARTMENTS Subcellular localization image for SOGA1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20813965
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SOGA1: view

Pathways & Interactions for SOGA1 Gene

SuperPathways for SOGA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway ISS 20813965
GO:0010506 regulation of autophagy ISS --
GO:0045721 negative regulation of gluconeogenesis ISS 20813965
genes like me logo Genes that share ontologies with SOGA1: view

No data available for Pathways by source and SIGNOR curated interactions for SOGA1 Gene

Drugs & Compounds for SOGA1 Gene

No Compound Related Data Available

Transcripts for SOGA1 Gene

mRNA/cDNA for SOGA1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOGA1 Gene

Suppressor of glucose, autophagy associated 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOGA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA1 Gene

No ASD Table

Relevant External Links for SOGA1 Gene

GeneLoc Exon Structure for
SOGA1
ECgene alternative splicing isoforms for
SOGA1

Expression for SOGA1 Gene

mRNA expression in normal human tissues for SOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for SOGA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for SOGA1 Gene

This gene is overexpressed in Lung (33.1) and Adrenal (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOGA1 Gene



SOURCE GeneReport for Unigene cluster for SOGA1 Gene Hs.460807

genes like me logo Genes that share expression patterns with SOGA1: view

Protein tissue co-expression partners for SOGA1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SOGA1 Gene

Orthologs for SOGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOGA1 35
  • 88.9 (n)
  • 92.13 (a)
SOGA1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOGA1 35
  • 90.11 (n)
  • 93.61 (a)
SOGA1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Soga1 35
  • 87.28 (n)
  • 91.89 (a)
Soga1 16
Soga1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOGA1 35
  • 99.32 (n)
  • 99.7 (a)
SOGA1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Soga1 35
  • 87.69 (n)
  • 92.35 (a)
oppossum
(Monodelphis domestica)
Mammalia SOGA1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SOGA1 35
  • 76.03 (n)
  • 73.22 (a)
SOGA1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOGA1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia soga1 35
  • 65.31 (n)
  • 64.69 (a)
zebrafish
(Danio rerio)
Actinopterygii soga1 35
  • 57.83 (n)
  • 53.98 (a)
soga1 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18304 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 36
  • 12 (a)
OneToMany
Species with no ortholog for SOGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOGA1 Gene

ENSEMBL:
Gene Tree for SOGA1 (if available)
TreeFam:
Gene Tree for SOGA1 (if available)

Paralogs for SOGA1 Gene

Paralogs for SOGA1 Gene

(3) SIMAP similar genes for SOGA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOGA1: view

Variants for SOGA1 Gene

Sequence variations from dbSNP and Humsavar for SOGA1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs61039880 -- 36,813,339(+) AAAAA(-/AAAAA)GGCAA intron-variant
rs61037412 -- 36,803,559(+) GACAC(C/T)GTGGA intron-variant
rs61036008 -- 36,810,750(+) TCTCT(-/CTCT)TTCAA intron-variant
rs61006290 -- 36,819,715(+) ATCCT(C/T)TGTGC intron-variant
rs60938678 -- 36,864,537(+) AAATT(A/C)GCCGG upstream-variant-2KB

Variation tolerance for SOGA1 Gene

Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOGA1 Gene

HapMap Linkage Disequilibrium report
SOGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SOGA1 Gene

Disorders for SOGA1 Gene

Relevant External Links for SOGA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOGA1
genes like me logo Genes that share disorders with SOGA1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOGA1 Gene

Publications for SOGA1 Gene

  1. Adiponectin lowers glucose production by increasing SOGA. (PMID: 20813965) Cowerd R.B. … Combs T.P. (Am. J. Pathol. 2010) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67
  5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai Y.C. … Cristea I.M. (Mol. Cell. Proteomics 2012) 67

Products for SOGA1 Gene

Sources for SOGA1 Gene

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