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Aliases for SOGA1 Gene

Aliases for SOGA1 Gene

  • Suppressor Of Glucose, Autophagy Associated 1 2 3
  • Suppressor Of Glucose By Autophagy 2 3 4
  • KIAA0889 2 3 4
  • Suppressor Of Glucose, Autophagy-Associated Protein 1 3 4
  • Suppressor Of Glucose From Autophagy 2 3
  • SOGA Family Member 1 3 4
  • C20orf117 3 4
  • SOGA 3 4
  • Chromosome 20 Open Reading Frame 117 2
  • Protein SOGA1 3

External Ids for SOGA1 Gene

Previous Symbols for SOGA1 Gene

  • C20orf117
  • KIAA0889

Summaries for SOGA1 Gene

GeneCards Summary for SOGA1 Gene

SOGA1 (Suppressor Of Glucose, Autophagy Associated 1) is a Protein Coding gene. An important paralog of this gene is SOGA3.

UniProtKB/Swiss-Prot for SOGA1 Gene

  • Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.

Gene Wiki entry for SOGA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOGA1 Gene

Genomics for SOGA1 Gene

Genomic Location for SOGA1 Gene

Start:
36,777,442 bp from pter
End:
36,863,686 bp from pter
Size:
86,245 bases
Orientation:
Minus strand

Genomic View for SOGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA1 Gene

No data available for Regulatory Elements for SOGA1 Gene

Proteins for SOGA1 Gene

  • Protein details for SOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94964-SOGA1_HUMAN
    Recommended name:
    Protein SOGA1
    Protein Accession:
    O94964
    Secondary Accessions:
    • A6NK10
    • Q14DB2
    • Q5JW51
    • Q6ZTG8

    Protein attributes for SOGA1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159760 Da
    Quaternary structure:
    • The C-terminal 25 kDa form occurs as a monomer.
    SequenceCaution:
    • Sequence=BAA74912.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOGA1 Gene

Proteomics data for SOGA1 Gene at MOPED

Post-translational modifications for SOGA1 Gene

  • Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys809, Lys867, Lys878, and Lys886

Other Protein References for SOGA1 Gene

No data available for DME Specific Peptides for SOGA1 Gene

Domains for SOGA1 Gene

Protein Domains for SOGA1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SOGA1_HUMAN
Family:
  • Belongs to the SOGA family.:
    • O94964
genes like me logo Genes that share domains with SOGA1: view

No data available for Gene Families for SOGA1 Gene

Function for SOGA1 Gene

Molecular function for SOGA1 Gene

UniProtKB/Swiss-Prot Function: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
UniProtKB/Swiss-Prot Induction: Up-regulated in the plasma by adiponectin in healthy fasting female.

Gene Ontology (GO) - Molecular Function for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SOGA1: view

Phenotypes for SOGA1 Gene

genes like me logo Genes that share phenotypes with SOGA1: view

miRNA for SOGA1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SOGA1 Gene

Localization for SOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA1 Gene

C-terminal 80 kDa form: Secreted. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20813965
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SOGA1: view

Pathways for SOGA1 Gene

SuperPathways for SOGA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway ISS 20813965
GO:0010506 regulation of autophagy ISS --
GO:0045721 negative regulation of gluconeogenesis ISS 20813965
genes like me logo Genes that share ontologies with SOGA1: view

No data available for Pathways by source for SOGA1 Gene

Transcripts for SOGA1 Gene

mRNA/cDNA for SOGA1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOGA1 Gene

Suppressor of glucose, autophagy associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA1 Gene

No ASD Table

Relevant External Links for SOGA1 Gene

GeneLoc Exon Structure for
SOGA1
ECgene alternative splicing isoforms for
SOGA1

Expression for SOGA1 Gene

mRNA expression in normal human tissues for SOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for SOGA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.9) and Brain - Cerebellum (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOGA1 Gene

SOURCE GeneReport for Unigene cluster for SOGA1 Gene Hs.460807

genes like me logo Genes that share expressions with SOGA1: view

Orthologs for SOGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOGA1 36
  • 99.32 (n)
  • 99.7 (a)
SOGA1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOGA1 36
  • 88.9 (n)
  • 92.13 (a)
SOGA1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOGA1 36
  • 90.11 (n)
  • 93.61 (a)
SOGA1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Soga1 36
  • 87.28 (n)
  • 91.89 (a)
Soga1 16
Soga1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOGA1 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 27 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Soga1 36
  • 87.69 (n)
  • 92.35 (a)
chicken
(Gallus gallus)
Aves SOGA1 36
  • 76.03 (n)
  • 73.22 (a)
SOGA1 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOGA1 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia soga1 36
  • 65.31 (n)
  • 64.69 (a)
zebrafish
(Danio rerio)
Actinopterygii soga1 36
  • 57.83 (n)
  • 53.98 (a)
soga1 37
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18304 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 37
  • 12 (a)
OneToMany
Species with no ortholog for SOGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOGA1 Gene

ENSEMBL:
Gene Tree for SOGA1 (if available)
TreeFam:
Gene Tree for SOGA1 (if available)

Paralogs for SOGA1 Gene

Paralogs for SOGA1 Gene

Selected SIMAP similar genes for SOGA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOGA1: view

Variants for SOGA1 Gene

Sequence variations from dbSNP and Humsavar for SOGA1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs926907 -- 36,862,483(-) CCCCT(C/T)TCAAC intron-variant
rs1016118 -- 36,850,837(+) tgaat(C/G)ataaa intron-variant
rs1016119 -- 36,849,949(+) GACAC(A/G)GAGAG intron-variant
rs1128743 -- 36,778,628(-) TCACC(C/T)CAAGA intron-variant
rs1128745 -- 36,778,627(-) CACCC(C/T)AAGAC intron-variant

Relevant External Links for SOGA1 Gene

HapMap Linkage Disequilibrium report
SOGA1

No data available for Structural Variations from Database of Genomic Variants (DGV) for SOGA1 Gene

Disorders for SOGA1 Gene

No disorders were found for SOGA1 Gene.

No data available for UniProtKB/Swiss-Prot for SOGA1 Gene

Publications for SOGA1 Gene

  1. Adiponectin lowers glucose production by increasing SOGA. (PMID: 20813965) Cowerd R.B. … Combs T.P. (Am. J. Pathol. 2010) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SOGA1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SOGA1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SOGA1
    • Block miRNA regulation of SOGA1 using miScript Target Protectors

    Sources for SOGA1 Gene

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