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Aliases for SOGA1 Gene

Aliases for SOGA1 Gene

  • Suppressor Of Glucose, Autophagy Associated 1 2 3 5
  • Suppressor Of Glucose By Autophagy 2 3 4
  • KIAA0889 2 3 4
  • Suppressor Of Glucose, Autophagy-Associated Protein 1 3 4
  • Suppressor Of Glucose From Autophagy 2 3
  • SOGA Family Member 1 3 4
  • C20orf117 3 4
  • SOGA 3 4
  • Chromosome 20 Open Reading Frame 117 2
  • Protein SOGA1 3

External Ids for SOGA1 Gene

Previous HGNC Symbols for SOGA1 Gene

  • C20orf117
  • KIAA0889

Previous GeneCards Identifiers for SOGA1 Gene

  • GC20M035407

Summaries for SOGA1 Gene

GeneCards Summary for SOGA1 Gene

SOGA1 (Suppressor Of Glucose, Autophagy Associated 1) is a Protein Coding gene. An important paralog of this gene is MTCL1.

UniProtKB/Swiss-Prot for SOGA1 Gene

  • Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.

Gene Wiki entry for SOGA1 Gene

Additional gene information for SOGA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOGA1 Gene

Genomics for SOGA1 Gene

GeneHancer (GH) Regulatory Elements for SOGA1 Gene

Promoters and enhancers for SOGA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I036854 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.8 +4.7 4733 11.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 ZNF207 SOGA1 RBL1 AAR2 RPN2 DSN1 NDRG3 DLGAP4-AS1 MANBAL GC20P036795
GH20I036864 Enhancer 0.9 ENCODE dbSUPER 550.8 -1.2 -1247 0.2 KLF1 PKNOX1 CEBPG ZFHX2 GLIS2 ZNF366 PATZ1 ADNP PRDM10 EGR2 SOGA1 RN7SL156P
GH20I036235 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.1 +627.1 627057 2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC AAR2 LOC105372602 SOGA1 CPNE1 RBM39 RBM12 ERGIC3 EIF6 RPL36P4 DSN1
GH20I035951 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.1 +909.8 909826 3.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 CNBD2 SCAND1 CPNE1 RBM12 RBM39 RPL36P4 SOGA1 TRPC4AP ERGIC3 DSN1
GH20I037042 Enhancer 1.1 Ensembl ENCODE 31.8 -180.2 -180224 2.1 HDGF PKNOX1 ZNF529 BMI1 BATF IRF4 ZNF121 ZNF213 ZNF354C ZNF138 TTI1 SOGA1 RBL1 AAR2 MANBAL DSN1 RPN2 MROH8 TLDC2 CTNNBL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOGA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SOGA1 Gene

Genomic Locations for SOGA1 Gene
chr20:36,777,442-36,863,686
(GRCh38/hg38)
Size:
86,245 bases
Orientation:
Minus strand
chr20:35,405,845-35,492,089
(GRCh37/hg19)

Genomic View for SOGA1 Gene

Genes around SOGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA1 Gene

Proteins for SOGA1 Gene

  • Protein details for SOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94964-SOGA1_HUMAN
    Recommended name:
    Protein SOGA1
    Protein Accession:
    O94964
    Secondary Accessions:
    • A6NK10
    • Q14DB2
    • Q5JW51
    • Q6ZTG8

    Protein attributes for SOGA1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159760 Da
    Quaternary structure:
    • The C-terminal 25 kDa form occurs as a monomer.
    SequenceCaution:
    • Sequence=BAA74912.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOGA1 Gene

Post-translational modifications for SOGA1 Gene

  • Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.
  • Ubiquitination at posLast=809809, posLast=867867, posLast=878878, and posLast=886886

Other Protein References for SOGA1 Gene

No data available for DME Specific Peptides for SOGA1 Gene

Domains & Families for SOGA1 Gene

Gene Families for SOGA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SOGA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94964

UniProtKB/Swiss-Prot:

SOGA1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with SOGA1: view

No data available for Suggested Antigen Peptide Sequences for SOGA1 Gene

Function for SOGA1 Gene

Molecular function for SOGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the plasma by adiponectin in healthy fasting female.

Phenotypes From GWAS Catalog for SOGA1 Gene

Gene Ontology (GO) - Molecular Function for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SOGA1: view
genes like me logo Genes that share phenotypes with SOGA1: view

miRNA for SOGA1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOGA1 Gene

Localization for SOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA1 Gene

C-terminal 80 kDa form: Secreted. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOGA1 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 20813965
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with SOGA1: view

Pathways & Interactions for SOGA1 Gene

SuperPathways for SOGA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway ISS 20813965
GO:0010506 regulation of autophagy ISS,IEA --
GO:0045721 negative regulation of gluconeogenesis ISS 20813965
genes like me logo Genes that share ontologies with SOGA1: view

No data available for Pathways by source and SIGNOR curated interactions for SOGA1 Gene

Drugs & Compounds for SOGA1 Gene

No Compound Related Data Available

Transcripts for SOGA1 Gene

mRNA/cDNA for SOGA1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOGA1 Gene

Suppressor of glucose, autophagy associated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA1 Gene

No ASD Table

Relevant External Links for SOGA1 Gene

GeneLoc Exon Structure for
SOGA1
ECgene alternative splicing isoforms for
SOGA1

Expression for SOGA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for SOGA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for SOGA1 Gene

This gene is overexpressed in Lung (33.1) and Adrenal (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOGA1 Gene



Protein tissue co-expression partners for SOGA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SOGA1 Gene:

SOGA1

SOURCE GeneReport for Unigene cluster for SOGA1 Gene:

Hs.460807

Evidence on tissue expression from TISSUES for SOGA1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with SOGA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOGA1 Gene

Orthologs for SOGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOGA1 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia SOGA1 33 34
  • 90.11 (n)
cow
(Bos Taurus)
Mammalia SOGA1 33 34
  • 88.9 (n)
rat
(Rattus norvegicus)
Mammalia Soga1 33
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Soga1 33 16 34
  • 87.28 (n)
oppossum
(Monodelphis domestica)
Mammalia SOGA1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SOGA1 33 34
  • 76.03 (n)
lizard
(Anolis carolinensis)
Reptilia SOGA1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia soga1 33
  • 65.31 (n)
zebrafish
(Danio rerio)
Actinopterygii soga1 33 34
  • 57.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18304 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 34
  • 12 (a)
OneToMany
Species where no ortholog for SOGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOGA1 Gene

ENSEMBL:
Gene Tree for SOGA1 (if available)
TreeFam:
Gene Tree for SOGA1 (if available)

Paralogs for SOGA1 Gene

Paralogs for SOGA1 Gene

(3) SIMAP similar genes for SOGA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOGA1: view

Variants for SOGA1 Gene

Sequence variations from dbSNP and Humsavar for SOGA1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000012996 -- 36,781,112(-) A/C 3_prime_UTR_variant, intron_variant
rs1000018826 -- 36,838,501(-) G/A intron_variant
rs1000079053 -- 36,786,076(-) G/A 3_prime_UTR_variant, intron_variant
rs1000126185 -- 36,799,469(-) G/A intron_variant
rs1000130704 -- 36,854,638(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SOGA1 Gene

Variant ID Type Subtype PubMed ID
dgv2247n106 CNV deletion 24896259
esv2722381 CNV deletion 23290073
esv2722382 CNV deletion 23290073
esv29717 CNV loss 19812545
esv3567957 CNV loss 25503493
esv3645741 CNV gain 21293372
esv3645742 CNV gain 21293372
esv3645744 CNV loss 21293372
esv3645745 CNV gain 21293372
nsv1057192 CNV loss 25217958
nsv1057845 CNV gain 25217958
nsv475979 CNV novel sequence insertion 20440878
nsv7341 OTHER inversion 18451855

Variation tolerance for SOGA1 Gene

Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOGA1 Gene

Disorders for SOGA1 Gene

Additional Disease Information for SOGA1

No disorders were found for SOGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOGA1 Gene

Publications for SOGA1 Gene

  1. Adiponectin lowers glucose production by increasing SOGA. (PMID: 20813965) Cowherd RB … Combs TP (The American journal of pathology 2010) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58

Products for SOGA1 Gene

Sources for SOGA1 Gene

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